広島大学

Basic Information

Major Professional Backgrounds

• 2013/08/01, Research Institute for Radiation Biology and Medicine, Hiroshima University, Department of Cellular Biology, Assistant professor
• 2013/07/01, 2013/07/31, Research Institute for Radiation Biology and Medicine, Hiroshima University, Department of Cellular Biology, Postdoctoral Fellow
• 2013/04/01, 2013/06/30, Radiation Biology Center, Kyoto University, Department of Radiation System Biology, Assistant Technical Staff

Educational Backgrounds

• Kyoto University, GRADUATE SCHOOL OF BIOSTUDIES, Division of Integrated Life Science, Japan
• Keio University, Japan

Academic Degrees

• Doctor of Philosophy, Kyoto University

Educational Activity

• [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
• [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
• [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
• [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

• Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals

Research Keywords

• Radiation Biology
• DNA Damage Response
• (4D) Nucleome
• Bioimaging

Educational Activity

Course in Charge

1. 2025, Undergraduate Education, Intensive, Practice for medical research
2. 2025, Graduate Education (Master's Program) , First Semester, Seminar
3. 2025, Graduate Education (Master's Program) , Second Semester, Seminar
4. 2025, Graduate Education (Master's Program) , First Semester, Research
5. 2025, Graduate Education (Master's Program) , Second Semester, Research
6. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
7. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
10. 2025, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
11. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular Biology
12. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular Biology
13. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular Biology
14. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular Biology
15. 2025, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

1. SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites, NUCLEUS, 9(1), 87-94, 2018
   Link to Paper Search Results by DOI
2. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition, CANCER SCIENCE, 104(12), 1593-1599, 201312
   Link to Paper Search Results by DOI
3. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, FASEB JOURNAL, 29(6), 2514-2525, 201506
   Link to Paper Search Results by DOI
4. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair, GENES TO CELLS, 20(9), 681-694, 201509
   Link to Paper Search Results by DOI
5. Matrin3 promotes homologous recombinational repair by regulation of RAD51, JOURNAL OF BIOCHEMISTRY, 166(4), 343-351, 201910
   Link to Paper Search Results by DOI
6. Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients, RADIATION RESEARCH, 195(3), 244-252, 202103
   Link to Paper Search Results by DOI
7. A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage, RADIATION RESEARCH, 197(4), 384-395, 202204
   Link to Paper Search Results by DOI
8. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage, JOURNAL OF CELL SCIENCE, 126(22), 5284-5292, 20131115
   Link to Paper Search Results by DOI
9. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1, SCIENTIFIC REPORTS, 4, 20140506
   Link to Paper Search Results by DOI
10. Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 89(4), 736-744, 20140715
    Link to Paper Search Results by DOI
11. Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20, PLOS ONE, 10(3), 20150323
    Link to Paper Search Results by DOI
12. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations, ELIFE, 7, 20180508
    Link to Paper Search Results by DOI
13. Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution, ISCIENCE, 24(4), 20210423
    Link to Paper Search Results by DOI
14. OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
    Link to Paper Search Results by DOI
15. Piwi–piRNA complexes induce stepwise changes innuclear architecture at target loci, EMBO JOURNAL, 40(18), 20210802
    Link to Paper Search Results by DOI
16. Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis., Clinical science, 137(2), 163-180, 20230131
17. Klotho protects chromosomal DNA from radiation-induced damage, JOURNAL OF BIOCHEMISTRY, 173(5), 375-382, 20230426
    Link to Paper Search Results by DOI
18. Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair, GENES TO CELLS, 29(11), 951-965, 20241106
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

1. Distinctive nuclear zone for RAD51-mediated homologous recombinational DNA repair, The 12th 3R+3C International Symposium, 2024/11/19, Without Invitation, English, Fukuoka
   Related URL
2. Nuclear topography of homologous recombinational repair., Yasunori Horikoshi, Atsuhiko Fukuto, Satoshi Tashiro, 2nd International Symposium of the Mathematics on Chromatin Live Dynamics, 2014/03/11, Without Invitation, English, Hiroshima
   Related URL
3. Nuclear Topography of Homologous Recombination Protein RAD51., Yasunori Horikoshi, Atsuhiko Fukuto, Satoshi Tashiro, The 4D Nucleome 2014, 2014/12/18, Without Invitation, English, Hiroshima
   Related URL
4. Topographical regulation of homologous recombination repair by RAD51, Yasunori Horikoshi, Atsuhiko Fukuto and Satoshi Tashiro, International Symposium on Chromatin Structure, Dynamics, and Function, 2015/08/24, Without Invitation, English, Awaji
   Related URL
5. Topographical regulation of homologous recombinational repair by RAD51, Yasunori Horikoshi, Atsuhiko Fukuto and Satoshi Tashiro, 5th International Symposium of the Mathematics on Chromatin Live Dynamics, 2017/03/07, Without Invitation, English, Higashi Hiroshima
   Related URL
6. Homologous pairing during recombinational DNA repair take place within distinctive nuclear compartment, Yasunori Horikoshi, Hiroki Shima, Wataru Kobayashi, Hiroshi Ochiai, Jiying Sun, Hitoshi Kurumizaka, Tsuyoshi Ikura, Shin-ichi Tate, Kazuhiko Igarashi, Thomas Cremer, Satoshi Tashiro, EMBO Workshop Chromatin and Epigenetics, 2019/05/02, Without Invitation, English, EMBL, Heidelberg
   Related URL

Social Activities

Organizing Academic Conferences, etc.

1. The 4D Nucleome 2014, Local Committee, 2014/12
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