YUKIO AGO

Last Updated :2024/09/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
E-mail
yukioagohiroshima-u.ac.jp
Self-introduction
We are working to elucidate the molecular mechanisms and neural circuits underlying complex brain function, mental illness, and pharmacotherapy. To understand CNS diseases caused by gene-environment interactions, we are conducting research using experimental models from cells to animals.

Basic Information

Major Professional Backgrounds

  • 2024/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Vice-Dean for International Affairs
  • 2024/04/01, Hiroshima University, School of Dentistry, Vice-Dean for Research
  • 2020/03/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Professor
  • 2018/06/01, 2020/02/29, Osaka University, Global Center for Medical Engineering and Informatics, Associate Professor (Concurrent post)
  • 2018/05/15, 2020/02/29, Osaka University, Laboratory of Innovative Food Science, Associate Professor (Concurrent post)
  • 2018/04/01, 2020/02/29, Osaka University, Graduate School of Dentistry, Associate Professor (Concurrent post)
  • 2018/04/01, 2020/02/29, Osaka University, Graduate School of Pharmaceutical Sciences, Associate Professor
  • 2007/04/01, 2018/03/31, Osaka University, Graduate School of Pharmaceutical Sciences, Assistant Professor
  • 2017/04/01, 2018/03/31, Osaka University, Graduate School of Dentistry, Assistant Professor (Concurrent post)
  • 2013/07/17, 2015/06/30, University of California, Los Angeles, David Geffen School of Medicine, Visiting Scholar
  • 2010/09/01, 2013/03/31, RIKEN, Center for Molecular Imaging Science, Visiting Researcher
  • 2005/04/01, 2007/03/31, Osaka University, Graduate School of Pharmaceutical Sciences, Research Associate

Educational Backgrounds

  • Osaka University, Graduate School of Pharmaceutical Sciences, Doctoral Course, Applied Biopharmaceutical Sciences, Japan, 2003/04, 2005/03
  • Osaka University, Graduate School of Pharmaceutical Sciences, Master's Course, Applied Biopharmaceutical Sciences, Japan, 2001/04, 2003/03
  • Osaka University, Faculty of Pharmaceutical Sciences, Japan, 1997/04, 2001/03

Academic Degrees

  • Ph.D., Osaka University
  • M.S., Osaka University

In Charge of Primary Major Programs

  • Dentistry
  • Oral Health Science
  • Oral Engineering

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology
  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy
  • Medicine,dentistry, and pharmacy;Boundary medicine;Applied pharmacology
  • Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology
  • Biology;Basic biology;Animal physiology / Animal behavior

Research Keywords

  • Psychiatric Disorders / Developmental Disorders / Brain Function / Gene-Environment Interactions / Animal Models / Pharmacotherapy

Affiliated Academic Societies

  • The Japanese Pharmacological Society
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  • The Japanese Society of Neuropsychopharmacology
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  • The Japanese Society of Clinical Pharmacology and Therapeutics
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  • The Japanese Society for Neurochemistry
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  • The Japan Neuroscience Society
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  • The Pharmaceutical Society of Japan
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  • The Japan Society of Drug Delivery System
  • Japanese Association for Oral Biology
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  • Japanese Society for Disability and Oral Health
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  • The Japanese Dental Society of Anesthesiology
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  • The Hiroshima University Dental Society
  • Society for Senescence-Accelerated Mouse (SAM) Research
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  • Japan Transporter Research Association
  • Society for Neuroscience (SfN)
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  • Collegium Internationale Neuro-Psychopharmacologicum (CINP)
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  • American Society for Neurochemistry (ASN)
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Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 4Term, Life Science
  2. 2024, Undergraduate Education, 3Term, Dental Pharmacology I
  3. 2024, Undergraduate Education, 4Term, Dental Pharmacology II
  4. 2024, Undergraduate Education, 1Term, Practice of Pharmacology
  5. 2024, Undergraduate Education, 1Term, Topics in Dental Research I
  6. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  7. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  8. 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
  9. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  10. 2024, Undergraduate Education, First Semester, Dental Research Practices IV （Cellular and Molecular Pharmacology）
  11. 2024, Undergraduate Education, 2Term, Pharmacology and Dental Pharmacology
  12. 2024, Undergraduate Education, Second Semester, Practice on Basic Dental Sciences
  13. 2024, Undergraduate Education, 2Term, Pharmacology and Dental Pharmacology
  14. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  15. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  16. 2024, Graduate Education (Master's Program) , First Semester, Research
  17. 2024, Graduate Education (Master's Program) , Second Semester, Research
  18. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  19. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  20. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  21. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  22. 2024, Graduate Education (Master's Program) , 4Term, General Pharmacology
  23. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular and Molecular Pharmacology
  24. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular and Molecular Pharmacology
  25. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular and Molecular Pharmacology
  26. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular and Molecular Pharmacology

