Tsunehiro Aki

Last Updated :2024/10/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
https://home.hiroshima-u.ac.jp/aki/
E-mail
akihiroshima-u.ac.jp
Other Contact Details
1-3-1, Kagamiyama, Higashi-Hiroshima, Japan
TEL : (+81)82-424-7755 FAX : (+81)82-424-7755
Self-introduction
We are conducting research aimed at genome breeding of microorganisms that produce useful fats and oils and their application to the fields of health foods, cosmetics, pharmaceuticals, chemicals, and bioenergy.

Basic Information

Major Professional Backgrounds

  • 1994/04/01, 1996/03/31, National Institutes of Health、 USA, Postdoctoral Fellow
  • 1996/04/01, 2001/09/30, Hiroshima University, Faculty of Engineering, Assistant Professor
  • 2001/10/01, 2007/03/31, Hiroshima University, Graduate School of Advanced Sciences of Matter, Associate Professor
  • 2007/04/01, 2014/08/31, Hiroshima University, Graduate School of Advanced Sciences of Matter, Associate Professor
  • 2014/09/01, 2019/03/31, Hiroshima University, Graduate School of Advanced Sciences of Matter, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor

Educational Backgrounds

  • Hiroshima University, Faculty of Engineering, 1985/04, 1989/03
  • Hiroshima University, Graduate School, Division of Engineering, 1989/04, 1994/03

Academic Degrees

  • Doctor of Engineering, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Engineering : Cluster 3(Applied Chemistry, Biotechnology and Chemical Engineering) : Program of Biotechnology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology

In Charge of Primary Major Programs

  • Biotechnology

Research Fields

  • Agricultural sciences;Agricultural chemistry;Applied microbiology
  • Engineering;Process / Chemical engineering;Biofunction / Bioprocess

