YUSUKE NAKATSU

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
E-mail
nakatsuhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Bioscience, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Metabolomics

Research Keywords

  • Insulin signaling
  • Diabetes
  • Pin1

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2025, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2025, Undergraduate Education, 4Term, Clinicobiochemistry
  4. 2025, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  5. 2025, Graduate Education (Master's Program) , Second Semester, Pathologic Basis of Diseases
  6. 2025, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences

Research Activities

Academic Papers

  1. Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(21), 202311
    Link to Paper Search Results by DOI
  2. The expression of prolyl isomerase Pin1 is expanded in the skin of patients with atopic dermatitis and facilitates IL-33 expression in HaCaT cells, JOURNAL OF DERMATOLOGY, 50(4), 462-471, 202304
    Link to Paper Search Results by DOI
  3. Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(10), 20230516
    Link to Paper Search Results by DOI
  4. Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation, CANCER MEDICINE, 12(7), 8464-8475, 202304
    Link to Paper Search Results by DOI
  5. ★, Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex, EXPERIMENTAL CELL RESEARCH, 425(2), 20230415
    Link to Paper Search Results by DOI
  6. miR-582-5p targets Skp1 and regulates NF-Kappa B signaling-mediated inflammation, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 734, 20230115
    Link to Paper Search Results by DOI
  7. Roles of peptidyl prolyl isomerase Pin1 in viral propagation, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20221025
    Link to Paper Search Results by DOI
  8. Prolyl Isomerase Pin1 Impacts on Metabolism in Muscle and Adipocytes, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 142(5), 449-456, 2022
    Link to Paper Search Results by DOI
  9. ★, Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis, METABOLISM-CLINICAL AND EXPERIMENTAL, 115, 202102
    Link to Paper Search Results by DOI
  10. ★, Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells, CANCER LETTERS, 470, 106-114, 2020
    Link to Paper Search Results by DOI
  11. ★, Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16, CELL REPORTS, 26(12), 3221-+, 20190319
    Link to Paper Search Results by DOI
  12. ★, The prolyl isomerase Pin1 increases beta-cell proliferation and enhances insulin secretion, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(28), 11886-11895, 20170714
    Link to Paper Search Results by DOI
  13. ★, Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the gamma Subunit, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(40), 24255-24266, 20151002
    Link to Paper Search Results by DOI
  14. Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes, BIOMEDICINES, 9(8), 202108
    Link to Paper Search Results by DOI
  15. Pathological Role of Pin1 in the Development of DSS-Induced Colitis, CELLS, 10(5), 202105
    Link to Paper Search Results by DOI
  16. Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(8), 202104
    Link to Paper Search Results by DOI
  17. Development of Pin1 Inhibitors and their Potential as Therapeutic Agents, CURRENT MEDICINAL CHEMISTRY, 27(20), 3314-3329, 2020
    Link to Paper Search Results by DOI
  18. Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins, CELLS, 8(12), 201912
    Link to Paper Search Results by DOI
  19. Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(19), 201910
    Link to Paper Search Results by DOI
  20. Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice, DIABETOLOGY & METABOLIC SYNDROME, 11, 20190722
    Link to Paper Search Results by DOI
  21. Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation, Oncotarget, 10(17), 1637-1648, 2019
  22. The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(12), 201812
    Link to Paper Search Results by DOI
  23. Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 201810
    Link to Paper Search Results by DOI
  24. Gut Microbiota as a Therapeutic Target for Metabolic Disorders, CURRENT MEDICINAL CHEMISTRY, 25(9), 984-1001, 2018
    Link to Paper Search Results by DOI
  25. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocyt es and Macrophages, MEDIATORS OF INFLAMMATION, 2018
    Link to Paper Search Results by DOI
  26. Trk-fused gene (TFG) regulates pancreatic beta cell mass and insulin secretory activity, SCIENTIFIC REPORTS, 7, 20171012
    Link to Paper Search Results by DOI
  27. The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(8), 201708
    Link to Paper Search Results by DOI
  28. USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 484(3), 522-528, 20170311
    Link to Paper Search Results by DOI
  29. Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2), 201702
    Link to Paper Search Results by DOI
  30. Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(9), 201609
    Link to Paper Search Results by DOI
  31. Involvement of resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice, SCIENTIFIC REPORTS, 6, 20160128
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  32. Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis, MEDIATORS OF INFLAMMATION, 2016
    Link to Paper Search Results by DOI
  33. Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus, DIABETOLOGY & METABOLIC SYNDROME, 7, 20151119
    Link to Paper Search Results by DOI
  34. Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet, PLOS ONE, 10(8), 20150812
    Link to Paper Search Results by DOI
  35. DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappa B activation, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 309(3), E214-E223, 20150801
    Link to Paper Search Results by DOI
  36. The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 309(1), G42-G51, 20150701
    Link to Paper Search Results by DOI
  37. Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines, PLOS ONE, 10(6), 20150603
    Link to Paper Search Results by DOI
  38. High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice, DIABETOLOGY & METABOLIC SYNDROME, 7, 20150602
    Link to Paper Search Results by DOI
  39. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity, NATURE COMMUNICATIONS, 6, 201504
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  40. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 308(2), G151-G158, 20150115
    Link to Paper Search Results by DOI
  41. LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis, MEDIATORS OF INFLAMMATION, 2015
    Link to Paper Search Results by DOI
  42. Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 305(12), G911-G918, 201312
    Link to Paper Search Results by DOI
  43. Resistin-Like Molecule Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(8), 1986-1993, 201308
    Link to Paper Search Results by DOI
  44. Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and Metabolic Actions, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(28), 20692-20701, 20130712
    Link to Paper Search Results by DOI
  45. Integrator complex plays an essential role in adipose differentiation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(2), 197-202, 20130503
    Link to Paper Search Results by DOI
  46. Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(53), 44526-44535, 20121228
    Link to Paper Search Results by DOI
  47. Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(2), 291-U282, 201202
    Link to Paper Search Results by DOI
  48. Valsartan, independently of AT1 receptor or PPAR gamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302(3), E286-E296, 201202
    Link to Paper Search Results by DOI
  49. LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8, OBESITY RESEARCH & CLINICAL PRACTICE, 6(3), E215-E224, 2012
    Link to Paper Search Results by DOI
  50. Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages, OBESITY RESEARCH & CLINICAL PRACTICE, 6(4), E288-E297, 2012
    Link to Paper Search Results by DOI
  51. ★, Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis., J. Biol. Chem., 286(23), 20812-20822, 20110701
  52. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, Am J Physiol Cell Physiol, 20110501
  53. Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity., J.Biol.chem, 285(43), 33018-33027, 20101001
  54. Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase, Obesity Research & Clinical Practice, 20100701
  55. Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death., J. Toxicol. Sci., 35, 245-251, 20100401
  56. Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy., Diabetes.Res.Clin.Prac, 87(1), 57-63, 20100101
  57. ★, Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate., Toxicol.Appl.Pharmacol., 240(2), 292-298, 20091001
  58. Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells., PLACENTA, 29(12), 1003-1008, 20081201
  59. ★, Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death., Toxicology and Applied Pharmacology, 230(3), 358-363, 20080801
  60. Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions, Biol Pharm Bull., 20070901
  61. Concentration dependence of the mechanisms of tributyltin-induced apoptosis., Toxicological Sciences, 97(2), 438-447, 20070601
  62. Tributyltin-induced cell death is mediated by calpain in PC12 cells., Neurotoxicology, 27(4), 587-593, 20060701
  63. Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons., Toxicological Sciences, 89(1), 235-242, 20060101
  64. The functions of SGLT2 and the recent advances in the studies of SGLT2 inhibitors., 46(1), 38-43, 20210130
  65. Crosstalk mechanism of the energy metabolism by AMPK, 65(4), 290-293, 2014
  66. Regulation of metabolism via mTORC1/2, 37(6), 667-675, 201312
  67. Glucose Transporter as a Molecule Target for the Treatment of Diabetes Mellitus, 31(5), 548-552, 2012
  68. Regulation of energy metabolism by AMPK, 140(3), 138-139, 20120901
  69. Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases, SCIENTIFIC REPORTS, 12(1), 20220204
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Prolyl isomerase Par14 associates with DNA-binding domain of androgen receptor, and enhancing both its transcriptional activity and prostate cancer proliferation, Miki Naito, Yusuke Nakatsu,Kenshiro Takemoto, Shunsuke Miyamoto, ​Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Kenichiro Ikeda, Akihiro Goriki, ​Keisuke Hieda, Tetsutaro Hayashi, Tomoichiro Asano, Nobuyuki Hinata, 2023/11/02, Without Invitation, Japanese

