MIKIHITO KAJIYA
Last Updated :2025/06/27
- Affiliations, Positions
- Center for Oral Clinical Examination, Professor
- E-mail
- mkajiya
hiroshima-u.ac.jp
- Self-introduction
- Periodontitis is an inflammatory periodontal tissue-destructive disease attributed to host immune responses to periodontal pathogenic bacteria, which leads to tooth loss. Otherwise, tissue regenerative therapy using stem cells, which exerts self-renewing properties and multipotency, has attracted scientific and medical attention. Thus, using mesenchymal stem cells and our own developed three-dimensional culture system, we will develop the novel promising periodontal tissue regenerative cell therapy.
Basic Information
Academic Degrees
- Doctor of Philosophy in Dental Science, Hiroshima University
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
Research Fields
- Medicine,dentistry, and pharmacy;Dentistry;Periodontology
Educational Activity
Course in Charge
- 2025, Liberal Arts Education Program1, 1Term, Foundation biology for life science
- 2025, Undergraduate Education, 4Term, Overview of Dentistry
- 2025, Undergraduate Education, 2Term, Topics in Dental Research II
- 2025, Undergraduate Education, 3Term, Examination and Diagnosis
- 2025, Undergraduate Education, First Semester, Dental Research Practices I
- 2025, Undergraduate Education, Second Semester, Dental Research Practices II
- 2025, Undergraduate Education, First Semester, Dental Research Practices III
- 2025, Undergraduate Education, Year, Clinical Practice (Oral Clinical Examination)
- 2025, Undergraduate Education, 1Term, Oral Health Management A
- 2025, Undergraduate Education, First Semester, Overview of Oral Engineering
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Innovation & Precision Dentistry
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Innovation & Precision Dentistry
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Innovation & Precision Dentistry
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Innovation & Precision Dentistry
Research Activities
Academic Papers
- Effect of Stimulated Salivary Volume on Dysbiosis of the Salivary Microbiome in Children and Young Adults, INTERNATIONAL DENTAL JOURNAL, 75(3), 1759-1770, 202506
- Consideration of the work environment in a case of an industrial homeworker with allergic contact dermatitis by UV-curing acrylic resin, ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, 79(9-10), 315-320, 20241125
- Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis, INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY, 10(1), 20241126
- Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model, ORAL DISEASES, 30(8), 5294-5304, 202411
- Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement, BIOFACTORS, 50(6), 1192-1207, 202411
- Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan, SCIENTIFIC REPORTS, 14(1), 20240515
- Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw, BONE, 187, 202410
- YAP/TAZ interacts with RBM39 to confer resistance against indisulam, ONCOGENESIS, 13(1), 20240715
- Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(8), 20240416
- Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells, STEM CELL REVIEWS AND REPORTS, 20(1), 347-361, 202401
- Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges, JAPANESE DENTAL SCIENCE REVIEW, 60, 95-108, 202412
- Skin Symptoms That Appeared after Fixation with a Titanium Plate in a Jaw Deformity Patient Suffering from Palmoplantar Pustulosis: A Case Report, DENTISTRY JOURNAL, 11(11), 202311
- Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study, JOURNAL OF PERSONALIZED MEDICINE, 13(11), 202311
- Distinctive Biological Properties between Mesenchymal Stem Cell Spheroids and Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes in 3D Culture Systems, APPLIED SCIENCES-BASEL, 13(23), 202312
- Relationship between CD4+T-cell counts at baseline and initial periodontal treatment efficacy in patients undergoing treatment for HIV infection: A retrospective observational study, JOURNAL OF CLINICAL PERIODONTOLOGY, 50(11), 1520-1529, 202311
- A case report of allergic reaction with acute facial swelling: a rare complication of dental acrylic resin, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 51(7), 202307
- AXL activates YAP through the EGFR-LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, ONCOGENE, 42(39), 2869-2877, 20230922
- Taste-taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic, SUPPORTIVE CARE IN CANCER, 31(9), 202309
- Resting saliva volume as a risk factor for hypogeusia: A retrospective study, PHYSIOLOGY & BEHAVIOR, 267, 20230801