Research Activities

Academic Papers

  1. ★, Cyclic Peptides KS-133 and KS-487 Multifunctionalized Nanoparticles Enable Efficient Brain Targeting for Treating Schizophrenia, JACS Au, 4(8), 2811-2817, 2024
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  2. ★, (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice, Molecular Psychiatry, 29(5), 1406-1416, 2024
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  3. ALKBH8 contributes to neurological function through oxidative stress regulation, PNAS Nexus, 3(3), pgae115, 2024
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  4. Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain, Journal of Oral Microbiology, 2024
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  5. A Behavioral and Electroencephalographic Study of Anesthetic State Induced by MK-801 Combined with Haloperidol, Ketamine and Riluzole in Mice, Anesthesia and Analgesia, 2024
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  6. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice, Neurochemistry International, 174, 105682, 2024
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  7. Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells, Journal of Pharmacological Sciences, 154(3), 139-147, 2024
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  8. Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways, Psychopharmacology, 241(4), 805-816, 202404
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  9. Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice, Journal of Pharmacological Sciences, 154(2), 72-76, 2024
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  10. Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring, Frontiers in Pediatrics, 11, 1203894, 2023
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  11. The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody, PLOS ONE, 18(7), e0286651, 2023
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  12. Overexpression of VIPR2 in mice results in microencephaly with paradoxical increased white matter volume, Experimental Neurology, 362, 114339, 2023
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  13. Development of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide for the treatment of schizophrenia, Nihon Yakurigaku Zasshi, 158(3), 242-245, 2023
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  14. Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy, J Nat Med, 77(3), 604-609, 2023
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  15. N-methyl-D-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice, Neurosci Lett, 802, 137175, 2023
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  16. Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway, Peptides, 161, 170940, 2023
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  17. Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites, Neuropharmacology, 223, 2023
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  18. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks, Genes Cells, 28(1), 53-67, 2023
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  19. A new method for assessing depressive-like behaviors in female mice, Nihon Yakurigaku Zasshi, 158(1), 35-38, 2023
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  20. Vasoactive intestinal peptide-VIPR2 signaling regulates tumor cell migration, Front Oncol, 12, 2022
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  21. AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2, Biochem Biophys Res Commun, 636, 10-16, 2022
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  22. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation, Neurochem Int, 160, 2022
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  23. Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death, Eur J Pharmacol, 933, 2022
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  24. Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation, Int Immunopharmacol, 112, 2022
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  25. Autism spectrum disorder model mice induced by prenatal exposure to valproic acid exhibit enhanced empathy-like behavior via oxytocinergic signaling, Biol Pharm Bull, 45(8), 1124-1132, 2022
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  26. High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain, Exp Neurol, 355, 114146, 2022
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  27. Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses, Sci Adv, 8(11), eabi6375, 2022
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  28. Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome, Mol Brain, 15(1), 26, 2022
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  29. Physicochemical and biochemical evaluation of amorphous solid dispersions of naringenin prepared using hot-melt extrusion, Front Nutr, 9, 850103, 2022
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  30. Examination of dissolution ratio of beta-carotene in water for practical application of beta-carotene amorphous solid dispersion, J Food Sci Technol, 59, 114-122, 2022
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  31. Generation of KS-133 as a novel bicyclic peptide with a potent and selective VIPR2 antagonist activity that counteracts cognitive decline in a mouse model of psychiatric disorders, Front Pharmacol, 12, 751587, 2021
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  32. Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia, Transl Psychiatry, 11(1), 548, 2021
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  33. Investigation of direct nose-to-brain peptide delivery enhanced by coadministration with penetratin, Pharmaceutics, 13, 1745, 2021
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  34. Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ WT/Q1038R mouse model of autism spectrum disorder, Mol Brain, 14(1), 56, 2021
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  35. The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory, Pharmacol Rep, 73(4), 1109-1121, 2021
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  36. Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate, J Control Release, 336, 105-111, 2021
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  37. Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models, Front Neurosci, 15, 717490, 2021
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  38. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes, Nat Commun, 11(1), 859, 2020
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  39. Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain, JCI Insight., 5(6), 133348, 2020
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  40. Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression, OncoImmunology, 9(1), 1734268, 2020
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  41. (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression, Pharmacol Biochem Behav, 191, 172876, 2020
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  42. Improved Bioavailability of beta-Carotene by Amorphous Solid Dispersion Technology in Rats, J Nutr Sci Vitaminol, 66(2), 207-210, 2020
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  43. Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism, Front Neurosci, 14, 521, 2020
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  44. Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice, Commun Biol, 3(1), 557, 2020
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  45. The Role of Genetic and Environmental Factors in Neuropsychiatric Disorders, The Journal of Hiroshima University Dental Society, 52(2), 55-61, 2020
  46. Autism-associated protein kinase D2 regulates embryonic cortical neuron development, Biochem Biophys Res Commun, 519(3), 626-632, 2019
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  47. (R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism, Int J Neuropsychopharmacol, 22(10), 665-674, 2019
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  48. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome, Neuropsychopharmacology, 44(12), 2125-2135, 2019
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  49. Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST, Nat Protoc, 14(5), 1509-1529, 2019
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  50. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation, J Neurosci, 39(22), 4208-4220, 2019
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  51. Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice, J Pharmacol Sci, 139(2), 72-76, 2019
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  52. The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation, J Cell Sci, 132(1), jcs220228, 2019
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  53. mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model, Pharmacol Biochem Behav, 176, 1-5, 2019
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  54. LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth, Biol Pharm Bull, 41(12), 1866-1869, 2018
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  55. Valproic acid attenuates immunosuppressive function of myeloid-derived suppressor cells, J Pharmacol Sci, 137(4), 359-365, 2018
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  56. Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety, Sci Rep, 8(1), 10454, 2018
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  57. Beta-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking, PLoS ONE, 13(5), e0196946, 2018
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  58. Pathophysiological implication of the VPAC2 receptor in psychiatric disorders, Nihon Yakurigaku Zasshi, 151(6), 249-253, 2018
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  59. Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism, EMBO Rep, 19(3), e44860, 2018
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  60. Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice., Neurobiol Learn Mem, 145, 222-231, 2017
