KODAI KUME

Last Updated :2022/12/02

Affiliations, Positions
Hiroshima University
Web Site
E-mail
kumekhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2020/04, 2021/03, Kagawa University, Faculty of Medicine
  • 2019/04, 2020/03, Hiroshima University, Research Institute for Radiation Biology and Medicine
  • 2018/04, 2019/03, Hiroshima University, Research Institute for Radiation Biology and Medicine
  • 2014/06, 2018/03, Kagawa University, Faculty of Medicine
  • 2010/04, 2014/05, Kagawa University, Faculty of Medicine
  • 2008/04, 2010/03, Kagawa University, University Hospital, Faculty of Medicine

Educational Backgrounds

  • Kagawa University, Japan, 2012/04, 2017/06
  • Kagawa University, Japan, 2002/04, 2008/03

Academic Degrees

  • Kagawa University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology
  • Biological Sciences;Genome science;Medical genome science

Research Keywords

  • Genetics
  • Next generation sequencer
  • Neurodegenerative disease

Affiliated Academic Societies

  • Japanese Society of Neurology
  • The Japanese Society of Human Genetics
  • Japanese Society for Bioinformatics
  • The Japan Neuroscience Society
  • The Japanese Society for Neurochemistry

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Intensive, Practice for medical research
  2. 2022, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  3. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  4. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular Epidemiology
  5. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular Epidemiology
  6. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular Epidemiology
  7. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular Epidemiology
  8. 2022, Graduate Education (Master's Program) , OutOfTerm(1st), Basic Training of Genome Editing
  9. 2022, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science
  10. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  11. 2022, Graduate Education (Master's Program) , First Semester, Research
  12. 2022, Graduate Education (Master's Program) , Second Semester, Research
  13. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  14. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  15. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  16. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  17. 2022, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  18. 2022, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B

Research Activities

Academic Papers

  1. Comparison of two families with and without ataxia harboring novel variants in PRKCG, JOURNAL OF HUMAN GENETICS, 67(10), 595-599, 202210
  2. Novel monoallelic variant in ERLIN2 causes spastic paraplegia converted to amyotrophic lateral sclerosis, Journal of the Neurological Sciences, 430, 119984, 20211115
  3. Premedication of hemin for eradication therapy of Helicobacter pylori in patients with porphyria., Clinical case reports, 9(2), 944-946, 202102
  4. The first Japanese case of primary familial brain calcification caused by an MYORG variant., Journal of human genetics, 65(10), 917-920, 202010
  5. Aggressive periodontitis and NOD2 variants., Journal of human genetics, 65(10), 841-846, 202010
  6. Optineurin regulates osteoblastogenesis through STAT1., Biochemical and biophysical research communications, 525(4), 889-894, 20200514
  7. Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia., Journal of human genetics, 65(4), 363-369, 202004
  8. Middle-age-onset cerebellar ataxia caused by a homozygous TWNK variant: a case report., BMC medical genetics, 21(1), 68-68, 20200331
  9. Biallelic mutation of HSD17B4 induces middle age-onset spinocerebellar ataxia., Neurology. Genetics, 6(1), e396, 202002
  10. Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-associated protein 410 mutation., Journal of neurology, neurosurgery, and psychiatry, 91(2), 220-222, 202002
  11. Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report, BMC Neurology, 19(1), 168, 201912
  12. C-terminal mutations in SYNE1 are associated with motor neuron disease in patients with SCAR8., Journal of the neurological sciences, 402, 118-120, 20190715
  13. Three cases of non-carryover fingolimod-PML: Is the risk in Japan increased?, Neurology(R) neuroimmunology & neuroinflammation, 6(3), e559, 201905
  14. Clinical significance of assaying anti-MOG antibody in cerebrospinal fluid in MOG-antibody-associated diseases: A case report., Multiple sclerosis and related disorders, 28, 165-166, 201902
  15. Subacute Sensorimotor Neuropathy Accompanied by Anti-ganglioside GM1 Antibody in a Patient with Lung Cancer., Internal medicine (Tokyo, Japan), 57(22), 3289-3292, 201811
  16. Serum microRNA expression profiling in patients with multiple system atrophy., Molecular medicine reports, 17(1), 852-860, 201801
  17. Acute Intermittent Porphyria Presenting with Posterior Reversible Encephalopathy Syndrome, Accompanied by Prolonged Vasoconstriction., Internal medicine (Tokyo, Japan), 56(6), 713-717, 2017
  18. Dialysis-induced Subdural Hematoma in an Arachnoid Cyst Associated with Autosomal Dominant Polycystic Kidney Disease., Internal medicine (Tokyo, Japan), 55(15), 2065-7, 2016
  19. Neuromyelitis optica spectrum disorder presenting with repeated hypersomnia due to involvement of the hypothalamus and hypothalamus-amygdala linkage., Multiple sclerosis (Houndmills, Basingstoke, England), 21(7), 960-2, 201506
  20. Significance of the hot-cross bun sign on T2*-weighted MRI for the diagnosis of multiple system atrophy., Journal of neurology, 262(6), 1433-9, 201506
  21. Unilateral mydriatic tonic pupil as an early isolated symptom of neurosyphilis., Journal of the neurological sciences, 344(1-2), 219-20, 20140915
  22. Usefulness of the modified F-ratio for assessments of proximal conduction in chronic inflammatory demyelinating polyneuropathy superimposed on Charcot Marie-Tooth disease type 1A., Journal of the neurological sciences, 343(1-2), 237-9, 20140815
  23. Advantage of C-11-methionine positron emission tomography for assessing IgG4-related central nervous system lesions, JOURNAL OF NEUROLOGY, 261(3), 625-627, 201403
  24. [Successful treatment of HIV-associated chronic inflammatory demyelinating polyneuropathy by early initiation of highly active anti-retroviral therapy]., Rinsho shinkeigaku = Clinical neurology, 53(5), 362-6, 2013
  25. Transcranial magnetic stimulation with the maximum voluntary muscle contraction facilitates motor neuron excitability and muscle force., Neurology research international, 2012, 847634-847634, 2012
  26. Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II., The Biochemical journal, 412(2), 223-31, 20080601
  27. p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase., The Biochemical journal, 401(2), 391-8, 20070115
  28. Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells., FEBS letters, 579(25), 5658-62, 20051024
  29. FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report, BMC NEUROLOGY, 21(1), 20211012
  30. Analysis of genetic risk factors in Japanese patients with Parkinson's disease., Journal of human genetics, 20210319
  31. Porencephaly causing limb size asymmetry., Acta neurologica Belgica, 20210316
  32. Premedication of hemin for eradication therapy of Helicobacter pylori in patients with porphyria., Clinical case reports, 9(2), 944-946, 202102

Invited Lecture, Oral Presentation, Poster Presentation

  1. The variant in FLNA identified in a patient with progressive supranuclear palsy, American Society of Human Genetics Annual Meeting 2022, 2022/10/25, Without Invitation, English
  2. C-terminal mutations in SYNE1 are associated with motor neuron disease in patients with SCAR8., NEURO2019, 2019/07/25, Without Invitation, English
  3. Middle-age-onset cerebellar ataxia caused by homozygous TWNK mutation., The 64th Annual Meeting of the Japan Society of Human Genetics, 2019/11/06, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2022, 2023
  2. Research grant, Development of a novel therapy using DNA methylation for repeat diseases
  3. Research incentive grants in 2021
  4. Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, 2020/04/01, 2022/03/31