DAISUKE KAWAHARA

Last Updated :2025/05/09

Affiliations, Positions
Hiroshima University Hospital(Division of Clinical Radiology), Associate Professor
E-mail
daika99hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Hiroshima University
  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Boundary medicine;Medical Physics and Radiological Technology
  • Informatics;Computing Technologies;Multimedia database

Affiliated Academic Societies

  • American Medical Physics Society
  • Japanese Society of Medical Physics
  • Japanese Society of Radiological Technology
  • Japanese Society of Radiation Oncology

Educational Activity

Course in Charge

  1. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Physics of Nuclear Medicine
  2. 2025, Graduate Education (Master's Program) , First Semester, English for Scientific Paper
  3. 2025, Graduate Education (Master's Program) , First Semester, Biostatistics
  4. 2025, Graduate Education (Master's Program) , Second Semester, Health Physics
  5. 2025, Graduate Education (Doctoral Program) , First Semester, Clinical Practicum in Medical Physics
  6. 2025, Graduate Education (Doctoral Program) , Second Semester, Clinical Practicum in Medical Physics
  7. 2025, Undergraduate Education, Intensive, Practice for medical research
  8. 2025, Graduate Education (Master's Program) , First Semester, Physics of Diagnostic Radiology
  9. 2025, Graduate Education (Master's Program) , First Semester, Radiation Oncology Physics
  10. 2025, Graduate Education (Master's Program) , Second Semester, Physics of Nuclear Medicine
  11. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Radiation Oncology Physics
  12. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Radiation Dosimetry
  13. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Physics of Diagnostic Imaging