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  61. Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism, Horm Behav, 96, 130-136, 2017
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  62. Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice, Psychopharmacology, 234(21), 3217-3228, 2017
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  63. Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain, Mol Autism, 8, 33, 2017
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  64. Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice, Behav Brain Res, 333, 67-73, 2017
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  65. High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates, Neuron, 94(6), 1085-1100, 2017
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  66. Psychopharmacology of combined activation of the serotonin1A and sigma1 receptors., Eur J Pharmacol, 809, 172-177, 2017
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  67. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior, J Exp Med, 214(5), 1431-1452, 2017
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  68. Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice, Int J Neuropsychopharmacol, 20(5), 410-421, 2017
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  69. Regulation of emotional behaviors by juvenile environmental factors, Nihon Yakurigaku Zasshi, 149(2), 76-78, 2017
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  70. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice, Br J Pharmacol, 174(4), 314-327, 2017
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  71. Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice, ACS Nano, 10(9), 8180-8191, 2016
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  72. Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction, Behav Brain Res, 314, 77-86, 2016
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  73. Involvement of GABAA receptors in 5-HT1A and sigma1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency, Psychopharmacology, 233(17), 3125-3134, 2016
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  74. Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation, Neurochem Res, 41(10), 2574-2584, 2016
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  75. High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons, J Comp Neurol, 524(18), 3827-3848, 2016
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  76. The novel method female encounter test, Nihon Yakurigaku Zasshi, 147(4), 230-234, 2016
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  77. Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism, Autism Res, 9(9), 926-939, 2016
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  78. Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice, Psychopharmacology, 233(3), 521-528, 2016
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  79. Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice, Epilepsy Res, 115, 109-112, 2015
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  80. The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice, Int J Neuropsychopharmacol, 18(11), pyv062, 2015
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  81. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice, Behav Pharmacol, 26, 681-690, 2015
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  82. p13 overexpression in pancreatic beta-cells ameliorates type 2 diabetes in high-fat-fed mice, Biochem Biophys Res Commun, 461(4), 612-617, 2015
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  83. Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide, Neuroscience, 297, 95-104, 2015
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  84. Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model, Behav Brain Res, 289, 39-47, 2015
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  85. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF, PLoS ONE, 10(3), e0120526, 2015
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  86. Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice, J Pharmacol Sci, 127(2), 232-235, 2015
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  87. Simultaneous neuron- and astrocyte-specific fluorescent marking, Biochem Biophys Res Commun, 459(1), 81-86, 2015
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  88. Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice, Mol Cell Biol, 35(9), 1557-1572, 2015
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  89. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice, Behav Brain Res, 284, 131-137, 2015
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  90. Anxiolytic-like effects of restraint during the dark cycle in adolescent mice, Behav Brain Res, 284, 103-111, 2015
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  91. Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist, Psychopharmacology, 232(12), 2181-2189, 2015
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  92. Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro, J Neurochem, 132(4), 418-428, 2015
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  93. Behavioral characterization of mice overexpressing human dysbindin-1, Mol Brain, 7, 74, 2014
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  94. Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism, Pharmacol Biochem Behav, 126, 43-49, 2014
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  95. An enriched environment ameliorates memory impairments in PACAP-deficient mice, Behav Brain Res, 272, 269-278, 2014
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  96. Neurochemical basis for social encounter-induced hyperactivity in post-weaning isolation-reared mice, Nihon Shinkei Seishin Yakurigaku Zasshi, 34(4), 101-107, 2014
  97. Potential role of serotonin1A receptors in post-weaning social isolation-induced abnormal behaviors in rodents, J Pharmacol Sci, 125(3), 237-241, 2014
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  98. The role of Pak-interacting exchange factor-beta phosphorylation at serines 340 and 583 by PKC gamma in dopamine release, J Neurosci, 34(28), 9268-9280, 2014
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  99. Galantamine promotes adult hippocampal neurogenesis via M₁ muscarinic and alpha7 nicotinic receptors in mice, Int J Neuropsychopharmacol, 17(12), 1957-1968, 2014
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  100. Social crowding in the night-time reduces an anxiety-like behavior and increases social interaction in adolescent mice, Behav Brain Res, 270, 37-46, 2014
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  101. Atomoxetine-induced increases in monoamine release in the prefrontal cortex are similar in spontaneously hypertensive rats and Wistar-Kyoto rats, Neurochem Res, 39(5), 825-832, 2014
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  102. Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum, Eur J Pharmacol, 729, 86-93, 2014
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  103. Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in isolation-reared mice, Int J Neuropsychopharmacol, 17(6), 883-893, 2014
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  104. Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain, Pharmacol Biochem Behav, 113, 46-52, 2013
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  105. Synergistic effect of 5-HT1A and sigma1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency, Neuropharmacology, 75, 53-61, 2013
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  106. Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal model of attention-deficit/hyperactivity disorder, through alpha2-adrenoceptor activation, Behav Pharmacol, 24(4), 328-331, 2013
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  107. Effect of overexpression of the brain-specific Na(+)/Ca(2+) exchanger splice variant NCX1.5 on NO cytotoxicity in HEK293 cells., J Pharmacol Sci, 121(4), 351-354, 2013
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  108. The glial sodium-calcium exchanger: a new target for nitric oxide-mediated cellular toxicity, Curr Protein Pept Sci, 14(1), 43-50, 2013
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  109. mGlu2/3 and mGlu5 receptors: potential targets for novel antidepressants, Neuropharmacology, 66, 40-52, 2013
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  110. Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal behaviors of isolation-reared mice, Neuropsychopharmacology, 38(8), 1535-1547, 2013
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  111. Effects of serotonin-norepinephrine reuptake inhibitors on locomotion and prefrontal monoamine release in spontaneously hypertensive rats, Eur J Pharmacol, 702(1-3), 250-257, 2013
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  112. Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice, Psychopharmacology, 227(2), 251-261, 2013
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  113. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide, Behav Pharmacol, 24(1), 74-77, 2013
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  114. Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice, Neuropharmacology, 65, 29-38, 2013
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  115. Galantamine increases hippocampal insulin-like growth factor 2 expression via alphs7 nicotinic acetylcholine receptors in mice, Psychopharmacology, 225(3), 543-551, 2013
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  116. Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid, Int J Neuropsychopharmacol, 16(1), 91-103, 2013
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  117. Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor, J Cereb Blood Flow Metab, 32(9), 1737-1746, 2012
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  118. Pharmacological profiles of galantamine: the involvement of muscarinic receptor, Nihon Shinkei Seishin Yakurigaku Zasshi, 32(1), 1-8, 2012
