YASUO UCHIDA

Last Updated :2024/05/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
yuchidahiroshima-u.ac.jp
Self-introduction
I was born in Oyama City, Tochigi Prefecture, Japan, and graduated from Oyama Jonan Junior High School and Tochigi High School. I spent my student days at Tohoku University Faculty of Pharmaceutical Sciences, where I worked as an assistant, assistant professor (studied at ETH Zurich as a JSPS overseas fellow for two years), lecturer and associate professor before moving to my current position at the Graduate School of Biomedical and Health Sciences, Hiroshima University in April 2023. I am developing cutting-edge research surrounded by students who are highly motivated in their research. We possess the technology to simultaneously quantify the abundance of thousands of proteins with high accuracy and sensitivity for membrane proteins by quantitative proteomics, which can be applied to a wide variety of samples, including frozen and FFPE human tissues, animals, cells, plants, insects and micro-organisms (The Young Scientists' Award, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology). We aim to open up the next generation of pharmaceutics called 'Molecular Systems Pharmaceutics', and to elucidate the mysteries of the brain, brain activity and the molecular mechanisms of human central nervous system disorders, as well as drug discovery for those disorders. We are currently recruiting staff and graduate students, so please feel free to contact us. E-mail, yuchida@hiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2023/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Professor
  • 2023/03/01, 2023/03/31, Tohoku University, Graduate School of Pharmaceutical Sciences, Associate Professor
  • 2018/09/01, 2023/02/28, Tohoku University, Graduate School of Pharmaceutical Sciences, Lecturer
  • 2014/04/01, 2016/03/31, ETH Zurich, Institute of Molecular Systems Biology (IMSB), Postdoctral Fellowship for Research Abroad
  • 2012/02/01, 2018/08/31, Tohoku University, Graduate School of Pharmaceutical Sciences, Assistant Professor
  • 2010/04/01, 2012/01/31, Tohoku University, Graduate School of Pharmaceutical Sciences, Research Associate
  • 2008/04/01, 2010/03/31, Tohoku University, Graduate School of Pharmaceutical Sciences, JSPS Research Fellowship for Young Scientists (DC1) (Ph.D. course student)

Educational Backgrounds

  • Tohoku University, Graduate School of Pharmaceutical Sciences, Ph.D. degree, Japan, 2012/01/18
  • Tohoku University, Graduate School of Pharmaceutical Sciences, Ph.D. course, Japan, 2008/04/01, 2010/03/31
  • Tohoku University, Graduate School of Pharmaceutical Sciences, Master course, Japan, 2006/04/01, 2008/03/31
  • Tohoku University, Faculty of Pharmaceutical Sciences, Japan, 2002/04/01, 2006/03/31
  • Tochigi High School, 1999/04/01, 2002/03/31
  • Oyama Jounan Junior High School, 1996/04/01, 1999/03/31

Academic Degrees

  • TOHOKU UNIVERSITY
  • TOHOKU UNIVERSITY

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy
  • Medicine,dentistry, and pharmacy;Basic medicine;Experimental pathology

Research Keywords

  • Quantitative proteomics of a variety of species including human tissue and membrane proteins (Simultaneous quantification of thousands of proteins)
  • The studies using human brain and spinal cord
  • Barrier regulation
  • Barrier systems biology
  • Central nervous system barrier drug discovery
  • Pharmaceutics
  • Pharmacokinetics

