YOSHINARI YAMAMOTO

Last Updated :2025/06/16

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
yamamo59hiroshima-u.ac.jp
Self-introduction
Based on immunology, we are exploring the bioregulatory effects of foods and microorganisms. Utilizing the results, we aim to develop the novel functional foods that prevent immune diseases.

Basic Information

Major Professional Backgrounds

  • 2016/04, 2018/03, Japan Society for the Promotion of Science
  • 2018/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor

Educational Backgrounds

  • Shinshu University, Japan, 2015/04, 2018/03
  • Shinshu University, Japan, 2013/04, 2015/03
  • Shinshu University, Japan, 2009/04, 2013/03

Academic Degrees

  • Shinshu University
  • Shinshu University

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Food Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science Program

Research Fields

  • Agricultural sciences;Animal life science;Integrative animal science
  • Agricultural sciences;Agricultural chemistry;Food science
  • Biology;Biological Science;Molecular biology

Research Keywords

  • Oligodeoxynucleotide
  • Lactic acid bacteria
  • Maternal immunity
  • Functional food
  • sepsis
  • neonatal disease
  • Allergy
  • mouse

Affiliated Academic Societies

  • Japan Society for Lactic Acid Bacteria
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japanese Society of Animal Science
  • Japanese Association for Food Immunology
  • Japanese Dairy Science Association
  • Japan Society of Nutrition and Food Science

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 3Term, Food safety and health science
  2. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  3. 2025, Undergraduate Education, Intensive, Laboratory Work in General Physics
  4. 2025, Undergraduate Education, 4Term, Research Front of Food and AgriLife Science
  5. 2025, Undergraduate Education, Second Semester, Graduation Thesis I
  6. 2025, Undergraduate Education, First Semester, Graduation Thesis II
  7. 2025, Undergraduate Education, Second Semester, Graduation Thesis III
  8. 2025, Undergraduate Education, Intensive, Laboratory Work in Food Chemistry
  9. 2025, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  10. 2025, Undergraduate Education, 1Term, Food Function (Functional Food Science)
  11. 2025, Undergraduate Education, Intensive, Training for Animal Food Processing
  12. 2025, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  13. 2025, Undergraduate Education, Intensive, Modern Food Science
  14. 2025, Undergraduate Education, Intensive, (AIMS) Molecular-Level Understanding of Functionality of Foods
  15. 2025, Undergraduate Education, Intensive, Molecular-Level Understanding of Functionality of Foods
  16. 2025, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  17. 2025, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  18. 2025, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  19. 2025, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  20. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Food andAgriLife Science

