SHINICHI NISHIMURA

Last Updated :2024/07/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
https://mbrc.hiroshima-u.ac.jp/
E-mail
nshinhiroshima-u.ac.jp
Self-introduction
Organisms produce huge variety of metabolites, some of which are secreted out of cells. They sometimes act as antibiotics to secure the niche. Others may play roles in adapting to harsh conditions. We're exploring novel metabolites with unexpected biological activities, from microbes and marine organisms.

Basic Information

Major Professional Backgrounds

  • 2023/01, Hiroshima University , Graduate School of Integrated Sciences for Life, Professor
  • 2018/03, 2022/12, The University of Tokyo, Graduate School of Agricultural and Life Sciences, Lecturer
  • 2016/08, 2017/08, Scripps Institution of Oceanography, Visiting Scholar
  • 2009/04, 2018/02, Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor
  • 2007/10, 2009/03, Kyoto University, Graduate School of Pharmaceutical Sciences, Postdoctoral researcher
  • 2004/10, 2007/09, Chemical Genetics Laboratory, RIKEN
  • 2004/04, 2004/09, Chemical Genetics Laboratory, RIKEN

Educational Backgrounds

  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Japan, 2001/04, 2004/03
  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Japan, 1999/04, 2001/03
  • The University of Tokyo, Faculty of Agriculture, Japan, 1995/04, 1999/03

Academic Degrees

  • MSc, The University of Tokyo
  • PhD, The University of Tokyo

Research Fields

  • Agricultural sciences;Agricultural chemistry;Bioorganic chemistry

Research Keywords

  • Natural products chemistry, chemical biology, microbiology.

Affiliated Academic Societies

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
    Related URL
  • Yeast Genetics Society of Japan
  • Japan Society for Chemical Biology

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 3Term, Organic Chemistry
  2. 2024, Undergraduate Education, 4Term, Research Front of Food and AgriLife Science
  3. 2024, Undergraduate Education, 4Term, Seafood Chemistry and Biochemistry
  4. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
  5. 2024, Undergraduate Education, First Semester, Graduation Thesis II
  6. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
  7. 2024, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  8. 2024, Undergraduate Education, Intensive, Laboratory Work in Marine Bioresources Chemistry
  9. 2024, Undergraduate Education, Intensive, Training for Marine Food Processing
  10. 2024, Undergraduate Education, First Semester, Graduate Thesis I
  11. 2024, Undergraduate Education, Second Semester, Graduate Thesis II
  12. 2024, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  13. 2024, Undergraduate Education, 3Term, Modern Food Science
  14. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  15. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  16. 2024, Graduate Education (Master's Program) , 2Term, Bioactive Natural Products Chemistry I
  17. 2024, Graduate Education (Master's Program) , 4Term, Bioactive Natural Products Chemistry II

Research Activities

Academic Papers

  1. Protocol for detecting threonine deaminase activity in fission yeast cell lysates, STAR PROTOCOLS, 4(4), 20231215
    Link to Paper Search Results by DOI
  2. A set of vectors and strains for chromosomal integration in fission yeast, Sci Rep, 13(1), 9295, 20230608
  3. FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast., iScience, 25(12), 105659, 20221124
  4. Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast., Sci Rep, 12(1), 17411, 20221027
  5. Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium., Nat Chem, 14(10), 1193-1201, 202210
  6. Differential Biosynthesis and Roles of Two Ferrichrome-Type Siderophores, ASP2397/AS2488053 and Ferricrocin, in Acremonium persicinum., ACS Chem Biol, 17(1), 207-216, 20220121

Invited Lecture, Oral Presentation, Poster Presentation

  1. Omics analyses of the cell membrane using marine natural products, Nishimura, S., Gordon Research Conference -Marine Natural Products-, 2024/03, With Invitation
  2. Lipotoxicity induced by pentadecanoic acid in the fission yeast Schizosaccharomyces pombe., Hoshikawa, Y., Shirota, N., Matsuyama, A., Kimura, S., Li, S., Yashiroda, Y., Boone, C., Tsugawa, H., Arita, M., Yoshida, M., Nishimura, S., Gordon Research Conference -Marine Natural Products-, 2024/03
  3. ASP2397 and synthetic analogues induce abnormal acceleration of retrograde pathway in the endosome., Hiratsuka, T., Hashizume, Y., Chibana, H., Umeyama, T., Nishimura, S., & Yoshida, M., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  4. Exogenous pentadecanoic acid perturbs the membrane lipid profile to generate the giant endoplasmic reticulum sheet., Hoshikawa, Y., Matsuyama, A., Li, S., Yashiroda, Y., Boone, C., Tsugawa, H., Arita, M., Yoshida, M., & Nishimura, S., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  5. Activation of Cdc42 and accumulation of Bgs proteins at growing tips by theonellamides, marine-derived antifungals., Nishimura, S., Nakao, K., Suganaga, A., Hiratsuka, T., Yashiroda, Y., Matsuyama, A., & Yoshida, M., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  6. Genome-wide screen identifies glutathione as a putative communication molecule in Schizosaccharomyces pombe., Yoshizumi, R., Miura, S., Matsuyama, A., Yashiroda, Y., Yoshida, M., & Nishimura, S., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  7. How do S. pombe cells produce and perceive the cell-cell communication molecules Nitrogen Signaling Factors (NSFs)?, Yashiroda, Y., Li, H., Hirai, G., Usui, M., Ohsawa, S., Nishimura, S., & Yoshida, M., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05