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 2Term, Introduction to Fundamental Industry
  2. 2024, Undergraduate Education, 3Term, Enzyme Chemistry
  3. 2024, Undergraduate Education, Intensive, Food Process Engineering II
  4. 2024, Undergraduate Education, Second Semester, Group Discussion of Current Biotechnology Topics
  5. 2024, Undergraduate Education, Year, Graduation Thesis
  6. 2024, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
  7. 2024, Graduate Education (Master's Program) , 2Term, Cell Function Science A
  8. 2024, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  9. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  10. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  11. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  12. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  13. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  14. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. Improvement of fatty acid productivity of thraustochytrid, Aurantiochytrium sp. by genome editing, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 131(4), 373-380, 202104
    Link to Paper Search Results by DOI
  2. Visualization of Gene Reciprocity among Lactic Acid Bacteria in Yogurt by RNase H-Assisted Rolling Circle Amplification-Fluorescence In Situ Hybridization, MICROORGANISMS, 9(6), 202106
    Link to Paper Search Results by DOI
  3. Direct detection of mRNA expression in microbial cells by fluorescence in situ hybridization using RNase H-assisted rolling circle amplification, SCIENTIFIC REPORTS, 10(1), 9588, 20200615
    Link to Paper Search Results by DOI
  4. Metabolite Profile Analysis of Aurantiochytrium limacinum SR21 Grown on Acetate-based Medium for Lipid Fermentation, JOURNAL OF OLEO SCIENCE, 68(6), 541-549, 201906
    Link to Paper Search Results by DOI
  5. Growth and fatty acid profiles of Halophytophthora vesicula and Salispina spinosa from Philippine mangrove leaves, LETTERS IN APPLIED MICROBIOLOGY, 69(3), 221-228, 201909
    Link to Paper Search Results by DOI
  6. Marine Oomycetes (Halophytophthora and Salispina): A Potential Source of Fatty Acids with Cytotoxic Activity Against Breast Adenocarcinoma Cells (MCF7), JOURNAL OF OLEO SCIENCE, 68(12), 1163-1174, 2019
    Link to Paper Search Results by DOI
  7. Complete genome sequence of Nitratireductor sp. strain OM-1: A lipid-producing bacterium with potential use in wastewater treatment, Biotechnology Reports, 24, e00366, 20190809
  8. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, JOURNAL OF BIOCHEMISTRY, 163(1), 51-60, 201801
    Link to Paper Search Results by DOI
  9. Efficient conversion of mannitol derived from brown seaweed to fructose for fermentation with a thraustochytrid, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 125(2), 180-184, 201802
    Link to Paper Search Results by DOI
  10. Isolation of High Carotenoid-producing Aurantiochytrium sp Mutants and Improvement of Astaxanthin Productivity Using Metabolic Information, JOURNAL OF OLEO SCIENCE, 67(5), 571-578, 201805
    Link to Paper Search Results by DOI
  11. RNase H-assisted RNA-primed rolling circle amplification for targeted RNA sequence detection, SCIENTIFIC REPORTS, 8, 20180517
    Link to Paper Search Results by DOI
  12. A Possible Trifunctional beta-Carotene Synthase Gene Identified in the Draft Genome of Aurantiochytrium sp Strain KH105, GENES, 9(4), 201804
    Link to Paper Search Results by DOI
  13. Decomposition kinetics of uronic acids obtained from kelp under hydrothermal condition, JOURNAL OF THE ENERGY INSTITUTE, 90(2), 185-190, 201704
    Link to Paper Search Results by DOI
  14. In-situ Mass Spectroscopic Analysis of Glucose Decomposition under Hydrothermal Condition: Quantitative Analysis for Reaction Kinetics, JOURNAL OF THE JAPAN PETROLEUM INSTITUTE, 60(2), 101-109, 201703
    Link to Paper Search Results by DOI
  15. In situ mass spectrometry of glucose decomposition under hydrothermal reactions, KOREAN JOURNAL OF CHEMICAL ENGINEERING, 34(5), 1524-1530, 201705
    Link to Paper Search Results by DOI
  16. Growth and Fatty Acid Production of Halophytophthora S13005YL1-3.1 under Different Salinity and pH Levels, PHILIPPINE AGRICULTURAL SCIENTIST, 100, S6-S11, 201707
  17. Real-Time Mass Spectrometric Analysis of Hydrothermal Reaction Products, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 56(36), 9993-9998, 20170913
    Link to Paper Search Results by DOI
