NOBUYUKI SAKAYORI

Last Updated :2020/10/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
Web Site
E-mail
sakayorihiroshima-u.ac.jp
Self-introduction
Investigating the roles of essential fatty acids in brain development and function

Basic Information

Educational Backgrounds

  • Tohoku University, Faculty of Science, 2005, 2009
  • Tohoku University, Graduate School of Medicine, 2009, 2011
  • Tohoku University, Graduate School of Medicine, 2011, 2014

Academic Degrees

  • TOHOKU UNIVERSITY
  • TOHOKU UNIVERSITY

Research Fields

  • Complex systems;Human life science;Eating habits
  • Biological Sciences;Neuroscience;Neurophysiology / General neuroscience
  • Biology;Biological Science;Developmental biology
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Affiliated Academic Societies

  • Japan Neuroscience Society
  • Japan Society of Nutrition and Food Science
  • Japan Society for Lipid Nutrition
  • Japanese Biochemical Society

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, 1Term, Oral Physiology
  2. 2020, Undergraduate Education, 2Term, Oral Physiology
  3. 2020, Undergraduate Education, 3Term, Practice of Oral Physiology
  4. 2020, Undergraduate Education, First Semester, Laboratory of Oral Function Sciences-Biochemistry,Physiology,Pharmacology-
  5. 2020, Undergraduate Education, First Semester, Dental Research Practices
  6. 2020, Undergraduate Education, Second Semester, Dental Research Practices
  7. 2020, Undergraduate Education, Intensive, Laboratory Work in Oral Physiology
  8. 2020, Undergraduate Education, 4Term, Physiology and Oral Physiology
  9. 2020, Undergraduate Education, 3Term, Practice on Basic Dental Sciences
  10. 2020, Undergraduate Education, 4Term, Physiology and Oral Physiology
  11. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Physiology and Oral Physiology
  12. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Physiology and Oral Physiology
  13. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Physiology and Oral Physiology
  14. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Physiology and Oral Physiology
  15. 2020, Graduate Education (Master's Program) , First Semester, Seminar
  16. 2020, Graduate Education (Master's Program) , Second Semester, Seminar
  17. 2020, Graduate Education (Master's Program) , First Semester, Research
  18. 2020, Graduate Education (Master's Program) , Second Semester, Research
  19. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  20. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  21. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  22. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiology and Oral Physiology
  23. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiology and Oral Physiology
  24. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiology and Oral Physiology
  25. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiology and Oral Physiology

Research Activities

Academic Papers

  1. ★, Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice, Communications Biology, 3, 2020.08
  2. Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon, Developmental Dynamics, 249(6), 698-710, 2020.06
  3. Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice, BMC Research Notes, 12, 2019.11
  4. Targeting the brain with a neuroprotective omega-3 fatty acid to enhance neurogenesis in hypoxic condition in culture, Molecular Neurobiology, 56(2), 986-999, 2019.02
  5. Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus, Molecular Brain, 12, 2019.02
  6. The role of essential fatty acids in brain development, Journal of Lipid Nutrition, 27(1), 14-20, 2018.03
  7. The role of docosahexaenoic acid in brain development, Journal of the Vitamin Society of Japan, 91(9), 547-554, 2017.09
  8. The effect of polyunsaturated fatty acids on neocortical development, The Journal of Japanese Biochemical Society, 89(2), 269-272, 2017.04
  9. Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases, Biochimie, 130(11), 163-167, 2016.11
  10. Maternal nutritional imbalance between linoleic acid and alpha-linolenic acid increases offspring’s anxious behavior with a sex-dependent manner in mice, The Tohoku Journal of Experimental Medicine, 240(1), 31-37, 2016.09
  11. Lipids for healthy brain development, Trends in the Sciences, 21(4), 59-62, 2016.04
  12. ★, Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites, Stem Cells, 34(2), 470-482, 2016.02
  13. Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells, PLoS One, 9(1), 2014.01
  14. Impact of lipid nutrition on neural stem/progenitor cells, Stem Cells International, 2013.10
  15. Ninein is essential for the maintenance of the cortical progenitor character by anchoring the centrosome to microtubules, Biology Open, 2(7), 739-749, 2013.06
  16. Polyunsaturated fatty acids and their metabolites in neural development and implications for psychiatric disorders, Current Psychopharmacology, 2(1), 73-83, 2013.03
  17. Reduced proliferation and excess astrogenesis of Pax6 heterozygous neural stem/progenitor cells, Neuroscience Research, 74(2), 116-121, 2012.10
  18. The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse, Stem Cells, 30(7), 1532-1543, 2012.07
  19. ★, Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells, Genes to Cells, 16(7), 778-790, 2011.07
  20. The function of fatty acid signals in neurogenesis, Japanese Journal of Neuropsychopharmacology, 31(3), 111-116, 2011.06
  21. Neural stem cells for neural development, The Medical Frontline, 64(6), 1259-1273, 2009.06

