TAKU NAKASHIMA

Last Updated :2022/12/02

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
Web Site
E-mail
tnakahiroshima-u.ac.jp
Self-introduction
Using mouse disease model, I am performing basic and clinical research focusing on pulmonary fibrosis, interstitial lung diseases, tissue resident stem cells, bone marrow cells, lung cancer, and lung injury with my colleagues.

Basic Information

Major Professional Backgrounds

  • 2001/04/01, 2003/03/31
  • 2003/04/01, 2004/06/30, Hiroshima University, Hospital, Medical Staff
  • 2007/04/01, 2009/03/31, Hiroshima University
  • 2009/04/01, 2010/03/31, Prefectural University of Hiroshima
  • 2010/04/01, 2012/06/30, Univ. of Michigan, Postdoctoral Fellow
  • 2012/07/01, 2012/11/30, Hiroshima University, Hospital, Research associate
  • 2012/12/01, Hiroshima University, Hospital, Research associate
  • 2017/10/01, Hiroshima University Hospital, Respiratory Medicine, Clinical Lecturer

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 2003/04, 2008/05
  • Hiroshima University, Faculty of Medicine, Japan, 1995/04, 2001/03

Academic Degrees

  • MD, PhD., Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • Pulmonary fibrosis, Interstitial lung diseases, bone marrow cells, tissue resident stem cells, lung cancer, lung injury

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2022, Undergraduate Education, First Semester, Internalz Medicine II