Research Activities

Academic Papers

  1. Radiomics and dosiomics for predicting complete response to definitive chemoradiotherapy patients with oesophageal squamous cell cancer using the hybrid institution model, EUROPEAN RADIOLOGY, 34(2), 1200-1209, 202402
  2. Unbiased evaluation of predicted gamma passing rate by an event-mixing technique, MEDICAL PHYSICS, 51(1), 5-17, 202401
  3. Dosiomics for intensity-modulated radiotherapy in patients with prostate cancer: survival analysis stratified by baseline prostate-specific antigen and Gleason grade group in a 2-institutional retrospective study, BRITISH JOURNAL OF RADIOLOGY, 97(1153), 142-149, 20240123
  4. Usability of synthesized image using generative adversarial network for prediction model of recurrence after radiotherapy in locally advanced cervical cancer, BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 89, 202403
  5. Artificial intelligence-based diagnosis of the depth of laryngopharyngeal cancer, AURIS NASUS LARYNX, 51(2), 417-424, 202404
  6. A simulation study on the radiation-induced immune response of tumors after single fraction high-dose irradiation, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 118, 202402
  7. CT number calibration audit in photon radiation therapy, MEDICAL PHYSICS, 51(3), 1571-1582, 202403
  8. Predicting the BRAF mutation with pretreatment MRI radiomics features for melanoma brain metastases receiving Gamma Knife radiosurgery, CLINICAL RADIOLOGY, 78(12), E934-E940, 202312
  9. Novel simulation for dosimetry impact of diaphragm respiratory motion in four-dimensional volumetric modulated arc therapy for esophageal cancer, RADIOTHERAPY AND ONCOLOGY, 187, 202310
  10. Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model, REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 28(4), 514-521, 20230801
  11. Dose uncertainty due to energy dependence in dual-energy computed tomography, POLISH JOURNAL OF RADIOLOGY, 88, e270-e274, 20230607
  12. A synthesized gamma distribution-based patient-specific VMAT QA using a generative adversarial network, MEDICAL PHYSICS, 50(4), 2488-2498, 202304
  13. Image masking using convolutional networks improves performance classification of radiation pneumonitis for non-small cell lung cancer, PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE, 46(2), 767-772, 202306
  14. Prognostic Value of Radiomics Analysis of Skeletal Muscle After Radical Irradiation of Esophageal Cancer, ANTICANCER RESEARCH, 43(4), 1749-1760, 202304
  15. Image masking using convolutional networks improves performance classification of radiation pneumonitis for non-small cell lung cancer, Physical and Engineering Sciences in Medicine, 46(2), 767-777, 20230101
  16. MRI image synthesis for fluid-attenuated inversion recovery and diffusion-weighted images with deep learning, Physical and Engineering Sciences in Medicine, 46(1), 313-323, 20230101
  17. A synthesized gamma distribution-based patient-specific VMAT QA using a generative adversarial network, Medical Physics, 50(4), 2488-2498, 202301
  18. Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy, JOURNAL OF RADIATION RESEARCH, 64(2), 328-334, 20230323
  19. Influence of different air CT numbers for IVDT on the dose distribution in TomoTherapy MVCT, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 24(2), 202302
  20. Tolerance levels of mass density for adaptive helical tomotherapy using MVCT, JOURNAL OF RADIATION RESEARCH, 64(1), 195-201, 20230120
  21. Predictive gamma passing rate of 3D detector array-based volumetric modulated arc therapy quality assurance for prostate cancer via deep learning, PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE, 45(4), 1073-1081, 202212
  22. Radiomic Analysis for Pretreatment Prediction of Recurrence Post-Radiotherapy in Cervical Squamous Cell Carcinoma Cancer, DIAGNOSTICS, 12(10), 202210
  23. Robust optimization of VMAT for prostate cancer accounting for geometric uncertainty, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 23(9), 202209
  24. DNA strand breaks based on Monte Carlo simulation in and around the Lipiodol with flattening filter and flattening filter-free photon beams, REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 27(3), 392-400, 2022
  25. Understanding Breast Cancers through Spatial and High-Resolution Visualization Using Imaging Technologies, CANCERS, 14(17), 202209
  26. Improved biological dosimetric margin model for different PTV margins with stereotactic body radiation therapy in homogeneous and nonhomogeneous tumor regions, Reports of Practical Oncology and Radiotherapy, 202208
  27. DNA strand breaks based on Monte Carlo simulation in and around the Lipiodol with flattening filter and flattening filter-free photon beams, Reports of Practical Oncology and Radiotherapy, 6, 392-400, 202206
  28. A prediction model for pathological findings after neoadjuvant chemoradiotherapy for resectable locally advanced esophageal squamous cell carcinoma based on endoscopic images using deep learning, BRITISH JOURNAL OF RADIOLOGY, 95(1135), 2022
  29. Development of a radiomics and machine learning model for predicting occult cervical lymph node metastasis in patients with tongue cancer, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 134(1), 93-101, 202207
  30. Deep learning-based auto segmentation using generative adversarial network on magnetic resonance images obtained for head and neck cancer patients, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 23(5), 202205
  31. Stoichiometric CT number calibration using three-parameter fit model for ion therapy, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 99, 22-30, 202207
  32. Stepwise deep neural network (stepwise-net) for head and neck auto-segmentation on CT images, COMPUTERS IN BIOLOGY AND MEDICINE, 143, 202204
