YU TAHARA

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
Web Site
E-mail
yutaharahiroshima-u.ac.jp
Self-introduction
Dr. Tahara was born in 1985 in Japan. He got Ph.D. in Waseda University in 2013. He was a visiting assistant professor in UCLA (2016-2019), then moved to Waseda University as an associate professor. He moved to Hiroshima University in 2022. His research topic is circadian clock in mammals, especially chrono-nutrition. His recent interest is to develop a personalized intervention algorithm to improve health and prevent diseases.

Basic Information

Major Professional Backgrounds

  • 2011/04/01, 2013/03/31, JSPS, Special Postdoctoral Researcher(DC2)
  • 2013/04/01, 2014/03/31, Waseda University, School of Advanced Science and Engineering, Research Associate
  • 2014/04/01, 2015/03/31, Waseda University, School of Advanced Science and Engineering, Assistant professor
  • 2015/04/01, 2016/12/31, Waseda University, Assistant professor
  • 2016/09/01, 2019/03/31, University of California, Los Angeles, School of Medicine, Visiting assistant professor
  • 2018/01/01, 2019/03/31, JSPS, JSPS research fellow
  • 2019/04/01, Waseda University, Researcher
  • 2019/04/01, 2022/03/31, Waseda University, Associate professor
  • 2022/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Associate professor

Educational Backgrounds

  • Waseda University, 2008/03/15
  • Waseda University, 2010/03/15
  • Waseda University, 2013/03/15

Academic Degrees

  • Waseda University
  • Waseda University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Environmental physiology (including physical medicine and nutritional physiology)

Research Keywords

  • Circadian clock, Chronobiology, Chrono-nutrition, health science

Affiliated Academic Societies

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Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Theories of Behavioral Sciences
  2. 2024, Graduate Education (Master's Program) , 1Term, Environmental Health

Research Activities

Academic Papers

  1. Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 77(4), 468-473, 202304
  2. Editiorial:The present and future of chrono-nutrition studies., Frontiers in nutrition, 2023
  3. Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract, BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH, 42(2), 114-123, 2023
  4. Polygalae Radix shortens the circadian period through activation of the CaMKII pathway., Pharmaceutical biology, 60(1), 689-698, 20221201
  5. Effects of Differences of Breakfast Styles, Such as Japanese and Western Breakfasts, on Eating Habits, NUTRIENTS, 14(23), 202212
  6. Association between blood pressure and circadian timing of physical activity of Japanese workers, FRONTIERS IN PHYSIOLOGY, 13, 20220926
  7. Interaction effects of sex on the sleep loss and social Jetlag-related negative mood in Japanese children and adolescents:A cross-sectional study, SLEEP Advances, 20220921
  8. Association between Breakfast Meal Categories and Timing of Physical Activity of Japanese Workers, Foods, 11(17), 2609, 20220828
  9. Association of Japanese Breakfast Intake with Macro- and Micronutrients and Morning Chronotype, Nutrients, 14(17), 3496, 20220825
  10. Relationship Between Protein Intake in Each Traditional Meal and Physical Activity: Cross-sectional Study, JMIR Public Health Surveill, 8(7), e35898, 20220612
  11. Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure., Frontiers in nutrition, 9, 853118, 20220304
  12. Timing of Food/Nutrient Intake and its Health Benefits., Journal of nutritional science and vitaminology 68(Supplelment)S2-S4, 2022
  13. Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning., Chronobiology international, 38(3), 426-442, 20210301
  14. Changes in sleep phase and body weight of mobile health App users during COVID-19 mild lockdown in Japan., International journal of obesity (2005), 45(10), 2021
  15. Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock., Cell reports, 36(1), 2021
  16. Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus., Neurobiology of sleep and circadian rhythms, 11, 2021
  17. Association between Irregular Meal Timing and the Mental Health of Japanese Workers., Nutrients, 13(8), 2021
  18. The circadian clock is disrupted in mice with adenine-induced tubulointerstitial nephropathy., Kidney international, 97(4), 2020
  19. Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder., Neurobiology of disease, 145, 2020
  20. Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay., Journal of applied toxicology : JAT, 39(2), 2019
  21. Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism., Biomaterials, 192, 2019
  22. The effect of night shift work on the expression of clock genes in beard hair follicle cells., Sleep medicine, 56, 2019
  23. Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function., Scientific reports, 8(1), 2018
  24. Chronotype and social jetlag influence human circadian clock gene expression., Scientific reports, 8(1), 2018
  25. Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease., Journal of biological rhythms, 33(5), 2018
  26. Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease., Journal of neuroscience research, 96(12), 2018
  27. Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition., Free radical biology & medicine, 119, 2018
  28. Night eating model shows time-specific depression-like behavior in the forced swimming test., Scientific reports, 8(1), 2018
  29. Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue., Scientific reports, 8(1), 2018
  30. The mammalian circadian clock and its entrainment by stress and exercise., The journal of physiological sciences : JPS, 67(1), 2017
  31. Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer., Hepatology (Baltimore, Md.), 65(3), 2017
  32. Positive association between physical activity and PER3 expression in older adults., Scientific reports, 7, 2017
  33. Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts., PloS one, 12(2), 2017
  34. Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice., Chronobiology international, 34(8), 2017
  35. Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation., NPJ aging and mechanisms of disease, 3, 2017
  36. Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice., Nutrition research (New York, N.Y.), 43, 2017
  37. Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells., PloS one, 12(8), 2017
  38. Circadian rhythms of liver physiology and disease: experimental and clinical evidence., Nature reviews. Gastroenterology & hepatology, 13(4), 2016
  39. Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice., Scientific reports, 6, 2016
  40. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120., PloS one, 10(7), 2015
  41. Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions., Scientific reports, 5, 2015
  42. Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model., Scientific reports, 5, 2015
  43. Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Reversed by Scheduled Feeding or Exercise., Journal of biological rhythms, 30(6), 2015
  44. Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model., Scientific reports, 5, 2015
  45. Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala., Sleep medicine, 16(11), 2015
  46. Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods., Chronobiology international, 32(2), 2015
  47. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice., Neuroscience research, 99, 2015
  48. Entrainment of the mouse circadian clock by sub-acute physical and psychological stress., Scientific reports, 5, 2015
  49. Circadian regulation of allergic reactions by the mast cell clock in mice., The Journal of allergy and clinical immunology, 133(2), 2014
  50. Circadian dysfunction in response to in vivo treatment with the mitochondrial toxin 3-nitropropionic acid., ASN neuro, 6(1), 2014
  51. Chrono-biology, chrono-pharmacology, and chrono-nutrition., Journal of pharmacological sciences, 124(3), 2014
  52. Disruption of the suprachiasmatic nucleus blunts a time of day-dependent variation in systemic anaphylactic reaction in mice., Journal of immunology research, 2014, 2014
  53. Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse., PloS one, 9(6), 2014
  54. Effect of quetiapine on Per1, Per2, and Bmal1 clock gene expression in the mouse amygdala and hippocampus., Journal of pharmacological sciences, 125(3), 2014
  55. Controlling access time to a high-fat diet during the inactive period protects against obesity in mice., Chronobiology international, 31(8), 2014
  56. A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice., Nutrition research (New York, N.Y.), 34(7), 2014
  57. Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice., British journal of pharmacology, 171(24), 2014
  58. Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus., Journal of neurophysiology, 110(5), 2013
  59. 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity., The Journal of pharmacology and experimental therapeutics, 340(3), 2012
  60. In vivo monitoring of peripheral circadian clocks in the mouse., Current biology : CB, 22(11), 2012
  61. Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism., Journal of circadian rhythms, 10(1), 2012
  62. Meal frequency patterns determine the phase of mouse peripheral circadian clocks., Scientific reports, 2, 2012
  63. Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction., The Journal of allergy and clinical immunology, 127(4), 2011
  64. Refeeding after fasting elicits insulin-dependent regulation of Per2 and Rev-erbα with shifts in the liver clock., Journal of biological rhythms, 26(3), 2011
  65. Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet., Journal of medicinal chemistry, 54(18), 2011
  66. Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice., Journal of biological rhythms, 25(1), 2010
  67. The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs., Advanced drug delivery reviews, 62(9-10), 2010
  68. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding., American journal of physiology. Gastrointestinal and liver physiology, 299(5), 2010
  69. A balanced diet is necessary for proper entrainment signals of the mouse liver clock., PloS one, 4(9), 2009

