TAKERO SHINDO
Last Updated :2025/07/14
- Affiliations, Positions
- Research Institute for Radiation Biology and Medicine, Associate Professor
- E-mail
- takero
hiroshima-u.ac.jp
- Self-introduction
- I am originally from Hiroshima, and I came back to Hiroshima for the first time in 30 years in 2023.
I work in the field of Hematology as a clinician, and I also conduct research focusing on transplant immunology and HTLV-1/ATL.
Whereas I am surprised at many things back in Hiroshima after a long time, I do my best to give back to my hometown.
Basic Information
Major Professional Backgrounds
- 1997/05/01, 1998/05/31, Kyoto University Hospital, Internal Medicine, Resident
- 1998/06/01, 2000/05/31, Shinko Hospital, Internal Medicine, Clinical Fellow
- 2000/06/01, 2002/03/31, Nagahama City Hospital, Department of Hematology/Oncology, Clinical Fellow
- 2007/04/01, 2008/12/31, Kansai Electric Power Hospital, Department of Hematology, Clinical Fellow
- 2025/04/01, 9999, Hiroshima University Research Institute for Radiation Biology and Medicine, Department of Hematology/Oncology, Associate Professor
- 2023/08/01, 2025/03/31, Hiroshima University Research Institute for Radiation Biology and Medicine, Next Generation Development of Genome and Cellular Therapy Program, Designated Professor
- 2016/11/01, 2023/07/31, Kyoto University Hospital, Department of Hematology and Oncology, Assistant Professor
- 2012/08/01, 2016/10/31, Saga University School of Medicine, Hematology/Respiratory Medicine and Oncology, Assistant Professor
- 2010/08/01, 2012/07/31, University of Miami Sylvester Comprehensive Cancer Center, Adult Stem Cell Transplant Program, Post-doctoral research fellow
- 2009/02/01, 2010/07/31, Fred Hutchinson Cancer Research Center, Clinical Research Division, Post-doctoral research fellow
Educational Backgrounds
- Kyoto University Graduate School of Medicine, School of Medicine, Hematology/Oncology, Japan, 2002/04, 2007/03
- Kyoto University, School of Medicine, Japan, 1991/04, 1997/03
Academic Degrees
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Hematology
- Medicine,dentistry, and pharmacy;Basic medicine;Immunology
Research Keywords
- HTLV-1
- Histocompatibility antigen
- Tumor immunology
- Transplant immunology
Affiliated Academic Societies
- The Japan Society of Transfusion Medicine and Cell Therapy, 2024/11
Educational Activity
Course in Charge
- 2025, Undergraduate Education, First Semester, Internal Medicine II
Research Activities
Academic Papers
- Significant detrimental impact of pre-transplant mogamulizumab in allogeneic hematopoietic cell transplantation, Bone Marrow Transplantation, 60(4), 552-554, 2025
- The Intersection of Lynch Syndrome and Hematological Malignancies: A Rare Case Report, eJHaem, 2025
- ★, Cross-organ hierarchy of HLA molecular mismatches in donor-specific antibody development in solid organ transplantations, Cell Reports Medicine, 6(6), 102153, 20250530
- ★, Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T-Cell Leukemia/Lymphoma, Cancer Science, 20250512
- ★, Phase I/II trial of iPSC-derived dopaminergic cells for Parkinson's disease, Nature, 641, 971-977, 20250416
- Impact of HLA Epitope Matching on Outcomes in Haploidentical HSCT With Distinct GVHD Prophylaxes, Transplantation, 109(7), 1241-1250, 20250214
- Trametinib Suppresses the Stimulated T Cells Through G1 Arrest and Apoptosis, EUROPEAN JOURNAL OF IMMUNOLOGY, 55(2), 202502
- Individual HLAs affect survival after allogeneic stem cell transplantation in adult T-cell leukemia/lymphoma, HLA, 103(6), e15555, 2024
- Long-term efficacy and safety of tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: Final analysis of phase IIb results, Haematologica, 109(10), 3357-3362, 2024