  18. Improved methanization and microbial diversity during batch mode cultivation with repetition of substrate addition using defined organic matter and marine sediment inoculum at seawater salinity, BIORESOURCE TECHNOLOGY, 245, 833-840, 201712
    Link to Paper Search Results by DOI
  19. Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2, ALLERGY, 72(11), 1728-1736, 201711
    Link to Paper Search Results by DOI
  20. Quantitative In Situ Mass Spectrometry Analysis of Mannitol Decomposition Products under Hydrothermal Conditions, ENERGY & FUELS, 31(10), 10866-10873, 201710
    Link to Paper Search Results by DOI
  21. Semi-continuous methane production from undiluted brown algae using a halophilic marine microbial community, BIORESOURCE TECHNOLOGY, 200, 616-623, 201601
    Link to Paper Search Results by DOI
  22. Isolation and characterization of bacterium producing lipid from short-chain fatty acids, BIORESOURCE TECHNOLOGY, 201, 215-221, 201602
    Link to Paper Search Results by DOI
  23. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases, JOURNAL OF LIPID RESEARCH, 57(1), 89-99, 201601
    Link to Paper Search Results by DOI
  24. Detection of Acyl-CoA Derivatized with Butylamide for in vitro Fatty Acid Desaturase Assay, JOURNAL OF OLEO SCIENCE, 65(2), 161-167, 201602
    Link to Paper Search Results by DOI
  25. High-rate Fermentation of Acetate to Methane under Saline Condition by Aceticlastic Methanogens Immobilized in Marine Sediment, PEDIATRIC NEUROLOGY, 55, 9-15, 201602
    Link to Paper Search Results by DOI
  26. Characterization of a halotolerant acetoclastic methanogen highly enriched from marine sediment and its application in removal of acetate, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 121(2), 196-202, 201602
    Link to Paper Search Results by DOI
  27. Bacterial community structure and predicted alginate metabolic pathway in an alginate-degrading bacterial consortium, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 121(3), 286-292, 201603
    Link to Paper Search Results by DOI
  28. Kinetics of Sorbitol Decomposition under Hydrothermal Condition, JOURNAL OF THE JAPAN PETROLEUM INSTITUTE, 59(4), 149-154, 201607
    Link to Paper Search Results by DOI
  29. Decomposition Kinetics of Mannose, Its Sugar Alcohol, and Its Uronic Acid under Hydrothermal Condition, JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 49(7), 663-667, 201607
    Link to Paper Search Results by DOI
  30. Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(41), 21607-21615, 20161007
    Link to Paper Search Results by DOI
  31. Determination of Mannitol Decomposition Rate under Hydrothermal Pretreatment Condition, JOURNAL OF THE JAPAN PETROLEUM INSTITUTE, 58(4), 252-255, 201507
    Link to Paper Search Results by DOI
  32. Improved methane production from brown algae under high salinity by fed-batch acclimation, BIORESOURCE TECHNOLOGY, 187, 275-281, 201507
    Link to Paper Search Results by DOI
  33. Effect of Salinity on Propionate Degradation by Acclimated Marine Sediments, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 177(7), 1541-1552, 201512
    Link to Paper Search Results by DOI
  34. Dysgonomonas alginatilytica sp nov., an alginate-degrading bacterium isolated from a microbial consortium, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 65, 3570-3575, 201510
    Link to Paper Search Results by DOI
  35. Regulation of Polyunsaturated Fatty Acid Biosynthesis by Seaweed Fucoxanthin and Its Metabolite in Cultured Hepatocytes, LIPIDS, 49(2), 133-141, 201402
    Link to Paper Search Results by DOI
  36. Enzymatic Analysis of Positional Distribution of Fatty Acids in Solid Fat by 1,3-Selective Transesterification with Candida antarctica Lipase B, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 91(8), 1323-1330, 201408
    Link to Paper Search Results by DOI
  37. Evaluation of marine sediments as microbial sources for methane production from brown algae under high salinity, BIORESOURCE TECHNOLOGY, 169, 362-366, 201410
    Link to Paper Search Results by DOI
  38. Value-added lipid production from brown seaweed biomass by two-stage fermentation using acetic acid bacterium and thraustochytrid, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98(22), 9207-9216, 201411
    Link to Paper Search Results by DOI
  39. Behavior of organics in kelp during hydrothermal pretreatment: Fundamental characteristics and effect of salt, J. Jpn. Inst. Energy, 93(5), 531-535, 201405
