KOICHI KATO
Last Updated :2025/05/09
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
- Web Site
- E-mail
- kokato
hiroshima-u.ac.jp
- Other Contact Details
- 1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-5645 FAX : (+81)82-257-5649
Basic Information
Major Professional Backgrounds
- 1996/05/01, 2001/03/31, Kobe University, Department of Chemical Science and Engineering, Research Associate
- 1999/02/01, 2000/02/29, University of Freiburg, Institute for Polymer Chemistry, Humboldt Postdoctoral Fellow
- 2001/04/01, 2007/03/31, Kyoto University, Institute for Frontier Medical Sciences, Associate Professor
- 2007/04/01, 2011/03/31, Kyoto University, Institute for Frontier Medical Sciences, Associate Professor
- 2011/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Professor
- 2012/03/01, Hiroshima University, Research Institute for Nanodevice and Bio Systems, Professor
- 2012/04/01, Hiroshima University, Center for Medical Specialist Graduate Education & Research, Director
- 2013/04/01, Hiroshima University, Institute of Biomedical & Health Sciences, Vice Dean (International Affairs)
- 2013/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Vice Dean (International Affairs)
- 2014/04/01, Hiroshima University, Basic Life Sciences, Institute of Biomedical & Health Sciences, Chairman
- 2014/04/01, Hiroshima University, Center for International Collaboration Development for Dentistry, Institute of Biomedical & Health Sciences, Director
- 2016/04/01, Hiroshima University, School of Dentistry, Dean
- 2016, 2016, Airlangga University, Faculty of Dental Medicine, Visiting Professor
- 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor
- 2021/06/01, Hiroshima University, Research Institute for Nanodevices, Vice Director
- 2022, 2022, Brawijaya University, Faculty of Dentistry, Visiting Professor
- 2023, Airlangga University, Faculty of Dental Medicine, Adjunct Professor
Educational Backgrounds
- Kyoto University, Graduate School, Division of Engineering, Department of Polymer Chemistry, Japan, 1991/04, 1994/03
- Kyoto University, Graduate School of Agriculture, Department of Wood Science and Technology, Japan, 1988/04, 1990/03
- Kyoto University, Faculty of Agriculture, Department of Wood Science and Technology, Japan, 1984/04, 1988/03
Academic Degrees
- Doctor of Engineering, Kyoto University
- Master of Agriculture, Kyoto University
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
Research Fields
- Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering
Research Keywords
- Biomaterials
- Regenerative medicine
- Stem cells
- Protein engineering
Affiliated Academic Societies
- The Japanese Society for Regenerative Medicine
- Japanese Society for Biomaterials, 1994
- The Japanese Society for Dental Materials and Devices, 2011
- The Society for Polymer Science, Japan, 1994
- The Chemical Society of Japan, 1996
- The Society of Nano Science and Technology, 2000
- American Chemical Society, 2006
- Japanese Association of Regenerative Dentistry
- Japan Nanomedicine Society
Educational Activity
Course in Charge
- 2025, Liberal Arts Education Program1, 2Term, General Chemistry
- 2025, Undergraduate Education, 4Term, Life Science
- 2025, Undergraduate Education, 1Term, Dental Materials and Devices I
- 2025, Undergraduate Education, 2Term, Dental Materials and Devices II
- 2025, Undergraduate Education, 3Term, Dental Materials and Devices Practice I
- 2025, Undergraduate Education, 4Term, Dental Materials and Devices Practice II
- 2025, Undergraduate Education, 2Term, Topics in Dental Research II
- 2025, Undergraduate Education, 2Term, Oral Implantology
- 2025, Undergraduate Education, First Semester, Dental Research Practices I
- 2025, Undergraduate Education, Second Semester, Dental Research Practices II
- 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
- 2025, Undergraduate Education, First Semester, Dental Research Practices III
- 2025, Undergraduate Education, 1Term, Dental Material
- 2025, Undergraduate Education, 1Term, Dental Material
- 2025, Undergraduate Education, 2Term, Biomaterials
- 2025, Graduate Education (Master's Program) , First Semester, Seminar
- 2025, Graduate Education (Master's Program) , Second Semester, Seminar