Invited Lecture, Oral Presentation, Poster Presentation

  1. The roles of essential fatty acids in dopaminergic neurogenesis and dopamine-dependent ingestive behaviors, Nobuyuki Sakayori, Kazuto Kobayashi, The 93rd Annual Meeting of the Japanese Biochemical Society, 2020/09, Without Invitation, Japanese
  2. Lipid molecules to produce willpower and its dysregulation by modern diets, Sakayori N, 2020/09, Without Invitation, English
  3. The roles of brain essential fatty acids in dopamine-dependent ingestive behaviors., Nobuyuki Sakayori, Kazuto Kobayashi, The 43rd Annual Meeting of the Japan Neuroscience Society, 2020/07, Without Invitation, English
  4. Maternal dietary imbalance of essential fatty acids induces palatable feeding in the offspring, Sakayori N, The 42nd Annual Meeting of the Molecular Biology Society of Japan, 2019/12, With Invitation, Japanese
  5. Interdisciplinary research between brain and nutrition, Sakayori N, The 8th Tohoku Brain Science Winter School, 2019/02, With Invitation, Japanese
  6. Roles of dietary lipids in brain development and function, Sakayori N, The 1st Meeting of the Willdynamics Investigators of Next Generations, 2017/11, With Invitation, Japanese
  7. Unbalanced n-6/n-3 polyunsaturated fatty acid ratio disturbs neocortical development in mice, Sakayori N, Osumi N, International Conference on Omega-3 and Human Health, 2016/05, With Invitation, English
  8. 妊娠中の偏った脂質摂取は仔の脳形成不全と不安障害を引き起こす, Sakayori N, 福島県立医科大学 研究連携セミナー2015, 2015/06, With Invitation, Japanese
  9. Unbalanced n-6/n-3 polyunsaturated fatty acid ratio disturbs neocortical development in mice, Sakayori N, Osumi N, 2014 ELyT Lab Workshop, 2014/02, With Invitation, English
  10. n-6/n-3多価不飽和脂肪酸摂取比の乱れは大脳新皮質形成を妨げる, Sakayori N, 第9回必須脂肪酸と健康研究会, 2013/08, With Invitation, Japanese
  11. Function of fatty acid signals in neural stem cells, Sakayori N, Osumi N, The 65th Annual Meeting of the Japan Society for Cell Biology, 2013/06, With Invitation, Japanese
  12. 多価不飽和脂肪酸摂取比の乱れが大脳皮質形成に及ぼす影響の解析, Sakayori N, The 67th Annual Meeting of the Japan Society of Nutrition and Food Science, 2013/05, With Invitation, Japanese
  13. 多価不飽和脂肪酸と脂肪酸結合タンパク質が神経幹細胞に及ぼす影響の解析, Sakayori N, 第8回必須脂肪酸と健康研究会, 2012/09, With Invitation, Japanese
  14. The effects of fatty acids on neural stem cells, Sakayori N, Osumi N, ELyT School in Sendai – Autumn 2010, 2010/10, With Invitation, English
  15. 神経系前駆細胞に対するアラキドン酸とDHAの効果の解析, Sakayori N, 第6回必須脂肪酸と健康研究会, 2010/09, With Invitation, Japanese
  16. 海馬神経新生および感覚運動フィルター機構における脂肪酸シグナルの役割, Osumi N, Matsumata M, Sakayori N, The 64th Annual Meeting of the Japan Society of Nutrition and Food Science, 2010/05, With Invitation, Japanese

