RYUTA BABA

Last Updated :2026/03/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Assistant Professor
Web Site
https://naika2.hiroshima-u.ac.jp/en/
E-mail
rtbabahiroshima-u.ac.jp
Self-introduction
Elucidation of the molecular mechanisms of Aldosterone synthesis and tumor formation in aldosterone-producing adenomas, the cause of primary aldosteronism.

Basic Information

Major Professional Backgrounds

  • 2022/04/01, 2024/03/31, Hiroshima University, Hospital, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical & Health Sciences , Japan, 2018/04, 2022/03

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Endocrinology

Research Keywords

  • adrenocortical insufficiency
  • primary aldosteronism
  • Cushing's syndrome
  • cortisol
  • Aldosterone
  • adrenal gland

Affiliated Academic Societies

  • The Japan Society of Internal Medicine
  • The Japan Endocrine Society
  • The Japan Diabetes Society

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2025, Undergraduate Education, First Semester, Internal Medicine II

Research Activities

Academic Papers

  1. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 2018
  2. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 2020
  3. Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung, ERJ OPEN RESEARCH, 6(4), 2020
  4. ★, Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 538, 2021
  5. ATP1A1Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(20), 2021
  6. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548, 2022
  7. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29(8), 495-502, 2022
  8. Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies., Circulation, 147(14), 2023
  9. Selective activation of PPAR alpha maintains thermogenic capacity of beige adipocytes, ISCIENCE, 26(7), 20230721
    Link to Paper Search Results by DOI
  10. Immunoprecipitation with an Anti-Epitope Tag Affinity Gelto Study Protein-Protein Interactions, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 202401
    Link to Paper Search Results by DOI
  11. Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(15), 20240806
    Link to Paper Search Results by DOI
  12. Effectiveness and safety of denosumab monotherapy in patients with primary hyperparathyroidism: A retrospective study, MEDICINE, 104(40), 20251003
    Link to Paper Search Results by DOI
  13. ★, Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural analyses, FRONTIERS IN ENDOCRINOLOGY, 16, 20251020
    Link to Paper Search Results by DOI
  14. Clinical characteristics of Japanese Americans with normal glucose tolerance with 1-h hyperglycemia: A cross-sectional study, JOURNAL OF DIABETES INVESTIGATION, 16(11), 2018-2026, 202511
    Link to Paper Search Results by DOI
  15. Blood glucose variability in early-onset adrenocorticotropic hormone deficiency induced by immune checkpoint inhibitor therapy with continuous blood glucose monitoring: a case report, DIABETOLOGY INTERNATIONAL, 17(1), 202601
    Link to Paper Search Results by DOI

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Research Activity Start-up), 2022, 2023
  2. 2025, 2030
  3. 2025, 2028