  119. Neuronal nitric oxide synthase inhibition attenuates the development of L-DOPA-induced dyskinesia in hemi-Parkinsonian rats, Eur J Pharmacol, 683(1-3), 166-173, 2012
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  120. Effect of prenatal valproic acid exposure on cortical morphology in female mice, J Pharmacol Sci, 118(4), 543-546, 2012
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  121. The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice, J Pharmacol Sci, 118(2), 295-298, 2012
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  122. Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release, Neuropharmacology, 62(4), 1634-1639, 2012
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  123. Involvement of Sigma-1 Receptors in the Pharmacological Properties of Fluvoxamine, Jap J Stress Sci, 27(1), 104-111, 2012
  124. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease, Neuropharmacology, 61(8), 1441-1451, 2011
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  125. Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo responses, Synapse, 65(12), 1373-1377, 2011
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  126. Preventive effects of an enriched environment on rodent psychiatric disorder models, J Pharmacol Sci, 117(2), 71-76, 2011
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  127. Pharmacological aspects of the acetylcholinesterase inhibitor galantamine, J Pharmacol Sci, 116(1), 6-17, 2011
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  128. The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells, Neurochem Int, 59(1), 51-58, 2011
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  129. Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and sigma(1) receptor activation, Psychopharmacology, 217(3), 377-386, 2011
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  130. Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission, Psychopharmacology, 217(3), 443-452, 2011
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  131. Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis, Neuroscience, 172, 554-561, 2011
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  132. Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice reared in social isolation, Br J Pharmacol, 162(3), 763-772, 2011
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  133. Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice, Neuropharmacology, 60(2-3), 397-404, 2011
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  134. Stress-evoked tyrosine phosphorylation of signal regulatory protein alpha regulates behavioral immobility in the forced swim test, J Neurosci, 30(31), 10472-10483, 2010
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  135. The Na+/Ca2+ exchanger-mediated Ca2+ influx triggers nitric oxide-induced cytotoxicity in cultured astrocytes., Neurochem Int, 57(1), 58-66, 2010
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  136. Effects of acute and chronic administration of atomoxetine and methylphenidate on extracellular levels of noradrenaline, dopamine and serotonin in the prefrontal cortex and striatum of mice, J Neurochem, 114(1), 259-270, 2010
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  137. Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice, Behav Brain Res, 209(2), 274-280, 2010
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  138. Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice, Br J Pharmacol, 156(1), 173-180, 2009
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  139. Role of prefrontal dopaminergic neurotransmission in glucocorticoid receptor-mediated modulation of methamphetamine-induced hyperactivity, Synapse, 63(1), 7-14, 2009
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  140. Depression and corticosteroid receptors, Nihon Yakurigaku Zasshi, 134(6), 304-308, 2009
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  141. Mitochondrial dysfunction and neuronal apoptosis: new molecular approach to prevent Alzheimer's disease, Nihon Yakurigaku Zasshi, 134(4), 180-183, 2009
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  142. Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression, Neuropharmacology, 55(8), 1355-1363, 2008
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  143. A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice, Neuropharmacology, 55(5), 654-660, 2008
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  144. Involvement of Prefrontal Serotonergic Neurons in Methamphetamine-Induced Behavioral Sensitization, Nihon Shinkei Seishin Yakurigaku Zasshi, 28(2), 85-91, 2008
  145. The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice, Eur J Pharmacol, 583(1), 164-169, 2008
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  146. Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice, Psychopharmacology, 196(2), 293-301, 2008
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  147. Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice, J Pharmacol Sci, 106(1), 15-21, 2008
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  148. Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice, Peptides, 28(9), 1674-1679, 2007
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  149. Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger, Glia, 55(13), 1325-1333, 2007
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  150. Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice, Synapse, 61(9), 757-763, 2007
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  151. Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test, J Pharmacol Sci, 104(2), 153-158, 2007
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  152. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum, J Pharmacol Exp Ther, 322(1), 274-281, 2007
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  153. Edaravone, a radical scavenger, inhibits mitochondrial permeability transition pore in rat brain, J Pharmacol Sci, 103(4), 434-437, 2007
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  154. Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex, Eur J Pharmacol, 559(2-3), 155-160, 2007
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  155. Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release in rat prefrontal cortex, J Pharmacol Sci, 102(4), 419-422, 2006
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  156. Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice, Behav Pharmacol, 17(7), 637-640, 2006
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  157. Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice, Pharmacol Biochem Behav, 85(1), 198-205, 2006
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  158. Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice, Synapse, 60(7), 479-484, 2006
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  159. Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation, Brain Res, 1112(1), 65-69, 2006
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  160. Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-), Ann N Y Acad Sci, 1070, 545-549, 2006
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  161. Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice, Neuropharmacology, 51(4), 914-922, 2006
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  162. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum, Eur J Pharmacol, 542(1-3), 92-99, 2006
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  163. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice, J Neurosci, 26(19), 5091-5097, 2006
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  164. T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons, Neurochem Int, 48(2), 124-130, 2006
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  165. Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex, Eur J Pharmacol, 528(1-3), 95-98, 2005
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  166. Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice, Eur J Pharmacol, 520(1-3), 86-90, 2005
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  167. SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia, Br J Pharmacol, 144(5), 669-679, 2005
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  168. Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex, Neuropsychopharmacology, 30(1), 43-51, 2005
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  169. Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588, Neurochem Res, 28(12), 1779-1783, 2003
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  170. Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex, Neuropharmacology, 45(8), 1050-1056, 2003
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  171. Protective effect of T-588 on toxic damage by serum deprivation and amyloid-beta protein in cultured neurons, J Pharmacol Sci, 92(2), 153-156, 2003
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  172. The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice, Psychopharmacology, 170(1), 73-79, 2003
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  173. The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze, Eur J Pharmacol, 458(1-2), 141-144, 2003
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  174. Brain microdialysis of isolation-reared mice under freely-moving conditions, Nihon Yakurigaku Zasshi, 122(2), 135-140, 2003
  175. Modulation by 5-hT2A receptors of aggressive behavior in isolated mice, Jpn J Pharmacol, 89(1), 89-92, 2002
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  176. Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice, J Neurochem, 83(2), 353-359, 2002
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  177. Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice, Eur J Pharmacol, 432(2-3), 163-166, 2001
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  178. Functional alteration of brain dopaminergic system in isolated aggressive mice, Nihon Shinkei Seishin Yakurigaku Zasshi, 21(3), 71-76, 2001

