MIKIHITO KAJIYA

Last Updated :2025/07/07

Affiliations, Positions
Center for Oral Clinical Examination, Professor
E-mail
mkajiyahiroshima-u.ac.jp
Self-introduction
Periodontitis is an inflammatory periodontal tissue-destructive disease attributed to host immune responses to periodontal pathogenic bacteria, which leads to tooth loss. Otherwise, tissue regenerative therapy using stem cells, which exerts self-renewing properties and multipotency, has attracted scientific and medical attention. Thus, using mesenchymal stem cells and our own developed three-dimensional culture system, we will develop the novel promising periodontal tissue regenerative cell therapy.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  2. 2025, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2025, Undergraduate Education, 2Term, Topics in Dental Research II
  4. 2025, Undergraduate Education, 3Term, Examination and Diagnosis
  5. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  6. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  7. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  8. 2025, Undergraduate Education, Year, Clinical Practice (Oral Clinical Examination)
  9. 2025, Undergraduate Education, 1Term, Oral Health Management A
  10. 2025, Undergraduate Education, First Semester, Overview of Oral Engineering
  11. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Innovation & Precision Dentistry
  12. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Innovation & Precision Dentistry
  13. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Innovation & Precision Dentistry
  14. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Innovation & Precision Dentistry

Research Activities

Academic Papers

  1. Effect of Stimulated Salivary Volume on Dysbiosis of the Salivary Microbiome in Children and Young Adults, INTERNATIONAL DENTAL JOURNAL, 75(3), 1759-1770, 202506
    Link to Paper Search Results by DOI
  2. Consideration of the work environment in a case of an industrial homeworker with allergic contact dermatitis by UV-curing acrylic resin, ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, 79(9-10), 315-320, 20241125
    Link to Paper Search Results by DOI
  3. Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis, INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY, 10(1), 20241126
    Link to Paper Search Results by DOI
  4. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model, ORAL DISEASES, 30(8), 5294-5304, 202411
    Link to Paper Search Results by DOI
  5. Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement, BIOFACTORS, 50(6), 1192-1207, 202411
    Link to Paper Search Results by DOI
  6. Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan, SCIENTIFIC REPORTS, 14(1), 20240515
    Link to Paper Search Results by DOI
  7. Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw, BONE, 187, 202410
    Link to Paper Search Results by DOI
  8. YAP/TAZ interacts with RBM39 to confer resistance against indisulam, ONCOGENESIS, 13(1), 20240715
    Link to Paper Search Results by DOI
  9. Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(8), 20240416
    Link to Paper Search Results by DOI
  10. Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells, STEM CELL REVIEWS AND REPORTS, 20(1), 347-361, 202401
    Link to Paper Search Results by DOI
  11. Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges, JAPANESE DENTAL SCIENCE REVIEW, 60, 95-108, 202412
    Link to Paper Search Results by DOI
  12. Skin Symptoms That Appeared after Fixation with a Titanium Plate in a Jaw Deformity Patient Suffering from Palmoplantar Pustulosis: A Case Report, DENTISTRY JOURNAL, 11(11), 202311
    Link to Paper Search Results by DOI
  13. Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study, JOURNAL OF PERSONALIZED MEDICINE, 13(11), 202311
    Link to Paper Search Results by DOI
  14. Distinctive Biological Properties between Mesenchymal Stem Cell Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems, APPLIED SCIENCES-BASEL, 13(23), 202312
    Link to Paper Search Results by DOI
  15. Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
    Link to Paper Search Results by DOI
  16. A case report of allergic reaction with acute facial swelling: a rare complication of dental acrylic resin, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 51(7), 202307