Research Activities

Academic Papers

  1. ★, Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis, J Allergy Clin Immun, 121(5), 1269-1276, 20080201
  2. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure., Clin Exp Allergy, 20081101
  3. ★, Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome., J Intern Med, 263(4), 432-439, 20080401
  4. Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis., Biochem Biophys Res Commun, 353(4), 1004-1010, 20070201
  5. Nicergoline improves Dysphagia by upregulating substance p in the elderly, Medicine (Baltimore), 90(4), 279-283, 20110701
  6. ★, Essential role of stem cell factor - c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis, J Pathol, 230(2), 205, 20130601
  7. ★, Lung Bone Marrow-Derived Hematopoietic Progenitor Cells Enhance Pulmonary Fibrosis, Am J Respir Crit Care Med, 20130901
  8. ★, Mucins Carrying Selectin Ligands as Predictive Biomarkers of Disseminated Intravascular Coagulation Complication in ARDS, CHEST, 139(2), 296-304, 201102
  9. A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline, BMJ OPEN, 4(7), 2014
  10. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106(7), 921-928, 201507
  11. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, PHARMACEUTICAL RESEARCH, 32(12), 3877-3885, 201512
  12. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
  13. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 2016
  14. Bone Marrow CD11c(+) Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis, JOURNAL OF IMMUNOLOGY, 197(1), 303-312, 20160701
  15. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22(1), 86-92, 201701
  16. ★, Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106, 1-9, 201705
  17. Chronic hepatitis C virus infection is associated with more severe asthma., Allergol Int, 60(3), 299-304, 201109
  18. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56(19), 2627-2631, 2017
  19. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8(55), 94382-94392, 20171107
  20. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56(24), 3327-3331, 2017
  21. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(1), 131-139, 201801
  22. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119, 21-24, 201805
  23. ★, Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51(5), 20180501
  24. Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32(5), 1155-1160, SEP-OCT 2018
  25. Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 698-706, SEP 7 2018
  26. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(4), 3070-3076, OCT 2018
  27. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9(5), 539-544, 201811
  28. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97(49), 201812
  29. Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442, 31-39, 2019
  30. High preoperative C-reactive protein level is a risk factor for acute exacerbation of interstitial lung disease after non-pulmonary surgery, MEDICINE, 98(5), 201902
  31. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma A case report, MEDICINE, 98(12), 201903
  32. Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 23(4), 2984-2994, 201904
  33. Performance Status Is a Risk Factor for Depression before the Diagnosis of Lung Cancer Patients, INTERNAL MEDICINE, 58(7), 915-920, 2019
  34. Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 15, 863-873, 20190410
  35. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, 136, 52-59, 20190520
  36. Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia, RESPIRATORY MEDICINE, 152, 44-50, 201906
  37. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer, RESPIRATORY INVESTIGATION, 57(5), 451-459, 201909
  38. C-C Motif Chemokine Ligand 15 May Be a Useful Biomarker for Predicting the Prognosis of Patients with Chronic Hypersensitivity Pneumonitis, RESPIRATION, 98(3), 212-220, 201909
  39. Chemotherapy-associated Acute Exacerbation of Interstitial Lung Disease Shortens Survival Especially in Small Cell Lung Cancer, ANTICANCER RESEARCH, 39(10), 5725-5731, 201910
  40. ★, Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Profibrogenic Alterations in Bone Marrow, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(8), 1032-1044, 20191015
  41. Non-small Cell Lung Cancer Treated by an Anti-programmed Cell Death-1 Antibody without a Flare-up of Preexisting Granulomatosis with Polyangiitis, INTERNAL MEDICINE, 58(21), 3129-3132, 2019
  42. Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 25(1), 74-81, 202001
  43. Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 25(1), 74-81, 202001
  44. Treatment rationale and design of the PROLONG study: safety and efficacy of pembrolizumab as first-line therapy for elderly patients with non-small cell lung cancer, JOURNAL OF THORACIC DISEASE, 12(3), 1079-1084, 202003
  45. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25(3), 275-280, 202003
  46. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21(1), 20200611
  47. Serum high-mobility group box 1 as a predictive marker for cytotoxic chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, RESPIRATORY MEDICINE, 172, 202010
  48. Extent of pulmonary fibrosis on high-resolution computed tomography is a prognostic factor in patients with pleuroparenchymal fibroelastosis, RESPIRATORY INVESTIGATION, 58(6), 465-472, 202011
  49. Coexisting TIF1 gamma-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1 gamma Antibody-positive Dermatomyositis, INTERNAL MEDICINE, 59(20), 2553-2558, 2020
  50. Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers, JAMA NETWORK OPEN, 3(11), 20201112
  51. Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer, CANCER SCIENCE, 112(1), 369-379, 202101
  52. Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma, CLINICAL RESPIRATORY JOURNAL, 15(1), 48-55, 202101
  53. Two Cases of Cranial Nerve Metastasis Treated with Radiotherapy and Chemotherapy in Patients with Lung Adenocarcinoma, CASE REPORTS IN ONCOLOGY, 13(3), 1495-1500, 2020
  54. Alectinib-induced Immune Hemolytic Anemia in a Patient with Lung Adenocarcinoma, INTERNAL MEDICINE, 60(4), 611-615, 2021
  55. Concomitant emphysema might increase the false-negative rate of urinary antigen tests in patients with pneumococcal pneumonia: results from a retrospective study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 40(4), 871-877, 202104
  56. Autoantibody Positivity Is a Risk Factor for Chemotherapy-induced Exacerbation of Interstitial Pneumonia in Lung Cancer, ANTICANCER RESEARCH, 41(3), 1497-1506, 202103
  57. Pulmonary lymphangitic carcinomatosis from recurrent gastric cancer 19 years after primary resection: a case report, CLINICAL JOURNAL OF GASTROENTEROLOGY, 14(2), 484-488, 202104
  58. Pulmonary arteriovenous malformation exhibiting recanalization >10 years after coil embolization Two case reports, MEDICINE, 99(2), 202001
  59. Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone, ANTICANCER RESEARCH, 41(5), 2661-2667, 202105
  60. Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients, SCIENTIFIC REPORTS, 11(1), 20210512
  61. Risk factors associated with increased discontinuation rate of trimethoprim-sulfamethoxazole used as a primary prophylaxis for Pneumocystis pneumonia: A retrospective cohort study, PULMONARY PHARMACOLOGY & THERAPEUTICS, 67, 202104
  62. D-dimer can be a diagnostic marker for cisplatin-related aortic thrombosis A case report, MEDICINE, 100(7), 20210219
  63. A machine-learning based approach to quantify fine crackles in the diagnosis of interstitial pneumonia A proof-of-concept study, MEDICINE, 100(7), 20210219
  64. IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis, PLOS ONE, 16(6), 20210604
  65. Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosis, ORPHANET JOURNAL OF RARE DISEASES, 16(1), 20210703
  66. Prediction of radiation pneumonitis after definitive radiotherapy for locally advanced non-small cell lung cancer using multi-region radiomics analysis, SCIENTIFIC REPORTS, 11(1), 20210810

