SHINICHI NISHIMURA

Last Updated :2026/04/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
https://mbrc.hiroshima-u.ac.jp/
E-mail
nshinhiroshima-u.ac.jp
Self-introduction
Organisms produce huge variety of metabolites, some of which are secreted out of cells. They sometimes act as antibiotics to secure the niche. Others may play roles in adapting to harsh conditions. We're exploring novel metabolites with unexpected biological activities, from microbes and marine organisms.

Basic Information

Major Professional Backgrounds

  • 2023/01, Hiroshima University , Graduate School of Integrated Sciences for Life, Professor
  • 2018/03, 2022/12, The University of Tokyo, Graduate School of Agricultural and Life Sciences, Lecturer
  • 2016/08, 2017/08, Scripps Institution of Oceanography, Visiting Scholar
  • 2009/04, 2018/02, Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor
  • 2007/10, 2009/03, Kyoto University, Graduate School of Pharmaceutical Sciences, Postdoctoral researcher
  • 2004/10, 2007/09, Chemical Genetics Laboratory, RIKEN
  • 2004/04, 2004/09, Chemical Genetics Laboratory, RIKEN

Educational Backgrounds

  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Japan, 2001/04, 2004/03
  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Japan, 1999/04, 2001/03
  • The University of Tokyo, Faculty of Agriculture, Japan, 1995/04, 1999/03

Academic Degrees

  • MSc, The University of Tokyo
  • PhD, The University of Tokyo

Research Fields

  • Agricultural sciences;Agricultural chemistry;Bioorganic chemistry

Research Keywords

  • Natural products chemistry, chemical biology, microbiology.

Affiliated Academic Societies

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
    Related URL
  • Yeast Genetics Society of Japan
  • Japan Society for Chemical Biology

Educational Activity

Course in Charge

  1. 2026, Liberal Arts Education Program1, 3Term, Organic Chemistry
  2. 2026, Liberal Arts Education Program1, 1Term, Introduction to Applied Biological Sciences toward SDGs
  3. 2026, Liberal Arts Education Program1, 3Term, Food safety and health science
  4. 2026, Undergraduate Education, 1Term, Introduction to Applied Biological Sciences
  5. 2026, Undergraduate Education, 4Term, Ethics of Science and Technology
  6. 2026, Undergraduate Education, 1Term, Laboratory Work in General Chemistry
  7. 2026, Undergraduate Education, 4Term, Seafood Chemistry and Biochemistry
  8. 2026, Undergraduate Education, Second Semester, Graduation Thesis I
  9. 2026, Undergraduate Education, First Semester, Graduation Thesis II
  10. 2026, Undergraduate Education, Second Semester, Graduation Thesis III
  11. 2026, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  12. 2026, Undergraduate Education, Intensive, Laboratory Work in Marine Bioresources Chemistry
  13. 2026, Undergraduate Education, Intensive, Training for Marine Food Processing
  14. 2026, Undergraduate Education, Intensive, Internship I
  15. 2026, Undergraduate Education, Intensive, Internship II
  16. 2026, Undergraduate Education, Intensive, Seminar in Fieldwork on Forest Ecosystems
  17. 2026, Undergraduate Education, Intensive, Seminar in Fildwork on Fruit Growing
  18. 2026, Undergraduate Education, Intensive, Practice in Livestock Farming
  19. 2026, Undergraduate Education, Intensive, Practice and seminar in forest field science
  20. 2026, Undergraduate Education, Intensive, Field Seminar of Forest, Satoyama and Marine Science
  21. 2026, Undergraduate Education, Intensive, Field Practice in Crop Production Sciences
  22. 2026, Undergraduate Education, Intensive, Practical training in fieldwork on food resources
  23. 2026, Undergraduate Education, Intensive, Field Practice on Hillside Farming
  24. 2026, Undergraduate Education, Intensive, Regional Agropolitics
  25. 2026, Undergraduate Education, Year, Special Practice I
  26. 2026, Undergraduate Education, Year, Practical Course in Marine Bioscience and Technology IV
  27. 2026, Undergraduate Education, Year, Practice on East China Sea Study
  28. 2026, Undergraduate Education, Year, Practical Course on Fisheries Science and the Marine Environment I-B
  29. 2026, Undergraduate Education, Year, Practice Course on Fisheries Science and the Marine Environment III
  30. 2026, Undergraduate Education, Year, Practical Course in Marine Bioscience and Technology I
  31. 2026, Undergraduate Education, Year, Practical Course in Marine Bioscience and Technology II
  32. 2026, Undergraduate Education, Intensive, Practice Course on Fisheries Science Data Analysis I
  33. 2026, Undergraduate Education, Intensive, Practice Course on Fisheries Science Data Analysis II
  34. 2026, Undergraduate Education, Intensive, Overseas Exercise of Applied Biological Science I
  35. 2026, Undergraduate Education, 1Term, Plant Breeding
  36. 2026, Undergraduate Education, Second Semester, Plant Pathology
  37. 2026, Undergraduate Education, First Semester, Graduate Thesis I
  38. 2026, Undergraduate Education, Second Semester, Graduate Thesis II
  39. 2026, Undergraduate Education, First Semester, Graduate Thesis III
  40. 2026, Undergraduate Education, Second Semester, Graduate Thesis IV
  41. 2026, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  42. 2026, Undergraduate Education, Intensive, Modern Food Science
  43. 2026, Undergraduate Education, Intensive, Independent study of International issues and challenge
  44. 2026, Undergraduate Education, Intensive, International Applied Biological Sciences I
  45. 2026, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
  46. 2026, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  47. 2026, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  48. 2026, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  49. 2026, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  50. 2026, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  51. 2026, Graduate Education (Master's Program) , 2Term, Bioactive Natural Products Chemistry I
  52. 2026, Graduate Education (Master's Program) , 4Term, Bioactive Natural Products Chemistry II