    Link to Paper Search Results by DOI
  17. AXL activates YAP through the EGFR-LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, ONCOGENE, 42(39), 2869-2877, 20230922
    Link to Paper Search Results by DOI
  18. Taste-taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic, SUPPORTIVE CARE IN CANCER, 31(9), 202309
    Link to Paper Search Results by DOI
  19. Resting saliva volume as a risk factor for hypogeusia: A retrospective study, PHYSIOLOGY & BEHAVIOR, 267, 20230801
    Link to Paper Search Results by DOI
  20. A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification, STEM CELL REVIEWS AND REPORTS, 19(6), 1812-1827, 202308
    Link to Paper Search Results by DOI
  21. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int, 1462-1469, 20071231
  22. Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells., J Periodontal Res, 43(5), 508-513, 200810
  23. Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells., J Periodontol, 79(11), 2182-2189, 200811
  24. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., Journal of Periodontology, 79(12), 2361-2370, 200812
  25. Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells, Journal of Endodontics, 35(3), 373-376, 200903
  26. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate, Biochemical and Biophysical Research Communications, 386(1), 11-15, 20090814
  27. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis, Biochemical and Biophysical Research Communications, 386(2), 316-321, 20090821
  28. Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death, Journal of Cellular Physiology, 221(3), 696-706, 200912
  29. Bacteria-derived hydrogen sulfide promotes IL-8 production from epithelial cells, Biochemical and Biophysical Research Communications, 391(1), 645-650, 20100101
  30. Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease, Journal of Oral Microbiology, 8(2), 201011
  31. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans, Biochemical Pharmacology, 79(10), 1496-1505, 20100515
  32. The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics, Journal of Endodontics, 36(6), 1009-1013, 201006
  33. Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration, Tissue Engineering PartA, 17(7), 955-967, 201104
  34. Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities, Journal of Neuroimmunology, 233(1), 37-45, 201104
  35. Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo, Experimental Cell Research, 317(10), 1454-1464, 20110610
  36. Aggregatibacter actinomycetemcomitans Omp29 is associated with bacterial entry to gingival epithelial cells by F-actin rearrangement, PLoS ONE, 6(4), e18287, 201104
  37. Irsogladine maleate counters the interleukin-1 beta-induced suppression in gap-junctional intercellular communication but does not affect the interleukin-1 beta-induced zonula occludens protein-1 levels in human gingival epithelial cells, J Periodontal Res, 43(1), 96-102, 200802
  38. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts, J Biol Chem, 20080606
  39. Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes, FEMS Immunology & Medical Microbiology, 62(3), 283-294, 201108
  40. Expression and possible immune-regulatory function of ghrelin in oral epithelium, Journal of Dental Research, 90(11), 1286-1292, 201111
  41. A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw, Journal of Dental Research, 90(11), 1339-1345, 201111
  42. Blocking of sodium and potassium ion-dependent adenosine triphosphatase-α1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis, European Journal of Pharmacology, 30(670), 409-418, 20111130
  43. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation, Molecular Pharmacology, 82(1), 115-24, 20120701
  44. The antimicrobial activity of the appetite peptide hormone ghrelin, Peptides, 36(2), 151-6, 20120801
  45. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201203
    Link to Paper Search Results by DOI
  46. Detection of periodontal pathogens in newborns and children with mixed dentition, 検索結果 European Journal of Clinical Microbiology & Infectious Diseases, 31(6), 1041-1050, 201206
  47. Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis., Journal of Periodontology, 83(5), 664-671, 201205
  48. Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion, Journal of Endodontics, 38(3), 346-350, 201203