  33. Availability of Using Diaphragm Matching in Stereotactic Body Radiotherapy (SBRT) at the Time in Breath-holding SBRT for Liver Cancer, Japanese journal of radiological technology, 70(1), 51-56, 201401
  34. Tolerance levels of mass density for CT number calibration in photon radiation therapy, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 20(6), 45-52, 201906
  35. Photon and electron backscatter dose and energy spectrum analysis around Lipiodol using flattened and unflattened beams, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 20(6), 178-183, 201906
  36. Availability of applying diaphragm matching with the breath-holding technique in stereotactic body radiation therapy for liver tumors, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 32(4), 557-561, 201606
  37. Impact of reduction of flux overlap region on kilovoltage cone beam computed tomography image quality and patient's exposure dose, Reports of practical oncology and radiotherapy, 21(5), 460-465, 201609
  38. Evaluation of beam modeling for small fields using a flattening filter free beam, Radiological Physics and Technology, 10(1), 33-40, 201705
  39. Marginal prescription equivalent to the isocenter prescription in lung stereotactic body radiotherapy: preliminary study for Japan Clinical Oncology Group trial (JCOG1408), Journal of Radiation Research, 58(1), 149-154, 201701
  40. ★, Dosimetric impact of Lipiodol in stereotactic body radiation therapy on liver after trans-arterial chemoembolization, Medical physics, 44(1), 342-348, 201701
  41. Absorbed dose and image quality of Varian TrueBeam CBCT compared with OBI CBCT, Physica Medica, 32(12), 1628-1633, 201612
  42. Evaluation of Absorbed Dose for CBCT in Image-guided Radiation Therapy: Comparison of Each Devices and Facilities., Japanese Journal of Radiological Technology, 73(4), 309-316, 201704
  43. Split-VMAT technique to control the expiratory breath-hold time in liver stereotactic body radiation therapy, Physica Medica, 40, 17-23, 201708
  44. Tolerance levels of CT number to electron density table for photon beam in radiotherapy treatment planning system, Journal of Applied Clinical Medical Physics, 19(1), 271-275, 201801
  45. Accuracy of the raw-data-based effective atomic numbers and monochromatic CT numbers for contrast medium with a dual-energy CT technique., The British journal of radiology, 91(1082), 201802
  46. Energy spectrum and dose enhancement due to the depth of the Lipiodol position using flattened and unflattened beams, Reports of Practical Oncology & Radiotherapy, 23(1), 50-56, 201802
  47. Interfractional diaphragm changes during breath-holding in stereotactic body radiotherapy for liver cancer, Reports of Practical Oncology and Radiotherapy, 23(2), 84-90, 201803
  48. Effect of secondary electron generation on dose enhancement in Lipiodol with and without a flattening filter, Journal of Applied Clinical Medical Physics, 19(2), 211-217, 201803
  49. Relative biological effectiveness study of Lipiodol based on microdosimetric-kinetic model, Physica Medica, 46, 89-95, 201802
  50. Estimation of patient-specific imaging dose for real-time tumor monitoring in lung patients during respiratory-gated radiotherapy., Physics in Medicine & Biology, 63(6), 201803
  51. A novel verification method using a plastic scintillator imagining system for assessment of gantry sag in radiotherapy, Medical Physics, 45(6), 2411-2424, 201806
  52. Automatic contrast medium extraction system using electron density data with dual-energy CT, The British journal of radiology, 91(1090), 201810
  53. Effect of dose-delivery time for flattened and flattening filter-free photon beams based on microdosimetric kinetic model, PLOS ONE, 13(11), 201811
  54. A novel risk analysis of clinical reference dosimetry based on failure modes and effects analysis, Physica Medcia, 58, 59-65, 201902
  55. Metal artifact reduction techniques for single energy CT and dual-energy CT with various metal materials, The British Institute of Radiology Open, 201907
  56. Tolerance levels of mass density for CT number calibration in photon radiation therapy, Journal of Applied Clinical Medical Physics, 20(6), 45-52, 201906
  57. Evaluation of raw-data-based and calculated electron density for contrast media with a dual-energy CT technique., Reports of Practical Oncology and Radiotherapy, 24(5), 499-506, 201909
  58. Dosimetric impact of Lipiodol in stereotactic body radiation therapy on liver after trans-arterial chemoembolization, 2018
  59. Availability of Using Diaphragm Matching in Stereotactic Body Radiotherapy (SBRT) in Breath-Holding SBRT for Liver Cancer, 2016
  60. Improving automatic contrast agent extraction system using monochromatic CT number, Australasian Physical & Engineering Sciences in Medicine, 42(3), 819-826, 201908
  61. Evaluation of raw-data-based and calculated electron density for contrast media with a dual-energy CT technique, REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 24(5), 499-506, 2019
  62. Biological dose-enhancement analysis with Monte Carlo simulation for Lipiodol for photon beams, REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 24(6), 681-687, 2019
  63. Predictive gamma passing rate for three-dimensional dose verification with finite detector elements via improved dose uncertainty potential accumulation model, MEDICAL PHYSICS, 47(3), 1349-1356, 202003
  64. Assessment of biological dosimetric margin for stereotactic body radiation therapy, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 21(4), 31-41, 202004
  65. Optimization of irradiation interval for fractionated stereotactic radiosurgery by a cellular automata model with reoxygenation effects, PHYSICS IN MEDICINE AND BIOLOGY, 65(8), 20200421