Publications such as books

  1. Nutrition and diet as potent regulators of the liver clock. Circadian thythms:Health and Disease, Wiley, 2015, 2015
  2. Chrono-biology, chrono-pharmacology, and chrono-nutrition, J pharm Sci, 2014, 2014
  3. Circadian rhythm and food/nutrition. Mechanisms of Circadian Systems in Animals and Their Clinical Relevance, Springer, 2014

Invited Lecture, Oral Presentation, Poster Presentation

  1. Basic research on Chrono-nutrition, 2022/11/30, With Invitation, Japanese
  2. Food-log app-based chrono-nutritional survey and intervention reveal effective information on weight loss and sleep, Yu Tahara1, 2, Masaki Takahashi2, 3, Shigenobu Shibata2, 2022/12/07, With Invitation, English
  3. Food-log app-based chrono-nutritional analysis reveals an association between low-carbohydrate at dinner and weight loss, Yu Tahara1, 2, Mai Kuwahara1, Saneyuki Makino1, Farnaz Roshanmehr1, Takae Shinto1, Gentaro Yokoyama1, Shion Hosoda1, Tsukasa Fukunaga1, Ayako Tada3, Nanako Abe3, Mikiko Michie3, Hyeon-Ki Kim1, Masaki Takahashi4, Michiaki Hamada1, Shigenobu Shibata1, EBRS2022(Europian Biological Rhythms Society), 2022/07/25, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2021/07, 2023/03
  2. 2021/04, 2023/03
  3. 2021/04, 2022/03
  4. 2021/04, 2024/03
  5. 2021/04, 2024/03
  6. 2020/11, 2023/03
  7. 2020/10, 2024/03
  8. 2020/04, 2022/03
  9. 2020/04, 2023/03
  10. 2019/06, 2021/03
  11. 2018/01, 2019/03
  12. 2015/04, 2017/03
  13. 2014/05, 2019/03
  14. 2013/08, 2015/03
  15. 2011, 2012