  49. Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis, Journal of Oral Microbiology, 4, 14832, 20120516
  50. GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence, PLoS ONE, 7(3), e33382, 20120516
  51. Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15(2), 340-347, 201302
    Link to Paper Search Results by DOI
  52. Comprehensive Oral Management for Collaborative Medical and Dental Care -Practical Approaches for Oral Care Support Team-, The Journal of Hiroshima University Dental Society, 45(1), 1-6, 20130601
  53. Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 48(2), 228-234, 201304
    Link to Paper Search Results by DOI
  54. The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46, 136-142, 201308
    Link to Paper Search Results by DOI
  55. The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(32), 23009-23020, 20130809
    Link to Paper Search Results by DOI
  56. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201409
    Link to Paper Search Results by DOI
  57. miR-584 Expressed in Human Gingival Epithelial Cells Is Induced by Porphyromonas gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor, JOURNAL OF PERIODONTOLOGY, 85(6), E198-E204, 201406
    Link to Paper Search Results by DOI
  58. Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells, CELLULAR IMMUNOLOGY, 290(2), 201-208, 201408
    Link to Paper Search Results by DOI
  59. Smad2 is Involved in Aggregatibacter actinomycetemcomitans-induced Apoptosis, JOURNAL OF DENTAL RESEARCH, 93(11), 1148-1154, 201411
    Link to Paper Search Results by DOI
  60. Nuclear Nrf2 Induction by Protein Transduction Attenuates Osteoclastogenesis, FREE RADICAL BIOLOGY AND MEDICINE, 77, 239-248, 201412
    Link to Paper Search Results by DOI
  61. Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells, JOURNAL OF DENTAL SCIENCES, 10(1), 88-94, 201503
    Link to Paper Search Results by DOI
  62. The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan, ORAL DISEASES, 21(5), 626-633, 201507
    Link to Paper Search Results by DOI
  63. Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17(7), 860-873, 201507
    Link to Paper Search Results by DOI
  64. Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1 beta and tumor necrosis factor-alpha, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 444-451, 201508
    Link to Paper Search Results by DOI
  65. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 479-485, 201508
    Link to Paper Search Results by DOI
  66. Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 486-493, 201508
    Link to Paper Search Results by DOI
  67. LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48(7), 673-679, 201507
    Link to Paper Search Results by DOI
  68. Involvement of smad2 and Erk/Akt cascade in TGF-beta 1-induced apoptosis in human gingival epithelial cells, CYTOKINE, 75(1), 165-173, 201509
    Link to Paper Search Results by DOI
  69. Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
    Link to Paper Search Results by DOI
  70. Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
    Link to Paper Search Results by DOI
  71. Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1 beta-Treated Endothelial Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 74(3), 399-406, 201609
    Link to Paper Search Results by DOI
  72. Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alpha, ARCHIVES OF ORAL BIOLOGY, 62, 64-69, 201602
    Link to Paper Search Results by DOI
  73. Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 186(2), 177-189, 201611
    Link to Paper Search Results by DOI
  74. A novel method of sampling gingival crevicular fluid from a mouse model of periodontitis, JOURNAL OF IMMUNOLOGICAL METHODS, 438, 21-25, 201611
    Link to Paper Search Results by DOI
  75. Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF--regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrin1/FAK cascade, CELLULAR MICROBIOLOGY, 18(12), 1723-1738, 201612
    Link to Paper Search Results by DOI
  76. Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 39(5), 1777-1786, 2016
    Link to Paper Search Results by DOI
  77. Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40(1), 240-247, 201702
    Link to Paper Search Results by DOI
  78. Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
    Link to Paper Search Results by DOI
