TAKERO SHINDO

Last Updated :2025/07/14

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
takerohiroshima-u.ac.jp
Self-introduction
I am originally from Hiroshima, and I came back to Hiroshima for the first time in 30 years in 2023. I work in the field of Hematology as a clinician, and I also conduct research focusing on transplant immunology and HTLV-1/ATL. Whereas I am surprised at many things back in Hiroshima after a long time, I do my best to give back to my hometown.

Basic Information

Major Professional Backgrounds

  • 1997/05/01, 1998/05/31, Kyoto University Hospital, Internal Medicine, Resident
  • 1998/06/01, 2000/05/31, Shinko Hospital, Internal Medicine, Clinical Fellow
  • 2000/06/01, 2002/03/31, Nagahama City Hospital, Department of Hematology/Oncology, Clinical Fellow
  • 2007/04/01, 2008/12/31, Kansai Electric Power Hospital, Department of Hematology, Clinical Fellow
  • 2025/04/01, 9999, Hiroshima University Research Institute for Radiation Biology and Medicine, Department of Hematology/Oncology, Associate Professor
  • 2023/08/01, 2025/03/31, Hiroshima University Research Institute for Radiation Biology and Medicine, Next Generation Development of Genome and Cellular Therapy Program, Designated Professor
  • 2016/11/01, 2023/07/31, Kyoto University Hospital, Department of Hematology and Oncology, Assistant Professor
  • 2012/08/01, 2016/10/31, Saga University School of Medicine, Hematology/Respiratory Medicine and Oncology, Assistant Professor
  • 2010/08/01, 2012/07/31, University of Miami Sylvester Comprehensive Cancer Center, Adult Stem Cell Transplant Program, Post-doctoral research fellow
  • 2009/02/01, 2010/07/31, Fred Hutchinson Cancer Research Center, Clinical Research Division, Post-doctoral research fellow

Educational Backgrounds

  • Kyoto University Graduate School of Medicine, School of Medicine, Hematology/Oncology, Japan, 2002/04, 2007/03
  • Kyoto University, School of Medicine, Japan, 1991/04, 1997/03

Academic Degrees

  • Ph.D., Kyoto University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Hematology
  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology

Research Keywords

  • HTLV-1
  • Histocompatibility antigen
  • Tumor immunology
  • Transplant immunology

Affiliated Academic Societies

  • The Japan Society of Transfusion Medicine and Cell Therapy, 2024/11
    Related URL

