YOSHINARI YAMAMOTO

Last Updated :2024/06/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
yamamo59hiroshima-u.ac.jp
Self-introduction
Based on immunology, we are exploring the bioregulatory effects of foods and microorganisms. Utilizing the results, we aim to develop the novel functional foods that prevent immune diseases.

Basic Information

Major Professional Backgrounds

  • 2016/04, 2018/03, Japan Society for the Promotion of Science
  • 2018/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor

Educational Backgrounds

  • Shinshu University, Japan, 2015/04, 2018/03
  • Shinshu University, Japan, 2013/04, 2015/03
  • Shinshu University, Japan, 2009/04, 2013/03

Academic Degrees

  • Shinshu University
  • Shinshu University

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Food Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science Program

Research Fields

  • Agricultural sciences;Animal life science;Integrative animal science
  • Agricultural sciences;Agricultural chemistry;Food science
  • Biology;Biological Science;Molecular biology

Research Keywords

  • Oligodeoxynucleotide
  • Lactic acid bacteria
  • Maternal immunity
  • Functional food
  • sepsis
  • neonatal disease
  • Allergy
  • mouse

Affiliated Academic Societies

  • Japan Society for Lactic Acid Bacteria
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japanese Society of Animal Science
  • Japanese Association for Food Immunology
  • Japanese Dairy Science Association
  • Japan Society of Nutrition and Food Science

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 3Term, Food safety and health science
  2. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  3. 2024, Undergraduate Education, Intensive, Laboratory Work in General Physics
  4. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
  5. 2024, Undergraduate Education, First Semester, Graduation Thesis II
  6. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
  7. 2024, Undergraduate Education, Intensive, Laboratory Work in Food Chemistry
  8. 2024, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  9. 2024, Undergraduate Education, 1Term, Food Function (Functional Food Science)
  10. 2024, Undergraduate Education, Intensive, Training for Animal Food Processing
  11. 2024, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  12. 2024, Undergraduate Education, 3Term, Modern Food Science
  13. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  14. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  15. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  16. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  17. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science

Research Activities

Academic Papers

  1. Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages., Animal science journal = Nihon chikusan Gakkaiho, 89(12), 2018
  2. Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-α production and induction of M2-type macrophages in colitic mice., Nutrition research (New York, N.Y.), 64, 2019
  3. Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice., Frontiers in immunology, 11, 2020
  4. Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production., Bioscience, biotechnology, and biochemistry, 84(11), 2020
  5. Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model., Foods (Basel, Switzerland), 10(2), 2021
  6. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes., Bioscience, biotechnology, and biochemistry, 85(7), 2021
  7. Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells., Archives of biochemistry and biophysics, 707, 2021
  8. Propionate and Dietary Fermentable Fibers Upregulate Intestinal Heat Shock protein70 in Intestinal Caco-2 Cells and Mouse Colon., Journal of agricultural and food chemistry, 69(30), 2021
  9. 3,5,7,3',4'-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells., Journal of agricultural and food chemistry, 69(35), 2021
  10. Ammonia impairs tight junction barriers by inducing mitochondrial dysfunction in Caco-2 cells., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(11), 2021
  11. Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest., Archives of biochemistry and biophysics, 712, 2021
  12. N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 736, 20230301
  13. Lentilactobacillus hilgardii H-50 strongly inhibits lipopolysaccharide-induced inflammatory responses in mouse splenocytes via its specific surface layer proteins, JOURNAL OF APPLIED MICROBIOLOGY, 134(3), 20230301
  14. Screening of Optimal CpG-Oligodeoxynucleotide for Anti-Inflammatory Responses in the Avian Macrophage Cell Line HD11, JOURNAL OF POULTRY SCIENCE, 60(1), 202301
  15. Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2020
  16. Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice, FRONTIERS IN IMMUNOLOGY, 11, 2020
  17. Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-α production and induction of M2-type macrophages in colitic mice., Nutrition research (New York, N.Y.), 64, 2019
  18. Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier, JOURNAL OF FUNCTIONAL FOODS, 52, 276-283, 201901
  19. Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages., Animal science journal = Nihon chikusan Gakkaiho, 2018
  20. Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells., Current microbiology, 75(1), 2018
  21. Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components., Animal science journal = Nihon chikusan Gakkaiho, 89(10), 2018
  22. Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis., Applied microbiology and biotechnology, 101(1), 2017
  23. Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production., BMC immunology, 18(1), 2017
  24. ★, Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase., Frontiers in immunology, 8, 2017
  25. Genetically modified Lactococcus lactis producing a green fluorescent protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells., Journal of Dairy Science
  26. ★, Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus., Animal science journal = Nihon chikusan Gakkaiho, 87(5), 2016
  27. Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice., Microbial cell factories, 14, 2015
  28. ★, Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice., Molecular therapy : the journal of the American Society of Gene Therapy, 23(2), 2015
  29. Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis., BioMed research international, 2014, 2014
  30. Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model, FOODS, 10(2), 202102
  31. Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 707, 20210815
  32. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 85(7), 1753-1758, 20210624
  33. Propionate and Dietary Fermentable Fibers Upregulate Intestinal Heat Shock protein70 in Intestinal Caco-2 Cells and Mouse Colon, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69(30), 8460-8470, 20210804
  34. 5,7-Dimethoxyflavone enhances barrier function by increasing occludin and reducing claudin-2 in human intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 85, 202110
  35. 3,5,7,3 ',4 '-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69(35), 10174-10183, 20210908
  36. Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 712, 20211115
  37. Ammonia impairs tight junction barriers by inducing mitochondrial dysfunction in Caco-2 cells, FASEB JOURNAL, 35(11), 202111
  38. Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice, JOURNAL OF APPLIED MICROBIOLOGY, 131(6), 3043-3055, 202112

Invited Lecture, Oral Presentation, Poster Presentation

  1. Screening of hiochi bacteria that exert anti-allergic effects, Fan Rong, Suzuki Takuya, Yoshinari Yamamoto, 2023/09/01, Without Invitation, English
  2. Lentilactobacillus hilgardii H-50 strain exerts anti-inflammatory potential via binding to lipopolysaccharide, Yoshinari Yamamoto, Tomofumi Yamaguchi, Kenta Yasui, The 12th Asian conference on lactic acid bacteria, 2022/10/11, Without Invitation, English
  3. Conformational difference between two types of biologically active oligodeoxynucleotides, Koji Umezawa, Yoshinari Yamamoto, Takeshi Shimosato, Tomohide Takaya, 2019/07/10, Without Invitation, Japanese
  4. Inhibitory effect of Th2 immune response by oral administration of Flavonifractor plautii, 2019/03/25, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2021, 2022
  2. KAKENHI(Grant-in-Aid for Research Activity Start-up), 2018, 2019

Social Activities

History as Peer Reviews of Academic Papers

  1. 2019, Bioscience, Biotechnology, and Biochemistry, Others, 1