- A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification, STEM CELL REVIEWS AND REPORTS, 19(6), 1812-1827, 202308
- Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int, 1462-1469, 20071231
- Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells., J Periodontal Res, 43(5), 508-513, 200810
- Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells., J Periodontol, 79(11), 2182-2189, 200811
- Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., Journal of Periodontology, 79(12), 2361-2370, 200812
- Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells, Journal of Endodontics, 35(3), 373-376, 200903
- Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate, Biochemical and Biophysical Research Communications, 386(1), 11-15, 20090814
- Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis, Biochemical and Biophysical Research Communications, 386(2), 316-321, 20090821
- Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death, Journal of Cellular Physiology, 221(3), 696-706, 200912
- Bacteria-derived hydrogen sulfide promotes IL-8 production from epithelial cells, Biochemical and Biophysical Research Communications, 391(1), 645-650, 20100101
- Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease, Journal of Oral Microbiology, 8(2), 201011
- Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans, Biochemical Pharmacology, 79(10), 1496-1505, 20100515
- The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics, Journal of Endodontics, 36(6), 1009-1013, 201006
- Characteristics of high-molecular-weight hyaluronic acid as a brain-derived neurotrophic factor scaffold in periodontal tissue regeneration, Tissue Engineering PartA, 17(7), 955-967, 201104
- Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities, Journal of Neuroimmunology, 233(1), 37-45, 201104
- Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo, Experimental Cell Research, 317(10), 1454-1464, 20110610
- Aggregatibacter actinomycetemcomitans Omp29 is associated with bacterial entry to gingival epithelial cells by F-actin rearrangement, PLoS ONE, 6(4), e18287, 201104
- Irsogladine maleate counters the interleukin-1 beta-induced suppression in gap-junctional intercellular communication but does not affect the interleukin-1 beta-induced zonula occludens protein-1 levels in human gingival epithelial cells, J Periodontal Res, 43(1), 96-102, 200802
- Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts, J Biol Chem, 20080606
- Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes, FEMS Immunology & Medical Microbiology, 62(3), 283-294, 201108
- Expression and possible immune-regulatory function of ghrelin in oral epithelium, Journal of Dental Research, 90(11), 1286-1292, 201111
- A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw, Journal of Dental Research, 90(11), 1339-1345, 201111
- Blocking of sodium and potassium ion-dependent adenosine triphosphatase-α1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis, European Journal of Pharmacology, 30(670), 409-418, 20111130
- Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation, Molecular Pharmacology, 82(1), 115-24, 20120701
- The antimicrobial activity of the appetite peptide hormone ghrelin, Peptides, 36(2), 151-6, 20120801
- Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alpha(V)beta(3)-FAK cascade, JOURNAL OF CELLULAR PHYSIOLOGY, 227(5), 2123-2129, 201203
- Detection of periodontal pathogens in newborns and children with mixed dentition, 検索結果
European Journal of Clinical Microbiology & Infectious Diseases, 31(6), 1041-1050, 201206
- Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis., Journal of Periodontology, 83(5), 664-671, 201205
- Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion, Journal of Endodontics, 38(3), 346-350, 201203
- Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis, Journal of Oral Microbiology, 4, 14832, 20120516
- GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence, PLoS ONE, 7(3), e33382, 20120516
- Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15(2), 340-347, 201302
- Comprehensive Oral Management for Collaborative Medical and Dental Care -Practical Approaches for Oral Care Support Team-, The Journal of Hiroshima University Dental Society, 45(1), 1-6, 20130601
- Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 48(2), 228-234, 201304
- The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46, 136-142, 201308
- The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(32), 23009-23020, 20130809
- BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade, INTERNATIONAL IMMUNOPHARMACOLOGY, 19(2), 245-252, 201409