Publications such as books

  1. 2021/01, The CELL, Research aimed at elucidating the molecular mechanism for stress-related psychiatric disorders and the development of therapeutic drug through PACAP signaling, 2021, 1, Scholarly Book, Joint work, 日本語, Atsuko Hayata, Yukio Ago, Hitoshi Hashimoto
  2. 2020/06, Medical Science Digest, Research aimed at elucidating the molecular mechanism for stress-related psychiatric disorders and the development of therapeutic drug through PACAP signaling, The New Science Co., Ltd., 2020, 6, Scholarly Book, Joint work, 日本語, Atsuko Hayata, Yukio Ago, Hitoshi Hashimoto
  3. 2016/04, Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants, and International Aspects, Methamphetamine-induced hyperlocomotion: a focus on the role of the prefrontal serotonergic system, Academic Press, 2016, Scholarly Book, Joint work, 英語, Ago Y, Takuma K, Matsuda T, 978-0128002124, 1182, 320-328
    Amazon URL
  4. 2016, Pituitary Adenylate Cyclase Activating Polypeptide — PACAP, PACAP modulation of CNS and peripheral inflammation, Springer, 2016, Scholarly Book, Joint work, 英語, Ago Y, Condro MC, Rajbhandari AK, Van C, Jayaram B, May V, Waschek JA, 978-3-319-35133-9, 651-670
  5. 2016, Pituitary Adenylate Cyclase Activating Polypeptide — PACAP, Implications of PACAP signaling in psychiatric disorders, Springer, 2016, Scholarly Book, Joint work, 英語, Hashimoto H, Shintani N, Ago Y, Hayata-Takano A, Nakazawa T, Hashimoto R, Matsuzaki S, Katayama T, Tohyama M, Matsuda T, Baba A, 978-3-319-35133-9, 757-766

