YASUO KITAJIMA

Last Updated :2023/01/05

Affiliations, Positions
Hiroshima University, Assistant Professor
E-mail
kitajimahiroshima-u.ac.jp
Self-introduction
I am investigating the mechanisms of skeletal muscle homeostasis from the fields of skeletal muscle and stem cells.

Basic Information

Major Professional Backgrounds

  • 2020/12/01, Excellent Young Researchers, Excellent Young Researchers
  • 2020/12/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
  • 2019/04, 2020/11, Kumamoto University, Institute of Molecular Embryology and Genetics
  • 2016/04, 2019/03
  • 2014/04, 2016/03, Tohoku University

Research Fields

  • Biology;Biological Science;Cell biology
  • Biological Sciences;Laboratory animal science;Laboratory animal science
  • Complex systems;Health / Sports science;Sports science

Research Keywords

  • muscle stem cell

Affiliated Academic Societies

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
  • JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY
  • THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE

Educational Activity

Course in Charge

  1. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  2. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  3. 2022, Graduate Education (Master's Program) , First Semester, Research
  4. 2022, Graduate Education (Master's Program) , Second Semester, Research
  5. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  6. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  7. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  8. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  9. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Immunology
  10. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Immunology
  11. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Immunology
  12. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Immunology

Research Activities

Academic Papers

  1. Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle, SCIENCE ADVANCES, 7(24), 202106
  2. Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration, CELLS, 11(11), 202206
  3. siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation, Experimental Cell Research, 20201201
  4. The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders., The journal of physiological sciences : JPS, 70(1), 40-40, 20200916
  5. The Body Region Specificity in Murine Models of Muscle Regeneration and Atrophy, Acta Physiologica, 202101
  6. Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy, Frontiers in Cell and Developmental Biology, 8, 20200902
  7. Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells, Stem Cell Reports, 202009
  8. A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues, Frontiers in Cell and Developmental Biology, 8, 20200813
  9. AMPK complex activation promotes sarcolemmal repair in dysferlinopathy, Molecular Therapy, 28(4), 1133-1153, 20200408
  10. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons., EBioMedicine, 45, 362-378, 201907
  11. The Ubiquitin-Proteasome System Is Indispensable for the Maintenance of Muscle Stem Cells., Stem cell reports, 11(6), 1523-1538, 20181211
  12. Antagonizing bone morphogenetic protein 4 attenuates disease progression in a rat model of amyotrophic lateral sclerosis., Experimental neurology, 307, 164-179, 201809
  13. Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line., Skeletal muscle, 8(1), 26, 201808
  14. Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration., Nature communications, 9(1), 1400, 201804
  15. Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis, JOURNAL OF NEUROSCIENCE RESEARCH, 96(2), 222-233, 201802
  16. Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells., Stem cells (Dayton, Ohio), 36(2), 278-285, 201802
  17. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice, ACTA PHYSIOLOGICA, 220(1), 99-112, 201705
  18. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism, MOLECULAR AND CELLULAR BIOLOGY, 36(11), 1655-1672, 201606
  19. Metabolome Analysis of Muscle Atrophy, 37, 213-220, 201606
  20. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway., Skeletal muscle, 6, 5-5, 2016
  21. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)., Autophagy, 12(1), 1-222, 2016
  22. Visualizing the Functional Heterogeneity of Muscle Stem Cells., Methods in molecular biology (Clifton, N.J.), 1516, 183-193, 2016
  23. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells., Pulmonary pharmacology & therapeutics, 33, 66-74, 201508
  24. Proteasome dysfunction induces muscle growth defects and protein aggregation., Journal of cell science, 127(Pt 24), 5204-17, 20141215
  25. Similar perceived exertion during slow jogging at walking speed, 25(1), 19-27, 201402
  26. Characterization of contraction-induced IL-6 up-regulation using contractile C2C12 myotubes., Endocrine journal, 60(2), 137-147, 2013
  27. Puromycin sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation, Journal of Cellular Physiology, 202107

Publications such as books

  1. 2017/03, Role of the Ubiquitin-Proteasome Pathway in Skeletal Muscle, Role of the Ubiquitin-Proteasome Pathway in Skeletal Muscle, Springer Nature, 2017/03, Contributor, kitajima yasuo

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2021, 2023
  2. 2020/12, 2025/03
  3. Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2020/04, 2024/03
  4. Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Physiological roles and mechanisms of a novel high density lipoprotein (HDL) production system in skeletal muscle., 2020/03, 2024/03
  5. Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, 2018/04, 2021/03
  6. 2020/04
  7. 2020/04
  8. Grants-in-Aid for Scientific Research Challenging Research (Exploratory), 2017/06/30, 2020/03/31
  9. 2018/04, 2019/03
  10. Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, 2016/04, 2019/03
  11. Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Elucidation of role of proteasome system in regulation of skeletal muscle mass, 2015/04, 2019/03
  12. 2017/04, 2018/03
  13. 2016/04, 2017/03
  14. 2015/04, 2016/03
  15. 2015/04, 2016/03
  16. 2013/04, 2014/03