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Internal Medicine II

Research Activities

Academic Papers

  1. Significant detrimental impact of pre-transplant mogamulizumab in allogeneic hematopoietic cell transplantation, Bone Marrow Transplantation, 60(4), 552-554, 2025
  2. The Intersection of Lynch Syndrome and Hematological Malignancies: A Rare Case Report, eJHaem, 2025
  3. ★, Cross-organ hierarchy of HLA molecular mismatches in donor-specific antibody development in solid organ transplantations, Cell Reports Medicine, 6(6), 102153, 20250530
  4. ★, Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T-Cell Leukemia/Lymphoma, Cancer Science, 20250512
  5. ★, Phase I/II trial of iPSC-derived dopaminergic cells for Parkinson's disease, Nature, 641, 971-977, 20250416
  6. Impact of HLA Epitope Matching on Outcomes in Haploidentical HSCT With Distinct GVHD Prophylaxes, Transplantation, 109(7), 1241-1250, 20250214
  7. Trametinib Suppresses the Stimulated T Cells Through G1 Arrest and Apoptosis, EUROPEAN JOURNAL OF IMMUNOLOGY, 55(2), 202502
    Link to Paper Search Results by DOI
  8. Individual HLAs affect survival after allogeneic stem cell transplantation in adult T-cell leukemia/lymphoma, HLA, 103(6), e15555, 2024
  9. Long-term efficacy and safety of tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: Final analysis of phase IIb results, Haematologica, 109(10), 3357-3362, 2024
  10. ★, Co-existence of oligoclonal and polyclonal HTLV-1-positive T cells with presentation of acute-type adult T-cell leukemia-lymphoma successfully treated by ultraviolet B phototherapy and etretinate, J Eur Acad Dermatol Venereol, 39(4), e297-e299, 20240808
  11. Acalabrutinib and obinutuzumab for chronic lymphocytic leukemia complicated with peripheral neuropathy, Cureus, 16(11), e74703, 2024
  12. KIR3DL1-HLA-Bw status in CML is associated with achievement of TFR: the POKSTIC trial, a multicenter observational study, Blood Neoplasia, 1(1), 100001-100001, 202403
  13. Successful treatment of severe splenic lymphoma-associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report, ONCOLOGY LETTERS, 27(5), 202405
    Link to Paper Search Results by DOI
  14. ★, Tucidinostat restores CCR4 expression in adult T-cell leukemia/lymphoma, Haematologica, 109(3), 1007-1009, 2023
  15. 18F-FDG-PET/MRI of the mandible for numb chin syndrome due to acute myeloid leukemia, Neurology and Clinical Neuroscience, 12(2), 121-122, 20230828
  16. Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity, Scientific Reports, 13(1), 13098, 20230811
  17. ★, Epitope Mismatch at HLA-DRB1 Associates with Reduced Relapse Risk in Cord Blood Transplantation for Standard-Risk Hematologic Malignancy, Transplantation and Cellular Therapy, 29(6), 347.e1-347.e11, 202306
  18. Regression of intestinal diffuse large B cell lymphoma after treatment with vedolizumab in a patient with Crohn's disease, European Journal of Cancer, 176, 189-192, 202211
  19. Oral HDAC inhibitor tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: phase IIb results, Haematologica, 108(3), 811-821, 20221006
  20. TCR repertoire reflects remission status in lenalidomide-treated myeloma, 1485-1485, 202210
  21. ★, Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis, Blood Advances, 7(1), 106-121, 20220425
  22. Favorable HLA Polymorphisms are Associated with Lower Molecular Relapse after Tyrosine Kinase Discontinuation in Patients with Chronic Myeloid Leukemia, Indian Journal of Hematology and Blood Transfusion, 20220418
  23. Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation, Frontiers in Immunology, 13, 811733-811733, 20220303
  24. Development of a novel Indium-111 radiolabeled mogamulizumab targeting CCR4 for imaging adult T-cell leukemia/lymphoma in vivo, Annals of Nuclear Medicine, 36(3), 319-326, 202203
  25. Small B-cell neoplasm responding to ibrutinib after 17 years of cold agglutinin disease symptom., Rinsho Ketsueki, 62(12), 1678-1683, 202112
  26. ★, Pharmacological MEK inhibition promotes polyclonal T-cell reconstitution and suppresses xenogeneic GVHD, Cellular Immunology, 367, 104410-104410, 202109
  27. ★, KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia, ImmunoHorizons, 5(8), 687-702, 20210801