  40. Unexpected T cell regulatory activity of anti-histone H1 autoantibody: Its mode of action in regulatory T cell-dependent and -independent manners, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431(2), 246-252, 20130208
    Link to Paper Search Results by DOI
  41. Utilization of Waste Syrup for Production of Polyunsaturated Fatty Acids and Xanthophylls by Aurantiochytrium, JOURNAL OF OLEO SCIENCE, 62(9), 729-736, 201309
    Link to Paper Search Results by DOI
  42. Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 113(4), 536-541, 201204
    Link to Paper Search Results by DOI
  43. Fermented sake lees with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation, Biosci. Biotechnol. Biochem., 20110301
  44. Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75(1), 140-144, 201101
    Link to Paper Search Results by DOI
  45. Metabolism and Synthesis of Lipids in the Polyunsaturated Fatty Acid-Producing Fungus Mortierella alliacea, JOURNAL OF OLEO SCIENCE, 60(1), 11-17, 201101
    Link to Paper Search Results by DOI
  46. Purification and characterization of intracellular lipase from the polyunsaturated fatty acid-producing fungus Mortierella alliacea, NEW BIOTECHNOLOGY, 28(2), 158-164, 20110228
    Link to Paper Search Results by DOI
  47. Simultaneous thermogravimetry and differential thermal analysis for comparing burning characteristics between oleaginous and non-oleaginous microorganisms, THERMOCHIMICA ACTA, 517(1-2), 115-120, 20110420
    Link to Paper Search Results by DOI
  48. Thermal analysis for differentiating between oleaginous and non-oleaginous microorganisms, BIOCHEMICAL ENGINEERING JOURNAL, 57, 23-29, 20111115
    Link to Paper Search Results by DOI
  49. Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease., World Allergy Organization J., 3(11), 262-265, 20101101
  50. A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(3), 504-509, 201003
    Link to Paper Search Results by DOI
  51. Molecular Cloning and Immunochemical Characterization of a Novel Major Japanese Cedar Pollen Allergen Belonging to the Aspartic Protease Family, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 152(3), 207-218, 2010
    Link to Paper Search Results by DOI
  52. Enhanced production of squalene in the thraustochytrid Aurantiochytrium mangrovei by medium optimization and treatment with terbinafine, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 26(7), 1303-1309, 201007
    Link to Paper Search Results by DOI
  53. Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp., NEW BIOTECHNOLOGY, 27(4), 382-389, 20100930
    Link to Paper Search Results by DOI
  54. Isolation and immunochemical characterization of native Der f 17, a new class of EF-hand calcium-binding allergen from the house dust mite, Dermatophagoides farinae., Proceedings of the World Allergy Congress 2009, 20090101
  55. Oral vaccination of lactic acid bacteria expressing a major allergen prevents nasal symptoms and IgE response in a murine model of cedar pollinosis, Proceedings of the World Allergy Congress 2009, 20090101
  56. Screening and Characterization of Squalene-Producing Thraustochytrids from Hong Kong Mangroves, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57(10), 4267-4272, 20090527
    Link to Paper Search Results by DOI
  57. Improvement of Stearidonic Acid Production in Oleaginous Saccharomyces cerevisiae, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73(6), 1447-1449, 200906
    Link to Paper Search Results by DOI
  58. Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity, BIOMEDICAL CHROMATOGRAPHY, 22(1), 13-19, 200801
    Link to Paper Search Results by DOI
  59. Heterologous production of dihomo-gamma-linolenic acid in Saccharomyces cerevisiae, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(21), 6965-6971, 200711
    Link to Paper Search Results by DOI
  60. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 144(2), 95-104, 2007
    Link to Paper Search Results by DOI
  61. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(10), 2551-2556, 200710
    Link to Paper Search Results by DOI
  62. Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 104(3), 200-206, 200709
    Link to Paper Search Results by DOI
  63. Anti-histone H1 autoantibody directly acts on T cells to exert its immunosuppressive activity., Animal Cell Technology: Basic & Applied Aspects, 15(IN PRESS), 20060925
