KATSUHIRO TAKEDA

Last Updated :2025/04/03

Affiliations, Positions
Hiroshima University Hospital(Dental), Associate Professor or Lecturer
E-mail
takeponhiroshima-u.ac.jp
Self-introduction
-Researcher, Department of Biological Endodontics, Hiroshima University Graduate School of Biomedical and Health sciences. -Ph.D. granted to basic studies on periodontal tissue regeneration therapy by application of brain-derived neurotrophic factor(BDNF). -Engaged in a series of in vitro and in vivo studies on BDNF up to the present

Basic Information

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Affiliated Academic Societies

  • The Japanese Society of Conservative Dentistry
  • Japan Endodontic Association

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 3Term, Endodontics I
  2. 2025, Undergraduate Education, 4Term, Endodontics II
  3. 2025, Undergraduate Education, 3Term, Operative Dentistry I
  4. 2025, Undergraduate Education, 4Term, Operative Dentistry II
  5. 2025, Undergraduate Education, 1Term, Basic Practice of Endodontics and Operative Dentistry I
  6. 2025, Undergraduate Education, 2Term, Basic Practice of Endodontics and Operative Dentistry II
  7. 2025, Undergraduate Education, 2Term, Advanced Course in Functional and Regenerative Oral Medicine
  8. 2025, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  9. 2025, Undergraduate Education, Academic Year, Clinical Practice (Endodontics and Operative Dentistry)
  10. 2025, Undergraduate Education, 3Term, Endodontology
  11. 2025, Undergraduate Education, 3Term, Endodontorogy
  12. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biological Endodontics
  13. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biological Endodontics
  14. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biological Endodontics
  15. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biological Endodontics