  28. ★, Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy, Frontiers in Immunology, 12, 695037-695037, 20210713
  29. Next-generation sequencing in two cases of de novo acute basophilic leukaemia, Journal of Cellular and Molecular Medicine, 25(14), 7095-7099, 202107
  30. ★, T-cell chimerism prior to graft-versus-host disease, European Journal of Cardio-Thoracic Surgery, 20210125
  31. Primary hepatic lymphoma as other iatrogenic immunodeficiency-related lymphoproliferative disorders: a case report and review of the literature, Modern Rheumatology Case Reports, 5(1), 172-177, 20210102
  32. HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia, Molecular Cancer Therapeutics, 20(1), 142-149, 202101
  33. Donor-dominant one-way matching of human leukocyte antigen-A/B/DR alleles predicts graft-versus-host disease following living donor liver transplantation, Hepatology Research, 51(1), 135-148, 202101
  34. GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma, Bone Marrow Transplantation, 56(1), 155-166, 202101
  35. Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation, International Journal of Hematology, 112(5), 609-613, 202011
  36. Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review, International Journal of Surgical Pathology, 29(5), 106689692096456-106689692096456, 20201009
  37. ★, The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation, Transplantation Direct, 6(9), e591-e591, 202009
  38. The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse, International Journal of Hematology, 112(2), 200-209, 202008
  39. Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia, Immunological Medicine, 1-8, 20200725
  40. Drug monitoring for mycophenolic acid in graft-versus-host disease prophylaxis in cord blood transplantation, British Journal of Clinical Pharmacology, 20200530
  41. ★, Reconstitution of NK cells expressing KIR3DL1 is associated with reduced NK cell activity and relapse of CML after allogeneic hematopoietic stem cell transplantation, International Journal of Hematology, 111(5), 733-738, 202005
  42. ★, Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation, Blood Advances, 4(4), 667-671, 20200225
  43. Role of cancer immunology in chronic myelogenous leukemia, Leukemia Research, 88, 106273-106273, 202001
  44. Hepatitis-associated Aplastic Anemia With Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis., Internal Medicine, 59(8), 1035-1040, 201912
  45. Allelic polymorphisms of KIRs and HLAs predict favorable responses to tyrosine kinase inhibitors in CML, 78, IS9-3, 201909
  46. ★, Trametinib Attenuates Delayed Rejection and Preserves Thymic Function in Rat Lung Transplantation, American Journal of Respiratory Cell and Molecular Biology, 61(3), 355-366, 201909
  47. Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/kymphoma., Ann Hematol, 98(2), 465-471, 201902
  48. Epstein-Barr virus-related diffuse large B cell lymphoma in mogamulizumab-treated adult T cell leukemia with incomplete T cell reconstitution., Int J Hematol, 109(2), 221-227, 201902
  49. Phosphorylation of ERK1/2 in CD4+ T cells is associated with GVHD after allo-HSCT, Rinsho Ketsueki, 59(9), 1524-1524, 201809
  50. Human BM-MSC derived extracellular vesicles modulate hematopoietic cells in GVHD mice, 59(9), 1515-1515, 201809
  51. Monitoring of citrulline and diamine oxidase levels as biomarkers for intestinal mucositis during early-phase of hematopoietic cell transplantation., Blood Cell Ther, 201808
  52. ★, Allelic polymorphisms of KIRs and HLAs predict favorable responses to tyrosine kinase inhibitors in CML, Cancer Immunology Research, 6(6), 745-754, 20180601
  53. Outcome of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation., Haematologica, 103(5), e211-e214, 201805
  54. ★, Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia, OncoImmunology, 7(3), e1405204, 20180304
  55. ★, Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations, Stem Cells, 36(3), 434-445, 201803
  56. Tocilizumab for severe cytokine-release syndrome after haploidentical donor transplantation in a patient with refractory Epstein-Barr virus-positive diffuse large B-cell lymphoma, Hematological Oncology, 36(1), 324-327, 20180201
  57. Successful autologous hematopoietic stem cell transplantation followed by bortezomib maintenance in a patient with relapsed CD138-low multiple solitary plasmacytomas harboring a 17p deletion, Internal Medicine, 57(6), 855-860, 2018