  79. A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation, JOURNAL OF IMMUNOLOGICAL METHODS, 445, 31-36, 201706
    Link to Paper Search Results by DOI
  80. DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption, JOURNAL OF DENTAL RESEARCH, 96(6), 685-693, 201706
    Link to Paper Search Results by DOI
  81. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
    Link to Paper Search Results by DOI
  82. Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice, JOURNAL OF ORAL SCIENCE, 59(4), 629-637, 201712
    Link to Paper Search Results by DOI
  83. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
    Link to Paper Search Results by DOI
  84. Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201803
    Link to Paper Search Results by DOI
  85. The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
    Link to Paper Search Results by DOI
  86. Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient, INTERNATIONAL ENDODONTIC JOURNAL, 51(9), 1059-1066, 201809
    Link to Paper Search Results by DOI
  87. Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis., J Immunol Methods, 457, 26-29, 201806
    Link to Paper Search Results by DOI
  88. The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice, ARTHRITIS RESEARCH & THERAPY, 20, 20181103
    Link to Paper Search Results by DOI
  89. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
    Link to Paper Search Results by DOI
  90. Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis, JOURNAL OF IMMUNOLOGICAL METHODS, 457, 26-29, 201806
    Link to Paper Search Results by DOI
  91. BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs, JOURNAL OF PERIODONTOLOGY, 90(1), 98-109, 201901
    Link to Paper Search Results by DOI
  92. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 68, 30-38, 201903
    Link to Paper Search Results by DOI
  93. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(16), 20190802
    Link to Paper Search Results by DOI
  94. Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population, CLINICAL ORAL INVESTIGATIONS, 23(11), 4099-4105, 201911
    Link to Paper Search Results by DOI
  95. Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan, JOURNAL OF CLINICAL MEDICINE, 8(10), 201910
    Link to Paper Search Results by DOI
  96. Microbe-Dependent Exacerbated Alveolar Bone Destruction in Heterozygous Cherubism Mice, JBMR PLUS, 4(6), 202006
    Link to Paper Search Results by DOI
  97. Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts, JOURNAL OF BONE AND MINERAL RESEARCH, 35(2), 382-395, 202002
    Link to Paper Search Results by DOI
  98. Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal stem cells, DIFFERENTIATION, 112, 47-57, 202004
    Link to Paper Search Results by DOI
  99. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  100. Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts, JOURNAL OF BONE AND MINERAL METABOLISM, 38(4), 442-455, 202007
    Link to Paper Search Results by DOI
  101. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
    Link to Paper Search Results by DOI
  102. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530(2), 448-454, 20200917
    Link to Paper Search Results by DOI
  103. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier, BRAIN SCIENCES, 10(10), 202010
    Link to Paper Search Results by DOI
  104. Effect ofPorphyromonas gingivalisinfection on gut dysbiosis and resultant arthritis exacerbation in mouse model, ARTHRITIS RESEARCH & THERAPY, 22(1), 20201019
    Link to Paper Search Results by DOI
  105. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 56(1), 69-82, 202101
    Link to Paper Search Results by DOI
  106. Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages, CELL BIOCHEMISTRY AND BIOPHYSICS, 79(2), 321-336, 202106
    Link to Paper Search Results by DOI
  107. 3D Clumps/Extracellular Matrix Complexes of Periodontal Ligament Stem Cells Ameliorate the Attenuating Effects of LPS on Proliferation and Osteogenic Potential, JOURNAL OF PERSONALIZED MEDICINE, 11(6), 202106
    Link to Paper Search Results by DOI
  108. The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth, FASEB JOURNAL, 35(7), 202107
    Link to Paper Search Results by DOI
  109. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
    Link to Paper Search Results by DOI
  110. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