Awards

  1. 2019/09, Best Poster Award, The 28th Annual Meeting of the Japan Society for Lipid Nutrition
  2. 2018/12, Excellent Presentation Award for Young Investigator, 次世代脳プロジェクト 冬のシンポジウム2018
  3. 2018/02, Excellent Poster Presentation Award, The 2nd Meeting of the Willdynamics Investigators of Next Generations
  4. 2017/02, Best Poster Award, The 6th Tohoku Brain Science Winter School
  5. 2016/02, Best Research Award, The 5th Tohoku Brain Science Winter School
  6. 2014/10, Excellent Presentation Award for Young Investigator, The 87th Annual Meeting of the Japanese Biochemical Society
  7. 2013/02, Excellent Presentation Award, The 2nd Tohoku Brain Science Winter School
  8. 2012/03, Graduate Student Award for Excellent Research, Tohoku University Graduate School of Medicine
  9. 2011/09, Sugawara Medicine Promotion Fund Scholarship, Sugawara Medicine Promotion Fund
  10. 2011/06, Full Exemption from Return of Student Loan by Excellent Achievements, Japan Student Services Organization
  11. 2010/09, Hasekura Fellowship, Tohoku Neuroscience Global COE “Basic and Translational Research Center for Global Brain Science”
  12. 2009/08, Hasekura Fellowship, Tohoku Neuroscience Global COE "Basic and Translational Research Center for Global Brain Science"

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-Aid for Young Scientists, 必須脂肪酸摂取の偏りに伴うドパミン神経回路の変容と不安行動, 2019/04, 2021/03
  2. Grant-in-Aid for Scientific Research on Innovative Areas, 意志力を生み出す脂質分子と現代の食環境による破綻, 2019/04, 2021/03
  3. Grant-in-Aid for JSPS Fellows, 脂肪酸摂取の偏りによって生得的に確立される嗜好品過剰摂取の脳内メカニズム, 2017/04, 2020/03
  4. Grant-in-Aid for Scientific Research on Innovative Areas, 現代の脂質食がもたらす意志力制御の先天的脆弱性と肥満, 2017/04, 2019/03
  5. Grant-in-Aid for Young Scientists (B), 母親の偏った多価不飽和脂肪酸摂取が仔の情動に与える影響とその機序の解明, 2016/04, 2019/03
  6. Grant for Young Scientists, Japan Society of Nutrition and Food Science, 胎生期における多価不飽和脂肪酸摂取に着目した糖質への依存機構の解明, 2016/04, 2017/03
  7. Japan Society for Lipid Nutrition, Otsuka Award (Research Grant), 発生期における偏った多価不飽和脂肪酸摂取に伴ううつ病の発症機序の解析, 2015/09, 2016/08
  8. Scientific Research Promotion Grant, Mishima Kaiun Memorial Foundation, 大脳新皮質形成におけるオメガ3脂肪酸DHAとEPAの異なる役割の解析, 2014/07, 2015/06
  9. Research Grant for Doctoral Researchers, Institute for International Advanced Research and Education, Tohoku University, 脂肪酸摂取比の乱れが大脳皮質形成および脳機能に及ぼす影響の解析, 2012/07, 2014/03
  10. Grant-in-Aid for JSPS Fellows, 胎生期における脂肪酸摂取比の乱れが大脳皮質形成および脳機能に及ぼす影響の解析, 2012/04, 2015/03
  11. Research Grant for Starter: Graduate School of Medicine, Tohoku University, 胎生期における脂肪酸摂取比の乱れが大脳皮質形成におよぼす影響の解析, 2011/04, 2012/03
  12. Research Grant for Master's Researchers, Institute for International Advanced Research and Education, Tohoku University, 神経幹細胞および神経前駆細胞におけるアラキドン酸とドコサヘキサエン酸の効果の解析, 2010/07, 2011/03

Social Activities

History as Committee Members

  1. Councillor, 2020/01, 2022/12, Japan Society for Lipid Nutrition
  2. President in Tohoku Area, 2012/03, 2013/03, Society for Young Researchers on Neuroscience

Organizing Academic Conferences, etc.

  1. 次世代脳プロジェクト冬のシンポジウム2018「意志動力学」「適応回路シフト」若手の会合同シンポジウム, オーガナイザー, 2018/12
  2. 発生発達基礎医学研究会, 実行委員, 2014/11
  3. The 2nd Tohoku Brain Science Winter School, 実行副委員長, 2013/02
  4. Tohoku Brain Science Winter School, 実行委員長, 2012/02