  66. Development of a CT number calibration audit phantom in photon radiation therapy: A pilot study, MEDICAL PHYSICS, 47(4), 1509-1522, 202004
  67. Analysis of cardiac toxicity after definitive chemoradiotherapy for esophageal cancer using a biological dose-volume histogram, JOURNAL OF RADIATION RESEARCH, 61(2), 298-306, 202003
  68. Evaluation of metal artefact techniques with same contrast scale for different commercially available dual-energy computed tomography scanners, PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE, 43(2), 539-546, 202006
  69. Dose compensation based on biological effectiveness due to interruption time for photon radiation therapy, BRITISH JOURNAL OF RADIOLOGY, 93(1111), 2020
  70. A Single Institution's Experience of Definitive Radiotherapy Using Volumetric-modulated Arc Therapy for Hypopharyngeal Cancers, ANTICANCER RESEARCH, 40(7), 4183-4190, 202007
  71. Synthesized effective atomic numbers for commercially available dual-energy CT, REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 25(4), 692-697, 2020
  72. Long-term outcomes of induction chemotherapy followed by chemoradiotherapy using volumetric-modulated arc therapy as an organ preservation approach in patients with stage IVA-B oropharyngeal or hypopharyngeal cancers, JOURNAL OF RADIATION RESEARCH, 61(4), 554-562, 202007
  73. Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 21(12), 288-294, 202012
  74. Image synthesis with deep convolutional generative adversarial networks for material decomposition in dual-energy CT from a kilovoltage CT, COMPUTERS IN BIOLOGY AND MEDICINE, 128, 202101
  75. Evaluation of optimization workflow using custom-made planning through predicted dose distribution for head and neck tumor treatment, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 80, 167-174, 202012
  76. Predicting the Local Response of Metastatic Brain Tumor to Gamma Knife Radiosurgery by Radiomics With a Machine Learning Method, FRONTIERS IN ONCOLOGY, 10, 20210111
  77. Formulation of objective indices to quantify machine failure risk analysis for interruptions in radiotherapy, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 22(1), 165-173, 202101
  78. Detecting MLC modeling errors using radiomics-based machine learning in patient-specific QA with an EPID for intensity-modulated radiation therapy, MEDICAL PHYSICS, 48(3), 991-1002, 202103
  79. Image synthesis of monoenergetic CT image in dual-energy CT using kilovoltage CT with deep convolutional generative adversarial networks, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 22(4), 184-192, 202104
  80. T1-weighted and T2-weighted MRI image synthesis with convolutional generative adversarial networks, REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 26(1), 35-42, 202101
  81. Efficacy and tolerability of preoperative chemoradiotherapy with S-1 alone for locally advanced rectal cancer, JOURNAL OF RADIATION RESEARCH, 62(2), 300-308, 202103
  82. Predicting the Local Response of Esophageal Squamous Cell Carcinoma to Neoadjuvant Chemoradiotherapy by Radiomics with a Machine Learning Method Using F-18-FDG PET Images, DIAGNOSTICS, 11(6), 202106
  83. A prediction model for degree of differentiation for resectable locally advanced esophageal squamous cell carcinoma based on CT images using radiomics and machine-learning, BRITISH JOURNAL OF RADIOLOGY, 94(1124), 2021
  84. Prediction of radiation pneumonitis after definitive radiotherapy for locally advanced non-small cell lung cancer using multi-region radiomics analysis, SCIENTIFIC REPORTS, 11(1), 20210810
  85. T1-weighted and T2-weighted MRI image synthesis with convolutional generative adversarial networks, Rep Pract Oncol Radiother, 26(1), 35-42, 20210121
  86. Efficacy and tolerability of preoperative chemoradiotherapy with S-1 alone for locally advanced rectal cancer, J Radiat Res, 62(2), 300-308, 20210303
  87. Detecting MLC modeling errors using radiomics-based machine learning in patient-specific QA with an EPID for intensity-modulated radiation therapy, Med Phys, 48(3), 991-1020-991-1020, 202103
  88. Reduction of margin to compensate the respiratory tumor motion by the analysis of dosimetric internal target volume in lung SBRT with nonuniform volume prescription method., Med Phys, 48(6), 3200-3207, 202106
  89. Predicting the local response of esophageal squamous cell carcinoma to neoadjuvant chemoradiotherapy by radiomics with a machine learning method using 18F-FDG PET images., 11(6), 1049-1049, 202106
  90. A prediction model for degree of differentiation for resectable locally advanced esophageal squamous cell carcinoma based on CT images using radiomics and machine-learning, 94(1124), 202108
  91. Prediction of radiation pneumonitis after definitive radiotherapy for locally advanced non-small cell lung cancer using multi-region radiomics analysis., 10(11), 16, 202108
  92. Reduction of margin to compensate the respiratory tumor motion by the analysis of dosimetric internal target volume in lung SBRT with nonuniform volume prescription method, MEDICAL PHYSICS, 48(6), 3200-3207, 202106
  93. Reduction of margin to compensate the respiratory tumor motion by the analysis of dosimetric internal target volume in lung SBRT with nonuniform volume prescription method, MEDICAL PHYSICS, 48(6), 3200-3207, 202106
  94. Improved cellular automata model shows that indirect apoptotic cell death due to vascular damage enhances the local control of tumors by single fraction high-dose irradiation, BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 8(1), 202201
  95. Potential benefits of volumetric modulated arc therapy to reduce the incidence of >= grade 2 radiation pneumonitis in radiotherapy for locally advanced non-small cell lung cancer patients, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 51(12), 1729-1735, 202112