  64. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 102(4), 323-327, 200610
    Link to Paper Search Results by DOI
  65. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 141(4), 313-321, 2006
    Link to Paper Search Results by DOI
  66. Production of industrially valuable lipids by marine microorganisms, Foods & Food Ingredients Journal of Japan, 210, 758-764, 20050801
  67. ★, Studies on the Biosynthesis and production of polyunsaturated fatty acids, 5, 589-599, 20051201
  68. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum, CLINICAL AND EXPERIMENTAL ALLERGY, 35(2), 234-243, 200502
    Link to Paper Search Results by DOI
  69. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: Its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 136(3), 258-265, 2005
    Link to Paper Search Results by DOI
  70. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation, TRANSPLANTATION PROCEEDINGS, 37(1), 80-81, 2005
    Link to Paper Search Results by DOI
  71. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 133(2), 125-135, 2004
    Link to Paper Search Results by DOI
  72. Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction, TRANSPLANTATION, 77(10), 1595-1603, 20040527
    Link to Paper Search Results by DOI
  73. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size, BIOFACTORS, 21(1-4), 163-166, 2004
    Link to Paper Search Results by DOI
  74. Microbial production of carotenoids, 3, 175-181, 20030401
  75. Extracellular secretion of free fatty acids by disruption of a fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 95(5), 435-440, 200305
    Link to Paper Search Results by DOI
  76. Evidence of isozymes for Delta 6 fatty acid desaturase in rat hepatocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67(2), 451-454, 200302
    Link to Paper Search Results by DOI
  77. Thraustochytrid as a potential source of carotenoids, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 80(8), 789-794, 200308
    Link to Paper Search Results by DOI
  78. cDNA cloning and functional expression of alpha-glucosidase from Mortierella alliacea, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62(2-3), 202-209, 200308
    Link to Paper Search Results by DOI
  79. Differential response to low temperature of two Delta 6 fatty acid desaturases from Mucor circinelloides, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62(4), 362-368, 200309
    Link to Paper Search Results by DOI
  80. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes, MARINE BIOTECHNOLOGY, 5(5), 450-457, 2003
    Link to Paper Search Results by DOI
  81. Analysis of immunosuppressive factors expressed in serum of liver transplanted rats., 12, 257-261, 20020401
  82. Identification of differentially expressed genes in atopic dermatitis-prone NC/Nga mouse., 12, 379-383, 20020401
  83. Gamma-linolenic acid suppresses IgE production in vitro as well as in vivo., 12, 461-465, 20020401
  84. Enzyme preparation of glycerides rich in docosahexaenoic acid from Thraustochytrid single cell oils by Candida rugosa Lipase., J. Oleo Sci., 51, 447-455, 20020401
  85. Inducing proliferative response of T cell on high-molecular-size antigen in Dermatophagoides farinae feces., Int. Archives Allergy Immunol, 127, 127、276-284, 20020501
  86. Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae, FEBS LETTERS, 516(1-3), 234-238, 20020410
    Link to Paper Search Results by DOI
  87. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(3), 613-621, 200203
    Link to Paper Search Results by DOI
  88. Induction of a proliferative response of T cells by a high-molecular antigen in Dermatophagoides farinae feces, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 127(4), 276-284, 200204
    Link to Paper Search Results by DOI
  89. Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family, CLINICAL AND EXPERIMENTAL ALLERGY, 32(7), 1064-1070, 200207
    Link to Paper Search Results by DOI
  90. Purification and characterization of a novel fungal alpha-glucosidase from Mortierella alliacea with high starch-hydrolytic activity, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(11), 2415-2423, 200211
    Link to Paper Search Results by DOI
  91. A high-molecular-weight mite antigen (HM1) fraction aggravates airway hyperresponsiveness of allergic mice to house dusts and whole mite cultures, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 129(3), 204-211, 200211
    Link to Paper Search Results by DOI