- ★, Co-existence of oligoclonal and polyclonal HTLV-1-positive T cells with presentation of acute-type adult T-cell leukemia-lymphoma successfully treated by ultraviolet B phototherapy and etretinate, J Eur Acad Dermatol Venereol, 39(4), e297-e299, 20240808
- Acalabrutinib and obinutuzumab for chronic lymphocytic leukemia complicated with peripheral neuropathy, Cureus, 16(11), e74703, 2024
- KIR3DL1-HLA-Bw status in CML is associated with achievement of TFR: the POKSTIC trial, a multicenter observational study, Blood Neoplasia, 1(1), 100001-100001, 202403
- Successful treatment of severe splenic lymphoma-associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report, ONCOLOGY LETTERS, 27(5), 202405
- ★, Tucidinostat restores CCR4 expression in adult T-cell leukemia/lymphoma, Haematologica, 109(3), 1007-1009, 2023
- 18F-FDG-PET/MRI of the mandible for numb chin syndrome due to acute myeloid leukemia, Neurology and Clinical Neuroscience, 12(2), 121-122, 20230828
- Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity, Scientific Reports, 13(1), 13098, 20230811
- ★, Epitope Mismatch at HLA-DRB1 Associates with Reduced Relapse Risk in Cord Blood Transplantation for Standard-Risk Hematologic Malignancy, Transplantation and Cellular Therapy, 29(6), 347.e1-347.e11, 202306
- Regression of intestinal diffuse large B cell lymphoma after treatment with vedolizumab in a patient with Crohn's disease, European Journal of Cancer, 176, 189-192, 202211
- Oral HDAC inhibitor tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: phase IIb results, Haematologica, 108(3), 811-821, 20221006
- TCR repertoire reflects remission status in lenalidomide-treated myeloma, 1485-1485, 202210
- ★, Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis, Blood Advances, 7(1), 106-121, 20220425
- Favorable HLA Polymorphisms are Associated with Lower Molecular Relapse after Tyrosine Kinase Discontinuation in Patients with Chronic Myeloid Leukemia, Indian Journal of Hematology and Blood Transfusion, 20220418
- Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation, Frontiers in Immunology, 13, 811733-811733, 20220303
- Development of a novel Indium-111 radiolabeled mogamulizumab targeting CCR4 for imaging adult T-cell leukemia/lymphoma in vivo, Annals of Nuclear Medicine, 36(3), 319-326, 202203
- Small B-cell neoplasm responding to ibrutinib after 17 years of cold agglutinin disease symptom., Rinsho Ketsueki, 62(12), 1678-1683, 202112
- ★, Pharmacological MEK inhibition promotes polyclonal T-cell reconstitution and suppresses xenogeneic GVHD, Cellular Immunology, 367, 104410-104410, 202109
- ★, KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia, ImmunoHorizons, 5(8), 687-702, 20210801
- ★, Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy, Frontiers in Immunology, 12, 695037-695037, 20210713
- Next-generation sequencing in two cases of de novo acute basophilic leukaemia, Journal of Cellular and Molecular Medicine, 25(14), 7095-7099, 202107
- ★, T-cell chimerism prior to graft-versus-host disease, European Journal of Cardio-Thoracic Surgery, 20210125
- Primary hepatic lymphoma as other iatrogenic immunodeficiency-related lymphoproliferative disorders: a case report and review of the literature, Modern Rheumatology Case Reports, 5(1), 172-177, 20210102
- HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia, Molecular Cancer Therapeutics, 20(1), 142-149, 202101
- Donor-dominant one-way matching of human leukocyte antigen-A/B/DR alleles predicts graft-versus-host disease following living donor liver transplantation, Hepatology Research, 51(1), 135-148, 202101
- GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma, Bone Marrow Transplantation, 56(1), 155-166, 202101
- Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation, International Journal of Hematology, 112(5), 609-613, 202011
- Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review, International Journal of Surgical Pathology, 29(5), 106689692096456-106689692096456, 20201009
- ★, The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation, Transplantation Direct, 6(9), e591-e591, 202009
- The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse, International Journal of Hematology, 112(2), 200-209, 202008
- Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia, Immunological Medicine, 1-8, 20200725
- Drug monitoring for mycophenolic acid in graft-versus-host disease prophylaxis in cord blood transplantation, British Journal of Clinical Pharmacology, 20200530
- ★, Reconstitution of NK cells expressing KIR3DL1 is associated with reduced NK cell activity and relapse of CML after allogeneic hematopoietic stem cell transplantation, International Journal of Hematology, 111(5), 733-738, 202005
- ★, Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation, Blood Advances, 4(4), 667-671, 20200225
- Role of cancer immunology in chronic myelogenous leukemia, Leukemia Research, 88, 106273-106273, 202001
- Hepatitis-associated Aplastic Anemia With Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis., Internal Medicine, 59(8), 1035-1040, 201912
- Allelic polymorphisms of KIRs and HLAs predict favorable responses to tyrosine kinase inhibitors in CML, 78, IS9-3, 201909
- ★, Trametinib Attenuates Delayed Rejection and Preserves Thymic Function in Rat Lung Transplantation, American Journal of Respiratory Cell and Molecular Biology, 61(3), 355-366, 201909
- Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/kymphoma., Ann Hematol, 98(2), 465-471, 201902
- Epstein-Barr virus-related diffuse large B cell lymphoma in mogamulizumab-treated adult T cell leukemia with incomplete T cell reconstitution., Int J Hematol, 109(2), 221-227, 201902
- Phosphorylation of ERK1/2 in CD4+ T cells is associated with GVHD after allo-HSCT, Rinsho Ketsueki, 59(9), 1524-1524, 201809
- Human BM-MSC derived extracellular vesicles modulate hematopoietic cells in GVHD mice, 59(9), 1515-1515, 201809
- Monitoring of citrulline and diamine oxidase levels as biomarkers for intestinal mucositis during early-phase of hematopoietic cell transplantation., Blood Cell Ther, 201808
- ★, Allelic polymorphisms of KIRs and HLAs predict favorable responses to tyrosine kinase inhibitors in CML, Cancer Immunology Research, 6(6), 745-754, 20180601
- Outcome of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation., Haematologica, 103(5), e211-e214, 201805
- ★, Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia, OncoImmunology, 7(3), e1405204, 20180304
- ★, Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations, Stem Cells, 36(3), 434-445, 201803
- Tocilizumab for severe cytokine-release syndrome after haploidentical donor transplantation in a patient with refractory Epstein-Barr virus-positive diffuse large B-cell lymphoma, Hematological Oncology, 36(1), 324-327, 20180201
- Successful autologous hematopoietic stem cell transplantation followed by bortezomib maintenance in a patient with relapsed CD138-low multiple solitary plasmacytomas harboring a 17p deletion, Internal Medicine, 57(6), 855-860, 2018
- Polymorphisms and avidity of KIR3DL1 and HLA-B alleles predict response to TKI in CML, Rinsho Ketsueki, 58(9), 1502-1502, 201709
- Autopsy case of systemic EBV-positive T-cell lymphoma of childhood with marked hepatomegaly in a middle-aged man, PATHOLOGY INTERNATIONAL, 67(8), 431-433, 201708