Awards

  1. 2015/05/25, 15th International Congress of Radiation Research, ICRR, Evaluation of beam modeling for small field using flattening filter free beam
  2. 2015/05/25, Young Investigation Travel Award (ICRR2015), ICRR
  3. 2016/11, Hiroshima University President Award, Hiroshima University
  4. 2018/04/16, 2017 Japan Society of Radiological Technology Awards: Research Encouragement Award and technology Rookie (therapeutic areas), JSRT

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2022/04/01, 2025/03/31
  2. Cloud Funding, 2022/04/01, 2027/03/30
  3. Varian Research Grant, Biological adaptive radiotherapy (BART) system for treatment interruption for short time or suspension for few days, 2022/06/01, 2024/03/30
  4. 2021 Research scholarship, 2021/04/01, 2023/03/30
  5. 2020/04/01, 2021/03/30
  6. Varian Research Grant, Predicting treatment response for esophagus cancer after radiosurgery from the radiomics analysis, pathological, and blood data by machine learning, 2020/04/01, 2022/03/31
  7. 2020/04/01, 2024/03/31
  8. 2020/04/01, 2023/03/31
  9. 2020/04/01, 2023/03/31
  10. Prediction model for local control after SRS wtth artificial intelligence
  11. General assignment B, 2015, 2015
  12. 2015 Research Grant, Usability of the Lipiodol for SBRT after TACE, 2015, 2015
  13. General assignment B, Iodine extraction system and create the dose calculation system, 2016, 2016
  14. 2016 research grants
  15. 12/5000 Scientific Research Fund (Young Research B), contrast medium extraction system and create the dose calculation system, 2015, 2018
  16. ICMP2016 Research Achievement Subsidy, 2016, 2016
  17. General assignment B, 2017, 2017
  18. 2018 foreign short-term study grants, 2018, 2018
  19. Research grant, 2018, 2018
  20. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2020, 2023

Social Activities

History as Committee Members

  1. Board of Education, Japan Medical Physics Certification Organization (JBMP), 2021/04/01, 2022/03/30
  2. Member of AI Subcommittee (WG), Future Planning Committee, Japan Society for Radiation Oncology (JASTRO), 2021/04, 2022/03
  3. JCOG Medical Physics Working Group Member, 2021
  4. JCOG Medical Physics Working Group Member, 2020/04, 2021/03
  5. National University Engineers Academic Summit Committee, 2020/04, 2021/03
  6. Radiology Medical Physics Association Education Course Certification Committee, 2020/04, 2021/03
  7. Hiroshima Prefectural Radiation Therapy Technology Study Group Multicenter Research Group, 2019/04, 2020/03
  8. National University Engineers Academic Summit Committee, 2019
  9. National University Engineers Academic Summit Committee, 2018

Organizing Academic Conferences, etc.

  1. 2022/11, 2022/11

History as Peer Reviews of Academic Papers

  1. 2021, Radiation and Oncology, Editor, 1
  2. 2021, International Journal of Clinical Oncology, Editor, 1
  3. 2021, Frontier Oncology, Editor, 1
  4. 2021, Radiological Physics and Technology, Editor, 2
  5. 2020, Radiological Physics and Technology, Editor, Reviewer, 2
  6. 2017, Radiological Physics and Technology, Editor, Reviewer, 2
  7. 2018, Radiological Physics and Technology, Editor, Reviewer, 2