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of hippocampal microglia in anxiodepressive-like behaviors of aged mice, Yoki Nakamura, Miku Yokohata, Keisuke Ikeda, Kazue Hisaoka-Nakashima, Yukio Ago, Ayami Sato, Akihito Ishigami, Norimitsu Morioka, 47th Annual Meeting of the Japan Society for Biomedical Gerontology, 2024/06/15, Without Invitation, English, Tokyo, Japan
  2. (R)-ketamine ameliorates depression-like behaviors and cognitive impairment via activation of the anterior insular cortex in social isolation-reared mice, Rei Yokoyama, Yukio Ago, Hisato Igarashi, Momoko Higuchi, Masato Tanuma, Yuto Shimazaki, Kaoru Seiriki, Misuzu Hayashida, Shun Yamaguchi, Hirokazu Tanaka, Takanobu Nakazawa, Kenji Hashimoto, Atsushi Kasai, Hitoshi Hashimoto, The 35th World Congress Collegium Internationale Neuro-Psychopharmacologicum (CINP2024), 2024/05/24, Without Invitation, English, Tokyo, Japan
  3. Overexpression of vasoactive intestinal peptide receptor 2 in neurons causes abnormal dendritic morphology in the prefrontal cortex and cognitive impairment, Ami Ono, Daichi Koan, Satoshi Asano, Tatsunori Miyaoka, Lu Chen, Shinsaku Nakagawa, Atsuko Hayata-Takano, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Kotaro Tanimoto, Yukio Ago, The 35th World Congress Collegium Internationale Neuro-Psychopharmacologicum (CINP2024), 2024/05/24, Without Invitation, English, Tokyo, Japan
  4. Periodontal infection in diet-induced obesity causes cognitive impairment associated with microglial activation, Kana Oue, Yusuke Morioka, Eiji Imado, Tetsuya Tamura, Yosuke Yamawaki, Kazuhisa Ouhara, Mitsuhiro Yoshida, Takashi Kanematsu, Yukio Ago, IAGG Asia-Oceania Regional Congress 2023, 2023/06/12, Without Invitation, English, Yokohama, Japan
  5. Network centralities of prefrontal and somatosensory cortices are decreased in a mouse model of developmental disorders, Hiroki Ueno, Yusuke Iyanaga, Yuta Hara, Jin Ohkubo, Yuka Nakai, Kaoru Seiriki, Shun Yamaguchi, Yukio Ago, Kazuhiro Takuma, Hitoshi Hashimoto, Atsushi Kasai, The 53rd Annual Meeting of the Society for Neuroscience (Neuroscience 2023), 2023/11/14, Without Invitation, English, Society for Neuroscience, Washington, D.C., USA
  6. (R)-ketamine enhances anterior insular cortex activity associated with social cognition, Rei Yokoyama, Yukio Ago, Masato Tanuma, Yuto Shimazaki, Kaoru Seiriki, Takanobu Nakazawa, Kenji Hashimoto, Atsushi Kasai, Hitoshi Hashimoto, The 53rd Annual Meeting of the Society for Neuroscience (Neuroscience 2023), 2023/11/14, Without Invitation, English, Society for Neuroscience, Washington, D.C., USA
  7. Oxytocin restores abnormal social behavior in a mouse model of 3q29 microdeletion, Tomoya Takemoto, Kohei Kitagawa, Kazuki Nagayasu, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Kazuhiro Takuma, Daisuke Mori, Norio Ozaki, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa, The 53rd Annual Meeting of the Society for Neuroscience (Neuroscience 2023), 2023/11/12, Without Invitation, English, Society for Neuroscience, Washington, D.C., USA
  8. Overexpression of VPAC2 receptors in the embryonic mouse central nervous system causes brain atrophy, increased white matter, and impaired sensorimotor gating, Yukio Ago, Allan J. MacKenzie-Graham, Hitoshi Hashimoto, James A. Waschek, The 8th Congress of the Asian College of Neuropsychopharmacology (AsCNP), 2023/09/22, Without Invitation, English, Xi'an, China
  9. Modeling VIPR2 linkage to schizophrenia and developing antipsychotic medication, Yukio Ago, Taiwanase Society of Biological Psychiatry and Neuropsychopharmacology (TSBPN) 2023 Annual Meeting, 2023/09/16, With Invitation, English, Taipei, Taiwan
  10. VIPR2 copy number variants as a risk factor for schizophrenia, Yukio Ago, Okinawa Institute of Science and Technology Graduate University (OIST) seminar, 2023/02/15, With Invitation, English, Okinawa, Japan
  11. Regulation of cancer migration by VIP−VPAC2 receptor signaling, Yukio Ago, Okinawa Institute of Science and Technology Graduate University (OIST) lecture, 2023/02/15, With Invitation, English, Okinawa, Japan
  12. Activation of the rostral agranular insular cortex is involved in the antidepressant actions of arketamine, Yukio Ago, Rei Yokoyama, Atsushi Kasai, Masato Tanuma, Misuzu Hayashida, Yuto Shimazaki, Momoko Higuchi, Hisato Igarashi, Kaoru Seiriki, Shun Yamaguchi, Takanobu Nakazawa, Kenji Hashimoto, Hitoshi Hashimoto, The 61st Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 2022/12/07, Without Invitation, English, American College of Neuropsychopharmacology, Phoenix, Arizona, USA
  13. Claustrum mediates stress-induced anxiety responses and stress resistance, Hitoshi Hashimoto, Misaki Niu, Masato Tanuma, Kaoru Seiriki, Yukio Ago, Shun Yamaguchi, Atsushi Kasai, The 61st Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 2022/12/07, Without Invitation, English, American College of Neuropsychopharmacology, Phoenix, Arizona, USA
  14. Involvement of the agranular insular cortex in antidepressant actions of arketamine, Rei Yokoyama, Yukio Ago, Atsushi Kasai, Masato Tanuma, Misuzu Hayashida, Yuto Shimazaki, Momoko Higuchi, Hisato Igarashi, Kaoru Seiriki, Shun Yamaguchi, Takanobu Nakazawa, Kenji Hashimoto, Hitoshi Hashimoto, The 96th Annual Meeting of the Japanese Pharmacological Society, 2022/12/03, Without Invitation, English, Japanese Pharmacological Society, Yokohama, Japan
  15. Inhibition of histone deacetylase in utero causes spinal microglial activation and mechanical allodynia in mice, Eiji Imado, Samnang Sun, Tran Ngoc Bao Huynh, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka, Norikazu Kiguchi, Satoshi Asano, Yukio Ago, The 96th Annual Meeting of the Japanese Pharmacological Society, 2022/12/02, Without Invitation, English, Japanese Pharmacological Society, Yokohama, Japan
  16. A TRPV1 antagonist AMG517 alleviates abnormal pain sensitivity and improves social deficits in the prenatal valproic acid-induced mouse model of autism, Takeru Tahara, Eiji Imado, Haruki Kawase, Momoko Higuchi, Hidekuni Yamakawa, Koichi Ogawa, Yaichiro Kotake, Kazuhiro Takuma, Hitoshi Hashimoto, Satoshi Asano, Yukio Ago, The 96th Annual Meeting of the Japanese Pharmacological Society, 2022/12/02, Without Invitation, English, Japanese Pharmacological Society, Yokohama, Japan
  17. New treatment perspectives in autism spectrum disorder: Role of brain region-specific opioid system balance in ameliorating social impairments, Yukio Ago, The 96th Annual Meeting of the Japanese Pharmacological Society, 2022/11/30, With Invitation, English, Japanese Pharmacological Society, Yokohama, Japan
  18. Phospholipase C like protein PRIP1 PH-domain-containing liposomes enhance apoptotic cell death in cisplatin resistant breast cancer cells, Satoshi Asano, Yukio Ago, Takashi Kanematsu, The 96th Annual Meeting of the Japanese Pharmacological Society, 2022/11/30, Without Invitation, English, Japanese Pharmacological Society, Yokohama, Japan
  19. Intranasal oxytocin administration suppresses social contact-induced neural activity in a POGZ-Q1038R mutant mouse model of autism spectrum disorder, Kohei Kitagawa, Masayuki Baba, Tomoya Takemoto, Masato Tanuma, Misuzu Hayashida, Shun Yamaguchi, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Kazuhiro Takuma, Atsushi Kasai, Hitoshi Hashimoto, Takanobu Nakazawa, The 52nd Annual Meeting of the Society for Neuroscience (Neuroscience 2022), 2022/11/15, Without Invitation, English, Society for Neuroscience, San Diego, USA
  20. Agranular insular cortex mediates the antidepressant actions of arketamine, Rei Yokoyama, Yukio Ago, Atsushi Kasai, Masato Tanuma, Misuzu Hayashida, Yuto Shimazaki, Momoko Higuchi, Hisato Igarashi, Kaoru Seiriki, Shun Yamaguchi, Takanobu Nakazawa, Kenji Hashimoto, Hitoshi Hashimoto, The 52nd Annual Meeting of the Society for Neuroscience (Neuroscience 2022), 2022/11/13, Without Invitation, English, Society for Neuroscience, San Diego, USA
  21. KS-133, a novel peptide antagonist targeting VIPR2 for the treatment of schizophrenia, Yukio Ago, Kotaro Sakamoto, Satoshi Asano, VPAC ISBAP 2022 (Joint symposium of the 1st Meeting of the International Society for Bioactive Peptides and the 15th International Symposium on VIP, PACAP and Related Peptides), 2022/11/01, With Invitation, English, International Society for Bioactive Peptides International Symposium on VIP, PACAP and Related Peptides, Osaka, Japan
  22. The VIP/VIPR2 pathway regulates breast cancer cell migration, Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Hitoshi Hashimoto, James A. Waschek, Yukio Ago, VPAC ISBAP 2022 (Joint symposium of the 1st Meeting of the International Society for Bioactive Peptides and the 15th International Symposium on VIP, PACAP and Related Peptides), 2022/10/31, Without Invitation, English, International Society for Bioactive Peptides International Symposium on VIP, PACAP and Related Peptides, Osaka, Japan
