Last Updated :2021/07/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Other Contact Details
1-7-1, Kagamiyama, Higashi-Hiroshima, Japan
TEL : (+81)82-424-6500 FAX : (+81)
I am studying about regulation of brain functions by lipid metabolism.

Basic Information

Major Professional Backgrounds

  • 2010, 2011, Grant-in-Aid for JSPS, Fellows (DC2)
  • 2012/04, 2015/03, Kwansei Gakuin University
  • 2015/04, 2019/03, Kwansei Gakuin University, Assistant Professor
  • 2019/04/01, Hiroshima University, Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Assistant Professor

Educational Backgrounds

  • Kwansei Gakuin University, 2009/04, 2012/03
  • Kwansei Gakuin University, 2007/04, 2009/03
  • Kwansei Gakuin University, 2003/04, 2007/03

Academic Degrees

  • Kwansei Gakuin University
  • Kwansei Gakuin University

Educational Activity

  • 【Bachelor Degree Program】School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences

Affiliated Academic Societies

  • The Japanese Biochemical Society
  • The Molecular Biology Society of Japan
  • The Japanese Society of Toxicology

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  2. 2021, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  3. 2021, Undergraduate Education, 2Term, Introduction to Life Sciences
  4. 2021, Undergraduate Education, 2Term, Functional Biochemistry I
  5. 2021, Undergraduate Education, 3Term, Functional Biochemistry II
  6. 2021, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  7. 2021, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  8. 2021, Undergraduate Education, 4Term, Functional Biochemistry III
  9. 2021, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  10. 2021, Undergraduate Education, 2Term, Fundamentals of Biochemistry II
  11. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  12. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  13. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  14. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  15. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Sp1 is a substrate of Keap1 and regulates the activity of CRL4A WDR23 ubiquitin ligase toward Nrf2., J. Biol. Chem., 296, 2021
  2. Involvement of the microglial aryl hydrocarbon receptor in neuroinflammation and vasogenic edema after ischemic stroke., Cells, 10(4):718, 2021
  3. DHA and Its Metabolites Have a Protective Role against Methylmercury-Induced Neurotoxicity in Mouse Primary Neuron and SH-SY5Y Cells., Int. J. Mol. Sci., 22(6):3213, 2021
  4. The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI)., PLoS One, 16(2):e0246531, 2021
  5. Feedback of hypoxia-inducible factor-1alpha (HIF-1alpha) transcriptional activity via redox factor-1 (Ref-1) induction by reactive oxygen species (ROS)., Free Radic Res., 2021
  6. ★, Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., BBA - Molecular and Cell Biology of Lipids, 2021
  7. Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor., J. Toxicol. Sci., 46(1), 1-10, 2021
  8. Measurement of the estradiol concentration in cerebrospinal fluid from infants and its correlation with serum estradiol and exosomal microRNA-126-5p., Biol Pharm Bull., 43(12), 1966-1968, 2020
  9. Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells., J. Toxicol. Sci., 45(12), 783-794, 2020
  10. WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes, Drug Metab. Pharmacokinet., S1347-4367(20), 30380-30383, 2020
  11. ★, Thioredoxin-related transmembrane protein 2 (TMX2) regulates the Ran protein gradient and importin-beta-dependent nuclear cargo transport., Sci. Rep., 9:15296, 2019
  12. Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus., Sci Rep., 2019
  13. Suppressive effects of levetiracetam on neuroinflammation and phagocytic microglia: A comparative study of levetiracetam, valproate and carbamazepine, NEUROSCIENCE LETTERS, 708, 2019
  14. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis., J Steroid Biochem Mol Biol., 193(105421), 2019
  15. 14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells., Pharmacology Research & Perspectives, 6(5):e00428, 2018
  16. Bisphenol A induces Nrf2-dependent drug-metabolizing enzymes through nitrosylation of Keap1, Drug Metabolism and Pharmacokinetics, 33(4), 194-202, 2018
  17. Bisphenol A and Its Derivatives Induce Degradation of HIF-1alpha via the Lysosomal Pathway in Human Hepatocarcinoma Cell Line, Hep3B, Biol. Pharm. Bull., 41(3), 374-382, 2018
  18. Chlorogenic acid modulates hypoxia response of Hep3B cells, Personalized Medicine Universe, 6, 12-16, 2017
  19. ★, Down-regulation of EPHX2 gene transcription by Sp1 under high glucose conditions., Biochem. J., 470(3), 281-291, 2015
  20. Protein factors and chemical compounds regulating hypoxic or oxidative stress responses, Personalized Medicine Universe, 4, 27-31, 2015
  21. The metabolism of lysophosphatidic acids by allelic variants of human soluble epoxide hydrolase, Drug Metab. Pharmacokinet., 30(1), 75-81, 2015
  22. Isolation and characterization of Xenopus soluble epoxide hydrolase., Biochim. Biophys. Acta., 1841(7), 954-962, 2014
  23. A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response, Biochem Biophys Res Commun., 445(1), 43-47, 2014
  24. Endoplasmic Reticulum Protein (ERp) 29 Binds As Strongly As Protein Disulfide Isomerase (PDI) to Bisphenol A, Chem Res Toxicol., 27(4), 501-506, 2014
  25. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase., Cardiovasc. Res., 93(1), 120-129, 2012
  26. ★, Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase, J. Lipid Res., 53(3), 505-512, 2012
  27. Overexpression of CYP3A4, but not CYP2D6, promotes hypoxic response and cell growth of Hep3B cells, Drug Metab. Pharmacokinet., 26(4), 407-415, 2011
  28. Contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to VEGF expression and cell growth, Biol. Pharm. Bull., 32(12), 1962-1967, 2009
  29. Regulation of soluble epoxide hydrolase (sEH) in mice with diabetes: High glucose suppresses sEH expression, Drug Metab. Pharmacokinet., 24(5), 438-445, 2009
  30. Epoxyeicosatrienoic Acids and/or Their Metabolites Promote Hypoxic Response of Cells, J Pharmacol Sci., 108, 79-88, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of DHA metabolites in protective effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease., Oguro A. and Ishihara Y, 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases, 2020, Without Invitation, English
  2. Bisphenol A is a villain or a hero: It suppresses VEGF expression in Hep3B cells and Erp29 binds to it, Devi Ayu, Lestari, Yukino Kobayashi, Ami Oguro, and Susumu Imaoka, The 23rd international Congress of Personalized Medicine, 2017, Without Invitation, Japanese
  3. CHLOROGENIC ACID MODULATES HYPOXIC RESPONSE OF HEP3B CELLS AND PROLONGS THE LIFESPAN OF Caenorhabditis elegans, Ferbian Milas Siswanto, Ami Oguro, Susumu Imaoka, 2016, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. JSPS KAKENHI Grant-in-Aid for Scientific Research (C), 2020, 2022
  2. 2020, 2022
  3. 2020, 2022
  4. 2019, 2020
  5. Grant-in-Aid for Young Scientists (B), 2016, 2018
  6. 2016
  7. 2016
  8. 2016
  9. 2016
  10. Grant-in-Aid for JSPS Fellows (DC2), 2010, 2011