KANA HARADA

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
Web Site
E-mail
haradakhiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima, Japan, Japan
TEL : (+81)82-257-5142 FAX : (+81)
Self-introduction
My research interests are the mechanisms regulating the function of serotonin transporter, a therapeutic target of depression.

Basic Information

Major Professional Backgrounds

  • 2011/04/01, 2013/02/28, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor (Special Appointment)
  • 2013/03/01, 2014/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Researcher
  • 2014/04/01, 2018/03/31, Hiroshima International University, Assistant Professor (Special Appointment)
  • 2018/04/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2007/10, 2011/03
  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2007/04, 2007/09
  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2005/04, 2007/03
  • Hiroshima University, Faculty of Medicine, Japan, 2001/04, 2005/03

Academic Degrees

  • Ph.D., Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General pharmacology
  • Medicine,dentistry, and pharmacy;Dentistry;Prosthodontics / Dental materials science and

Research Keywords

  • serotonin transporter
  • polyphosphate
  • macrophage
  • microglia
  • bone

Affiliated Academic Societies

  • The Japanese Pharmacological Society
  • The Japanese Society for Neurochemistry
  • The Pharmaceutical Society of Japan

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Biological Responses
  2. 2022, Undergraduate Education, Year, Methodology in advanced medical sciences

Research Activities

Academic Papers

  1. GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice, Neurobiology of Disease, 172, 105811, 20221001
  2. Potential role of inducible GPR3 expression under stimulated T cell conditions, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148(3), 307-314, 202203
  3. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148(1), 187-195, 202201
  4. GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons, MOLECULAR AND CELLULAR NEUROSCIENCE, 118, 202201
  5. Syntaxin 3 interacts with serotonin transporter and regulates its function, JOURNAL OF PHARMACOLOGICAL SCIENCES, 145(4), 297-307, 202104
  6. Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 534, 583-589, 20210101
  7. Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system, BRAIN RESEARCH, 1750, 20210101
  8. Component of nicotine-induced intracellular calcium elevation mediated through alpha 3-and alpha 5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells, PLOS ONE, 15(11), 20201130
  9. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884, 20201005
  10. Anti-seizure effect and neuronal activity change in the genetic-epileptic model rat with acute and chronic vagus nerve stimulation, Epilepsy Research, 155, 106159, 201909
  11. Data on the effect of maternal separation coupled with social isolation in a forced swim test and gene expression of glial fibrillary acid protein in the prefrontal cortex of rats, Data in Brief, 18, 496-500, 20180616
  12. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice, Brain Research, 1680, 13-38, 20180201
  13. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling, Neurochemistry International, 93, 82-94, 201602
  14. ★, Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblasts, PLOS ONE, 9, e98285, 20140527
  15. Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion, Biology Open, 3(6), 463-474, 20140508
  16. ★, Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts, PLOS ONE, 8, e78612, 20131104
  17. ★, Inorganic polyphosphate suppresses lipopolysaccharide- induced inducible nitric oxide synthase (iNOS) expression in macrophages, PLOS ONE, 8, e74650, 20130909
  18. ★, Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia, Journal of Neurochemistry, 116(6), 1138-1147, 201103
  19. Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role, Journal of Neuroscience Research, 83(8), 1461-1470, 200606

