JIAQI WU

Last Updated :2025/05/16

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Web Site
https://researchmap.jp/wujiaqi
E-mail
wujiaqi06gmail.com
Self-introduction
My research is grounded in evolutionary biology and statistical genetics, with a focus on mining biological insights from large-scale genomic data to uncover the genetic mechanisms underlying complex traits. Focusing primarily on mammals and birds, I work on statistical modeling of genomic variants associated with complex traits, inference of evolutionary histories of biological characteristics, and prediction of potential biological features from unknown genomes. These findings are further applied to genetic breeding and medical research. In addition, I conduct virological studies, including analyses of viral evolutionary histories, frequency analysis of viral mutations, monitoring of high-risk variants, and providing information to support viral control strategies.

Basic Information

Major Professional Backgrounds

  • 2025/04/01, School of Applied Biological Sciences, Hiroshima University, Assistant Professor
  • 2024/04/01, 2025/03/31, School of Applied Biological Sciences, Hiroshima University, CAP Research Fellow
  • 2023/05/01, 2023/06/30, School of Applied Biological Sciences, Hiroshima University, Research Fellow
  • 2021/04/01, 2023/03/31, Japan Science and Technology Agency, CREST Research Fellow
  • 2021/04/01, 2023/03/31, Tokai University School of Medicine, Research Fellow
  • 2018/09/01, 2021/03/31, Japan Society for the Promotion of Science, Tokyo University of Science (former Tokyo Institute of Technology) School of Bioscience and Biotechnology, JSPS Special Researcher Fellow(PD)
  • 2014/06/01, 2014/08/30, Japan Society for the Promotion of Science, Tokyo University of Science (former Tokyo Institute of Technology) School of Bioscience and Biotechnology, Research Fellow
  • 2018/04/01, 2018/08/31, Institute of Evolutionary Biology, Visiting Researchers (Senior and Senior Researcher Class)
  • 2014/10/04, 2015/03/31, The University of Tokyo, Graduate School of Agriculture and Life Sciences, Research Student
  • 2009/07/01, 2010/06/30, Fudan University (China) Institute of Biomedical Research and Shanghai Municipal Public Health Clinical Center, Laboratory Technician

Educational Backgrounds

  • The University of Tokyo, Graduate School of Agricultural and Life Sciences, Department of Agricultural and Environmental Biology, Japan, 2015/04/01, 2018/03/22
  • Northeast Normal University, Pre-study school for Chinese students going to Japan, China, 2013/09/01, 2014/10/01
  • Fudan University, School of Life Sciences, Department of Evolutionary Biology and Ecology, China, 2009/09/01, 2013/06/30
  • Shandong University, School of Medicine, School of Public Health, China, 2004/09/01, 2009/07/01

Academic Degrees

  • Shandong University
  • Fudan University
  • The University of Tokyo

Research Fields

  • Agricultural sciences;Plant production and environmental agriculture;Science in genetics and breeding
  • Biology;Basic biology;Evolutionary biology
  • Biological Sciences;Genome science;Genome biology