- miR-584 Expressed in Human Gingival Epithelial Cells Is Induced by Porphyromonas gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor, JOURNAL OF PERIODONTOLOGY, 85(6), E198-E204, 201406
- Amphotericin B down-regulates Aggregatibacter actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells, CELLULAR IMMUNOLOGY, 290(2), 201-208, 201408
- Smad2 is Involved in Aggregatibacter actinomycetemcomitans-induced Apoptosis, JOURNAL OF DENTAL RESEARCH, 93(11), 1148-1154, 201411
- Nuclear Nrf2 Induction by Protein Transduction Attenuates Osteoclastogenesis, FREE RADICAL BIOLOGY AND MEDICINE, 77, 239-248, 201412
- Houttuynia cordata suppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells, JOURNAL OF DENTAL SCIENCES, 10(1), 88-94, 201503
- The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan, ORAL DISEASES, 21(5), 626-633, 201507
- Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17(7), 860-873, 201507
- Brain-derived neurotrophic factor prevents the endothelial barrier dysfunction induced by interleukin-1 beta and tumor necrosis factor-alpha, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 444-451, 201508
- Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 479-485, 201508
- Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 486-493, 201508
- LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48(7), 673-679, 201507
- Involvement of smad2 and Erk/Akt cascade in TGF-beta 1-induced apoptosis in human gingival epithelial cells, CYTOKINE, 75(1), 165-173, 201509
- Sequential process in brain-derived neurotrophic factor-induced functional periodontal tissue regeneration, EUROPEAN JOURNAL OF ORAL SCIENCES, 124(2), 141-150, 201604
- Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 117(7), 1543-1555, 201607
- Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1 beta-Treated Endothelial Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 74(3), 399-406, 201609
- Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alpha, ARCHIVES OF ORAL BIOLOGY, 62, 64-69, 201602
- Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 186(2), 177-189, 201611
- A novel method of sampling gingival crevicular fluid from a mouse model of periodontitis, JOURNAL OF IMMUNOLOGICAL METHODS, 438, 21-25, 201611
- Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF--regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrin1/FAK cascade, CELLULAR MICROBIOLOGY, 18(12), 1723-1738, 201612
- Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 39(5), 1777-1786, 2016
- Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40(1), 240-247, 201702
- Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
- A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation, JOURNAL OF IMMUNOLOGICAL METHODS, 445, 31-36, 201706
- DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption, JOURNAL OF DENTAL RESEARCH, 96(6), 685-693, 201706
- MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
- Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice, JOURNAL OF ORAL SCIENCE, 59(4), 629-637, 201712
- Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
- Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201803
- The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
- Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient, INTERNATIONAL ENDODONTIC JOURNAL, 51(9), 1059-1066, 201809
- Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis., J Immunol Methods, 457, 26-29, 201806
- The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice, ARTHRITIS RESEARCH & THERAPY, 20, 20181103
- Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
- Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis, JOURNAL OF IMMUNOLOGICAL METHODS, 457, 26-29, 201806
- BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs, JOURNAL OF PERIODONTOLOGY, 90(1), 98-109, 201901
- Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 68, 30-38, 201903
- Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(16), 20190802
- Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population, CLINICAL ORAL INVESTIGATIONS, 23(11), 4099-4105, 201911
- Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan, JOURNAL OF CLINICAL MEDICINE, 8(10), 201910
- Microbe-Dependent Exacerbated Alveolar Bone Destruction in Heterozygous Cherubism Mice, JBMR PLUS, 4(6), 202006
- Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts, JOURNAL OF BONE AND MINERAL RESEARCH, 35(2), 382-395, 202002
- Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal stem cells, DIFFERENTIATION, 112, 47-57, 202004
- Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
- Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts, JOURNAL OF BONE AND MINERAL METABOLISM, 38(4), 442-455, 202007
- Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
- Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530(2), 448-454, 20200917
- IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier, BRAIN SCIENCES, 10(10), 202010
- Effect ofPorphyromonas gingivalisinfection on gut dysbiosis and resultant arthritis exacerbation in mouse model, ARTHRITIS RESEARCH & THERAPY, 22(1), 20201019
- Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 56(1), 69-82, 202101
- Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages, CELL BIOCHEMISTRY AND BIOPHYSICS, 79(2), 321-336, 202106
- 3D Clumps/Extracellular Matrix Complexes of Periodontal Ligament Stem Cells Ameliorate the Attenuating Effects of LPS on Proliferation and Osteogenic Potential, JOURNAL OF PERSONALIZED MEDICINE, 11(6), 202106
- The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth, FASEB JOURNAL, 35(7), 202107
- Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
- External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
- Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification, BIOMEDICINES, 9(10), 202110
- Editorial: Stem Cells in Oral Cavity: From Development to Regeneration, Frontiers in Cell and Developmental Biology, 10, 840771-840771, 20220120
- Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
- Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice, BIOMEDICINES, 10(12), 202212
- Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine, JOURNAL OF PERSONALIZED MEDICINE, 12(10), 202210
- Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage, NPJ REGENERATIVE MEDICINE, 7(1), 20220915
- Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
- Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
- Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-? induces rat calvarial bone regeneration, REGENERATIVE THERAPY, 20, 117-125, 202206
- Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption, BONE REPORTS, 16, 202206
- Microbial differences between active and remission peri-implantitis, SCIENTIFIC REPORTS, 12(1), 20220328
- Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration, JOURNAL OF PERIODONTOLOGY, 93(2), 269-286, 202202
- Retrospective study on the therapeutic efficacy of zinc acetate hydrate administration to patients with hypozincemia-induced dysgeusia, BMC ORAL HEALTH, 23(1), 20230318
- Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
- A Third Supernumerary Tooth Occurring in the Same Region: A Case Report, DENTISTRY JOURNAL, 11(2), 202302
Invited Lecture, Oral Presentation, Poster Presentation
- YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells, Yoshii Hiroki, Yoshino Mai, Yoshimoto Tetsuya, Kajiya Mikihito, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03, Without Invitation, English
- The Development of a Human Bone Marrow Adipose Tissue-Like Cellular Construct, Yoshino Mai, Yoshii Hiroki, Yoshimoto Tetsuya, Kajiya Mikihito, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03, Without Invitation, English
- Development of Bio-3D Printed Grafting Tissue for Periodontal Regeneration, Mikihito Kajiya, Hiroki Yoshii, Mai Yoshino, Tetsuya Yoshimoto, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03, Without Invitation, English
- Development of Periodontal Tissue Regenerative Therapy Using Mesenchymal Stem Cells and Bio-3D Printer, Mikihito Kajiya, AADOR Florida-JSPS Joint Meeting, 2024/02/17, With Invitation, English
- Inflamed osteocytes directly induce inflammatory osteolysis through MYD88 signaling in bacterial bone infection, Tetsuya Yoshimoto, Mikihito Kajiya, 2023/10, Without Invitation, English
- New Avenues for Regenerative Medicine Opened by 3D Cell Clumps Culture Techniques and Nanodevices, Mikihit Kajiya, 2022/11/25, With Invitation, English
- AXL activates YAP and confers resistance to EGFR inhibitors in oral squamous cell carcinoma, 2022/06/11, Without Invitation, Japanese
- Clumps of Mesenchymal Stem Cell for Periodontal TIssue Regeneration, Mikihito Kajiya, 2021IADR/AADR/CADR General Session and Exhibition, 2021/07, With Invitation, English
- BDNF regulates p75-JNK signaling cascade to induce gingival epithelial cells apoptosis., 2014/06, Without Invitation, Japanese
- TGF-β1 induces mitochondria-dependent apoptosis in human gingival epithelial cells., 2014/06, Without Invitation, English
- BMP-2 expression induced by LL37 in human pulp cells, Shiba H., Kajiya M., Ouhara K., Kurihara H, 2014/12, Without Invitation, English