Publications such as books

  1. Acute Respiratory Distress Syndrome, Serum markers of ARDS: How can we know the severity and prognosis from the serum markers?, Springer Nature, Scholarly Book, Joint work, English, Nakashima T, Hattori N
  2. 2014, Respiratory Medical Research, 2014, Scholarly Book, Joint work, 日本語

Invited Lecture, Oral Presentation, Poster Presentation

  1. Mesenchymal stem cells cultured in serum-free medium suppress murine bleomycin-induced pulmonary fibrosis by enhancing regulatory T cell induction, Takao S, Nakashima T, Masuda T, Namba M, Sakamoto S, Yamaguchi K, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Nakashima A, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English
  2. The characteristics of bone marrow cells in mouse with or without pulmonary fibrosis, Taku Nakashima, The 60th JRS meeting, 2020/09/20, With Invitation, Japanese, Japan Respiratory Society, Nagoya
  3. Pulmonary fibrosis and bone marrow-derived cells, Taku Nakashima, 2013/04/19, With Invitation, Japanese, Japan Respiratory Society, Tokyo, Japan
  4. Association between glucose intolerance and chemotherapy-induced lung injury in lung cancer with interstitial pneumonia, Otani T, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N., 2021/02/18, Without Invitation, English
  5. Association of Pre-Existing Interstitial Lung Abnormalities with Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients with Non-Lung Cancers, Shimoji K, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, MiyamotoS, Iwamoto H, Fujitaka K, Hamada H, Takeno S, Hide M, Teishima J, Ohdan H, Hattori N., 2021/02/18, Without Invitation, English
  6. Decline of lung function in adults with a history of childhood asthma, Miura S, Iwamoto H, Omori K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Yokoyama A, Hattori N., JSA/WAO Joint Congress 2020, 2020/09/17, Without Invitation, English
  7. Real-world study of prescription pattern of inhaled corticosteroids in adult asthma, Nakanishi Y, Iwamoto H, Nakao S, Higaki N, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Matsumoto N, Nakashima T, Miyamoto S, Onari Y, Fujitaka K, Haruta Y, Hamada H, Hozawa S, Hattori N., JSA/WAO Joint Congress 2020, 2020/09/17, Without Invitation, English
  8. Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma, Higaki N, Iwamoto H, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Hattori N., JSA/WAO Joint Congress 2020, 2020/09/17, Without Invitation, English
  9. Pivotal role of the HMGB1/sRAGE axis in drug-induced lung injury in advanced lung cancer with pre-existing interstitial lung disease, Nakao S, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N., 30th International Congress of the European Respiratory Society, 2020/09/05, Without Invitation, English
  10. IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis, Nakanishi Y, Horimasu Y, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N., 30th International Congress of the European Respiratory Society, 2020/09/05, Without Invitation, English
  11. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, Yamaguchi K, Iwamoto H, Mazur W*, Miura S, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N., 30th International Congress of the European Respiratory Society, 2020/09/05, Without Invitation, English
  12. Increased fraction of small round lymphocyte in BALF is a diagnostic indicator for sarcoidosis, Horimasu Y, Yamaguchi K, Sakamoto S, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N., 30th International Congress of the European Respiratory Society, 2020/09/05, Without Invitation, English
  13. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-NSCLC cancers., Shimoji K, Masuda T, Nakanishi Y, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N., 2020 ASCO Annual Meeting, 2020/05/29, Without Invitation, English
  14. Clinical significance of BIM deletion polymorphism on chemoradiotherapy in patients with non-small cell lung cancer, Wakabayashi Y, Masuda T, Nakashima T, Fujitaka K, Yamaguchi K, Sakamoto S, Nishimura Y, Horimasu Y, Miyamoto S, Senoo T, IwamotoH, Ohshimo S, Hamada H, Hattori N., 2020 ASCO Annual Meeting, 2020/05/29, Without Invitation, English