Research Activities

Academic Papers

  1. High altitude adaptation of the schizothoracine fishes (Cyprinidae) revealed by the mitochondrial genome analyses, Gene, 517(2), 169-178, 2013
    Link to Paper Search Results by DOI
  2. ★, Importance of synonymous substitutions under dense taxon sampling and appropriate modeling in reconstructing the mitogenomic tree of Eutheria, Genes & genetic systems, 89(5), 237-251, 2014
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  3. ★, Phylogeographic and Demographic Analysis of the Asian Black Bear (Ursus thibetanus) Based on Mitochondrial DNA, PLoS One, 10(9), e0136398, 2015
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  4. Phylogenomics and morphology of extinct paleognaths reveal the origin and evolution of the ratites, Current Biology, 28(7), 68-77, 2017
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  5. Computational Identification of Amino-Acid Mutations that Further Improve the Activity of a Chalcone–Flavonone Isomerase from Glycine max, Frontiers in Plant Science, 8, 248, 2017
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  6. Expression map of a complete set of gustatory receptor genes in chemosensory organs of Bombyx mori, Insect Biochemistry and Molecular Biology, 82, 74-82, 2017
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  7. ★, Rates of molecular evolution suggest natural history of life history traits and a post-K-Pg nocturnal bottleneck of placentals, Current Biology, 27(19), 3025-3033. e5, 2017
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  8. ★, Genomic adaptation to polyphagy and insecticides in a major East Asian noctuid pest, Nature ecology & evolution, 1(11), 1747-1756, 2017
  9. A single pheromone receptor gene conserved across 400 My of vertebrate evolution, Molecular Biology and Evolution, 35(12), 2928-2939, 2018
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  10. Comparative genomic analyses illuminate the distinct evolution of megabats within Chiroptera, DNA Research, 27(4), dsaa021, 2020
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  11. ★, Evolution of reproductive life history in mammals and the associated change of functional constraints, Genes, 12(5), 740, 2021
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  12. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity, Cell host & microbe, 29(7), 1124-1136. e11, 2021
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  13. ★, World-wide prevalence of substitutions in HCV genome associated with resistance to direct-acting antiviral agents, Clinical Gastroenterology and Hepatology, 19(9), 1906-1914. e25, 2021
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  14. SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion, Nature, 599(7883), 114-119, 2021
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  15. ★, The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance, Cell reports, 38(2), 2022
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  16. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation, Nature, 602(7896), 300-306, 2022
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  17. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity, Nature, 603(7902), 706-714, 2022
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  18. ★, Molecular Evolutionary Rate Predicts Intraspecific Genetic Polymorphism and Species-Specific Selection, Genes, 13(4), 708, 2022
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  19. Paleogenomics reveals independent and hybrid origins of two morphologically distinct wolf lineages endemic to Japan, Current Biology, 32(11), 2494-2504. e5, 2022
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  20. ★, Massive loss of transcription factors promotes the initial diversification of placental mammals, International Journal of Molecular Sciences, 23(17), 9720, 2022
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  21. Characterization of the immune resistance of severe acute respiratory syndrome coronavirus 2 mu variant and the robust immunity induced by mu infection, The Journal of Infectious Diseases, 226(7), 1200-1203, 2022
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  22. Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assay, STAR protocols, 3(4), 101773, 2022
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  23. ★, The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant, Iscience, 25(12), 2022
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  24. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant, Nature Communications, 14(1), 2671, 2023
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  25. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, Nature communications, 14(1), 2800, 2023
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  26. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA. 1, BA. 2, and BA. 5, Communications Biology, 6(1), 1-12, 2023
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  27. SARS-CoV-2 HaploGraph: visualization of SARS-CoV-2 haplotype spread in Japan, Genes & Genetic Systems, 98(5), 221-237, 2023
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  28. ★, Multiple mutations of SARS-CoV-2 Omicron BA. 2 variant orchestrate its virological characteristics, Journal of virology, 97(10), e01011-23, 2024
  29. Origin and spatial population structure of Malagasy native chickens based on mitochondrial DNA, Scientific Reports, 14(1), 569, 2024
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  30. Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution, Journal of Virology, 98(5), e01784-23, 2024
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  31. Conserved genetic background but geographically differentiated DNA methylation patterns in invasive alligator weed (Alternanthera philoxeroides) populations of China and Japan, Biological Invasions, 26(7), 2351-2365, 2024
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  32. ★, SGV-caller: SARS-CoV-2 genome variation caller, Heliyon, 11(4), e42613, 2025
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  33. ★, Evolutionary analysis and population dynamics in the global transmission of Kaposi's sarcoma-associated herpesvirus, ARCHIVES OF VIROLOGY, 170(5), 2025
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Awards

  1. 2012/12/13, National Scholarship, Ministry of Education of the People's Republic of China
  2. 2013/01/09, Luk Chung Lam Scholarship, Fudan University
  3. 2018/03/22, Dean's Award, Graduate School of Agricultural and Life Sciences, the University of Tokyo