TAKAHIRO CHIHARA
Last Updated :2023/11/01
- Affiliations, Positions
- Graduate School of Integrated Sciences for Life, Professor
- E-mail
- tchihara
hiroshima-u.ac.jp
- Self-introduction
- I am trying to reveal the molecular mechanism how nervous system regulates animal behavior and physiology by using fruit fly, Drosophila melanogaster.
Basic Information
Major Professional Backgrounds
- 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor
- 2016/03/28, 2019/03/31, Hiroshima University, Graduate School of Science, Department of Biological Science, Professor
- 2013/10, 2016/03/27, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor
- 2010/08, 2013/09, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Lecturer
- 2009/10, 2013/03, JST, PRESTO, PRESTO Researcher
- 2007/04, 2010/07, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor
- 2006/04, 2007/03, The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor
- 2001/04, 2002/01, National Institute of Genetics, Lab for Invertebrate Genetics, JSPS Research Fellow (PD)
- 2002/02, 2004/01, Stanford University, Department of Biological Science, JST young scientist abroad
- 2004/02, 2006/01, Stanford University, Department of Biological Science, JSPS Research Fellow abroad
- 2006/02, 2006/03, Stanford University, Department of Biological Science, Stanford University postdoc fellow
Academic Degrees
- Kumamoto University
- The Graduate University for Advanced Studies
Educational Activity
- [Bachelor Degree Program] School of Science : Biological Sciences : Biology
- [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
- [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
- [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
- [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
In Charge of Primary Major Programs
Research Fields
- Biology;Biological Science;Developmental biology
- Biology;Biological Science;Cell biology
- Biological Sciences;Neuroscience;Neurophysiology / General neuroscience
Research Keywords
- Olfaction, Aging, Innate immunity, animal behavior, Sleep, Neural network, Synapse, dendrite, Unfolded Stress Response, Vesicle trafficking, ALS, Drosophila
Affiliated Academic Societies
- Japanese Society for Developmental Society, The Japan Society for Neurochemistry, The Japan Neuroscience Society, The Molecular Biology Society of Japan, The Japanese Biochemical Society, Japan Society for Cell Biology, Society for Neuroscience, Genetic Society of America, American Society for Cell Biology
Educational Activity
Course in Charge
- 2023, Liberal Arts Education Program1, 1Term, Fundamentals of Biology
- 2023, Liberal Arts Education Program1, 3Term, Introduction to Biology
- 2023, Undergraduate Education, 4Term, Introduction to Biological Sciences B
- 2023, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
- 2023, Undergraduate Education, 2Term, Advanced Biology
- 2023, Undergraduate Education, Second Semester, Seminar for Cell Biology
- 2023, Undergraduate Education, First Semester, Special Study for Graduation
- 2023, Undergraduate Education, Second Semester, Special Study for Graduation
- 2023, Undergraduate Education, 1Term, Molecular Cell Biology
- 2023, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
- 2023, Undergraduate Education, First Semester, Model organisms unravel Biological defense systems and Aging control mechanisms
- 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
- 2023, Graduate Education (Master's Program) , 1Term, Cellular life science
- 2023, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
- 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
- 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
- 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
- 2023, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
- 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
- 2023, Graduate Education (Master's Program) , First Semester, Special Lecture on Biomedical Science
- 2023, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
- 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
- 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
- 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
- 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
- 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
- 2023, Graduate Education (Master's Program) , 4Term, Introduction to Genetics and Genomics
Research Activities
Academic Papers
- Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies, PLOS Genetics, 2023
- Crosstalk between the mTOR and Hippo pathways, Development, Growth and Differentiation, 2023
- Dynamin-2 regulates microtubule stability via an endocytosis-independent mechanism, CYTOSKELETON, 79(9-11), 94-104, 202209
- Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila, Genes to Cells, 27(6), 381-391, 202206
- ★, Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization, Developmental Biology, 484, 30-39, 202204
