広島大学

Basic Information

Major Professional Backgrounds

• 2011/10, 2015/06, Weill Cornell Medical Colledge, Burke Medical Resarch Institutte, Post doctoral Fellow
• 2015/08, 2018/07, National Institute for Basic Biology, National Institutes of Natural Sciences, NIBB Research Fellow
• 2018/08, 2020/02, National Institute for Basic Biology, National Institutes of Natural Sciences, Researcher
• 2020/03, 2021/03, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
• 2021/04, 2021/09, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor (Special Appointment)
• 2021/10/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor

Educational Backgrounds

• Osaka University, Japan, 2005/04, 2011/03
• Kansai University, School of Engineering , Japan, 2001/04, 2005/03

Academic Degrees

• Osaka University
• Osaka University

Educational Activity

• [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
• [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
• [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
• [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Keywords

• Nuclear envelope

Affiliated Academic Societies

• Japana Society for Cell Biology
• The Biomedical Society of Stress Response, Japan
• The Japanese Biochemical Society

Educational Activity

Course in Charge

1. 2026, Liberal Arts Education Program1, 2Term, Cell Science
2. 2026, Undergraduate Education, Year, Physiology and Biochemistry
3. 2026, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry

Research Activities

Academic Papers

1. Hypertonicity-induced RNF183 targets NKCC1 to protect kidney collecting duct cells but induces apoptosis in colon cells, Commun Biol ., 20260406
2. Severe hyperosmotic stress causes dysregulation of replication-dependent histone mRNA expression and induces DNA replication stress, J Biochem, 20260309
3. Unfolded protein response modulates Tyrosinase levels and melanin production during melanogenesis, J Dermatol Sci, 202501
4. VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma, NUCLEUS, 15(1), 20241231
   Link to Paper Search Results by DOI
5. Embryonic stem cells maintain high origin activity and slow forks to coordinate replication with cell cycle progression, EMBO REPORTS, 25(9), 3757-3776, 20240910
   Link to Paper Search Results by DOI
6. AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer, MOLECULAR CANCER RESEARCH, 22(4), 373-385, 20240402
   Link to Paper Search Results by DOI
7. Impact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma, CELL DEATH DISCOVERY, 9(1), 20230708
   Link to Paper Search Results by DOI
8. p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS, CELL REPORTS, 42(5), 20230530
   Link to Paper Search Results by DOI
9. Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System, NEUROCHEMICAL RESEARCH, 47, 2478-2487, 202209
10. Advances in understanding the mechanisms of repairing damaged nuclear envelope, JOURNAL OF BIOCHEMISTRY, 171(6), 609-617, 20220527
    Link to Paper Search Results by DOI
11. OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
    Link to Paper Search Results by DOI
12. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215
    Link to Paper Search Results by DOI
13. Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1, Cell Reports, 25(7), 1756-1771, 201811
14. ★, Histone demethylation maintains Prdm14 and Tsix expression and represses Xist in embryonic stem cells, PLOS One, 10(5), 201505
15. The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression, Stem Cell Reports, 4(3), 390-403, 201503
16. The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated, Epigenetics, 9(6), 834-841, 201403
17. The dynamics of X-chromosome inactivation in mouse development, Mol Reprod Dev, 81(2), 201312
18. Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance, Dev Cell, 26(2), 123-135, 201307
19. Cell type-specific transcriptional regulation of the gene encoding importin-alpha1, Exp Cell Res, 317(14), 1970-1978, 201108
20. Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1, BMC Mol Biol, 12(48), 201111
21. Triggering neural differentiation of ES cells by subtype switching of importin-alpha, Nat Cell Biol, 9, 72-79, 200612

Invited Lecture, Oral Presentation, Poster Presentation

1. Toward understanding the molecular mechanisms of Nuclear Envelope Stress Response and its physiological impact, Yasunao Kamikawa, Zuqian Wu, Atsushi Saito, Kazunori Imaizumi, The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 2023/03/15, With Invitation, English
2. Cell type-specific response to rupture of the nuclear envelope, Yasunao Kamikawa, Atsushi Saito, Zuqian Wu, Kazunori Imaizumi, American Society for Cell Biology 2022, 2022/12/04, Without Invitation, English, Washington D. C., USA
3. Molecular mechanism of nuclear envelope stress response mediated by ER-resident transcription factor OASIS in astrocytes, Yasunao Kamikawa, Atsushi Saito, Kazunori Imaizumi, NEURO2022, 2022/07/02, Without Invitation, English, Okinawa, JAPAN