NEN SAITO

Last Updated :2025/05/09

Affiliations, Positions
Hiroshima University, Associate Professor
Web Site
https://sites.google.com/view/saito-lab/
E-mail
nensaitohiroshima-u.ac.jp
Self-introduction
Biophysics/Theoretical Biology/Mathematical Modeling

Basic Information

Academic Degrees

  • Osaka University
  • Osaka University

Research Keywords

  • complex systems
  • mathematical biology
  • biophysics

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 3Term, Introduction to Information Mathematics
  2. 2025, Undergraduate Education, 2Term, Theory of Complex Systems
  3. 2025, Undergraduate Education, First Semester, Special Study of Mathematics and Informatics for Graduation
  4. 2025, Undergraduate Education, Second Semester, Special Study of Mathematics and Informatics for Graduation
  5. 2025, Undergraduate Education, First Semester, Special Lectures in Mathematics(Dynamics and self-organization of living matter)
  6. 2025, Undergraduate Education, First Semester, Special Lectures in Mathematics(Mathematical analysis of morphological properties and its applications)
  7. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
  8. 2025, Graduate Education (Master's Program) , 3Term, Mathematical Modeling A
  9. 2025, Graduate Education (Master's Program) , First Semester, Special Lecture on Mathematical and Life Sciences A(Mathematical analysis of morphological properties and its applications)
  10. 2025, Graduate Education (Master's Program) , First Semester, Special Lecture on Mathematical and Life Sciences B (Dynamics and self-organization of living matter)
  11. 2025, Graduate Education (Master's Program) , First Semester, Exercises in Applied Mathematics and Computational Science A
  12. 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Applied Mathematics and Computational Science B
  13. 2025, Graduate Education (Doctoral Program) , Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  14. 2025, Graduate Education (Doctoral Program) , First Semester, Special Lecture on Mathematical and Life Sciences E (Mathematical analysis of morphological properties and its applications)
  15. 2025, Graduate Education (Doctoral Program) , First Semester, Special Lecture on Mathematical and Life Sciences F (Dynamics and self-organization of living matter)
  16. 2025, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science

Research Activities

Academic Papers

  1. ★, Cell deformability drives fluid-to-fluid phase transition in active cell monolayers, SCIENCE ADVANCES, 10(19), 20240508
    Link to Paper Search Results by DOI
  2. Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis, NATURE COMMUNICATIONS, 14(1), 20231207
    Link to Paper Search Results by DOI
  3. Evolution of hierarchy and irreversibility in theoretical cell differentiation model, PNAS NEXUS, 3(1), 20231221
    Link to Paper Search Results by DOI
  4. A deep learning approach for morphological feature extraction based on variational auto-encoder: an application to mandible shape, NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 9(1), 20230706
    Link to Paper Search Results by DOI
  5. Rare-event sampling analysis uncovers the fitness landscape of the genetic code, PLOS COMPUTATIONAL BIOLOGY, 19(4), 202304
    Link to Paper Search Results by DOI
  6. Emergence of Bow-tie Architecture in Evolving Feedforward Networks, bioRxiv, 202303
  7. Microtopographical guidance of macropinocytic signaling patches, Proceedings of the National Academy of Sciences, 118(50), 20211214
  8. ★, Three-dimensional morphodynamic simulations of macropinocytic cups, iScience, 24(10), 103087-103087, 202110
  9. Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space, PLOS Computational Biology, 17(8), e1009237-e1009237, 20210812
  10. Adaptation of metabolite leakiness leads to symbiotic chemical exchange and to a resilient microbial ecosystem, PLOS Computational Biology, 17(6), 20210623
  11. Advantage of Leakage of Essential Metabolites for Cells, Physical Review Letters, 124(4), 20200128
  12. Embedding dual function into molecular motors through collective motion, SCIENTIFIC REPORTS, 7, 201703
  13. Symbiotic Cell Differentiation and Cooperative Growth in Multicellular Aggregates, PLOS COMPUTATIONAL BIOLOGY, 12(10), 201610
  14. Motif analysis for small-number effects in chemical reaction dynamics, JOURNAL OF CHEMICAL PHYSICS, 145(9), 201609
  15. Theoretical analysis of discreteness-induced transition in autocatalytic reaction dynamics, PHYSICAL REVIEW E, 91(2), 201502
  16. Multicanonical MCMC for sampling rare events: an illustrative review, ANNALS OF THE INSTITUTE OF STATISTICAL MATHEMATICS, 66(3), 611-645, 201406
  17. Evolution of genetic redundancy: the relevance of complexity in genotype-phenotype mapping, NEW JOURNAL OF PHYSICS, 16, 201406
  18. Baldwin effect under multipeaked fitness landscapes: Phenotypic fluctuation accelerates evolutionary rate, PHYSICAL REVIEW E, 87(5), 20130502
  19. Robustness leads close to the edge of chaos in coupled map networks: toward the understanding of biological networks, NEW JOURNAL OF PHYSICS, 15, 201305
  20. Probability of graphs with large spectral gap by multicanonical Monte Carlo, COMPUTER PHYSICS COMMUNICATIONS, 182(1), 223-225, 201101
  21. Multicanonical sampling of rare events in random matrices, PHYSICAL REVIEW E, 82(3), 201009

External Funds

Acceptance Results of Competitive Funds

  1. 2023, 2025
  2. 2021/04/01, 2024/03/31
  3. Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A), A theoretical study of 3D morphogenesis shaped by tissue-scale cytoskeletal alignment, 2021/09, 2023/03
  4. 2018/04, 2021/03
  5. 2014/04, 2016/03