  92. Toward elucidating the full spectrum of mite allergens - State of the art, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 94(4), 285-298, 200210
    Link to Paper Search Results by DOI
  93. Production of polyunsaturated fatty acids by genetic engineering of yeast., J. Oleo Sci., 50(5), 359-365, 20010501
  94. Biosynthesis of polyunsaturated fatty acids in Labyrinthula, 23, 46-51, 20010201
  95. Biosynthesis of polyunsaturated fatty acids -- fatty acid modifying enzymes and their utilization --, 75, 61-66, 20010201
  96. Immunosuppressive autoreactive antibodies induced by liver transplantation., Scandinavian Journal of Immunology, 54(S1), 109, 20010401
  97. Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 65(2), 431-434, 200102
    Link to Paper Search Results by DOI
  98. Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 78(6), 599-604, 200106
    Link to Paper Search Results by DOI
  99. Profile of polyunsaturated fatty acids produced by Thraustochytrium sp KK17-3, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 78(6), 605-610, 200106
    Link to Paper Search Results by DOI
  100. Newly described house dust mite allergens., Allergy Clin. Immunol. Int., (Suppl.) 1, 74-76, 20001001
  101. Mammalian Delta-6 fatty acid desaturase: Molecular cloning and physiological significance, 49, 3-10, 20000101
  102. Fatty acid desaturation system and fusion enzyme, 38, 520-527, 20000801
  103. Purification and characterization of sea squirt alpha-N-acetylgalactosaminidase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89(1), 84-86, 200001
    Link to Paper Search Results by DOI
  104. T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae, IMMUNOLOGY LETTERS, 72(1), 53-60, 20000403
    Link to Paper Search Results by DOI
  105. Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae., Biochim= Biophys. Acta, 1454, 201-7, 19990401
  106. Molecular cloning and functional characterization of rat Delta-6 fatty acid desaturase., Biochem. Biophys. Res. Commun., 255(3), 575-579, 19990201
  107. Purification and characterization of M-177, a 177 kD allergen, from the house dust mite, Dermatophagoides farinae., Allergol. Int., 48, 43-51, 19990101
  108. A newly identified allergen p29, the C-terminal fragment of Cry j 1, induces potently conjunctival congestion of patients with cedar pollenosis., The 9th Tohwa University International Symposium, 271-274, 19990401
  109. Altered antigenicity of M-177, a 177-KDa allergen from the house dust mite, Dermatophagoides farinae, in stored extract., Clin. Exp. Allergy, 28, 1549-58, 19980401
  110. Lipid composition of a newly isolated polyunsaturated fatty acid-producing fungus, Achlya sp. ma-2801., J. Ferment. Bioeng., 86(5), 504-507, 19981101
  111. Transcription regulation by repressosome and by RNA polymerase contact., Cold Spring Harbor Symp. Quant. Biol., 62, 1-10, 19980401
  112. Identification on T-cell epitope sequences on an important mite antigen, Clin. Exp. Allergy, 27, 1086-94, 19970401
  113. Repressor induced site-specific binding of HU for transcriptional regulation., EMBO J., 16, 3666-3674, 19970601
  114. Repression and activation of promoter-bound RNA polymerase by Gal repressor., J. Mol. Biol., 272, 293-300, 19970901
  115. Atomic force microscopic demonstration of DNA looping by GalR and HU., Nucl. Acids Res., 25, 873-876, 19970201
  116. Cloning and characterization of a new allergen, Mag3, from the house dust mite, Dermatophagoides farinae: Cross-reactivity with high-molocular-weight allergen., Mol. Immunol., 33, 311-319, 19960401
  117. Histone-like protein HU as a specific transcriptional regulator: co-factor role in repression of gal transcription by Gal repressor., Genes Cells, 1, 179-188, 19960201
  118. Repression and activation of transcription by Gal and Lac repressors: involvement of alpha subunit of RNA polymerase., EMBO J., 14, 4523-4529, 19950901
  119. Cloning and expression of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae. Homology with human heat shock cognate proteins in the heat shock protein 70 family, J. Biochem., 115, 435-440, 19940401
  120. Structure of IgE epitopes on a new 39 kD allergen molecule from the house dust mite, Dermatophagoides farinae., Int. Arch. Allergy Immunol., 103, 357-364, 19940101
  121. Cloning and characterization of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae., Int. Arch. Allergy Immunol., 103, 349-356, 19940101