- The Molecular Analysis of Rheumatoid Arthritis-related Gene LRG1 in Periodontitis, IADR/AADR/CADR General Session & Exhibition, 2015/03/14, Without Invitation, English
- BDNF Regulates p75-JNK Signaling Cascade to Induce Gingival Epithelial Cells Apoptosis, Kei Kashiwai, Hidemi Kurihara, Mikihito Kajiya, Shinji Matsuda, Katsuhiro Takeda, Tsuyoshi Fujita, and Hideki Shiba, 2015/03/12, Without Invitation, English
- Possible Role of gd-T Cells in Bisphosphonate-related Jaw Osteonecrosis, Kazuaki Nishimura, Kazuaki Nishimura, Tomomi Kiyama, Hani Mawardi, Mikihito Kajiya, isao ichimoji, and Toshihisa Kawai, IADR/AADR/CADR General Session & Exhibition, 2015/03/14, Without Invitation, English
- Porphyromonas Gingivalis Infection Exacerbates Rheumatoid Arthritis in Experimental Mice Model, Masahiro Yamakawa, Kazuhisa Ouhara, Mikihito Kajiya, MIzuho Kittaka, Katsuhiro Takeda, Tsuyoshi Fujita, Hideki Shiba, and Hidemi Kurihara, IADR/AADR/CADR General Session & Exhibition, 2014/03/14, Without Invitation, English
- The development of immunomodulatory Clumps of a MSC/ECM complex for novel allograft cell transplantation therapy, 2015/05, Without Invitation, Japanese
- Behavior of clumps of mesenchymal stem cells against the stimulation of bacterial components and inflammatory cytokines, Nguyen Quoc Truong, Mikihito Kajiya, Manabu Takewaki, Kei Takeshita, Tsuyohi Fujita, Hidemi Kurihara, 2015/06, Without Invitation, English
- Distinction between Cell Proliferation and Apoptosis Signals Regulated by BDNF in Human Periodontal Ligament Cells and Gingival Epithelial Cells, 2015/10, Without Invitation, English
- Development of Calcineurin Inhibitor Induced Gingival Hyperplasia Mice Model, 2015/10, Without Invitation, English
- The effects of optineurin on periodontal tissue destruction, Shinobu Matsui, Noriyoshi Mizuno, Shinji Matsuda, Manabu Takewaki, Masahiro Yamakawa, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tomoyuki Iwata,Tsuyoshi Fujita,Hidemi, 94th Annual Meeting of the International Association for Dental Research, 2016/06/23, Without Invitation, English
- Elucidation of the role of NR4A1 in drug induced gingival overgrowth, 2016/07/02, Without Invitation, Japanese
- Clumps of a mesenchymal stem cell/extracellular matrix complex induces periodontal tissue regeneration, 2017/09/23, Without Invitation, English
- Effects of brain-derived neurotrophic factor (BDNF) as an adjunct to non-surgical periodontal treatment on ligature-induced periodontitis in dogs, 2017/09/23, Without Invitation, English
- Effects of Brain-derived Neurotrophic Factor (BDNF) as an Adjunct to Non-surgical
Periodontal Treatment on Ligature-induced Periodontitis in Dogs, 2018/03/29, Without Invitation, English
- Elucidation of the Role of NR4A1 in CsA Induced Gingival Overgrowth, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
- Involvement of C5a in the Progression of Experimental Arthritis in SKG Mice Induced by
Porphyromonas gingivalis Infection, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
- Mechanotransduction in 3D Culture Clumps of Mesenchymal Stem Cells/Extracellular
Matrix Complexes Regulates the Cell Fate, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03/29, Without Invitation, English
- Induction of functional human mesenchymal stromal cells from iPSCs in xeno-free condition, Kamiya D, Takenaka N, Kajiya M, Sakurai H, Kurihara H and Ikeya M, International Society for Stem Cell Research anual meeting 2018, 2018/06/23, Without Invitation, English
- Morphological change and cellular response of periodontal tissues in ligature induced experimental
periodontitis in mice, The 5th joint scientific meeting in dentistry, 2018/10/02, Without Invitation, English
- Identification of a causative gene in a family case with aggressive periodontitis by exome sequencing and
linkage analysis, The 58th General Session of Korean Academy of Periodontology, 2018/10/20, Without Invitation, English
- The Elucidation of Developmental Process on Ligature-Induced Experimental Periodontitis in Mice, 2019/06, Without Invitation, English
Patented
- Patent, 7105487, 2022/07/14
- Patent, 8992998, 2015/03/31, MAPK inhibition by H2
External Funds
Acceptance Results of Competitive Funds
- ‐, 2023//6//2, 2024//3//3
- KAKENHI(Grant-in-Aid for Scientific Research (B)), 2022, 2024
- Program of Start-up incubation from Core Research (SCORE), 2021/08/16, 2022/03/31
- KAKENHI, 2017, 2018
- 2014/11/18, 2015/11/17
- KAKENHI, 2014, 2015
- KAKENHI, Development of novel periodontal tissue regenerative therapy by small molecule ligands induced TrkB transactivation, 2012, 2013
- -, 2019/07/18, 2020/03/31