Research Activities

Academic Papers

  1. Xylobiose treatment strengthens intestinal barrier function by regulating claudin 2 and heat shock protein 27 expression in human Caco-2 cells, JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 104(4), 2518-2525, 20240315
    Link to Paper Search Results by DOI
  2. Microbial metabolite n-butyrate upregulates intestinal claudin-23 expression through SP1 and AMPK pathways in mouse colon and human intestinal Caco-2 cells, LIFE SCIENCES, 329, 20230915
    Link to Paper Search Results by DOI
  3. Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages., Animal science journal = Nihon chikusan Gakkaiho, 89(12), 2018
  4. Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-α production and induction of M2-type macrophages in colitic mice., Nutrition research (New York, N.Y.), 64, 2019
  5. Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice., Frontiers in immunology, 11, 2020
  6. Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production., Bioscience, biotechnology, and biochemistry, 84(11), 2020
  7. Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model., Foods (Basel, Switzerland), 10(2), 2021
  8. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes., Bioscience, biotechnology, and biochemistry, 85(7), 2021
  9. Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells., Archives of biochemistry and biophysics, 707, 2021
  10. Propionate and Dietary Fermentable Fibers Upregulate Intestinal Heat Shock protein70 in Intestinal Caco-2 Cells and Mouse Colon., Journal of agricultural and food chemistry, 69(30), 2021
  11. 3,5,7,3',4'-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells., Journal of agricultural and food chemistry, 69(35), 2021
  12. Ammonia impairs tight junction barriers by inducing mitochondrial dysfunction in Caco-2 cells., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(11), 2021
  13. Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest., Archives of biochemistry and biophysics, 712, 2021
  14. Propionate regulates tight junction barrier by increasing endothelial-cell selective adhesion molecule in human intestinal Caco-2 cells, EXPERIMENTAL CELL RESEARCH, 425(2), 20230415
    Link to Paper Search Results by DOI
  15. Partially hydrolyzed guar gum upregulates heat shock protein 27 in intestinal Caco-2 cells and mouse intestine via mTOR and ERK signaling, JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103(10), 5165-5170, 20230815
    Link to Paper Search Results by DOI
  16. N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 736, 20230301
    Link to Paper Search Results by DOI
  17. Lentilactobacillus hilgardii H-50 strongly inhibits lipopolysaccharide-induced inflammatory responses in mouse splenocytes via its specific surface layer proteins, JOURNAL OF APPLIED MICROBIOLOGY, 134(3), 20230301
    Link to Paper Search Results by DOI
  18. Screening of Optimal CpG-Oligodeoxynucleotide for Anti-Inflammatory Responses in the Avian Macrophage Cell Line HD11, JOURNAL OF POULTRY SCIENCE, 60(1), 202301
    Link to Paper Search Results by DOI
  19. Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier, JOURNAL OF FUNCTIONAL FOODS, 52, 276-283, 201901
    Link to Paper Search Results by DOI
  20. Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells., Current microbiology, 75(1), 2018
  21. Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components., Animal science journal = Nihon chikusan Gakkaiho, 89(10), 2018
  22. Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis., Applied microbiology and biotechnology, 101(1), 2017
  23. Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production., BMC immunology, 18(1), 2017
  24. ★, Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase., Frontiers in immunology, 8, 2017
  25. Genetically modified Lactococcus lactis producing a green fluorescent protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells., Journal of Dairy Science
  26. ★, Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus., Animal science journal = Nihon chikusan Gakkaiho, 87(5), 2016
  27. Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice., Microbial cell factories, 14, 2015
  28. ★, Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice., Molecular therapy : the journal of the American Society of Gene Therapy, 23(2), 2015
  29. Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis., BioMed research international, 2014, 2014
  30. 5,7-Dimethoxyflavone enhances barrier function by increasing occludin and reducing claudin-2 in human intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 85, 202110
    Link to Paper Search Results by DOI
  31. Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice, JOURNAL OF APPLIED MICROBIOLOGY, 131(6), 3043-3055, 202112
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Enhancement of IgA production from mouse peyer's patches cells by acetic acid bacteria, Sokleap. Heng, Rina. Kanazawa, Takuya. Suzuki and Yoshinari. Yamamoto, AAAP and AAAS Animal Production Congress 2024, 2024/07/12, Without Invitation, English
  2. The preventive effects of Lentilactobacillus hilgardii H-50 strain that binds to lipopolysaccharide on dextran sulfate sodium-induced acute colitis in mice, Rina Kanazawa, Sokleap Heng, Takuya Suzuki, Yoshinari Yamamoto, AAAP and AAAS Animal Production Congress 2024, 2024/07/12, Without Invitation, English
  3. Screening of hiochi bacteria that exert anti-allergic effects, Fan Rong, Suzuki Takuya, Yoshinari Yamamoto, 2023/09/01, Without Invitation, English
  4. Lentilactobacillus hilgardii H-50 strain exerts anti-inflammatory potential via binding to lipopolysaccharide, Yoshinari Yamamoto, Tomofumi Yamaguchi, Kenta Yasui, The 12th Asian conference on lactic acid bacteria, 2022/10/11, Without Invitation, English
  5. Conformational difference between two types of biologically active oligodeoxynucleotides, Koji Umezawa, Yoshinari Yamamoto, Takeshi Shimosato, Tomohide Takaya, 2019/07/10, Without Invitation, Japanese
  6. Inhibitory effect of Th2 immune response by oral administration of Flavonifractor plautii, 2019/03/25, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2024/04/01, 2025/03/31
  2. 2024/04/01, 2026/03/31
  3. 2024/04/01, 2028/03/31
  4. 2023/04/01, 2025/03/31
  5. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2021/04/01, 2023/03/31
  6. KAKENHI(Grant-in-Aid for Research Activity Start-up), 2018/10/01, 2020/03/31

Social Activities

History as Peer Reviews of Academic Papers

  1. 2024, Bioscience of Microbiota, Food and Health, Others, 1
  2. 2023, Bioscience of Microbiota, Food and Health, Others, 1
  3. 2019, Bioscience, Biotechnology, and Biochemistry, Others, 1