  15. EGFR gene mutation is not a significant risk factor in patients with EGFR mutated non-small cell lung cancer who receive best supportive care alone, Masuda T, Wakabayashi Y, Shimoji K, Yamaguchi K, Sakamoto S, Nishimura Y, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N., 2020 ASCO Annual Meeting, 2020/05/29, Without Invitation, English
  16. Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer, Nakanishi Y, Masuda T, Sakamoto S, Yamaguchi K, Horimasu Y, Nakashima T, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N., The 24th Congress of the Asian Pacific Society of Respirology (APSR 2019), 2019/11/14, Without Invitation, English
  17. The incidence and risk factors for acute exacerbation of interstitial lung disease after non-pulmonary surgery, Takao S, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N., The 24th Congress of the Asian Pacific Society of Respirology (APSR 2019), 2019/11/14, Without Invitation, English
  18. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer, Masuda T, Nakanishi Y, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N., The 24th Congress of the Asian Pacific Society of Respirology (APSR 2019), 2019/11/14, Without Invitation, English
  19. Clinical Utility of BALF CCL15 as a prognostic biomarker for Chronic Hypersensitivity Pneumonitis, Watanabe M,Horimasu Y, Iwamoto H, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Ohshimo S, Fujitaka K, Hamada H, Kohno N, Hattori N., European Respiratory Society International Congress 2019, 2019/09/28, Without Invitation, English
  20. Serum high mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, Yamaguchi K, Iwamoto H, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N., European Respiratory Society International Congress 2019, 2019/09/28, Without Invitation, English
  21. Fine crackles quantitative value can help the diagnosis of interstitial lung diseases – Clinical utility of the innovative analyzing system of respiratory sounds, Horimasu Y, Ohshimo S, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Sadamori T*, Fujitaka K, Hamada H, Shime N*, Hattori N., European Respiratory Society International Congress 2019, 2019/09/28, Without Invitation, English
  22. Extent of the Honeycombing Area and the Presence of Traction Bronchiectasis are Risk Factors for Poorer Prognosis in Patients with Pleuroparenchymal Fibroelastosis., Namba M, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Nakashima T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N, ATS 2018 International Conference, 2018/05/18, Without Invitation, English
  23. Vascular Endothelial Growth Factor Knockdown by Intratracheal administration of Small-Interfering RNA Dry Powder Inhibits Tumor Growth In a Mouse Lung Metastasis Model., Miwata K, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N, ATS 2018 International Conference, 2018/05/18, Without Invitation, English
  24. Airway reversibility assessed by oscillometry in patients with asthma, Higaki N, Iwamoto H, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, hattori N., European Respiratory Society 2017, 2017/09/09, Without Invitation, English
  25. PAI-1 plays an important role in radiation-induced pulmonary fibrosis, Sachiko Shioya , Noboru Hattori , Takeshi Masuda , Tadashi Senoo , Yasushi Horimasu , Taku Nakashima , Hiroshi Iwamoto , Kazunori Fujitaka , Nobuoki Kohno, ATS 2016, 2016/05/13, Without Invitation, English
  26. Anti-Tumor Effect of MT95-4, a Fully Humanized Anti-Aminopeptidase N Monoclonal Antibody, on Tumor Progression in an Animal Model of Malignant Pleural Mesothelioma, Takahiko Otsuki , Noboru Hattori , Hironobu Hamada , Yusuke Takayama , Yasushi Horimasu , Takeshi Masuda , Shintarou Miyamoto , Taku Nakashima , Hiroshi Iwamoto , Kazunori Fujitaka , Nobuoki Kohno, ATS 2016, 2016/05/13, Without Invitation, Japanese
  27. PAI-1 plays an important role in lung cancer progression through the association with differentiation of cancer-associated fibroblasts to myofibroblasts, Takeshi Masuda , Noboru Hattori , Yasushi Horimasu , Shintarou Miyamoto , Taku Nakashima , Hiroshi Iwamoto , Kazunori Fujitaka , Nobuoki Kohno ,, American Thoracic Society 2016, 2016/05/13, Without Invitation, English
