ATSUKO IKEDA

Last Updated :2024/06/04

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
atsukoikedahiroshima-u.ac.jp
Self-introduction
[Research on organelle homeostasis in yeast] Saccharomyces cerevisiae (budding yeast) is a model organism for eukaryotic cells, and its complex intracellular mechanisms are very similar to those of humans. Cells contain various organelles surrounded by lipid membranes, each of which plays an individual role in an independent compartment. They also function in cooperation with each other to carry out life activities of the whole cell. Our research is focusing on "communication between organelles using lipids," which is important for maintaining cooperativity in cells. For example, we are studying how lipids are transported and how lipids affect the morphology and function of organelles, in order to elucidate the universal mechanism that living organisms have in general. On the other hand, yeast is also used in alcohol brewing and bread fermentation, but these industrial fermentation production environments are harsh stress environments for yeast. Therefore, we aim to contribute to the advancement of industrial technology related to yeast, such as improving the quality and production of industrially used yeast, by understanding the mechanism provided by yeast in response to stress and utilizing the obtained knowledge.

Basic Information

Academic Degrees

  • Hiroshima University
  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Molecular Agro-Life Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
  2. 2024, Undergraduate Education, First Semester, Graduation Thesis II
  3. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
  4. 2024, Undergraduate Education, Intensive, Laboratory Work in Molecular Agro-life ScienceIII

Research Activities

Academic Papers

  1. Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast, Journal of cell science, 127(2), 376-387, 2014
  2. Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis, Journal of cell science, 128(14), 2454-2467, 2015
  3. Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis, Yeast, 33(2), 37-42, 2016
  4. Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast, Genetics, 212(1), 175-186, 2019
  5. Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as a GPI flippase, FEBS letters, 594(15), 2431-2439, 2020
  6. Ceramide chain length-dependent protein sorting into selective endoplasmic reticulum exit sites, Science advances, 6(50), eaba8237, 2020
  7. ★, Tricalbins Are Required for Non-vesicular Ceramide Transport at ER-Golgi Contacts and Modulate Lipid Droplet Biogenesis, iScience, 23(10), 101603, 2020
  8. Protocol for measuring sphingolipid metabolism in budding yeast, STAR Protoc., 2(2), 100412, 2021
  9. Structural analysis of the GPI glycan, PloS one, 16(9), 2021
  10. Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis, Membranes, 11(12), 2021
  11. Quality-controlled ceramide-based GPI-anchored protein sorting into selective ER exit sites, Cell reports, 39(5), 2022
  12. The Ceramide Synthase Subunit Lac1 Regulates Cell Growth and Size in Fission Yeast, International journal of molecular sciences, 23(1), 2022
  13. Vacuole membrane contact sites regulate liquid-ordered domain formation during glucose starvation., FEBS letters, 597(11), 1462-1468, 2023

Invited Lecture, Oral Presentation, Poster Presentation

  1. Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast, Kentaro Kajiwara, Atsuko Ikeda, Auxiliadora Aguilera-Romero, Guillaume A. Castillon, Satoshi Kagiwada, Kentaro Hanada Howard Riezman, Manuel Muniz and Kouichi Funato., Kentaro Kajiwara, Atsuko Ikeda, Auxiliadora Aguilera-Romero, Guillaume A. Castillon, Satoshi Kagiwada, Kentaro Hanada Howard Riezman, Manuel Muniz and Kouichi Funato., FEBS workshop: Lipids as molecular Switches, 2014/08/26, With Invitation, English, Island of Spetses, Greece

External Funds

Acceptance Results of Competitive Funds

  1. 2022, 2024
  2. KAKENHI(Grant-in-Aid for Research Activity Start-up), 2021, 2022