YASUO KITAJIMA
Last Updated :2025/06/25
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences, Assistant Professor
- E-mail
- kitajima
hiroshima-u.ac.jp
- Self-introduction
- I am investigating the mechanisms of skeletal muscle homeostasis from the fields of skeletal muscle and stem cells.
Basic Information
Major Professional Backgrounds
- 2020/12/01, Excellent Young Researchers, Excellent Young Researchers
- 2020/12/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
- 2019/04, 2020/11, Kumamoto University, Institute of Molecular Embryology and Genetics
- 2016/04, 2019/03
- 2014/04, 2016/03, Tohoku University
Academic Degrees
Research Fields
- Biology;Biological Science;Cell biology
- Biological Sciences;Laboratory animal science;Laboratory animal science
- Complex systems;Health / Sports science;Sports science
Research Keywords
Affiliated Academic Societies
- THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
- JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY
- THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE
Educational Activity
Course in Charge
- 2025, Undergraduate Education, Year, Biological Responses
- 2025, Graduate Education (Master's Program) , First Semester, Seminar
- 2025, Graduate Education (Master's Program) , Second Semester, Seminar
- 2025, Graduate Education (Master's Program) , First Semester, Research
- 2025, Graduate Education (Master's Program) , Second Semester, Research
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Immunology
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Immunology
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Immunology
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Immunology
Research Activities
Academic Papers
- Mg2+ influx mediated by TRPM7 triggers the initiation of muscle stem cell activation, SCIENCE ADVANCES, 11(14), 20250404
- Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans, FRONTIERS IN IMMUNOLOGY, 16, 20250225
- Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion, JOURNAL OF CELL SCIENCE, 137(15), 202408
- The neuronal nitric oxide synthase expression increases during satellite cell-derived primary myoblasts differentiation, CELLULAR AND MOLECULAR BIOLOGY, 69(13), 128-133, 2023
- The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT-TFE3 pathway in C2C12 myoblasts, JOURNAL OF CELLULAR PHYSIOLOGY, 238(9), 2103-2119, 202309
- Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, COMMUNICATIONS BIOLOGY, 6(1), 20230411
- Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen, INTERNATIONAL IMMUNOLOGY, 35(4), 197-207, 20230404
- Little involvement of recycled-amino acids from proteasomal proteolysis in de novo protein synthesis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 634, 40-47, 20221217
- The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration, LIFE SCIENCE ALLIANCE, 6(2), 202202
- Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells, CANCERS, 14(17), 202209
- Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle, SCIENCE ADVANCES, 7(24), 202106
- Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration, CELLS, 11(11), 202206
- siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation, Experimental Cell Research, 20201201
- The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders., The journal of physiological sciences : JPS, 70(1), 40-40, 20200916
- The Body Region Specificity in Murine Models of Muscle Regeneration and Atrophy, Acta Physiologica, 202101
- Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy, Frontiers in Cell and Developmental Biology, 8, 20200902
- Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells, Stem Cell Reports, 202009
- A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues, Frontiers in Cell and Developmental Biology, 8, 20200813
- AMPK complex activation promotes sarcolemmal repair in dysferlinopathy, Molecular Therapy, 28(4), 1133-1153, 20200408
- Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons., EBioMedicine, 45, 362-378, 201907
- The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells., Stem cell reports, 11(6), 1523-1538, 20181211
- Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis., Experimental neurology, 307, 164-179, 201809
- Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line., Skeletal muscle, 8(1), 26, 201808
- Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration., Nature communications, 9(1), 1400, 201804
- Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis, JOURNAL OF NEUROSCIENCE RESEARCH, 96(2), 222-233, 201802
- Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells., Stem cells (Dayton, Ohio), 36(2), 278-285, 201802
- Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice, ACTA PHYSIOLOGICA, 220(1), 99-112, 201705
- Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism, MOLECULAR AND CELLULAR BIOLOGY, 36(11), 1655-1672, 201606
- Metabolome Analysis of Muscle Atrophy, 37, 213-220, 201606
- Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway., Skeletal muscle, 6, 5-5, 2016
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)., Autophagy, 12(1), 1-222, 2016
- Visualizing the Functional Heterogeneity of Muscle Stem Cells., Methods in molecular biology (Clifton, N.J.), 1516, 183-193, 2016
- The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells., Pulmonary pharmacology & therapeutics, 33, 66-74, 201508
- Proteasome dysfunction induces muscle growth defects and protein aggregation., Journal of cell science, 127(Pt 24), 5204-17, 20141215
- Characterization of contraction-induced IL-6 up-regulation using contractile C2C12 myotubes., Endocrine journal, 60(2), 137-147, 2013
- Puromycin sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation, Journal of Cellular Physiology, 202107
Invited Lecture, Oral Presentation, Poster Presentation
- Co-expression of CD276 and Lag3 are early activation markers of functional cytotoxic CD4 T cell in humans, Yumi Tamura, Yasuo Kitajima, 2024/12/03, Without Invitation, Japanese
- Characterization and functional analysis of myeloid cells derived from long-term proliferating cultured common lymphoid progenitors, Yohei Kawano, Yasuo Kitajima, 2024/12/03, Without Invitation, Japanese
- Characterization and functional analysis of myeloid cells derived from long-term proliferating cultured common lymphoid progenitors, Yohei Kawano, Yasuo Kitajima, 2024/11/27, Without Invitation, Japanese
- Sequential exposure to different SARS-CoV-2 antigens induces broadly neutralizing antibodies in mice., Hitoshi Azuma, Yasuo Kitajima, Without Invitation, Japanese
- Immunogenic conversion of cold tumors boosts tumor-specific immune surveillance., Keita Yamane, Yasuo Kitajima, 2024/01/17, Without Invitation, Japanese
- nNOS expression patterns in the differentiation of primary myoblasts, Masaki Kusano, Sakai Kazuya, Yuki Tomiga, Yasuo Kitajima, Kentaro Kawanaka, Shihoko Nakashima, Yoshinari Uehara, Yasuki Higaki, 2023 ACSM annual meeting and world congresses, 2023/06/02, Without Invitation, English
- Properties and functional analysis of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M)., Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda, The 51th Annual Meeting of The Japanese Society for Immunology, 2022/12/07, Without Invitation, Japanese
- Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T cells in response to EBV infected B cells., Yumi Tamura, Keita Yamane, Moeka Mori, Yohei Kawano, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., The 51st Annual Meeting of the Japanese Society for Immunology, 2022/12/07, Without Invitation, Japanese
- nNOS DNA methylation level and nNOS gene expression in the differentiation of primary myoblasts, Kusano M, Kusano M, Sakai K, Tomiga Y, Kitajima Y, Ito A, Kawanaka K, Nakashima S, Uehara Y, Higaki Y, ACSM 2022 Annual Meeting and World Congresses, 2022/06/04, Without Invitation, English
External Funds
Acceptance Results of Competitive Funds
- KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2024, 2026
- KAKENHI(Grant-in-Aid for Scientific Research (B)), 2023, 2026
- KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2021, 2023
- 2020/12, 2025/11
- Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2020/04, 2024/03
- Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Physiological roles and mechanisms of a novel high density lipoprotein (HDL) production system in skeletal muscle., 2020/03, 2024/03
- Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, 2018/04, 2021/03
- 2020/04
- 2020/04
- Grants-in-Aid for Scientific Research Challenging Research (Exploratory), 2017/06/30, 2020/03/31
- 2018/04, 2019/03
- Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, 2016/04, 2019/03
- Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Elucidation of role of proteasome system in regulation of skeletal muscle mass, 2015/04, 2019/03
- 2017/04, 2018/03
- 2016/04, 2017/03
- 2015/04, 2016/03
- 2015/04, 2016/03
- 2013/04, 2014/03