  28. Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, Kakuhiro Yamaguchi, Hiroshi Iwamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Kazunori Fujitaka, Noboru Hattori, Witold Mazur, Nobuoki Kohno, 56th International conference, JRS, 2016/04/08, Without Invitation, English
  29. Clinically remitted childhood asthma is a risk factor for airflow obstruction in middle-aged adults, Keitaro Omori, Noboru Hattori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Akihito Yokoyama, Nobuoki Kohno, European respiratory society annual congress 2015, 2015/09/26, Without Invitation, English, European Respiratory Society, Amsterdam, Netherlands
  30. Annual changes in pulmonary function are independent prognostic factors for the patiets with chronic hypersensitivity pneumonia, Horimasu Y,Ishikawa N,Nakashima T,Iwamoto H,Senoo T,Ohshimo S,Fitaka K,Haruta Y,Murai H,Hattori N,Kohno N, European Respiratory Society Annual Congress, 2014/09/06, Without Invitation, English
  31. Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis, Iwamoto H,Horimasu Y,Nakashima T,Senoo T,Ohshimo S,Ishikawa N,Fujitaka K,Haruta Y,Murai H,Hattori N,M azur W,Kohno N, European Respiratory Society Annual Congres, 2014/09/06, Without Invitation, English
  32. Intratracheal administration of dry powdered low-molecular-weight chitosan/siRNA suppressed gene expression in the airway, alveoli, and tumors in murine lung, Ihara D,Hattori N,Nakashima T,Iwamoto H,Ishikawa N,Fujitaka K,Haruta Y,Murai H,Kohno N, 2014/04/25, Without Invitation, English
  33. KL-6 as serum biomarkers for early detection of interstitial lung diseases, Hamai K, Ishikawa N,Nakashima T,Iwamoto H,O hshimo S,Fujitaka K,Haruta Y,Murai H,Hattori N,Kohno N, 2014/04/25, Without Invitation, English
  34. Bronchoalveolar lavage cellular pattern can predict the prognosis of patients with chronic hypersensitivity pneumonia, Horimasu Y,Ishikawa N,Nakashima T,Senoo T,O hshimo S,Fujitaka K,Haruta Y,Murai H,Hattori N,Kohno N, 2014/04/25, Without Invitation, English
  35. Suplatast tosilate inhibits hyperoxic lung injury in vivo and exhibits antioxidant activity in vitro, 2014/04/25, Without Invitation, English
  36. Annual decline in lung function can predict the prognosis of patients with chronic hypersensitivity pneumonia, Horimasu Y,Ishikawa N,Nakashima T,Iwamoto H,Senoo T, Ohshimo S,Fujitaka K,Haruta Y,Murai H,Hattori N,Kohno N, 2014, Without Invitation, English, American Thoracic Society
  37. Autoantibody positivity is a risk factor for chemotherapy-induced exacerbation of interstitial pneumonia in lung cancer, Ito N, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English
  38. The role of circulatory high-mobility group box 1 for predicting checkpoint inhibitor pneumonitis caused by anti-PD-1/PD-L1 antibody monotherapy, Yamaguchi K, Tanahashi H, Kurose K, Nakao S, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Oga T, Oka M, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English
  39. Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity, Takahashi H, Nakashima T, Masuda T, Namba M, Sakamoto S, Yamaguchi K, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English
  40. Clinical characteristics of Preserved Ratio Impaired Spirometry in Japan, Miura S, Iwamoto H, Omori K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Yokoyama A, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English
  41. A case of pulmonary alveolar proteinosis with severe respiratory failure improved by segmental lung lavage with fiberoptic bronchoscopy under general anesthesia, Matsumoto Y, Masuda T, Takahashi H, Hashimoto K, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Iwamoto H, Ohshimo S, Fujitaka K, Yamasaki M, Hamada M, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English
  42. The associations between patients' preference for inhaled medications and asthma control, Nakanishi Y, Iwamoto H, Miyamoto S, Nakao S, Higaki N, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Matsumoto N, Nakashima T, Onari Y, Fujitaka K, Haruta Y, Hamada H, Hozawa S, Hattori N, The 25th Congress of the Asian Pacific Society of Respirology, 2021/11/20, Without Invitation, English

Awards

  1. 2008/05, ATS Travel Award, Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2014
  2. KAKENHI, 2015, 2016
  3. KAKENHI, 2013, 2016
  4. KAKENHI (Grant-in-Aid for Scientific Research (C)), 2017, 2019