Last Updated :2023/09/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Associate Professor (Special Recognition)
Other Contact Details
1-2-3 Kasumi Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5327 FAX : (+81)
I am studying about regulation of brain functions by lipid metabolism.

Basic Information

Major Professional Backgrounds

  • 2010, 2011, Grant-in-Aid for JSPS, Fellows (DC2)
  • 2012/04, 2015/03, Kwansei Gakuin University
  • 2015/04, 2019/03, Kwansei Gakuin University, Assistant Professor
  • 2019/04/01, 2022/03/31, Hiroshima University, Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2022/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
  • 2022/06/28, Hiroshima University, Associate Professor (Special Recognition)

Educational Backgrounds

  • Kwansei Gakuin University, 2009/04, 2012/03
  • Kwansei Gakuin University, 2007/04, 2009/03
  • Kwansei Gakuin University, 2003/04, 2007/03

Academic Degrees

  • Kwansei Gakuin University
  • Kwansei Gakuin University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

Affiliated Academic Societies

  • The Japanese Society of Toxicology
  • The Japanese Biochemical Society
  • The Molecular Biology Society of Japan
  • the Pharmaceutical Society of Japan
  • The Japanese Society for the Study of Xenobiotics

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, 3Term, Public Health Chemistry III
  2. 2023, Undergraduate Education, First Semester, Experiments of Public health Chemistry
  3. 2023, Graduate Education (Master's Program) , 2Term, Lecture on Neurochemistry and Environmental Health Sciences

Research Activities

Academic Papers

  1. Hydrogen peroxide activates APE1/Ref-1 via NF-& kappa;B and Parkin: a role in liver cancer resistance to oxidative stress, FREE RADICAL RESEARCH, 57(3), 223-238, 20230304
  2. Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation, Particle and Fibre Toxicology, 20(1):6, 202302
  3. Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes., mBio., 17:e0305122, 202301
  4. Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia., Sci. Rep., 12(21265), 2022
  5. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter., J. Toxicol. Sci.,, 47(5), 201-210, 2022
  6. Diagnosis of Parkinson's disease by investigating the inhibitory effect of serum components on P450 inhibition assay, Sci Rep., 12(1), 6622, 2022
  7. Chlorogenic acid activates Nrf2/SKN-1 and prolongs the lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 pathway and activation of DAF16f., J Gerontol A Biol Sci Med Sci., 2022
  8. Sp1 is a substrate of Keap1 and regulates the activity of CRL4A WDR23 ubiquitin ligase toward Nrf2., J. Biol. Chem., 296, 2021
  9. ★, Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., BBA - Molecular and Cell Biology of Lipids, 2021
  10. Feedback of hypoxia-inducible factor-1alpha (HIF-1alpha) transcriptional activity via redox factor-1 (Ref-1) induction by reactive oxygen species (ROS)., Free Radic Res., 2021
  11. The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI)., PLoS One, 16(2):e0246531, 2021
  12. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells., Int. J. Mol. Sci., 22(6):3213, 2021
  13. Involvement of the microglial aryl hydrocarbon receptor in neuroinflammation and vasogenic edema after ischemic stroke., Cells, 10(4):718, 2021
  14. Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor., J. Toxicol. Sci., 46(1), 1-10, 2021
  15. Measurement of the estradiol concentration in cerebrospinal fluid from infants and its correlation with serum estradiol and exosomal microRNA-126-5p., Biol Pharm Bull., 43(12), 1966-1968, 2020
  16. WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes, Drug Metab. Pharmacokinet., S1347-4367(20), 30380-30383, 2020
  17. Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells., J. Toxicol. Sci., 45(12), 783-794, 2020
  18. ★, Thioredoxin-related transmembrane protein 2 (TMX2) regulates the Ran protein gradient and importin-beta-dependent nuclear cargo transport., Sci. Rep., 9:15296, 2019
  19. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Sci Rep., 2019
  20. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol., 193(105421), 2019
  21. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 2019
  22. 14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells., Pharmacology Research & Perspectives, 6(5):e00428, 2018
  23. Bisphenol A induces Nrf2-dependent drug-metabolizing enzymes through nitrosylation of Keap1, Drug Metabolism and Pharmacokinetics, 33(4), 194-202, 2018
  24. Bisphenol A and Its Derivatives Induce Degradation of HIF-1alpha via the Lysosomal Pathway in Human Hepatocarcinoma Cell Line, Hep3B, Biol. Pharm. Bull., 41(3), 374-382, 2018
  25. Chlorogenic acid modulates hypoxia response of Hep3B cells, Personalized Medicine Universe, 6, 12-16, 2017
  26. ★, Down-regulation of EPHX2 gene transcription by Sp1 under high glucose conditions., Biochem. J., 470(3), 281-291, 2015
  27. Protein factors and chemical compounds regulating hypoxic or oxidative stress responses, Personalized Medicine Universe, 4, 27-31, 2015
  28. The metabolism of lysophosphatidic acids by allelic variants of human soluble epoxide hydrolase, Drug Metab. Pharmacokinet., 30(1), 75-81, 2015
  29. Isolation and characterization of Xenopus soluble epoxide hydrolase., Biochim. Biophys. Acta., 1841(7), 954-962, 2014
  30. Endoplasmic Reticulum Protein (ERp) 29 Binds As Strongly As Protein Disulfide Isomerase (PDI) to Bisphenol A, Chem Res Toxicol., 27(4), 501-506, 2014
  31. A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response, Biochem Biophys Res Commun., 445(1), 43-47, 2014
  32. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase., Cardiovasc. Res., 93(1), 120-129, 2012
  33. ★, Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase, J. Lipid Res., 53(3), 505-512, 2012
  34. Overexpression of CYP3A4, but not CYP2D6, promotes hypoxic response and cell growth of Hep3B cells, Drug Metab. Pharmacokinet., 26(4), 407-415, 2011
  35. Contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to VEGF expression and cell growth, Biol. Pharm. Bull., 32(12), 1962-1967, 2009
  36. Regulation of soluble epoxide hydrolase (sEH) in mice with diabetes: High glucose suppresses sEH expression, Drug Metab. Pharmacokinet., 24(5), 438-445, 2009
  37. Epoxyeicosatrienoic Acids and/or Their Metabolites Promote Hypoxic Response of Cells, J Pharmacol Sci., 108, 79-88, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., Oguro A. and Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases, 2020, Without Invitation, English
  2. Bisphenol A is a villain or a hero: It suppresses VEGF expression in Hep3B cells and Erp29 binds to it, Devi Ayu, Lestari, Yukino Kobayashi, Ami Oguro, and Susumu Imaoka, The 23rd international Congress of Personalized Medicine, 2017, Without Invitation, Japanese
  3. CHLOROGENIC ACID MODULATES HYPOXIC RESPONSE OF HEP3B CELLS AND PROLONGS THE LIFESPAN OF Caenorhabditis elegans, Ferbian Milas Siswanto, Ami Oguro, Susumu Imaoka, 2016, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2023, 2024
  2. 2022, 2025
  3. JSPS KAKENHI Grant-in-Aid for Scientific Research (C), 2020, 2022
  4. 2022, 2023
  5. 2022, 2023
  6. 2020, 2022
  7. 2020, 2022
  8. 2019, 2020
  9. Grant-in-Aid for Young Scientists (B), 2016, 2018
  10. 2016
  11. 2016
  12. 2016
  13. 2016
  14. Grant-in-Aid for JSPS Fellows (DC2), 2010, 2011