- 2025, Graduate Education (Master's Program) , First Semester, Research
- 2025, Graduate Education (Master's Program) , Second Semester, Research
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2025, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biomaterials
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biomaterials
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biomaterials
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biomaterials
Research Activities
Academic Papers
- Chimeric proteins consisting of bone morphogenetic protein-2 and a collagen-binding peptide: An in silico analysis, Dent. J., accepted, 2025
- A dilution method to increase the yield of engineered basic fibroblast growth factor, Dent. J., 58(3), 219-223, 2025
- Enhanced infiltration of myoblasts into collagen scaffolds loaded with engineered basic fibroblast growth factor, Dent. Mater. J., Epub ahead of print, 2025
- Chitosan nanoparticles as a targeted delivery system for anti-fibrotic microRNAs for oral submucosal fibrosis treatment, Colloid. Surf. B Biointerfaces, 252, 114657, 2025
- A case of bone resorption in the mentum caused by hyaluronic acid filler in a patient with skeletal Class II jaw deformity, Clin. Case Rep., 12, e9150, 2024
- Collagen-binding bone morphogenetic protein-2 designed for use in bone tissue engineering, Dent. Mater. J., 43(5), 718-728, 2024
- International education at Hiroshima University School of Dentistry: Bilingual education enabled diverse initiatives, J. Jpn. Dent. Edu. Assoc., 40(1), 20-23, 2024
- Structure and function of engineered stromal cell-derived factor-1alpha, Dent. Mater. J., 43(2), 286-293, 2024
- Bioengineering challenges in regenerative medicine: Biofunctional materials design, Biomedical Engineering: Imaging Systems, Electric Devices, and Medical Materials, 283-299, 2024
- Regenerative nanotechnology: Engineered surfaces for stem cell production, Nanomedicine, 605-622, 2023
- Solid-phase cytometry using antibody microarrays, J. Hiroshima Univ. Dent. Soc., 54(1), 1-10, 2022
- Recombinant protein synthesis for nanomaterial assembly: Technical overview, Bull. Soc. Nano Sci. Technol., 20(2), 31-37, 2022
- Enhancement of intercellular interaction between iPSC-derived neural progenitor cells and activated endothelial cells using cell surface modification with functional oligopeptides, Biomater. Sci., 10(4), 925-938, 2022
- Quantitative cell subset analysis using antibody microarrays, ACS Appl. Bio Mater., 4(10), 7673-7681, 2021
- Mucoadhesion of polyamphoteric hydrogels synthesized from acrylic acid and N,N-dimethylaminopropyl acrylamide, Int. J. Adhes. Adhes., 104, 102746, 2021
- Evaluation of a peptide motif designed for protein tethering to polymer surfaces, J. Biomater. Sci., Polym. Ed., 32(1), 76-92, 2021
- Epidermal growth factor-immobilized surfaces for the selective cultivation of neural progenitor cells derived from induced pluripotent stem cells, Biotechnol. Bioeng., 117(9), 2741-2748, 2020
- Oriented immobilization of basic fibroblast growth factor: Bioengineered surface design for the expansion of human mesenchymal stromal cells, Sci. Rep., 10, 8762-8762, 2020
- Optimization of culture conditions for the efficient differentiation of mouse induced pluripotent stem cells into dental epithelial-like cells, In Vitro Cell. Dev. Biol. Animal, 56, 816-824, 2020
- Effect of laser groove treatment on shear bond strength of adhesive resin cement to polyetheretherketone (PEEK), J. Prosthodontic Res., 63, 52-57, 2019
- Differentiation of mouse induced pluripotent stem cells into dental epithelial-like cells in the absence of added serum, In Vitro Cell. Dev. Biol. Animal, 55(2), 130-137, 2019
- Enhancement of calcification by osteoblasts cultured on hydroxyapatite surfaces with adsorbed inorganic polyphosphate, In Vitro Cell. Dev. Biol. Animal, 54, 449-457, 2018
- Wnt3a promotes differentiation of bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell. Dev. Biol. Animal, 54, 468-476, 2018
- Formation of chemical bonds at zirconia surfaces with acidic functional monomers, J. Oral Sci., 60, 187-193, 2018
- Molecular level analyses of mechanical properties of PTFE sterilized by Co-60 gamma-ray irradiation for clinical use, Radiation Phys. Chem., 139, 126-131, 201710
