HARUKO TAKAHASHI

Last Updated :2021/07/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Web Site
E-mail
harukothiroshima-u.ac.jp
Other Contact Details
1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, JAPAN, Japan
TEL : (+81)82-424-7441 FAX : (+81)
Self-introduction
Development of 3D in vitro cancer model including tumor microenvironment for cancer research, drug discovery and diagnosis.

Basic Information

Major Professional Backgrounds

  • 2010/04, 2012/03, Japan Society for the Promotion of Science, JSPS Ph.D. Student Research Fellow
  • 2012/04, 2013/03, Japan Society for the Promotion of Science, JSPS Postdoctoral Research Fellow
  • 2012/07, 2015/12, School of Dentistry, University of Michigan, USA, Visiting postdoctoral scholar
  • 2014/04, 2015/12, Japan Society for the Promotion of Science, JSPS postdoctoral fellow for research abroad
  • 2016/01/01, 2018/03/31, The University of Tokyo, Institute of Industrial Science, Assistant Professor (Special Appointment)
  • 2018/04/01, 2019/03/31, Hiroshima University, Graduate School of Science, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor

Academic Degrees

  • Master (Medical science), Tokyo Medical and Dental University
  • Ph.D (Philosophy), Tokyo Medical and Dental University

In Charge of Primary Major Programs

  • Biology

Research Fields

  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering
  • Interdisciplinary science and engineering;Nano / Micro science;Nano / Microsystems
  • Biological Sciences;Oncology;Tumor biology

Research Keywords

  • Molecular Biology, Tumor Model, Biomaterial Science, Biomedical Engineering

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 3Term, Introduction to Biology
  2. 2021, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  3. 2021, Undergraduate Education, 2Term, Advanced Biology
  4. 2021, Undergraduate Education, 2Term, Developmental Biology B
  5. 2021, Undergraduate Education, Second Semester, Seminar for Developmental Biology
  6. 2021, Undergraduate Education, First Semester, Practice for Fundamental Biology III
  7. 2021, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  8. 2021, Undergraduate Education, 4Term, Biological Informatics
  9. 2021, Graduate Education (Master's Program) , First Semester, Seminar for Biological Science (Lecture)
  10. 2021, Graduate Education (Master's Program) , Second Semester, Seminar for Biological Science (Lecture)
  11. 2021, Graduate Education (Master's Program) , First Semester, Developmental Biology (Seminar)
  12. 2021, Graduate Education (Master's Program) , Second Semester, Developmental Biology (Seminar)
  13. 2021, Graduate Education (Doctoral Program) , First Semester, Developmental Biology (Seminar)
  14. 2021, Graduate Education (Doctoral Program) , Second Semester, Developmental Biology (Seminar)
  15. 2021, Graduate Education (Master's Program) , 2Term, Seminar for Advanced Research in Basic Biology A
  16. 2021, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology B
  17. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Basic Biology A
  18. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Basic Biology A
  19. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Basic Biology B
  20. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Basic Biology B
  21. 2021, Graduate Education (Master's Program) , 4Term, Cell Dynamics and Genomics
  22. 2021, Graduate Education (Master's Program) , 2Term, Seminar for Advanced Research in Basic Biology C
  23. 2021, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology D
  24. 2021, Graduate Education (Doctoral Program) , 2Term, Seminar for Advanced Research in Basic Biology E
  25. 2021, Graduate Education (Doctoral Program) , 3Term, Seminar for Advanced Research in Basic Biology F
  26. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  27. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  28. 2021, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  29. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  30. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  31. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Amphiphilic Polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria, Biomaterials Science, 2021
  2. Synthetic Biomimetic polymethacrylates: Promising platform for the design of anti-cyanobacterial and anti-algal agents, Polymers, 13, 1025, 2021
  3. ★, Anticancer polymers designed for killing dormant prostate cancer cells, Scientific Reports, 9, 1096, 2019
  4. Branched Poly(ethylene imine)s as Anti-algal and Anti-cyanobacterial Agents with Selective Flocculation Behavior to Cyanobacteria over Algae, Macromolecular Bioscience, 18, 1800187, 2018
  5. A 3D in vitro pericyte-supported microvessel model: visualisation and quantitative characterisation of multistep angiogenesis, Journal of Materials Chemistry B, 6, 1085-1094, 2018
  6. A vascular endothelial growth factor-dependent sprouting angiogenesis assay based on an in vitro human blood vessel model for the study of anti-angiogenic drugs, EBioMedicine, 27, 225-236, 2018
  7. Bundle gel fibers with tunable microenvironment for in vitro neuron cell guiding, ACS Applied Materials and Interfaces, 9, 43250-43257, 2017
  8. A vascular permeability assay using an in vitro human microvessel model mimicking the inflammatory condition, Nanotheranostics, 1, 103-113, 2017
  9. ★, Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography, Scientific Reports, 7, 42426, 2017
  10. Synthetic random copolymers as a molecular platform to mimic host-defense antimicrobial peptides, Bioconjugate Chemistry, 28, 1340-1350, 2017
  11. Cationic amphiphilic polymers with antimicrobial activity for oral care applications: Eradication of S. mutans biofilm, Biomacromolecules, 18, 257-265, 2017
  12. A cationic amphiphilic random copolymer with pH-responsive activity against methicillin-resistant Staphylococcus aureus, PLoS ONE, 12, e0169262, 2017
  13. Radical-medicated end-group transformation of amphiphilic methacrylate random copolymers for modulation of antimicrobial and hemolytic activities, Journal of Polymer Science Part A: Polymer Chemistry, 55, 304-312, 2017
  14. Multiwalled carbon nanotube reinforced biomimetic bundled gel fibres, Biomaterials Science, 4, 1197-1201, 2016
  15. Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity, Chemical Communications, 51, 12597-12600, 2015
  16. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques, Mucosal Immunology, 8, 1144-1153, 2015
  17. Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers, Macromolecular Bioscience, 13, 1285-1299, 2013
  18. Nanogel-based antigen-delivery system for nasal vaccines, Biotechnology and Genetic Engineering Reviews, 29, 61-72, 2013
  19. Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effectcive protein refolding, RSC Advences, 3, 25716-25718, 2013
  20. Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation, Biomaterials Science, 1, 842-849, 2013
  21. Activation of platelets upon contact with a vitamin E-coated/non-coated surface, Journal of Artificial Organs, 16, 193-205, 2013
  22. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae, Infection and Immunity, 81, 1625-1634, 2013
  23. Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle, Biomacromolecules, 14, 56-63, 2013
  24. Artificial chaperone polysaccharide nanogels for protein delivery: a thermodynamic study of protein-nanogel interactions using fluorescence correlation spectroscopy, Current Drug Discovery Technologies, 8, 308-313, 2011
  25. Amphiphilic polysaccharide nanoballs: a new building block for nanogel biomedical engineering and artificial chaperones, ACS nano, 5, 337-345, 2011
  26. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines, Nature materials, 9, 572-578, 2010
  27. The binding of pullulan modified cholesteryl nanogels to AB oligomers and their suppression of cytotoxicity, Biomaterials, 30, 5583-5591, 2009