  23. Neuron-specific overexpression of human VPAC2 receptors in mice causes cognitive dysfunction, Ami Ono, Daichi Koan, Satoshi Asano, Tatsunori Miyaoka, Lu Chen, Mei Yamada, Shinsaku Nakagawa, Atsuko Hayata-Takano, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Yukio Ago, VPAC ISBAP 2022 (Joint symposium of the 1st Meeting of the International Society for Bioactive Peptides and the 15th International Symposium on VIP, PACAP and Related Peptides), 2022/10/30, Without Invitation, English, International Society for Bioactive Peptides International Symposium on VIP, PACAP and Related Peptides, Osaka, Japan
  24. Impaired neurodevelopment in iPS cell-derived neural stem cells from psychiatric patients with 7q36.3 microduplication, Kohei Kitagawa, Masayuki Baba, Tomoya Takemoto, Kazuki Nagayasu, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Yukio Ago, Takanobu Nakazawa, VPAC ISBAP 2022 (Joint symposium of the 1st Meeting of the International Society for Bioactive Peptides and the 15th International Symposium on VIP, PACAP and Related Peptides), 2022/10/30, Without Invitation, English, International Society for Bioactive Peptides International Symposium on VIP, PACAP and Related Peptides, Osaka, Japan
  25. The neuropeptide receptor VIPR2 regulates tumor cell migration through PI3K pathway, Satoshi Asano, Yukio Ago, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/19, Without Invitation, Japanese, Japanese Association for Oral Biology, Tokushima, Japan
  26. Prenatal exposure to valproic acid induces proliferation of microglia in the spinal cord and mechanical allodynia in mice, Yukio Ago. Eiji Imado, Sun Samnang, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka, Kazuhiro Takuma, Norikazu Kiguchi, Satoshi Asano, Neuro2022, 2022/06/30, Without Invitation, English
  27. Pharmacological study of a novel peptide antagonist targeting VIPR2, a class-B GPCR, for the treatment of schizophrenia, Yukio Ago, Kotaro Sakamoto, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/09, With Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  28. Functional importance of the oligomer formation of the neuropeptide receptor VIPR2, Satoshi Asano, Kairi Ozasa, Takanobu Nakazawa, James A. Waschek, Yukio Ago, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/09, Without Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  29. A neuropeptide VIP induces cell migration by activating the PI3K pathway via VPAC2 receptors, Kairi Ozasa, Satoshi Asano, Misa Yamasaka, Atsuko Hayata, Takanobu Nakazawa, Hitoshi Hashimoto, James A. Waschek, Yukio Ago, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/09, Without Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  30. The effect of neutralizing antibody against high-mobility group box 1 on cognitive impairment in mice with neuropathic pain, Natsuki Yoshimoto, Kazue Hisaoka-Nakashima, Kazuto Ohata, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Yukio Ago, Masahiro Nishibori, Norimitsu Morioka, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  31. Involvement of microglia in mechanical allodynia in a mouse model of neurodevelopmental disorder, Eiji Imado, Sun Samnang, Abrar Abawa, Satoshi Asano, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka, Kazuhiro Tsuga, Masahiro Irifune, Kazuhiro Takuma, Norikazu Kiguchi, Yukio Ago, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  32. Reduced prefrontal hub function in brain networks associated with social deficits of an ASD model mouse, Atsushi Kasai, Yusuke Iyanaga, Hiroki Ueno, Yuka Nakai, Yuta Hara, Hiroki Miura, Masato Tanuma, Misuzu Hayashida, Rei Yokoyama, Jin Ohkubo, Kaoru Seiriki, Atsuko Hayata-Takano, Shun Yamaguchi, Shiho Kitaoka, Tomoyuki Furuyashiki, Yukio Ago, Takanobu Nakazawa, Kazuhiro Takuma, Hitoshi Hashimoto, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/08, Without Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  33. Animal models of depression: A lesson from the pharmacologic sensitivity of antidepressant drugs and candidates, Yukio Ago, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/07, With Invitation, Japanese, The Japanese Pharmacological Society, Fukuoka
  34. A potent and highly selective VPAC2 receptor antagonist peptide KS-133 counteracts cognitive impairment in a mouse model relevant to schizophrenia, Yukio Ago, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Shinsaku Nakagawa, Satoshi Asano, Kotaro Sakamoto, The 60th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 2021/12/05, Without Invitation, English, American College of Neuropsychopharmacology (ACNP), Puerto Rico
  35. Overexpression of VIPR2 in neurons causes defects in dendritic growth and cognitive impairment, Tatsunori Miyaoka, Lu Chen, Mei Yamada, Daichi Koan, Satoshi Asano, Kenji Ishimoto, Shinsaku Nakagawa, Atsuko Hayata, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Yukio Ago, The 7th Congress of the Asian College of Neuropsychopharmacology (AsCNP), 2021/10/22, Without Invitation, English, Asian College of Neuropsychopharmacology (AsCNP), On-line
  36. The neuropeptide VIP-VPAC2 signaling is a novel mechanism of regulating tumor cell migration, Satoshi Asano, Yukio Ago, The 63rd Annual Meeting of Japanese Association for Oral Biology, 2021/10/09, Without Invitation, Japanese
  37. Abnormal pain sensitivity in a prenatal valproic acid-induced mouse model of autism spectrum disorder, Eiji Imado, Sun Samnang, Abrar Rizal Abawa, Satoshi Asano, Kazuhiro Tsuga, Masahiro Irifune, Yukio Ago, The 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English, On-line
  38. Regulation of tumor cell migration by vasoactive intestinal peptide (VIP)−VPAC2 receptor signaling, Satoshi Asano, Misa Yamasaka, Kairi Ozasa, James A. Waschek, Yukio Ago, The 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English, On-line
  39. Role of the VPAC2 receptor-mediated signals in cell migration, Misa Yamasaka, Satoshi Asano, Atsuko Hayata, Takanobu Nakazawa, Hitoshi Hashimoto, James Waschek, Yukio Ago, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/29, Without Invitation, Japanese, Hiroshima
  40. Neuron-specific VPAC2 receptor overexpression leads to cognitive impairment in mice, Daichi Koan, Eiji Imado, Satoshi Asano, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Kenji Ishimoto, Shinsaku Nakagawa, Atsuko Hayata, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James Waschek, Yukio Ago, The 141st Annual Meeting of the Pharmaceutical Society of Japan, 2021/03/28, Without Invitation, Japanese, Hiroshima
  41. Epigenetic modulation with valproic acid impedes invasion of monocytic myeloid-derived suppressor cells into tumors, Xie Z, Ago Y, Okada N, Tachibana M, The 27th International Symposium on Molecular Cell Biology of Macrophages (MMCB2020), 2020/06/16, Without Invitation, English
  42. PACAP signaling involved in the pathophysiological pathway of psychiatric disorders, Hashimoto H, Hayata-Takano A, Shintani Y, Ago Y, The Akira Arimura Memorial VIP/PACAP and Related Peptides Symposium: 30 years after PACAP Discovery, 2019/11/03, With Invitation, English
  43. ASD-associated de novo POGZ mutations disrupt cortical development, Matsumura K, Seiriki K, Nagase M, Ayabe S, Yamada I, Furuse T, Yamamoto K, Kitagawa K, Baba M, Kasai A, Ago Y, Hayata-Takano A, Shintani N, Iguchi T, Sato M, Yamaguchi S, Tamura M, Wakana S, Yoshiki A, Watabe AM, Okano H, Takuma K, Hashimoto R, Hashimoto H, Nakazawa T, The 49th Annual Meeting of the Society for Neuroscience (Neuroscience 2019), 2019/10/19, Without Invitation, English
  44. In vivo imaging of alkynylated S-citalopram using surface-enhanced Raman scattering, Tanuma M, Kasai A, Bando K, Kotoku N, Higashino K, Ago Y, Kawata S, Fujita K, Hashimoto H, The 49th Annual Meeting of the Society for Neuroscience (Neuroscience 2019), 2019/10/19, Without Invitation, English
  45. Differential behavioral and neurochemical effects of ketamine enantiomers and their metabolites, Yukio Ago, Hitoshi Hashimoto, The 6th Asian College of Neuropsychopharmacology (AsCNP), 2019/10/11, With Invitation, English
  46. Role of the VPAC2 receptor overactivation implicated in schizophrenia susceptibility, Yukio Ago, Oral Neuroscience 2018, 2018/10/07, With Invitation, English, Osaka University, Graduate School of Dentistry, Osaka
  47. Synergistic neurochemical effect of combined sigma1 and 5-HT1A receptor activation under the circulating neuroactive steroid-deficient conditions, Yukio Ago, APSN/JSN 2012, 2012, With Invitation, English, The Asia-Pacific Society for Neurochemistry/The Japanese Society for Neurochemistry, Kobe
  48. Antidepressant-like effect of a metabotropic glutamate 2/3 receptor antagonist, Yukio Ago, The 7th International Meeting on Metabotropic Glutamate Receptors, 2011, With Invitation, English, Taormina, Italy