- Seeding of mesenchymal stem cells into inner part of interconnected porous biodegradable scaffold by a new method with a filter paper, Dent. Mater. J., 34(1), 78-85, 2015
- Antibody arrays for quality control of mesenchymal stem cells, ACS Appl. Mater. Interfaces, 7(30), 16828-16836, 2015
- Optimization of surface-immobilized extracellular matrices for the proliferation of neural progenitor cells derived from induced pluripotent stem cells, Biotechnol. Bioeng., 112(11), 2388-2396, 2015
- Biodental engineering, JOURNAL OF ORAL BIOSCIENCES, 57(2), 80-85, 2015
- New development of carbonate apatite-chitosan scaffold based on lyophilization technique for bone tissue engineering, DENTAL MATERIALS JOURNAL, 32(2), 317-325, 2013
- Cell orientation and regulation of cell-cell communication in human mesenchymal stem cells on different patterns of electrospun fibers, BIOMEDICAL MATERIALS, 8(5), 55002, 2013
- In Vivo Study on the Survival of Neural Stem Cells Transplanted into the Rat Brain with a Collagen Hydrogel That Incorporates Laminin-Derived Polypeptides, BIOCONJUGATE CHEMISTRY, 24(11), 1798-1804, 2013
- Influence of alkyl chain length on calcium phosphate deposition onto titanium surfaces modified with alkylphosphonic acid monolayers, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 101(8), 2267-2272, 2013
- Selective and rapid expansion of human neural progenitor cells on substrates with terminally anchored growth factors, BIOMATERIALS, 34(25), 6008-6014, 2013
- Monitoring neural stem cell differentiation using PEDOT-PSS based MEA, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1830(9), 4329-4333, 2013
- Improvement of neural stem cell survival in collagen hydrogels by incorporating laminin-derived cell adhesive polypeptides, Bioconjugate Chemistry, 23(2), 212-221, 2012
- Design of Biointerfaces for Regenerative Medicine, ADVANCES IN POLYMER SCIENCE, POLYMERS IN NANOMEDICINE, 247, 167-200, 2012
- Synthesis of Functional Artificial Lymphoid Tissues, DISCOVERY MEDICINE, 65, 351-362, 2011
- Design of culture substrates for large-scale expansion of neural stem cells, BIOMATERIALS, 32(4), 992-1001, 2011
- Enhanced proliferation of neural stem cells in a collagen hydrogel incorporating engineered epidermal growth factor, BIOMATERIALS, 32(21), 4737-4743, 2011
- Array-based functional screening of growth factors toward optimizing neural stem cell microenvironments, BIOMATERIALS, 32(22), 5015-5022, 2011
- High-throughput analyses of gene functions on a cell chip by electroporation, METHODS IN MOLECULAR BIOLOGY; CELL-BASED MICROARRAYS, 706, 181-190, 2011
- Layer-by-layer assembly of small interfering RNA and poly(ethyleneimine) for substrate-mediated electroporation with high efficiency, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 397(2), 571-578, 2010
- Prolonged durability of electroporation microarrays as a result of addition of saccharides to nucleic acids, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 393(2), 607-614, 2009
- Surface-Anchoring of Spontaneously Dimerized Epidermal Growth Factor for Highly Selective Expansion of Neural Stem Cells, BIOCONJUGATE CHEMISTRY, 20(1), 102-110, 2009
- Enhanced Survival of Neural Cells Embedded in Hydrogels Composed of Collagen and Laminin-Derived Cell Adhesive Peptide, BIOCONJUGATE CHEMISTRY, 20(5), 976-983, 2009
- Surface-Displayed Antibodies as a Tool for Simultaneously Controlling the Arrangement and Morphology of Multiple Cell Types with Microscale Precision, ACS APPLIED MATERIALS & INTERFACES, 1(1), 53-55, 2009
- Hyaluronic acid hydrogel loaded with genetically-engineered brain-derived neurotrophic factor as a neural cell carrier, BIOMATERIALS, 30(27), 4581-4589, 2009
- Use of microarrays in transfection of mammalian cells with dicer-digested small interfering RNAs, ANALYTICAL BIOCHEMISTRY, 374(2), 417-422, 2008
- Multifunctional chimeric proteins for the sequential regulation of neural stem cell differentiation, BIOCONJUGATE CHEMISTRY, 19(2), 516-524, 2008
- Self-assembling chimeric protein for the construction of biodegradable hydrogels capable of interaction with Integrins expressed on neural stem/progenitor cells, BIOMACROMOLECULES, 9(5), 1411-1416, 2008
