YU TAHARA

Last Updated :2024/07/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
Web Site
https://researchmap.jp/yutahara
https://www.yutahara.com/
E-mail
yutaharahiroshima-u.ac.jp
Self-introduction
Dr. Tahara was born in 1985 in Japan. He got Ph.D. in Waseda University in 2013. He was a visiting assistant professor in UCLA (2016-2019), then moved to Waseda University as an associate professor. He moved to Hiroshima University in 2022. His research topic is circadian clock in mammals, especially chrono-nutrition. His recent interest is to develop a personalized intervention algorithm to improve health and prevent diseases.

Basic Information

Major Professional Backgrounds

  • 2011/04/01, 2013/03/31, JSPS, Special Postdoctoral Researcher(DC2)
  • 2013/04/01, 2014/03/31, Waseda University, School of Advanced Science and Engineering, Research Associate
  • 2014/04/01, 2015/03/31, Waseda University, School of Advanced Science and Engineering, Assistant professor
  • 2015/04/01, 2016/12/31, Waseda University, Assistant professor
  • 2016/09/01, 2019/03/31, University of California, Los Angeles, School of Medicine, Visiting assistant professor
  • 2018/01/01, 2019/03/31, JSPS, JSPS research fellow
  • 2019/04/01, Waseda University, Researcher
  • 2019/04/01, 2022/03/31, Waseda University, Associate professor
  • 2022/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Associate professor

Educational Backgrounds

  • Waseda University, 2008/03/15
  • Waseda University, 2010/03/15
  • Waseda University, 2013/03/15

Academic Degrees

  • Waseda University
  • Waseda University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Environmental physiology (including physical medicine and nutritional physiology)

Research Keywords

  • Circadian clock, Chronobiology, Chrono-nutrition, health science

Affiliated Academic Societies

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Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Theories of Behavioral Sciences
  2. 2024, Graduate Education (Master's Program) , 1Term, Environmental Health