  58. Polymorphisms and avidity of KIR3DL1 and HLA-B alleles predict response to TKI in CML, Rinsho Ketsueki, 58(9), 1502-1502, 201709
  59. Autopsy case of systemic EBV-positive T-cell lymphoma of childhood with marked hepatomegaly in a middle-aged man, PATHOLOGY INTERNATIONAL, 67(8), 431-433, 201708
  60. Elderly Patients With Chronic Myeloid Leukemia Benefit From a Dasatinib Dose as Low as 20 mg, CLINICAL LYMPHOMA MYELOMA AND LEUKEMIA, 17(6), 370-374, 201706
  61. 5q-syndrome-like features as the first manifestation of myelodysplastic syndrome in a patient with an unbalanced whole-arm translocation der(5;19)(p10;q10), INTERNATIONAL JOURNAL OF HEMATOLOGY, 105(5), 692-696, 201705
  62. Chronic myelogenous leukemia and NK cell immunity, Rinsho Ketsueki, 58(4), 381-388, 201704
  63. Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement, INTERNAL MEDICINE, 56(18), 2431-2433, 2017
  64. ★, Altered homeostasis of CD4(+) memory T cells in allogeneic hematopoietic stem cell transplant recipients: Chronic graft-versus-host disease enhances T cell differentiation and exhausts central memory T cell pool, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 13(10), 1176-1184, 200710
  65. Friend or foe? Mogamulizumab in allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma, Stem Cell Investigation, 2016(70), 20161001
  66. Subdural hematoma associated with dasatinib and intrathecal methotrexate treatment in Ph+ALL, Rinsho Ketsueki, 57(9), 1721-1721, 201609
  67. PET-CT in lvmphoma-associated hemophagocytic syndrome in an Epstein-Barr virus-positive patient, Rinsho Ketsueki, 57(9), 1743-1743, 201609
  68. ★, Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia, CANCER IMMUNOLOGY RESEARCH, 4(8), 644-649, 201608
  69. ★, The MEK inhibitor trametinib separates murine Graft-versus-Host Disease from Graft-versus-Tumor Effects, JCI Insight, 1(10), e86331, 201607
  70. Domino-Style Cerebral Bleeding in a Patient With Immune Thrombocytopenic Purpura, JAMA NEUROLOGY, 73(4), 474-475, 201604
  71. Rituximab-induced Acute Thrombocytopenia in High Tumor Burden Follicular Lymphoma, INTERNAL MEDICINE, 55(15), 2061-2064, 2016
  72. Subdural Hematoma Associated with Dasatinib and Intrathecal Methotrexate Treatment in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia, INTERNAL MEDICINE, 55(18), 2703-2706, 201609
  73. Coexistence of ALK-anaplastic large cell lymphoma and CD4+T cell large granular lymphocytic leukemia, ANNALS OF HEMATOLOGY, 94(3), 539-540, 201503
  74. Brainstem Encephalitis with anti-ganglioside antibody associated with mogamulizumab treatment, Rinsho Ketsueki, 55(9), 1489-1489, 201409
  75. T-Cell Characterization Using Multicolor Flow Cytometry After Allogeneic Hematopoietic Stem-Cell Transplantation, JOURNAL OF CLINICAL ONCOLOGY, 32(17), 1859-1860, 201406
  76. Therapeutic management in cardiac lymphoma, LEUKEMIA AND LYMPHOMA, 55(5), 1215-1217, 201405
  77. 10 cases of Mogamulizumab treatment for Adult T cell leukemia in Saga prefecture, Rinsho Ketsueki, 54(9), 1438-1438, 201309
  78. ★, MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner., Blood, 121(23), 4617-4626, 201306
  79. ★, Growth and differentiation advantages of CD4(+)OX40(+) T cells from allogeneic hematopoietic stem cell transplantation recipients, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14(3), 268-281, 200803
  80. Nonsecretory primary plasma cell leukemia successfully treated with VAD and MP therapy., Rinsho Ketsueki, 43(2), 107-111, 200202
  81. Clinical impact of the CONUT score in patients with multiple myeloma, Annals of hematology, 99(1), 113-119, 201911
  82. Allelic polymorphism of KIRs in chronic myeloid leukemia, MHC, 25(3), 187-195, 201812
  83. Immune defects in multiple myeloma., Nippon Rinsho, 73(1), 52-56, 201501
  84. 電子カルテと輸血管理システムの連携による輸血後鉄過剰症モニタリングの運用とその課題, 60(1), 12-17, 201401
  85. Management of transfusional iron overload., Japanese J of Transfusion and Cell Therapy, 59(1), 73-78, 201301

Awards

  1. 2011/12, Abstract Achievement Award, The 53rd annual meeting of the American Society of Hematology
  2. 2011, Best Post-doctoral Fellow, University of Miami Sylvester Comprehensive Cancer Center