Invited Lecture, Oral Presentation, Poster Presentation

  1. OpTER: a Low-Cost, Reproducible and Customizable Method to Assess the Cellular Barrier Function, 2022/07/02, Without Invitation, English
  2. Divergent functions of G protein-coupled receptor 3 in neurite outgrowth, polarity formation, survival, and axonal regeneration in neurons, 2022/07/01, Without Invitation, English
  3. Spatiotemporal analysis of propofol-induced PKC translocation -Subcellular Localization of PKC Activation by propofol-, Soma Noguchi, Taketoshi Kajimoto, Tomoaki Urabe, Yuki Yanase, Soshi Narasaki, Kana Harada, Shigeru Tanaka, Izumi Hide, Norio Sakai, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/09, Without Invitation, English, Fukuoka
  4. PKC domains involved in propofol-induced PKC translocation, Soshi Narasaki, Soma Noguchi, Tomoaki Urabe, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuki Yanase, Taketoshi Kajimoto, Norio Sakai, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/09, Without Invitation, English, Fukuoka
  5. Diversity and functional roles of G protein-coupled receptor 3 in nonneuronal cells, Shigeru Tanaka, Hiroko Shiraki, Yun Guo, Yuhki Yanase, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/09, Without Invitation, English, Fukuoka
  6. Potential role of G protein-coupled receptor 3 in the axonal regeneration after optic nerve injury in mice, Shun Masuda, Shigeru Tanaka, Hiroko Shiraki, Yuusuke Sotomaru, Kana Harada, Izumi Hide, Yoshiaki Kiuchi, Norio Sakai, The 95th Annual Meeting of the Japanese Pharmacological Society, 2022/03/07, Without Invitation, English, Fukuoka
  7. The mechanism underlying the propofol-induced elevation of intracellular calcium, Tomoaki Urabe, Norio Sakai, Serika Motoike, Kana Harada, Izumi Hide, Shigeru Tanaka, Neuroscience 2019, 2019/10/23, Without Invitation, English, Chicago
  8. NECAB2 is a major calcium-binding protein of GPR3-positive neurons in various regions of the mouse brain, Fumiaki Ikawa, Shigeru Tanaka, Kana Harada, Izumi Hide, Norio Sakai, Neuroscience 2019, 2019/10/23, Without Invitation, English, Chicago
  9. GPR3 is upregulated in rodent mast cells immediately after brain ischemia and modulates degranulation, Shigeru Tanaka, Yuhki Hamakawa, Yuhki Yanase, M Yamamoto, Hiroko Shiraki, Kana Harada, Izumi Hide, Norio Sakai, Neuroscience 2019, 2019/10/20, Without Invitation, English, Chicago
  10. Differentiation-induced G protein-coupled receptor 3 modulates phosphorylation of synapsin in PC12 cells, Humiaki Ikawa, Shigeru Tanaka, Kenta Sasaki, Tomohiro Noguchi, Kana Harada, Izumi Hide, Norio Sakai, NEURO2019 The 42nd Annual Meeting of the Japan Neuroscience Society The 62nd Annual Meeting of the Japanese Society for Neurochemistry, 2019/07/27, Without Invitation, English, Niigata
  11. Expression and function of P2Y2 and P2Y13 receptors in purinergic and Toll-like receptor 4-activated microglia, Izumi Hide, Yoichiro Morita, Hiroko Shiraki, Yuhki Yanase, Kana Harada, Shigeru Tanaka, Norio Sakai, NEURO2019 The 42nd Annual Meeting of the Japan Neuroscience Society The 62nd Annual Meeting of the Japanese Society for Neurochemistry, 2019/07/27, Without Invitation, English, Niigata
  12. The potential role of G protein-coupled receptor 3 in mast cell degranulation following brain ischemia, Shigeru Tanaka, Yuhki Yanase, Yuhki Hamakawa, Masahiro Yamamoto, Hiroko Shiraki, Kana Harada, Izumi Hide, Norio Sakai, NEURO2019 The 42nd Annual Meeting of the Japan Neuroscience Society The 62nd Annual Meeting of the Japanese Society for Neurochemistry, 2019/07/26, Without Invitation, English, Niigata
  13. Intrinsic expresson of G protein-coupled receptor 3 accelerates the axon specification in cultured hippocampal neurons, Tanaka Shigeru, Naoto Shimada, Hiroko Shiraki, Tatsuhiro Miyagi, Kana Harada, Izumi Hide, Norio Sakai, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/15, Without Invitation, Japanese, Osaka