Research Activities

Academic Papers

  1. Nobiletin Stimulates Adrenal Hormones and Modulates the Circadian Clock in Mice, NUTRIENTS, 16(10), 20240405
    Link to Paper Search Results by DOI
  2. Synchronizers of Circadian Rhythms, Chronobiology and Chronomedicine, 20240223
  3. Protective Effects of Inulin on Stress-Recurrent Inflammatory Bowel Disease, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(5), 20240221
    Link to Paper Search Results by DOI
  4. Effect of breakfast protein intake on muscle mass and strength in adults: a scoping review, Nutrition Reviews, 20240114
    Link to Paper Search Results by DOI
  5. Association between disruption of circadian activity rhythms and obesity, Chronobiology International, 20231202
    Link to Paper Search Results by DOI
  6. Association between circadian clock gene expressions and meal timing in young and older adults., Chronobiology international, 20230918
    Link to Paper Search Results by DOI
  7. Association of breakfast styles such as Japanese, Western, and cereals with sleeping habits, eating habits, and lifestyle in preschool and elementary school children, FRONTIERS IN NUTRITION, 10, 20230630
    Link to Paper Search Results by DOI
  8. Association of Eating Pattern, Chronotype, and Social Jetlag: A Cross-Sectional Study Using Data Accumulated in a Japanese Food-Logging Mobile Health Application, NUTRIENTS, 15(9), 20230430
    Link to Paper Search Results by DOI
  9. Editiorial:The present and future of chrono-nutrition studies., Frontiers in nutrition, 20230403
  10. Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract, BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH, 42(2), 114-123, 20230301
    Link to Paper Search Results by DOI
  11. Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 77(4), 468-473, 202304
    Link to Paper Search Results by DOI
  12. Timing of Food/Nutrient Intake and Its Health Benefits, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 68, S2-S4, 2022
    Link to Paper Search Results by DOI
  13. Polygalae Radix shortens the circadian period through activation of the CaMKII pathway., Pharmaceutical biology, 60(1), 689-698, 20221201
  14. Effects of Differences of Breakfast Styles, Such as Japanese and Western Breakfasts, on Eating Habits, NUTRIENTS, 14(23), 202212
    Link to Paper Search Results by DOI
  15. Association between blood pressure and circadian timing of physical activity of Japanese workers, FRONTIERS IN PHYSIOLOGY, 13, 20220926
    Link to Paper Search Results by DOI
  16. Interaction effects of sex on the sleep loss and social Jetlag-related negative mood in Japanese children and adolescents:A cross-sectional study, SLEEP Advances, 20220921
  17. Association between Breakfast Meal Categories and Timing of Physical Activity of Japanese Workers, Foods, 11(17), 2609, 20220828
  18. Association of Japanese Breakfast Intake with Macro- and Micronutrients and Morning Chronotype, Nutrients, 14(17), 3496, 20220825
  19. Relationship Between Protein Intake in Each Traditional Meal and Physical Activity: Cross-sectional Study, JMIR Public Health Surveill, 8(7), e35898, 20220612
  20. Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure., Frontiers in nutrition, 9, 853118, 20220304
  21. Timing of Food/Nutrient Intake and its Health Benefits., Journal of nutritional science and vitaminology 68(Supplelment)S2-S4, 2022
  22. Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning., Chronobiology international, 38(3), 426-442, 20210301
  23. Changes in sleep phase and body weight of mobile health App users during COVID-19 mild lockdown in Japan., International journal of obesity (2005), 45(10), 2021
  24. Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock., Cell reports, 36(1), 2021
  25. Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus., Neurobiology of sleep and circadian rhythms, 11, 2021
  26. Association between Irregular Meal Timing and the Mental Health of Japanese Workers., Nutrients, 13(8), 2021
  27. The circadian clock is disrupted in mice with adenine-induced tubulointerstitial nephropathy., Kidney international, 97(4), 2020
  28. Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder., Neurobiology of disease, 145, 2020
  29. Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay., Journal of applied toxicology : JAT, 39(2), 2019
  30. Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism., Biomaterials, 192, 2019
  31. The effect of night shift work on the expression of clock genes in beard hair follicle cells., Sleep medicine, 56, 2019
  32. Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function., Scientific reports, 8(1), 2018
  33. Chronotype and social jetlag influence human circadian clock gene expression., Scientific reports, 8(1), 2018
  34. Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease., Journal of biological rhythms, 33(5), 2018
  35. Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease., Journal of neuroscience research, 96(12), 2018
  36. Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition., Free radical biology & medicine, 119, 2018
  37. Night eating model shows time-specific depression-like behavior in the forced swimming test., Scientific reports, 8(1), 2018
  38. Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue., Scientific reports, 8(1), 2018
  39. The mammalian circadian clock and its entrainment by stress and exercise., The journal of physiological sciences : JPS, 67(1), 2017
  40. Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer., Hepatology (Baltimore, Md.), 65(3), 2017
  41. Positive association between physical activity and PER3 expression in older adults., Scientific reports, 7, 2017
  42. Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts., PloS one, 12(2), 2017
  43. Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice., Chronobiology international, 34(8), 2017
  44. Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation., NPJ aging and mechanisms of disease, 3, 2017
  45. Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice., Nutrition research (New York, N.Y.), 43, 2017
  46. Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells., PloS one, 12(8), 2017
  47. Circadian rhythms of liver physiology and disease: experimental and clinical evidence., Nature reviews. Gastroenterology & hepatology, 13(4), 2016
  48. Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice., Scientific reports, 6, 2016
  49. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120., PloS one, 10(7), 2015
  50. Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions., Scientific reports, 5, 2015
  51. Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model., Scientific reports, 5, 2015
  52. Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Reversed by Scheduled Feeding or Exercise., Journal of biological rhythms, 30(6), 2015
  53. Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model., Scientific reports, 5, 2015
  54. Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala., Sleep medicine, 16(11), 2015
  55. Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods., Chronobiology international, 32(2), 2015
  56. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice., Neuroscience research, 99, 2015
  57. Entrainment of the mouse circadian clock by sub-acute physical and psychological stress., Scientific reports, 5, 2015
  58. Circadian regulation of allergic reactions by the mast cell clock in mice., The Journal of allergy and clinical immunology, 133(2), 2014
  59. Circadian dysfunction in response to in vivo treatment with the mitochondrial toxin 3-nitropropionic acid., ASN neuro, 6(1), 2014
  60. Chrono-biology, chrono-pharmacology, and chrono-nutrition., Journal of pharmacological sciences, 124(3), 2014
  61. Disruption of the suprachiasmatic nucleus blunts a time of day-dependent variation in systemic anaphylactic reaction in mice., Journal of immunology research, 2014, 2014
  62. Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse., PloS one, 9(6), 2014
  63. Effect of quetiapine on Per1, Per2, and Bmal1 clock gene expression in the mouse amygdala and hippocampus., Journal of pharmacological sciences, 125(3), 2014
  64. Controlling access time to a high-fat diet during the inactive period protects against obesity in mice., Chronobiology international, 31(8), 2014
  65. A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice., Nutrition research (New York, N.Y.), 34(7), 2014
  66. Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice., British journal of pharmacology, 171(24), 2014
  67. Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus., Journal of neurophysiology, 110(5), 2013
  68. 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity., The Journal of pharmacology and experimental therapeutics, 340(3), 2012
  69. In vivo monitoring of peripheral circadian clocks in the mouse., Current biology : CB, 22(11), 2012
  70. Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism., Journal of circadian rhythms, 10(1), 2012
  71. Meal frequency patterns determine the phase of mouse peripheral circadian clocks., Scientific reports, 2, 2012
  72. Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction., The Journal of allergy and clinical immunology, 127(4), 2011
  73. Refeeding after fasting elicits insulin-dependent regulation of Per2 and Rev-erbα with shifts in the liver clock., Journal of biological rhythms, 26(3), 2011
  74. Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet., Journal of medicinal chemistry, 54(18), 2011
  75. Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice., Journal of biological rhythms, 25(1), 2010
  76. The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs., Advanced drug delivery reviews, 62(9-10), 2010
  77. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding., American journal of physiology. Gastrointestinal and liver physiology, 299(5), 2010
  78. A balanced diet is necessary for proper entrainment signals of the mouse liver clock., PloS one, 4(9), 2009