Publications such as books

  1. 2010/05, Biocatalysis and Biomolecular Engineering, 2010, 05, Scholarly Book, Cocompilation, 9780470487594, 490
  2. 2006/12, Biocatalysis and Biotechnology for Functional Foods and Industrial Products , 2006, 12, Scholarly Book, Joint work
  3. 2005/04, Handbook of Industrial Biocatalysis , 2005, 04, Scholarly Book, Joint work
  4. 2005/01, Fatty acid-modifying enzymes: imprications for industrial applications. , CRC Press= Taylor ＆ Fransis Group, 2005, 01, Scholarly Book, Joint work

Invited Lecture, Oral Presentation, Poster Presentation

  1. Genomic breeding of oleaginous marine protist, Aurantiochytrium sp., for biorefinery processing, Tsunehiro Aki, Lecture for students of the Universiry of Santo Tomas, 2021/08/31, With Invitation, English, Universiry of Santo Tomas, Online
  2. Improvement of lipid productivity of Aurantiochytrium sp. by genome editing, Watanabe K., Perez C. M. T., Kitahori T., Hata K., Aoi M., Takahashi H., Sakuma T., Okamura Y., Nakashimada Y., Yamamoto T., Matsuyama K., Mayuzumi S. and Aki T., 2021 American Oil Chemists Society Annual Meeting & Expo, 2021/05/11, With Invitation, English, American Oil Chemists Society, Online
  3. Gas-to-lipids bioprocessing by acetogens and thraustochytrids, 15th International Symposium on Biocatalysis and Agricultural Biotechnology, 2019/09/19, With Invitation, English
  4. Gas-to-lipids bioprocessing by acetogens and thraustochytrids, Marine Biotechnology Conference 2019, 2019/09/13, Without Invitation, English
  5. Gas-to-lipids bioprocessing by acetogens and thraustochytrids, First International Conference on Labyrinthulean Protists, 2019/08/30, With Invitation, English
  6. Gas-to-lipids bioprocessing by acetogens and thraustochytrids, 2019 American Oil Chemists' Society Annual Meeting and Expo, 2019/05/06, With Invitation, English
  7. Lipid biorefinery using versatile microbial catalysts, 14th International Symposium on Biocatalysis and Agricultural Biotechnology, 2018/10/23, With Invitation, English
  8. Biorefinery technologies for sustainable lipid production by thraustochytrids, Japan Oil Chemists' Society Annual Meeting (JOCS-AOCS joint symposium), 2018/09/06, With Invitation, English
  9. Biorefinery process for valuable lipid production by thraustochytrids, 2018 American Oil Chemists' Society Annual Meeting and Expo, 2018/05/06, With Invitation, English
  10. Bioprocess for valuable oil production by thraustochytrids, 13th International Symposium on Biocatalysis and Agricultural Biotechnology, 2017/10/19, With Invitation, English
  11. Regulation of carotenoid biosynthesis in marine thraustochytrid, Aurantiochytrium sp., 2017 American Oil Chemists' Society Annual Meeting and Industry Showcases, 2017/05/02, With Invitation, English
  12. Effective utilization of marine biological resources for production of value-added lipids, 3rd International Symposium on Molecular Science, 2016/12/01, With Invitation, English, Manila, Philippines
  13. Bioconversion of marine biomass into value-added lipids by marine thraustochytrids, 12th International Symposium on Biocatalysis and Agricultural Biotechnology, 2016/10/17, With Invitation, English, Hong Kong, China
  14. Bioconversion of marine and industrial biomass for production of value-added lipids and terpenoids, 45th Philippine Society for Microbiology Annual Convention and Scientific Meeting and 7th Asia Pacific Biotechnology Congress, 2016/07/22, With Invitation, English, Vigan, Philippines
  15. Production of biomethane and functional lipids from marine macroalgae, 107th American Oil Chemists' Society Annual Meeting & Expo, 2016/05/04, With Invitation, English, Salt Lake City, UT, USA
  16. Bioconversion of marine biomass for production of valuable lipids, 11th International Symposium on Biocatalysis and Agricultural Biotechnology, 2015/09/14, With Invitation, English, International Symposium on Biocatalysis and Agricultural Biotechnology, Banff, Canada

Patented

  1. Patent, JP第7048056号, 2022/03/28
  2. Patent, JP第6722209号, 2020/06/23
  3. Patent, JP第6685137号, 2020/04/02
  4. Patent, JP第6639858号, 2020/01/07
  5. Patent, JP第6553411号, 2019/07/12
  6. Patent, JP第6351328号, 2018/06/15

External Funds

Acceptance Results of Competitive Funds

  1. 2020/08/01, 2024/03/31
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022
  3. Strategic Basic Research Programs(CREST), 2012/10/01, 2018/03/31
  4. KAKENHI, 2014, 2016
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  5. KAKENHI, Studies on the molecular mechanisms of gain-of-function in thraustochytrids, 2011, 2013
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  6. KAKENHI, 2004, 2005
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  7. 2003
  8. 2002
  9. KAKENHI, 2001, 2002
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  10. KAKENHI, 1998, 1999
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Social Activities

History as Committee Members

  1. Secretary, 2019/04, Interdisciplinary Lipid Creation Forum， The Society for Biotechnology， Japan
  2. Editor， Biocatalysis and Agricultural Biotechnology, 2016/01
  3. Councilor, 2015/04, Western Japan Branch， The Society for Biotechnology， Japan
  4. Editor， Oleo Science, 2008/04, Japan Oil Chemists' Society
  5. Secretary, 2001/04, Chugoku-Shikoku Branch， The Japan Society for Bioscience， Biotechnology， and Agrochemistry

Organizing Academic Conferences, etc.

  1. The 15th International Symposium on Biocatalysis and Agricultural Biotechnology, Local Chair, 2019/09