- A collagen-binding mimetic of neural cell adhesion molecule, BIOCONJUGATE CHEMISTRY, 19(6), 1119-1123, 2008
- Essential role of structural integrity and firm attachment of surface-anchored epidermal growth factor in adherent culture of neural stem cells, BIOMATERIALS, 29(33), 4403-4408, 2008
- Electroporation microarray for parallel transfer of small interfering RNA into mammalian cells, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 392(7-8), 1309-1316, 2008
- Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation, BIOMATERIALS, 28(6), 1048-1060, 2007
- Antibody arrays for quantitative immunophenotyping, BIOMATERIALS, 28(6), 1289-1297, 2007
- Oriented immobilization of epidermal growth factor onto culture substrates for the selective expansion of neural stem cells, BIOMATERIALS, 28(24), 3517-3529, 2007
- High-throughput immunophenotyping by surface plasmon resonance imaging, ANALYTICAL CHEMISTRY, 79(22), 8616-8623, 2007
- Array-based functional screening for genes that regulate vascular endothelial differentiation of Flk1-positive progenitors derived from embryonic stem cells, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1085-1097, 2007
- Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils, BIOCONJUGATE CHEMISTRY, 18(6), 2137-2143, 2007
- Fabrication of cell-based arrays using micropatterned alkanethiol monolayers for the parallel silencing of specific genes by small interfering RNA, BIOCONJUGATE CHEMISTRY, 17(6), 1404-1410, 2006
- Layer-by-layer assembly of cationic lipid and plasmid DNA onto gold surface for stent-assisted gene transfer, BIOMATERIALS, 27(18), 3497-3504, 2006
- A thin carboxymethyl cellulose culture substrate for the
cellulase-induced harvesting of an endothelial cell sheet, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 16(10), 1277-1292, 2005
- Layer-by-layer assembly of poly(ethyleneimine) and plasmid DNA onto transparent indium-tin oxide electrodes for temporally- and spatially-specific gene transfe, LANGMUIR, 21(18), 8360-8367, 2005
- Immobilization of histidine-tagged recombinant proteins onto micropatterned surfaces for cell-based functional assays, LANGMUIR, 21(16), 7071-7075, 2005
- Parallel analysis of multiple surface markers expressed on rat neural stem cells using antibody microarrays, BIOMATERIALS, 26(23), 4882-4891, 2005
- Antibody microarray for correlating cell phenotype with surface marker, BIOMATERIALS, 26(6), 687-696, 2005
- Synthesis and characterization of stimuli-sensitive hydrogels having a different length of ethylene glycol chains carrying phosphate groups: loading and release of lysozyme, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 15(11), 1435-1446, 2004
- Spatially and temporally controlled electroporation of adherent cells on plasmid DNA-loaded electrode, NUCLEIC ACIDS RESEARCH, 32(22), e187, 2004
- Drug permeation through temperature-sensitive microfiltration membranes prepared from poly(vinylidene fluoride) with grafted poly(N-isopropylacrylamide) side chains, JOURNAL OF MEMBRANE SCIENCE, 243(1,2), 253-262, 2004
- Adsorption of enantiomeric poly(lactide)s on surface-grafted poly(L-lactide), LANGMUIR, 20(16), 6748-6753, 2004
- Micropatterned, self-assembled monolayers for fabrication of transfected cell microarrays, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1672(3), 138-147, 2004
- Polymer surface with graft chains, PROGRESS IN POLYMER SCIENCE, 28(2), 209-259, 2003
- The interplay between surface micro-topography and -mechanics of type I collagen fibrils in air and aqueous media: An atomic force microscopy study, EUROPEAN PHYSICAL JOURNAL E, 6(1), 7-14, 2001
- Glistening formation in an AcrySof lens initiated by spinodal decompositionof the polymer network by temperature change, JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 27(9), 1493-1498, 2001
- Synthesis of bioadhesive hydrogels from chitin derivatives, INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, 21(3), 227-232, 2001
- Optical and atomic force microscopy of an explanted AcrySof intraocular lens with glistenings, JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 26(4), 571-575, 2000
- Collagen immobilization onto the surface of artificial hair for improving the tissue adhesion, JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 14(5), 635-650, 2000