- Systemic innate immune response induces death of olfactory receptor neurons in Drosophila, Genes to Cells, 27(2), 113-123, 202202
- Efficient visual screening of CRISPR/Cas9 genome editing in the nematode Pristionchus pacificus, Development, Growth & differentiation, 63(9), 488-500, 20211123
- ★, Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila, Genes to Cells, 26(4), 230-239, 202104
- Different combinations of serotonin receptors regulate predatory and bacterial feeding behaviors in the nematode Pristionchus pacificus, G3:Genes, Genomes, Genetics, 11(2), jkab011, 20210120
- Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes, Neuroscience Research, 154, 9-19, 202005
- Screening for CRISPR/Cas9-induced mutations using a co-injection marker in the nematode Pristionchus pacificus, Development Genes and evolution, 230(3), 257-264, 202005
- ROS regulate caspase-dependent cell delamination without apoptosis in the Drosophila pupal notum, iScience, 23(8), 101413
- Impairment of cytokinesis by cancer-associated DAPK3 mutations, Biochem Biophys Res Commun, 553(4), 1095-1101, 20201217
- Non-apoptotic function of Drosophila caspase activation in epithelial thorax closure and wound healing, Development, 146(4), 201902
- Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum, Current Biology, 29(9), 1512-+, 20190506
- Multiple functions of the ER-resident VAP and its extracellular role in neural development and disease, Journal of Biochemistry, 165(5), 391-400, 201905
- Dronc-independent basal executioner caspase activity sustains Drosophila imaginal tissue growth., Proc Natl Acad Sci U S A, in press, 201909
- ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity, NATURE COMMUNICATIONS, 9, 20180823
- ★, Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila, GENES & DEVELOPMENT, 31(10), 1054-1065, 20170515
- Role of the STRIPAK complex and the Hippo pathway in synaptic terminal formation, Neural Regen Res, 12, 578-579, 2017
- Tissue non-autonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila., Proc Natl Acad Sci U S A, 113, 1835-1840, 2016
- ★, Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos., Genes to Cells, 21, 53-64, 2016
- ★, The Strip-Hippo pathway regulates synaptic terminal formation by modulating actin organization at the Drosophila neuromuscular synapses, Cell Reports, 16, 2289-2297, 2016
- Biallelic TBCD Mutations Cause Early-Onset Neurodegenerative Encephalopathy, Am J Hum Genet, 99(4), 950-961, 20161006
- Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43., J Biol Chem, 291, 23464-23476, 2016
- Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development., Neural Regen Res, 11, 1394-1395, 2016
- ★, A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability., Scientific Reports, 5, 17769, 2015
- The roles of tubulin-folding cofactors in neuronal morphogenesis and disease., Neural Regeneration Research, 10(9), 1388-1389, 2015
- ★, Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis., The Journal of Neuroscience, 35(5), 1979-1990, 2015
- Drosophila Strip serves as a platform for early endosome organization during axon elongation., Nature Communications, 5, 5180, 2014
- ★, Caspase inhibition in select olfactory neurons restores innate attraction behavior in aged Drosophila., PLOS Genetics, 10(6), e1004437, 2014
- ★, Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit., Genes and Genetic Systems, 89(1), 17-26, 2014
- RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy, Hum. Mol. Genet., 22, 4474-4484, 2013
- ★, Meigo governs dendrite targeting specificity by modulating Ephrin level and N-glycosylation, Nature Neuroscience, 16, 683-689, 2013
- Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster, PLOS ONE, 7, e30265, 2012
- Histon deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero, The Journal of Neuroscience, 21, 9939-9946, 2010
- Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain, Development, 137, 43-51, 2010
- ★, Organelles in developing neurons: essential regulators of neuronal morphogenesis and function, Int. J. Dev. Biol., 53, 19-27, 2009
- ★, Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization, Nature Neuroscience, 10, 828-837, 2007
- Wiring stability of the adult Drosophila olfactory circuit after lesion, The Journal of Neuroscience, 26, 3367-3376, 2006
- Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea, Development, 131, 5253-5261, 2004
- Like poles repel: Molecular mechanisms of dendritic tiling, Cell, 119, 148-149, 2004
- Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila, Development, 130, 1419-1428, 2003
- Control of tracheal tubulogenesis by Wingless signaling, Development, 127, 4433-4442, 2000
- Myeloid ELF-1-like factor up-regulates lysozyme transcription in epithelial cells, The Journal of Biological Chemistry, 274, 20098-20102, 1999