Research Activities

Academic Papers

  1. ★, Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast, PNAS, 122, e2422126122, 20250527
    Link to Paper Search Results by DOI
  2. A new pyranonaphthoquinone metabolite, actinoquinonal A, and its congeners from the combined-culture of Streptomyces sp. 23-50 and Tsukamurella pulmonis TP-B0596., J. Antibiot., 78, 350-358, 20250422
    Link to Paper Search Results by DOI
  3. Protocol for detecting threonine deaminase activity in fission yeast cell lysates, STAR PROTOCOLS, 4(4), 20231215
    Link to Paper Search Results by DOI
  4. A set of vectors and strains for chromosomal integration in fission yeast, Sci Rep, 13(1), 9295, 20230608
  5. FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast., iScience, 25(12), 105659, 20221124
  6. Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast., Sci Rep, 12(1), 17411, 20221027
  7. Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium., Nat Chem, 14(10), 1193-1201, 202210
  8. Differential Biosynthesis and Roles of Two Ferrichrome-Type Siderophores, ASP2397/AS2488053 and Ferricrocin, in Acremonium persicinum., ACS Chem Biol, 17(1), 207-216, 20220121

Invited Lecture, Oral Presentation, Poster Presentation

  1. Discovery of a new pyranonaphthoquinone, actinoquinonal A: Combined-culture of Streptomyces sp. 23-50 with Tsukamurella pulmonis TP-B0596 triggers a shunt of the mevalonate pathway of Streptomyces sp. 23-50., Yanagisawa, K., Kaneko, K., Ikeda, H., Iwata, S., Muranaka, A., Koshino, H., Nagao, N., Watari, S., Nishimura, S., Shinzato, N., Onaka, H., Kakeya, H., The 5th Intenational Conference on Natural Product Discovery and Development in the Genomic Era., 2025/01, San Diego, CA, USA
  2. Omics analyses of the cell membrane using marine natural products, Nishimura, S., Gordon Research Conference -Marine Natural Products-, 2024/03, With Invitation
  3. Lipotoxicity induced by pentadecanoic acid in the fission yeast Schizosaccharomyces pombe, Hoshikawa, Y., Shirota, N., Matsuyama, A., Kimura, S., Li, S., Yashiroda, Y., Boone, C., Tsugawa, H., Arita, M., Yoshida, M., Nishimura, S., Gordon Research Conference -Marine Natural Products-, 2024/03
  4. ASP2397 and synthetic analogues induce abnormal acceleration of retrograde pathway in the endosome., Hiratsuka, T., Hashizume, Y., Chibana, H., Umeyama, T., Nishimura, S., & Yoshida, M., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  5. Exogenous pentadecanoic acid perturbs the membrane lipid profile to generate the giant endoplasmic reticulum sheet, Hoshikawa, Y., Matsuyama, A., Li, S., Yashiroda, Y., Boone, C., Tsugawa, H., Arita, M., Yoshida, M., & Nishimura, S., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  6. Activation of Cdc42 and accumulation of Bgs proteins at growing tips by theonellamides, marine-derived antifungals, Nishimura, S., Nakao, K., Suganaga, A., Hiratsuka, T., Yashiroda, Y., Matsuyama, A., & Yoshida, M., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  7. Genome-wide screen identifies glutathione as a putative communication molecule in Schizosaccharomyces pombe, Yoshizumi, R., Miura, S., Matsuyama, A., Yashiroda, Y., Yoshida, M., & Nishimura, S., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05
  8. How do S. pombe cells produce and perceive the cell-cell communication molecules Nitrogen Signaling Factors (NSFs)?, Yashiroda, Y., Li, H., Hirai, G., Usui, M., Ohsawa, S., Nishimura, S., & Yoshida, M., The 11th International Fission Yeast Meeting (Pombe2023), 2023/05