Affiliated Academic Societies

  • The Pharmaceutical Society of Japan
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  • The Japanese Society for the Study of Xenobiotics
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  • The Academy of Pharmaceutical Science and Technology, Japan
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  • International Society for Neurochemistry (Handling Editor of Journal of Neurochemistry)
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  • International Brain Barrier Society
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  • Human Proteome Organization
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  • International Society of Study on Xenobiotics
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  • American Association of Pharmaceutical Scientists
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  • Japan Transporter Research Association
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Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 2Term, Functional Morphology
  2. 2024, Undergraduate Education, 3Term, Biopharmaceutics
  3. 2024, Undergraduate Education, First Semester, Research Practice A
  4. 2024, Undergraduate Education, Second Semester, Research Practice B
  5. 2024, Undergraduate Education, First Semester, Practice of Drug Delivery System
  6. 2024, Undergraduate Education, 1Term, Pharmacokinetics
  7. 2024, Undergraduate Education, Intensive, Pharmacokinetics
  8. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  9. 2024, Undergraduate Education, First Semester, Practice of Pharmaceutics
  10. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  11. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  12. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  13. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  14. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  15. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  16. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  17. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular Systems Pharmaceutics
  18. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular Systems Pharmaceutics
  19. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular Systems Pharmaceutics
  20. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular Systems Pharmaceutics
  21. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  22. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  23. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Drug Delivery Sciences
  24. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Drug Delivery Sciences
  25. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Systems Pharmaceutics
  26. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Systems Pharmaceutics
  27. 2024, Graduate Education (Master's Program) , First Semester, Advanced Research on Molecular Systems Pharmaceutics
  28. 2024, Graduate Education (Master's Program) , Second Semester, Advanced Research on Molecular Systems Pharmaceutics
  29. 2024, Graduate Education (Master's Program) , Second Semester, Lecutre on Molecular Systems Pharmaceutics
  30. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular Systems Pharmaceutics
  31. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular Systems Pharmaceutics
  32. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular Systems Pharmaceutics
  33. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular Systems Pharmaceutics

Research Activities

Academic Papers

  1. Next generation quantitative proteomics-based central nervous system barrier transporter studies, Pharmaceutics, 83, 72-77, 2023
  2. Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method, NAR Genom Bioinform, 5, lqad022, 2023
  3. Design and Synthesis of Orexin 1 Receptor-Selective Agonists, J Med Chem, 66, 5453-5464, 2023
  4. COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion, J Neurosurg, 138, 639-648, 2023
  5. The molecules and their functions involved in transport, Clinical Neuroscience, 40(12), 1531-1534, 2022
  6. ★, Blood-arachnoid barrier as a dynamic physiological and pharmacological interface between cerebrospinal fluid and blood, Drug Delivery to the Brain, 93-121, 2022
  7. Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery, Pharm Res, 39, 1363-1392, 2022
  8. Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells, Cells, 11, 3963, 2022
  9. Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier, Pharmaceutics, 14, 1683, 2022
  10. ★, ssPalm-based lipid nanoparticles achieve efficient mRNA transfection in brain capillary endothelial cells, Pharmaceutics, 14, 1560, 2022
  11. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library, Eur J Med Chem, 240, 114505, 2022
  12. ★, Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method, Fluids Barriers CNS, 19, 56, 2022
  13. Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients, J Cereb Blood Flow Metab, 42, 2134-2150, 2022
  14. Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression, J Biol Chem, 298, 102011, 2022
  15. Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs, Pharm Res, 39, 1393-1413, 2022
  16. ★, A human blood-arachnoid barrier atlas of transporters, receptors, enzymes, and tight junction and marker proteins: Comparison with dog and pig in absolute abundance, J Neurochem, 161, 187-208, 2022
  17. SWATH-Based Comprehensive Determination of the Localization of Apical and Basolateral Membrane Proteins Using Mouse Liver as a Model Tissue, Biomedicines, 10, 383, 2022
  18. Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis, J Neurochem, 160, 662-674, 2022
  19. Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-Eclampsia, Biol Pharm Bull, 44, 804-815, 2021
  20. An Atlas of the Quantitative Protein Expression of Anti- Epileptic-Drug Transporters, Metabolizing Enzymes and Tight Junctions at the Blood-Brain Barrier in Epileptic Patients, Pharmaceutics, 13, 2122, 2021