Publications such as books

  1. Nutrition and diet as potent regulators of the liver clock. Circadian thythms:Health and Disease, Wiley, 2015, 2015
  2. Chrono-biology, chrono-pharmacology, and chrono-nutrition, J pharm Sci, 2014, 2014
  3. Circadian rhythm and food/nutrition. Mechanisms of Circadian Systems in Animals and Their Clinical Relevance, Springer, 2014

Invited Lecture, Oral Presentation, Poster Presentation

  1. Chrono-nutritional analysis of iron intake timing during pregnancy., 2024 Society for Research on Biological Rhythms, 2024/05/18, Without Invitation, English
  2. "Chrono-Nutrition" -Importance of timing of food/nutrient intake-, 2023/12/11, With Invitation, English
  3. Circadian clock regulation by nobiletin, 2023/12/09, With Invitation, English
  4. "Chrono-Nutrition" - Importance of timing of food/nutrient intake -, 2023/08/23, With Invitation, English
  5. "Chrono-Nutrition" - Importance of timing of food/nutrient intake -, 2023/07/06, With Invitation, English
  6. Translational and reverse-translational "Chrono-nutrition"research in Japan, 38th Annual Scientific Confrence of Nutrition Society of Malaysia, 2023/07/05, With Invitation, English
  7. Basic research on Chrono-nutrition, 2022/11/30, With Invitation, Japanese
  8. Food-log app-based chrono-nutritional survey and intervention reveal effective information on weight loss and sleep, Yu Tahara1, 2, Masaki Takahashi2, 3, Shigenobu Shibata2, 2022/12/07, With Invitation, English
  9. Food-log app-based chrono-nutritional analysis reveals an association between low-carbohydrate at dinner and weight loss, Yu Tahara1, 2, Mai Kuwahara1, Saneyuki Makino1, Farnaz Roshanmehr1, Takae Shinto1, Gentaro Yokoyama1, Shion Hosoda1, Tsukasa Fukunaga1, Ayako Tada3, Nanako Abe3, Mikiko Michie3, Hyeon-Ki Kim1, Masaki Takahashi4, Michiaki Hamada1, Shigenobu Shibata1, EBRS2022(Europian Biological Rhythms Society), 2022/07/25, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2021/07, 2023/03
  2. 2021/04, 2023/03
  3. 2021/04, 2022/03
  4. 2021/04, 2024/03
  5. 2021/04, 2024/03
  6. 2020/11, 2023/03
  7. 2020/10, 2024/03
  8. 2020/04, 2022/03
  9. 2020/04, 2023/03
  10. 2019/06, 2021/03
  11. 2018/01, 2019/03
  12. 2015/04, 2017/03
  13. 2014/05, 2019/03
  14. 2013/08, 2015/03
  15. 2011, 2012