    Link to Paper Search Results by DOI
  111. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification, BIOMEDICINES, 9(10), 202110
    Link to Paper Search Results by DOI
  112. Editorial: Stem Cells in Oral Cavity: From Development to Regeneration, Frontiers in Cell and Developmental Biology, 10, 840771-840771, 20220120
  113. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
    Link to Paper Search Results by DOI
  114. Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice, BIOMEDICINES, 10(12), 202212
    Link to Paper Search Results by DOI
  115. Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine, JOURNAL OF PERSONALIZED MEDICINE, 12(10), 202210
    Link to Paper Search Results by DOI
  116. Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage, NPJ REGENERATIVE MEDICINE, 7(1), 20220915
    Link to Paper Search Results by DOI
  117. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
    Link to Paper Search Results by DOI
  118. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
    Link to Paper Search Results by DOI
  119. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-? induces rat calvarial bone regeneration, REGENERATIVE THERAPY, 20, 117-125, 202206
    Link to Paper Search Results by DOI
  120. Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption, BONE REPORTS, 16, 202206
    Link to Paper Search Results by DOI
  121. Microbial differences between active and remission peri-implantitis, SCIENTIFIC REPORTS, 12(1), 20220328
    Link to Paper Search Results by DOI
  122. Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration, JOURNAL OF PERIODONTOLOGY, 93(2), 269-286, 202202
    Link to Paper Search Results by DOI
  123. Retrospective study on the therapeutic efficacy of zinc acetate hydrate administration to patients with hypozincemia-induced dysgeusia, BMC ORAL HEALTH, 23(1), 20230318
    Link to Paper Search Results by DOI
  124. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
    Link to Paper Search Results by DOI
  125. A Third Supernumerary Tooth Occurring in the Same Region: A Case Report, DENTISTRY JOURNAL, 11(2), 202302
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells, Yoshii Hiroki, Yoshino Mai, Yoshimoto Tetsuya, Kajiya Mikihito, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03, Without Invitation, English
  2. The Development of a Human Bone Marrow Adipose Tissue-Like Cellular Construct, Yoshino Mai, Yoshii Hiroki, Yoshimoto Tetsuya, Kajiya Mikihito, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03, Without Invitation, English
  3. Development of Bio-3D Printed Grafting Tissue for Periodontal Regeneration, Mikihito Kajiya, Hiroki Yoshii, Mai Yoshino, Tetsuya Yoshimoto, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03, Without Invitation, English
  4. Development of Periodontal Tissue Regenerative Therapy Using Mesenchymal Stem Cells and Bio-3D Printer, Mikihito Kajiya, AADOR Florida-JSPS Joint Meeting, 2024/02/17, With Invitation, English
  5. Inflamed osteocytes directly induce inflammatory osteolysis through MYD88 signaling in bacterial bone infection, Tetsuya Yoshimoto, Mikihito Kajiya, 2023/10, Without Invitation, English
  6. New Avenues for Regenerative Medicine Opened by 3D Cell Clumps Culture Techniques and Nanodevices, Mikihit Kajiya, 2022/11/25, With Invitation, English
  7. AXL activates YAP and confers resistance to EGFR inhibitors in oral squamous cell carcinoma, 2022/06/11, Without Invitation, Japanese
  8. Clumps of Mesenchymal Stem Cell for Periodontal TIssue Regeneration, Mikihito Kajiya, 2021IADR/AADR/CADR General Session and Exhibition, 2021/07, With Invitation, English
  9. BDNF regulates p75-JNK signaling cascade to induce gingival epithelial cells apoptosis., 2014/06, Without Invitation, Japanese
  10. TGF-β1 induces mitochondria-dependent apoptosis in human gingival epithelial cells., 2014/06, Without Invitation, English
  11. BMP-2 expression induced by LL37 in human pulp cells, Shiba H., Kajiya M., Ouhara K., Kurihara H, 2014/12, Without Invitation, English
  12. The Molecular Analysis of Rheumatoid Arthritis-related Gene LRG1 in Periodontitis, IADR/AADR/CADR General Session & Exhibition, 2015/03/14, Without Invitation, English