Awards

  1. 2024/05/08, NPPR Reviewer Award 2024, Editor in Chief, Neuropsychopharmacology Reports
  2. 2023/09/23, Best Poster Award at 8th Congress of Asian Colleage of Neuropsychopharamacology and 11th Chinese Schizophrenia Forum Conference, Congress Organizing Committee, Asian College of Neuropsychopharmacology, Overexpression of VPAC2 receptors in the embryonic mouse central nervous system causes brain atrophy, increased white matter, and impaired sensorimotor gating.
  3. 2023/09/16, 2023 TSBPN-JSNP Academic Exchange Award, President of Taiwanase Society of Biological Psychiatry and Neuropsychopharmacology, Modeling VIPR2 linkage to schizophrenia and developing antipsychotic medication.
  4. 2022/10/23, NPPR Reviewer Award 2022, Editor in Chief, Neuropsychopharmacology Reports
  5. 2022/03/07, Journal of Pharmacological Sciences Excellent Reviewer Award 2021, The Japanese Pharmacological Society
  6. 2019/11/05, Translational Science Award, The 2019 Akira Arimura Memorial VIP/PACAP and Related Peptides International Symposium
  7. 2019/11/05, Poster Award, The 2019 Akira Arimura Memorial VIP/PACAP and Related Peptides International Symposium
  8. 2019/10/11, Neuropsychopharmacology Reports Reviewer Award 2019, The Japanese Society of Neuropsychopharmacology
  9. 2018/03/10, Journal of Pharmacological Sciences Excellent Reviewer Award 2017, The Japanese Pharmacological Society
  10. 2016/07/02, JSNP Excellent Presentation Award for CINP 2016, The Japanese Society of Neuropsychopharmacology
  11. 2016/05/13, Matsuo Award for Encouragement of Young Investigators, The Society for the Study of GPCR
  12. 2014/07/08, Osaka University Presidential Awards for Encouragement, Osaka University
  13. 2014/03/20, The 29th Award for Encouragement of Young Investigators, The Japanese Pharmacological Society
  14. 2014/02/18, Osaka University Presidential Commendation, Osaka University
  15. 2013/10/25, Young Investigator Award, The Japanese Society of Neuropsychopharmacology
  16. 2012/09/30, The Award for Young Investigator, The Japanese Society for Neurochemistry
  17. 2011/09/24, The 2nd Congress of AsCNP Fellowship Award, Asian College of Neuropsychopharmacology (AsCNP)
  18. 2010/01/08, The Young Scientist Award, The Kinki Division of the Pharmaceutical Society of Japan
  19. 2007/07/13, Excellent Presentation Award, Joint Meeting of the 29th Annual Meeting of Japanese Society of Biological Psychiatry and the 37th Annual Meeting of Japanese Society of Neuropsychopharmacology

External Funds

Acceptance Results of Competitive Funds

  1. Grants-in-Aid for Scientific Research (B), Elucidation of the pathological mechanism of treatment-refractory schizophrenia and drug discovery research focusing on abnormalities in peptide signaling during brain development, 2024, 2026
  2. Grant-in-Aid for Challenging Research (Exploratory), 2021, 2022
  3. Grants-in-Aid for Scientific Research (B), 2020, 2023
  4. Grant-in-Aid for Scientific Research (C), 2016, 2018
  5. Grant-in-Aid for Scientific Research (C), 2013, 2015
  6. Grant-in-Aid for Young Scientists (B), 2011, 2012
  7. Grant-in-Aid for Young Scientists (B), 2009, 2010
  8. Grant-in-Aid for Young Scientists (B), 2006, 2007

Social Activities

History as Committee Members

  1. Director, 2024/04, 2026/03, The Japanese Pharmacological Society
  2. Chairperson, General Affairs Committee, 2024/04, 2026/03, The Japanese Pharmacological Society
  3. DX Promotion Committee, 2024/04, 2026/03, The Japanese Pharmacological Society
  4. Councilor, 2023/04, 2026/03, The Japan Neuroscience Society
  5. Director, 2022/11, 2024/11, The Japanese Society of Neuropsychopharmacology
  6. International Scientific Program Committee, 2021/04, 2022/06, International College of Neuropsychopharmacology (CINP)

History as Peer Reviews of Academic Papers

  1. 2024, Pharmacology, Biochemistry and Behavior, Editorial Advisory Board
  2. 2024, Neurochemistry International, Editor, Editorial Advisory Board
  3. 2024, Frontiers in Pharmacology, Review Editor
  4. 2023, Journal of Pharmacological Sciences, Associate Editor
  5. 2023, Neurochemistry International, Editor, Editorial Advisory Board
  6. 2023, Pharmacology, Biochemistry and Behavior, Editorial Advisory Board
  7. 2023, Frontiers in Pharmacology, Review Editor
  8. 2022, Journal of Pharmacological Sciences, Associate Editor
  9. 2022, Neurochemistry International, Editor, Editorial Advisory Board
  10. 2022, Pharmacology, Biochemistry and Behavior, Editorial Advisory Board
  11. 2022, Frontiers in Pharmacology, Review Editor
  12. 2021, Neurochemistry International, Editor, Editorial Advisory Board
  13. 2021, Pharmacology, Biochemistry and Behavior, Editorial Advisory Board
  14. 2021, Journal of Pharmacological Sciences, Editorial Advisory Board
  15. 2021, Frontiers in Pharmacology, Review Editor
  16. 2020, Pharmacology, Biochemistry and Behavior, Editorial Advisory Board
  17. 2020, Journal of Pharmacological Sciences, Editorial Advisory Board
  18. 2020, Frontiers in Pharmacology, Review Editor
  19. 2019, Pharmacology, Biochemistry and Behavior, Editorial Advisory Board
  20. 2019, Journal of Pharmacological Sciences, Editorial Advisory Board
  21. 2019, Journal of Neuroscience Research, Editorial Advisory Board
  22. 2019, Frontiers in Pharmacology, Review Editor
  23. 2018, Journal of Pharmacological Sciences, Editorial Advisory Board
  24. 2018, Journal of Neuroscience Research, Editorial Advisory Board
  25. 2018, Frontiers in Pharmacology, Review Editor
  26. 2017, Journal of Neuroscience Research, Editorial Advisory Board
  27. 2017, Frontiers in Pharmacology, Review Editor
  28. 2016, Journal of Neuroscience Research, Editorial Advisory Board
  29. 2016, Frontiers in Pharmacology, Review Editor
  30. 2015, Frontiers in Pharmacology, Review Editor