KATSUHIRO TAKEDA
Last Updated :2025/04/03
- Affiliations, Positions
- Hiroshima University Hospital(Dental), Associate Professor or Lecturer
- E-mail
- takepon
hiroshima-u.ac.jp
- Self-introduction
- -Researcher, Department of Biological Endodontics, Hiroshima University Graduate School of Biomedical and Health sciences.
-Ph.D. granted to basic studies on periodontal tissue regeneration therapy by application of brain-derived neurotrophic factor(BDNF).
-Engaged in a series of in vitro and in vivo studies on BDNF up to the present
Basic Information
Academic Degrees
- Doctor of Philosophy in Dental Science, Hiroshima University
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
Research Fields
- Medicine,dentistry, and pharmacy;Dentistry;Periodontology
Affiliated Academic Societies
- The Japanese Society of Conservative Dentistry
- Japan Endodontic Association
Educational Activity
Course in Charge
- 2025, Undergraduate Education, 3Term, Endodontics I
- 2025, Undergraduate Education, 4Term, Endodontics II
- 2025, Undergraduate Education, 3Term, Operative Dentistry I
- 2025, Undergraduate Education, 4Term, Operative Dentistry II
- 2025, Undergraduate Education, 1Term, Basic Practice of Endodontics and Operative Dentistry I
- 2025, Undergraduate Education, 2Term, Basic Practice of Endodontics and Operative Dentistry II
- 2025, Undergraduate Education, 2Term, Advanced Course in Functional and Regenerative Oral Medicine
- 2025, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
- 2025, Undergraduate Education, Academic Year, Clinical Practice (Endodontics and Operative Dentistry)
- 2025, Undergraduate Education, 3Term, Endodontology
- 2025, Undergraduate Education, 3Term, Endodontorogy
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biological Endodontics
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biological Endodontics
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biological Endodontics
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biological Endodontics
Research Activities
Academic Papers
- Three cases of endo-periodontal lesions, 65(5), 20221031
- Opposing genetic polymorphisms of two ABC transporters contribute to the variation of nukacin resistance in Streptococcus mutans, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(3), 20240320
- Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
- Rare root canal morphology of maxillary second molars: A report of three cases, CLINICAL CASE REPORTS, 11(7), 202307
- Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
- Successful regenerative response of a severe bone defect in a right lower central incisor affected by a cemental tear, CLINICAL CASE REPORTS, 10(11), 202211
- Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
- Oxidative stress impairs the calcification ability of human dental pulp cells, BMC ORAL HEALTH, 22(1), 20221003
- Oxytocin suppresses CXCL10 production in TNF-alpha-stimulated human dental pulp stem cells, CELL BIOLOGY INTERNATIONAL, 46(9), 1530-1535, 202209
- Successful outcome of generalized chronic periodontitis (Stage III Grade A) treated with delayed autotransplantation and multiple periodontal surgeries: a case report., 64(4), 20210831
- Endodontic Approach and Periodontal Regenerative Therapy for a Mandibular Right Central Incisor Affected by a Perforation and Cemental Tear., Int J Periodontics Restorative Dent., 41(5), 202109
- Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration, JOURNAL OF PERIODONTOLOGY, 93(2), 269-286, 202202
- Brain-Derived Neurotrophic Factor Protects Cementoblasts From Serum Starvation-Induced Cell Death, JOURNAL OF CELLULAR PHYSIOLOGY, 221(3), 696-706, 200912
- Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans, BIOCHEMICAL PHARMACOLOGY, 79(10), 1496-1505, 20100515
- The expressions of claudin-1 and E-cadherin in junctional epithelium, JOURNAL OF PERIODONTAL RESEARCH, 45(4), 579-582, 201008
- Regulation of IL-8 by Irsogladine maleate is involved in abolishment of actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 20060401
- Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects, J. Periodontol, 77, 1003-1007, 20060401
- Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal Res., 42(3), 283-6, 20070601
- Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int, 31(12), 1462-1469, 20071201
- Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., J. Periodontol., 77(5), 800-807, 20060501
- ★, Brain-derived neurotrophic factor enhances periodontal tissue regeneration, Tissue Engineering, 11(9-10), 1618-29, 20050901
- Neurotrophins in cultured cells from periodontal tissues, journal of periodontology, 74(1), 76-84., 20030101
- Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts, The Journal of Biological Chemistry, 283(23), 16259-16267, 20080601
- Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells, Journal of Periodontal Research, 43(5), 508-513, 20081001
- Effect of Neurotrophin-4/5 on Bone/Cementum-Related Protein Expressions and DNA Synthesis in Cultures of Human Periodontal Ligament Cells, Journal of Periodontology, 79(11), 2182-2189, 20081101
- Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells, Journal of Periodontology, 79(12), 2361-2370, 20081201
- Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells, Journal of Endodontics, 35(3), 373-376, 20090301
- Brain-derived neurotrophic factor enhances periodontal tissue regeneration, TISSUE ENGINEERING, 11(9-10), 1618-1629, 200509
- Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201205
- Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 48(2), 228-234, 201304
- The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46, 136-142, 201308
- BDNF protects human vascular endothelial cells from TNF alpha-induced apoptosis, BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 91(5), 341-349, 201310
- The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects, PLOS ONE, 9(1), 20140114
- BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201404
- Introduction of a Mixture of beta-Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration, JOURNAL OF PERIODONTOLOGY, 86(3), 456-464, 201503
- Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17(7), 860-873, 201507
- Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1 beta and tumor necrosis factor-alpha, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 444-451, 201508
- LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48(7), 673-679, 201507
- Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
- ★, Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration, Tissue Eng Part A, Apr;17(7-8), 955-967, 2011
- Development of cytokine therapy with BDNF (brain-derived neurotrophic factor) for periodontal tissue regeneration, 11(1), 16-28, 20151231
- Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
- Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1 beta-Treated Endothelial Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 74(3), 399-406, 201609
- Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 186(2), 177-189, 201611
- Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 39(5), 1777-1786, 2016
- Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40(1), 240-247, 201702
- Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
- MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
- Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
- Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201805
- The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
- Combined endodontic and periodontal management of a class 3 invasive cervical resorption in a mandibular first molar, CLINICAL CASE REPORTS, 6(10), 2005-2010, 201810
- The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice, ARTHRITIS RESEARCH & THERAPY, 20, 20181103
- Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
- BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs, JOURNAL OF PERIODONTOLOGY, 90(1), 98-109, 201901
- Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population, CLINICAL ORAL INVESTIGATIONS, 23(11), 4099-4105, 201911
- Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal stem cells, DIFFERENTIATION, 112, 47-57, 2020
- Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
- A mandibular second molar with a middle mesial root canal, CLINICAL CASE REPORTS, 8(6), 1015-1020, 202006
- Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
- Semaphorin3A released from human dental pulp cells inhibits the increase in interleukin-6 and CXC chemokine ligand 10 production induced by tumor necrosis factor-alpha through suppression of nuclear factor-kappa B activation, CELL BIOLOGY INTERNATIONAL, 45(1), 238-244, 202101
- Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 56(1), 69-82, 202101
- Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
- Environmental improvement on and around the tooth stump for root canal treatment, 41(3), 155-164, 20201015
- Endodontic Approach and Periodontal Regenerative Therapy for a Mandibular Right Central Incisor Affected by a Perforation and Cemental Tear, INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, 41(5), E205-E212, 20210901
Publications such as books
- 2022/04/01, Endodontics (6th edition), 2022, Textbook, Joint work
Invited Lecture, Oral Presentation, Poster Presentation
- Promotion of reosseointegration by brain-derived neurotrophic factor (BDNF) in canine periimplantitis model, 2023/10/13, Without Invitation, Japanese
- Endodontic topics: Invasive cervical resorption, Katsuhiro Takeda, Stovit Online Series committee Faculty of Dental Medicine Airlangga University, 2022/07/16, With Invitation, English
- Three cases of endodontic-periodontal lesions, Takayoshi Nagahara, Katsuhiro Takeda, Hideki Shiba, 2022/06/16, Without Invitation, Japanese
- A case of autotransplantation for a radicular-cyst-affected tooth with root fracture and periapical osteoperiostitis, Takayoshi Nagahara, Keinoshin Wada, Daisuke Furutama, Katsuhiro Takeda, Hideki Shiba, 2022/07/09, Without Invitation, Japanese
- A case report of invasive cervical resorption of maxillary central incisor, Katsuhiro Takeda, Hideki Shiba, 2022/07/09, Without Invitation, Japanese
- Endodontic and periodontal treatment of invasive cervical resorption in a maxillary right central incisor, Katsuhiro Takeda, Hideki Shiba, 12th IFEA world endodontic congress 2020NE &29th National Congress of Indian Endodontic Society, 2021/07/31, Without Invitation, English
- Perforation repair and periodontal regeneration therapy in mandibular central incisor with cemental tear showed a favorable clinical outcome, 2020/06/27, Without Invitation, Japanese
- Brain-derived neurotrophic factor / hyaluronic acid complex enhances periodontal tissue regeneration, Katsuhiro Takeda, Konishi A, Kajiya M, Matsuda S, Fujita T, Shiba H. and Kurihara H., The 64th General sessions of the Japanese society for Dental Materials and Devices, 2014/10/04, Without Invitation, English, other
- Effects of Brain-derived neurotrophic factor on antiinflammation and bone-dentin related proteins expression in human pulp cells, Naoko Tokunaga, Takeda K, Kajiya M, Matsuda S, Fujita T, Shiba H. and Kurihara H., 35th Annual scientific meeting of JEA, 2014/07/12, Without Invitation, English, other
- Brain-derived neurotrophic factor / hyaluronic acid complex enhances periodontal tissue regeneration, Katsuhiro Takeda, Konishi A, Kajiya M, Matsuda S, Fujita T and Kurihara H., The 88th General sessions of the Japanese Tissue Culture Association, 2015/05/26, Without Invitation, Japanese
- Anti-inflammatory effect of Brain-deraived neurotrophic factor(BDNF) in human pulp cells, Naoko tokunaga, Katsuhiro takeda, Mikihito kajiya, Akihiro konishi, Yuushi uchida, Tsuyoshi fujita, Hideki shiba, 36th Annual Scientific Meeting of JEA, 2015/07/11, Without Invitation, Japanese
- Anti-inflammatory effect of Brain-deraived neurotrophic factor(BDNF) in human pulp cells, Naoko tokunaga, Katsuhiro takeda, Mikihito kajiya, Tsuyoshi fujita, Hidemi kurihara, Scientific Meeting of 99th Hiroshima University Dental Society, 2015/11/08, Without Invitation, Japanese
- Effects of BDNF as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, Sinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 2017/09/22, Without Invitation, English
- Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, Shinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita and Hidemi Kurihara, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
Awards
- 2010/11/28, Best Poster Presentation Award, The Korean Academy of Periodontology