Awards

  1. 2010/12/04, Research travel grant, 第22回分子糖尿病学シンポジウム代表世話人
  2. 2009/06/25, 69th American Diabetes Association travel award, American Diabetes Association

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021
  2. KAKENHI, 2016, 2018
  3. KAKENHI, 2013, 2015
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  4. KAKENHI, The role of prolyl isomerase Pin1 in energy metabolism, 2011, 2012
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  5. KAKENHI, Role of the prolyl isomerase Pin1 in diabetes, 2008, 2009
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  6. 2022, 2025
  7. 2022
  8. 2021/01/01, 2022/12/31
  9. 2021, 2022
  10. 2020, 2023
  11. 2020, 2022
  12. 2019, 2020
  13. 2018, 2020
  14. 2017, 2019
  15. 2016, 2017
  16. 2016, 2017
  17. 2016, 2019
  18. 2016/04/01, 2017/03/31
  19. 2016, 2017
  20. 2013, 2014
  21. 2012, 2013
  22. 2011, 2013
  23. 2011, 2012
  24. 2011, 2012
  25. 2014/04/01, 2017/03/31
  26. 2010, 2012
  27. KAKENHI, Elucidation of the role of Pin1 on the adipose differentiation, 2010, 2011
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  28. KAKENHI, Cellular signaling systems regulated by oxidative stress and ROS-sensitive phosphatases, 2008, 2013
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  29. KAKENHI, Elucidation of the molecular mechanisms underlying insulin resistance and metabolic disorders using a proteomics technology, 2008, 2010
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Social Activities

History as Peer Reviews of Academic Papers

  1. 2022, Experimental Gerontology, Reviewer, 1
  2. 2022, Redox Biology, Reviewer, 1
  3. 2020, Experimental Cell Research, Reviewer, 1
  4. 2020, Redox Biology, Reviewer, 1
  5. 2019, Metabolism, Reviewer, 1
  6. 2019, DIABETES RESEARCH AND CLINICAL PRACTICE., Reviewer, 1
  7. 2018, Drug Design, Development and Therapy, Reviewer, 1
  8. 2018, Cellular Signaling, Reviewer, 1
  9. 2018, Biomedicine & Pharmacotherapy, Reviewer, 1
  10. 2017, Biomedicine & Pharmacotherapy, Reviewer, 1
  11. 2015, Plos one, Reviewer, 1