Research Activities

Academic Papers

  1. Three cases of endo-periodontal lesions, 65(5), 20221031
  2. Opposing genetic polymorphisms of two ABC transporters contribute to the variation of nukacin resistance in Streptococcus mutans, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(3), 20240320
    Link to Paper Search Results by DOI
  3. Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
    Link to Paper Search Results by DOI
  4. Rare root canal morphology of maxillary second molars: A report of three cases, CLINICAL CASE REPORTS, 11(7), 202307
    Link to Paper Search Results by DOI
  5. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
    Link to Paper Search Results by DOI
  6. Successful regenerative response of a severe bone defect in a right lower central incisor affected by a cemental tear, CLINICAL CASE REPORTS, 10(11), 202211
    Link to Paper Search Results by DOI
  7. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
    Link to Paper Search Results by DOI
  8. Oxidative stress impairs the calcification ability of human dental pulp cells, BMC ORAL HEALTH, 22(1), 20221003
    Link to Paper Search Results by DOI
  9. Oxytocin suppresses CXCL10 production in TNF-alpha-stimulated human dental pulp stem cells, CELL BIOLOGY INTERNATIONAL, 46(9), 1530-1535, 202209
    Link to Paper Search Results by DOI
  10. Successful outcome of generalized chronic periodontitis (Stage III Grade A) treated with delayed autotransplantation and multiple periodontal surgeries: a case report., 64(4), 20210831
  11. Endodontic Approach and Periodontal Regenerative Therapy for a Mandibular Right Central Incisor Affected by a Perforation and Cemental Tear., Int J Periodontics Restorative Dent., 41(5), 202109
  12. Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration, JOURNAL OF PERIODONTOLOGY, 93(2), 269-286, 202202
    Link to Paper Search Results by DOI
  13. Brain-Derived Neurotrophic Factor Protects Cementoblasts From Serum Starvation-Induced Cell Death, JOURNAL OF CELLULAR PHYSIOLOGY, 221(3), 696-706, 200912
    Link to Paper Search Results by DOI
  14. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans, BIOCHEMICAL PHARMACOLOGY, 79(10), 1496-1505, 20100515
    Link to Paper Search Results by DOI
  15. The expressions of claudin-1 and E-cadherin in junctional epithelium, JOURNAL OF PERIODONTAL RESEARCH, 45(4), 579-582, 201008
    Link to Paper Search Results by DOI
  16. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 20060401
  17. Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects, J. Periodontol, 77, 1003-1007, 20060401
  18. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal Res., 42(3), 283-6, 20070601
  19. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int, 31(12), 1462-1469, 20071201
  20. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., J. Periodontol., 77(5), 800-807, 20060501
  21. ★, Brain-derived neurotrophic factor enhances periodontal tissue regeneration, Tissue Engineering, 11(9-10), 1618-29, 20050901
  22. Neurotrophins in cultured cells from periodontal tissues, journal of periodontology, 74(1), 76-84., 20030101
  23. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts, The Journal of Biological Chemistry, 283(23), 16259-16267, 20080601
  24. Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells, Journal of Periodontal Research, 43(5), 508-513, 20081001
  25. Effect of Neurotrophin-4/5 on Bone/Cementum-Related Protein Expressions and DNA Synthesis in Cultures of Human Periodontal Ligament Cells, Journal of Periodontology, 79(11), 2182-2189, 20081101
  26. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells, Journal of Periodontology, 79(12), 2361-2370, 20081201
  27. Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells, Journal of Endodontics, 35(3), 373-376, 20090301
  28. Brain-derived neurotrophic factor enhances periodontal tissue regeneration, TISSUE ENGINEERING, 11(9-10), 1618-1629, 200509
    Link to Paper Search Results by DOI
  29. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201205
    Link to Paper Search Results by DOI
  30. Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 48(2), 228-234, 201304
    Link to Paper Search Results by DOI
  31. The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46, 136-142, 201308
    Link to Paper Search Results by DOI
  32. BDNF protects human vascular endothelial cells from TNF alpha-induced apoptosis, BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 91(5), 341-349, 201310
    Link to Paper Search Results by DOI
  33. The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects, PLOS ONE, 9(1), 20140114
    Link to Paper Search Results by DOI
  34. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201404
    Link to Paper Search Results by DOI
  35. Introduction of a Mixture of beta-Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration, JOURNAL OF PERIODONTOLOGY, 86(3), 456-464, 201503
    Link to Paper Search Results by DOI
  36. Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17(7), 860-873, 201507
    Link to Paper Search Results by DOI
  37. Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1 beta and tumor necrosis factor-alpha, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 444-451, 201508
    Link to Paper Search Results by DOI
  38. LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48(7), 673-679, 201507
    Link to Paper Search Results by DOI
  39. Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
    Link to Paper Search Results by DOI
  40. ★, Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration, Tissue Eng Part A, Apr;17(7-8), 955-967, 2011
  41. Development of cytokine therapy with BDNF (brain-derived neurotrophic factor) for periodontal tissue regeneration, 11(1), 16-28, 20151231
  42. Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
    Link to Paper Search Results by DOI
  43. Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1 beta-Treated Endothelial Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 74(3), 399-406, 201609
    Link to Paper Search Results by DOI
  44. Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 186(2), 177-189, 201611
    Link to Paper Search Results by DOI
  45. Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 39(5), 1777-1786, 2016
    Link to Paper Search Results by DOI
  46. Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40(1), 240-247, 201702
    Link to Paper Search Results by DOI
  47. Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
    Link to Paper Search Results by DOI
  48. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
    Link to Paper Search Results by DOI
  49. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
    Link to Paper Search Results by DOI
  50. Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201805
    Link to Paper Search Results by DOI
  51. The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
    Link to Paper Search Results by DOI
  52. Combined endodontic and periodontal management of a class 3 invasive cervical resorption in a mandibular first molar, CLINICAL CASE REPORTS, 6(10), 2005-2010, 201810
    Link to Paper Search Results by DOI
  53. The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice, ARTHRITIS RESEARCH & THERAPY, 20, 20181103
    Link to Paper Search Results by DOI
  54. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
    Link to Paper Search Results by DOI
  55. BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs, JOURNAL OF PERIODONTOLOGY, 90(1), 98-109, 201901
    Link to Paper Search Results by DOI
  56. Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population, CLINICAL ORAL INVESTIGATIONS, 23(11), 4099-4105, 201911
    Link to Paper Search Results by DOI
  57. Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal stem cells, DIFFERENTIATION, 112, 47-57, 2020
    Link to Paper Search Results by DOI
  58. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  59. A mandibular second molar with a middle mesial root canal, CLINICAL CASE REPORTS, 8(6), 1015-1020, 202006
    Link to Paper Search Results by DOI
  60. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
    Link to Paper Search Results by DOI
  61. Semaphorin3A released from human dental pulp cells inhibits the increase in interleukin-6 and CXC chemokine ligand 10 production induced by tumor necrosis factor-alpha through suppression of nuclear factor-kappa B activation, CELL BIOLOGY INTERNATIONAL, 45(1), 238-244, 202101
    Link to Paper Search Results by DOI
  62. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 56(1), 69-82, 202101
    Link to Paper Search Results by DOI
  63. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
    Link to Paper Search Results by DOI
  64. Environmental improvement on and around the tooth stump for root canal treatment, 41(3), 155-164, 20201015
  65. Endodontic Approach and Periodontal Regenerative Therapy for a Mandibular Right Central Incisor Affected by a Perforation and Cemental Tear, INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, 41(5), E205-E212, 20210901
    Link to Paper Search Results by DOI