- Preparation of DNA-immobilized immunoadsorbents for treatment of systemic lupus erythematosus, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 10(3), 341-350, 1999
- Surface oxidation of cellulose fibers by vacuum ultraviolet irradiation, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 37(3), 357-361, 1999
- Lysozyme loading and release from hydrogels carrying pendant phosphate groups, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 9(1), 43-53, 1998
- Surface modification of polymers by grafting, ADVANCES IN POLYMER SCIENCE, 137, 1-39, 1998
- Histologic and mechanical evaluation for bone bonding of polymer surfaces grafted with a phosphate-containing polymer, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 37(3), 384-393, 1997
- In situ hydroxyapatite crystallization for the formation of hydroxyapatite / polymer composites, JOURNAL OF MATERIALS SCIENCE, 32(20), 5533-5543, 1997
- Ultrastructure of the interface between cultured osteoblasts and surface-modified polymer substrates, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 37(1), 29-36, 1997
- Studies on tumor-promoting activity of polyethylene: Inhibitory activity of metabolic cooperation on polyethylene surfaces is markedly decreased by surface modification with collagen but not with RGDS peptide, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 35(3), 391-397, 1997
- Polymeric supports for immunoadsorption, RECENT RESEARCH DEVELOPMENTS IN MACROMOLECULAR RESEARCH, 2, 157-173, 1997
- Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration, TISSUE ENGINEERING, 2(4), 315-326, 1996
- Deposition of a hydroxyapatite thin layer onto a polymer surface carrying grafted phosphate polymer chains, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 32(4), 687-691, 1996
- Surface modification and functionalization of polytetrafluoroethylene films, MACROMOLECULES, 29(21), 6872-6879, 1996
- Plasma treatment of polyaniline films: Effect on the intrinsic oxidation states, JOURNAL OF MATERIALS RESEARCH, 11(6), 1570-1573, 1996
- XPS Characterization of surface functionalized electroactive polymers, SURFACE AND INTERFACE ANALYSIS, 24(9), 597-604, 1996
- Immobilization of DNA onto a polymer support and its potentiality as immunoadsorbent, BIOTECHNOLOGY AND BIOENGINEERING, 51(5), 581-590, 1996
- Surface graft polymerization of glycidyl methacrylate onto polyethylene and the adhesion with epoxy resin, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 33(15), 2629-2638, 1995
- Selective adsorption of proteins to their ligands covalently immobilized onto microfibers, BIOTECHNOLOGY AND BIOENGINEERING, 47(5), 557-566, 1995
- Protein adsorption onto ionic surfaces, COLLOIDS AND SURFACES B: BIOINTERFACES, 4(4), 221-230, 1995
- Peroxide generation and decomposition on polymer surface, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 33(2), 323-330, 1995
- In vitro hydroxyapatite deposition onto a film surface-grafted with organophosphate polymer, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 28(11), 1365-1373, 1994
- Introduction of functional groups onto the surface of polyethylene for protein immobilization, BIOMATERIALS, 14(11), 817-822, 1993
- Trypsin immobilization on to polymer surface through grafted layer and its reaction with inhibitors, BIOMATERIALS, 14(10), 763-769, 1993
Publications such as books
- 2023, Nanomedicine, Regenerative nanotechnology: Engineered surfaces for stem cell production, Springer, 2023, 2023, Scholarly Book, Contributor, English, Ayana Nakano, Koichi Kato, 895
- 2016, Synthetic Immunology, Engineering of artificial lymph node, Springer, 2016, Scholarly Book, Joint work, English, Makoto Nakamura, Kenichi Arai, Takahito Mimura, Jungo Tagawa, Hirotoshi Yoshida, Koichi Kato, Tadashi Nakaji-Hirabayashi, Yuka Kobayashi, Takeshi Watanabe
- 2016, Synthetic Immunology, Synthesis of functional tertiary lymphoid organs, Springer, 2016, Scholarly Book, Joint work, English, Y. Kobayashi, K. Kato, M. Nakamura, T. Watanabe
Awards
- 1998, Young Investigator Award from the Society of Polymer Science, Japan, 1998
- 2004, The Award for Young Investigator of Japanese Society for Biomaterials, 2004