Publications such as books

  1. 2015, Encyclopedia of Polymeric Nanomaterials, Vaccine, Springer, 2015, English, Haruko Takahashi, Kazunari Akiyoshi

Invited Lecture, Oral Presentation, Poster Presentation

  1. Integrative understanding of musculotendinous junction formation and maturation during musculoskeletal system development in mammals, Haruko Takahashi, Yasuhisa Yamamoto, Ikkei Kumoyama, Hikaru Ikeda, Mingcong Xu, Yutaka Kikuchi, 43rd Annual Meeting of the Molecular Biology Society of Japan, 2020/12, With Invitation, English
  2. Molecular engineering of antimicrobial polymers to target biofilms, Haruko Takahashi, ACS 257th National Meeting & Exposition, 2019/04, With Invitation, English
  3. Non-invasive visualization of angiogenesis dynamics in 3D in vitro microvasculature model by OCT, Haruko Takahashi, Yukiko T. Matsunaga, ICBS 2016, 2016/11, Without Invitation, English
  4. On-demand control of antimicrobial activity of methacrylate random copolymers using amphiphilic polysaccharide nanogels, Haruko Takahashi, Kazunari Akiyoshi, Kenichi Kuroda, ACS 248th National Meeting & Exposition, 2014/08, Without Invitation, English
  5. Antimicrobial polymers and macromolecules, Haruko Takahashi, Kenichi Kuroda, Symposium in honor of Bill DeGrado, 2014/08, With Invitation, English

Social Activities

Other Social Contributions

  1. Interview in "Female Researchers", Science Communication Fellowship Program, 2019/05, Interviewee