  14. The mechanism underlying the propofol-induced elevation of intracellular calcium, Tomoaki Urabe, Kana Harada, Izumi Hide, Shigeru Tanaka, Masashi Kawamoto, Norio Sakai, The 92nd Annual Meeting of the Japanese Pharmacological Society, 2019/03/14, Without Invitation, English, Osaka
  15. c-Fos immunoreactivity in the rat brain induced by vagus nerve stimulation, Masaya Katagiri, Koji Iida, Kumatoshi Ishihara, Kana Harada, Kota Kagawa, Akira Hashizume, Ryosuke Hanaya, Kazunori Arita, Kaoru Kurisu, 11th Asian & Oceanian Epilepsy Congress, 2016/05/15, Without Invitation, English, HongKong
  16. Induction of c-Fos immunoreactivity by vagus nerve stimulation in the rat brain, Masaya Katagiri, Koji Iida, Kumatoshi Ishihara, Kana Harada, Kota Kagawa, Akira Hashizume, Ryosuke Hanaya, Kazunori Arita, Kaoru Kurisu, American Epilepsy Society 69th Annual meeting, 2015/12/04, Without Invitation, English, Philadelphia
  17. Induction of c-Fos immunoreactivity by vagus nerve stimulation in the rat brain, Masaya Katagiri, Koji Iida, Kumatoshi Ishihara, Kana Harada, Kota Kagawa, Akira Hashizume, Ryosuke Hanaya, Kazunori Arita, Kaoru Kurisu, The 49th Congress of the Japan Epilepsy Society, 2015/10/30, Without Invitation, English, Nagasaki
  18. PRIP modulates autophagosomal maturation containing invasive bacteria, Kae Harada, Kana Harada, Seiya Hayashi, Hanae Ikeda, Takashi Kanematsu, 5th Hiroshima Conference on Education and Science in Dentistry, 2013/10/12, Without Invitation, English, Hiroshima
  19. Enhanced survival and phagocytic activity by Toll-like receptor 4 activation in rat microglia, Izumi Hide, Yuhki Yanase, Mayumi Kamigaki, Kana Harada, Takahiro Seki, Shigeru Tanaka, Michihiro Hide, Norio Sakai, The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry, 2012/10/01, Without Invitation, Kobe
  20. Toll-like receptor 4 activation promotes survival and phagocytic clearance in microglia: Possible involvement of purinergic receptors, Izumi Hide, Kana Harada, Yuhki Yanase, Takahiro Seki, Shigeru Tanaka, Norio Sakai, Purine 2012, 2012/06/01, Without Invitation, English, Fukuoka
  21. Death or survival of Toll-like receptor 4-activated microglia is regulated by extracellular ATP, Kana Harada, Izumi Hide, Shunsuke Fujiwara, Takahiro Seki, Shigeru Tanaka, Yoshihiro Nakata, Norio Sakai, Neuro 2010 (Joint conference of the 33rd Annual Meeting of the Japan Neuroscience Society, the 53rd Annual Meeting of the Japanese Society for Neurochemistry, and the 20th Annual Meeting of Japanese Neural Network Society), 2010/09/03, Without Invitation, English, Kobe
  22. alpha7 nicotinic acetylcholine receptor signaling and modulation of cytokine production in microglia, Izumi Hide, Kana Harada, Hiroaki Matsubayashi, Norio Sakai, Yoshihiro Nakata, USA-JAPAN joint meeting for Glial Research, 2008/03/19, Without Invitation, English, Philadelphia
  23. Immunohistochemical assessment of neuronal activity in rat thalamus with vagus nerve stimulation, 2014/10, Without Invitation

Awards

  1. 2014/08/09, Young Investigators Award, 日本病態プロテアーゼ学会, オートファジー系を介した黄色ブドウ球菌排除機構におけるPRIPの役割解明

External Funds

Acceptance Results of Competitive Funds

  1. Grants-in-Aid for Scientific Research, 2022, 2024
  2. Grants-in-Aid for Scientific Research, 2019, 2021
  3. Grants-in-Aid for Scientific Research, 2016, 2018
  4. Grants-in-Aid for Scientific Research, Effects of polyphosphate on inflammatory bone resorption: Development of novel treatment strategies for peri-implantitis, 2014, 2015
  5. Grants-in-Aid for Scientific Research, A study for the application of inorganic polyphosphate in peri-implantitis treatment, 2011, 2012