Publications such as books

  1. 2022/04/01, Endodontics (6th edition), 2022, Textbook, Joint work

Invited Lecture, Oral Presentation, Poster Presentation

  1. Promotion of reosseointegration by brain-derived neurotrophic factor (BDNF) in canine periimplantitis model, 2023/10/13, Without Invitation, Japanese
  2. Endodontic topics: Invasive cervical resorption, Katsuhiro Takeda, Stovit Online Series committee Faculty of Dental Medicine Airlangga University, 2022/07/16, With Invitation, English
  3. Three cases of endodontic-periodontal lesions, Takayoshi Nagahara, Katsuhiro Takeda, Hideki Shiba, 2022/06/16, Without Invitation, Japanese
  4. A case of autotransplantation for a radicular-cyst-affected tooth with root fracture and periapical osteoperiostitis, Takayoshi Nagahara, Keinoshin Wada, Daisuke Furutama, Katsuhiro Takeda, Hideki Shiba, 2022/07/09, Without Invitation, Japanese
  5. A case report of invasive cervical resorption of maxillary central incisor, Katsuhiro Takeda, Hideki Shiba, 2022/07/09, Without Invitation, Japanese
  6. Endodontic and periodontal treatment of invasive cervical resorption in a maxillary right central incisor, Katsuhiro Takeda, Hideki Shiba, 12th IFEA world endodontic congress 2020NE &29th National Congress of Indian Endodontic Society, 2021/07/31, Without Invitation, English
  7. Perforation repair and periodontal regeneration therapy in mandibular central incisor with cemental tear showed a favorable clinical outcome, 2020/06/27, Without Invitation, Japanese
  8. Brain-derived neurotrophic factor / hyaluronic acid complex enhances periodontal tissue regeneration, Katsuhiro Takeda, Konishi A, Kajiya M, Matsuda S, Fujita T, Shiba H. and Kurihara H., The 64th General sessions of the Japanese society for Dental Materials and Devices, 2014/10/04, Without Invitation, English, other
  9. Effects of Brain-derived neurotrophic factor on antiinflammation and bone-dentin related proteins expression in human pulp cells, Naoko Tokunaga, Takeda K, Kajiya M, Matsuda S, Fujita T, Shiba H. and Kurihara H., 35th Annual scientific meeting of JEA, 2014/07/12, Without Invitation, English, other
  10. Brain-derived neurotrophic factor / hyaluronic acid complex enhances periodontal tissue regeneration, Katsuhiro Takeda, Konishi A, Kajiya M, Matsuda S, Fujita T and Kurihara H., The 88th General sessions of the Japanese Tissue Culture Association, 2015/05/26, Without Invitation, Japanese
  11. Anti-inflammatory effect of Brain-deraived neurotrophic factor（BDNF） in human pulp cells, Naoko tokunaga, Katsuhiro takeda, Mikihito kajiya, Akihiro konishi, Yuushi uchida, Tsuyoshi fujita, Hideki shiba, 36th Annual Scientific Meeting of JEA, 2015/07/11, Without Invitation, Japanese
  12. Anti-inflammatory effect of Brain-deraived neurotrophic factor（BDNF） in human pulp cells, Naoko tokunaga, Katsuhiro takeda, Mikihito kajiya, Tsuyoshi fujita, Hidemi kurihara, Scientific Meeting of 99th Hiroshima University Dental Society, 2015/11/08, Without Invitation, Japanese
  13. Effects of BDNF as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, Sinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 2017/09/22, Without Invitation, English
  14. Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, Shinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita and Hidemi Kurihara, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English

Awards

  1. 2010/11/28, Best Poster Presentation Award, The Korean Academy of Periodontology