Invited Lecture, Oral Presentation, Poster Presentation

  1. Next-generation quantitative proteomics opens up new horizons in CNS research, Y Uchida, 6th Mass Spectrometry Society of Japan, 2023/03/30, With Invitation, Japanese, Sendai
  2. Mechanisms of brain-selective migration of exosomes from metastatic melanoma in the brain, Y Uchida, 2022 conference of extracellular fine particles, 2023/01/31, Without Invitation, Japanese, Kumamoto
  3. New horizons in CNS research opened up by next-generation quantitative proteomics, Y Uchida, Brain Molecular Exploration seminar, 2022/12/26, With Invitation, Japanese, Tokyo
  4. Discovery for new substrates for MFSD10, a transporter highly expressed in the blood-brain barrier, Rhalib reda Akagawa, Tetsu Sato, Taiho Kambe, Yasuo Uchida, 61st Annual Meeting of the Tohoku Branch of the Pharmaceutical Society of Japan, 2022/11/27, Without Invitation, Japanese, online
  5. Blood-brain barrier MFSD10 limits drug brain migration and central effects of drugs, Tetsu Sato, Rhalib reda Akagawa, Yasuo Uchida, 61st Annual Meeting of the Tohoku Branch of the Pharmaceutical Society of Japan, 2022/11/27, Without Invitation, Japanese, online
  6. Next-generation proteomics opens up new central nervous system barrier, Y Uchida, 21st Seminar for Young Researchers in Medical Pharmacy, 2022/11/12, With Invitation, Japanese, Sendai
  7. Bottom-up construction of brain-shaped nanoparticles for a breakthrough in the delivery of polymeric medicines to the brain, Y Uchida, 2nd meeting of bottom-up biotech, 2022/09/26, Without Invitation, Japanese, Rusutsu
  8. Report on collaborative research based on the quantitative proteomics SWATH method, Y Uchida, 2022 conference of biometal science, 2022/09/03, Without Invitation, Japanese, Rusutsu
  9. Central nervous system barrier research using quantitative proteomics, Y Uchida, 5th conference of extracellular fine particles, 2022/07/21, Without Invitation, Japanese, online
  10. Next generation quantitative proteomics and its application to metal transport study, Y Uchida, The 22nd Annual Meeting of the Protein Science Society of Japan, 2022/06/09, With Invitation, Japanese, Tsukuba
  11. New central barrier opened up by new technologies, Y Uchida, APSTJ 37th annual meeting, 2022/05/26, With Invitation, Japanese, Kyoto
  12. The role of the blood-brain barrier, blood-arachnoid barrier and blood-cerebrospinal fluid barrier in metal dynamics in the human brain, Y Uchida, 2022 1st meeting of biometal science, 2022/05/21, Without Invitation, Japanese, Tokyo
  13. Establishment of a diagnostic basis for personalised pharmacotherapy of refractory cancers based on reconstruction of the molecular clouding environment of cancer cells, Y Uchida, 6th meeting of molecular clouding chemistry, 2022/01/27, Without Invitation, Japanese, online

Awards

  1. 2022/04/01, CREST extracellular fine particle Young Innovator Award, JST CREST

External Funds

Acceptance Results of Competitive Funds

  1. Grants from The Research Foundation for Pharmaceutical Sciences, 2023
  2. Japan Epilepsy Research Foundation 2022 Grants, 2022, 2024
  3. Grants-in-Aid for Scientific Research, Scientific Research(A), 2022, 2025
  4. Grants-in-Aid for Scientific Research, Innovative Areas (Research in a proposed research area) Single-year Grants, 2022, 2023
  5. Grants-in-Aid for Scientific Research, Transformative Research Areas (A), 2022, 2023
  6. AMED, Research and Development Grants for Dementia, 2022, 2024
  7. CREST Young Scientist Challenge, 2022, 2022
  8. AMED, Practical Research for Innovative Cancer Control, 2021, 2023
  9. Grants-in-Aid for Scientific Research, Challenging Research (Exploratory), 2021, 2022
  10. Takeda Science Foundation 2021 Pharmaceutical Research Grants, 2021, 2023
  11. Collaborative research budget from Proteomedix Frontiers, 2020, 2022
  12. Grants-in-Aid for Scientific Research, Scientific Research(B), 2020, 2022
  13. Grants-in-Aid for Scientific Research, Scientific Research(B), 2023, 2025
  14. Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)), 2019, 2023