- Elderly Patients With Chronic Myeloid Leukemia Benefit From a Dasatinib Dose as Low as 20 mg, CLINICAL LYMPHOMA MYELOMA AND LEUKEMIA, 17(6), 370-374, 201706
- 5q-syndrome-like features as the first manifestation of myelodysplastic syndrome in a patient with an unbalanced whole-arm translocation der(5;19)(p10;q10), INTERNATIONAL JOURNAL OF HEMATOLOGY, 105(5), 692-696, 201705
- Chronic myelogenous leukemia and NK cell immunity, Rinsho Ketsueki, 58(4), 381-388, 201704
- Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement, INTERNAL MEDICINE, 56(18), 2431-2433, 2017
- ★, Altered homeostasis of CD4(+) memory T cells in allogeneic hematopoietic stem cell transplant recipients: Chronic graft-versus-host disease enhances T cell differentiation and exhausts central memory T cell pool, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 13(10), 1176-1184, 200710
- Friend or foe? Mogamulizumab in allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma, Stem Cell Investigation, 2016(70), 20161001
- Subdural hematoma associated with dasatinib and intrathecal methotrexate treatment in Ph+ALL, Rinsho Ketsueki, 57(9), 1721-1721, 201609
- PET-CT in lvmphoma-associated hemophagocytic syndrome in an Epstein-Barr virus-positive patient, Rinsho Ketsueki, 57(9), 1743-1743, 201609
- ★, Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia, CANCER IMMUNOLOGY RESEARCH, 4(8), 644-649, 201608
- ★, The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects, JCI Insight, 1(10), e86331, 201607
- Domino-Style Cerebral Bleeding in a Patient With Immune Thrombocytopenic Purpura, JAMA NEUROLOGY, 73(4), 474-475, 201604
- Rituximab-induced Acute Thrombocytopenia in High Tumor Burden Follicular Lymphoma, INTERNAL MEDICINE, 55(15), 2061-2064, 2016
- Subdural Hematoma Associated with Dasatinib and Intrathecal Methotrexate Treatment in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia, INTERNAL MEDICINE, 55(18), 2703-2706, 201609
- Coexistence of ALK-anaplastic large cell lymphoma and CD4+T cell large granular lymphocytic leukemia, ANNALS OF HEMATOLOGY, 94(3), 539-540, 201503
- Brainstem Encephalitis with anti-ganglioside antibody associated with mogamulizumab treatment, Rinsho Ketsueki, 55(9), 1489-1489, 201409
- T-Cell Characterization Using Multicolor Flow Cytometry After Allogeneic Hematopoietic Stem-Cell Transplantation, JOURNAL OF CLINICAL ONCOLOGY, 32(17), 1859-1860, 201406
- Therapeutic management in cardiac lymphoma, LEUKEMIA AND LYMPHOMA, 55(5), 1215-1217, 201405
- 10 cases of Mogamulizumab treatment for Adult T cell leukemia in Saga prefecture, Rinsho Ketsueki, 54(9), 1438-1438, 201309
- ★, MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner., Blood, 121(23), 4617-4626, 201306
- ★, Growth and differentiation advantages of CD4(+)OX40(+) T cells from allogeneic hematopoietic stem cell transplantation recipients, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14(3), 268-281, 200803
- Nonsecretory primary plasma cell leukemia successfully treated with VAD and MP therapy., Rinsho Ketsueki, 43(2), 107-111, 200202
- Clinical impact of the CONUT score in patients with multiple myeloma, Annals of hematology, 99(1), 113-119, 201911
- Allelic polymorphism of KIRs in chronic myeloid leukemia, MHC, 25(3), 187-195, 201812
- Immune defects in multiple myeloma., Nippon Rinsho, 73(1), 52-56, 201501
- 電子カルテと輸血管理システムの連携による輸血後鉄過剰症モニタリングの運用とその課題, 60(1), 12-17, 201401
- Management of transfusional iron overload., Japanese J of Transfusion and Cell Therapy, 59(1), 73-78, 201301
Awards
- 2011/12, Abstract Achievement Award, The 53rd annual meeting of the American Society of Hematology
- 2011, Best Post-doctoral Fellow, University of Miami Sylvester Comprehensive Cancer Center