  13. BDNF Regulates p75-JNK Signaling Cascade to Induce Gingival Epithelial Cells Apoptosis, Kei Kashiwai, Hidemi Kurihara, Mikihito Kajiya, Shinji Matsuda, Katsuhiro Takeda, Tsuyoshi Fujita, and Hideki Shiba, 2015/03/12, Without Invitation, English
  14. Possible Role of gd-T Cells in Bisphosphonate-related Jaw Osteonecrosis, Kazuaki Nishimura, Kazuaki Nishimura, Tomomi Kiyama, Hani Mawardi, Mikihito Kajiya, isao ichimoji, and Toshihisa Kawai, IADR/AADR/CADR General Session & Exhibition, 2015/03/14, Without Invitation, English
  15. Porphyromonas Gingivalis Infection Exacerbates Rheumatoid Arthritis in Experimental Mice Model, Masahiro Yamakawa, Kazuhisa Ouhara, Mikihito Kajiya, MIzuho Kittaka, Katsuhiro Takeda, Tsuyoshi Fujita, Hideki Shiba, and Hidemi Kurihara, IADR/AADR/CADR General Session & Exhibition, 2014/03/14, Without Invitation, English
  16. The development of immunomodulatory Clumps of a MSC/ECM complex for novel allograft cell transplantation therapy, 2015/05, Without Invitation, Japanese
  17. Behavior of clumps of mesenchymal stem cells against the stimulation of bacterial components and inflammatory cytokines, Nguyen Quoc Truong, Mikihito Kajiya, Manabu Takewaki, Kei Takeshita, Tsuyohi Fujita, Hidemi Kurihara, 2015/06, Without Invitation, English
  18. Distinction between Cell Proliferation and Apoptosis Signals Regulated by BDNF in Human Periodontal Ligament Cells and Gingival Epithelial Cells, 2015/10, Without Invitation, English
  19. Development of Calcineurin Inhibitor Induced Gingival Hyperplasia Mice Model, 2015/10, Without Invitation, English
  20. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui, Noriyoshi Mizuno, Shinji Matsuda, Manabu Takewaki, Masahiro Yamakawa, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tomoyuki Iwata,Tsuyoshi Fujita,Hidemi, 94th Annual Meeting of the International Association for Dental Research, 2016/06/23, Without Invitation, English
  21. Elucidation of the role of NR4A1 in drug induced gingival overgrowth, 2016/07/02, Without Invitation, Japanese
  22. Clumps of a mesenchymal stem cell/extracellular matrix complex induces periodontal tissue regeneration, 2017/09/23, Without Invitation, English
  23. Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, 2017/09/23, Without Invitation, English
  24. Effects of Brain-derived Neurotrophic Factor (BDNF) as an Adjunct to Non-surgical Periodontal Treatment on Ligature-induced Periodontitis in Dogs, 2018/03/29, Without Invitation, English
  25. Elucidation of the Role of NR4A1 in CsA Induced Gingival Overgrowth, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
  26. Involvement of C5a in the Progression of Experimental Arthritis in SKG Mice Induced by Porphyromonas gingivalis Infection, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
  27. Mechanotransduction in 3D Culture Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Regulates the Cell Fate, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
  28. Induction of functional human mesenchymal stromal cells from iPSCs in xeno-free condition, Kamiya D, Takenaka N, Kajiya M, Sakurai H, Kurihara H and Ikeya M, International Society for Stem Cell Research anual meeting 2018, 2018/06/23, Without Invitation, English
  29. Morphological change and cellular response of periodontal tissues in ligature induced experimental periodontitis in mice, The 5th joint scientific meeting in dentistry, 2018/10/02, Without Invitation, English
  30. Identification of a causative gene in a family case with aggressive periodontitis by exome sequencing and linkage analysis, The 58th General Session of Korean Academy of Periodontology, 2018/10/20, Without Invitation, English
  31. The Elucidation of Developmental Process on Ligature-Induced Experimental Periodontitis in Mice, 2019/06, Without Invitation, English

Patented

  1. Patent, 7105487, 2022/07/14
  2. Patent, 8992998, 2015/03/31, MAPK inhibition by H2

External Funds

Acceptance Results of Competitive Funds

  1. ‐, 2023//6//2, 2024//3//3
  2. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2022, 2024
  3. Program of Start-up incubation from Core Research (SCORE), 2021/08/16, 2022/03/31
  4. KAKENHI, 2017, 2018
  5. 2014/11/18, 2015/11/17
  6. KAKENHI, 2014, 2015
    Permalink
  7. KAKENHI, Development of novel periodontal tissue regenerative therapy by small molecule ligands induced TrkB transactivation, 2012, 2013
    Permalink
  8. -, 2019/07/18, 2020/03/31