Last Updated :2024/06/04

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Web Site
Other Contact Details
1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, JAPAN, Japan
TEL : (+81)82-424-7441 FAX : (+81)
Development of 3D in vitro cancer model including tumor microenvironment for cancer research, drug discovery and diagnosis.

Basic Information

Major Professional Backgrounds

  • 2010/04, 2012/03, Japan Society for the Promotion of Science, JSPS Ph.D. Student Research Fellow
  • 2012/04, 2013/03, Japan Society for the Promotion of Science, JSPS Postdoctoral Research Fellow
  • 2012/07, 2015/12, School of Dentistry, University of Michigan, USA, Visiting postdoctoral scholar
  • 2014/04, 2015/12, Japan Society for the Promotion of Science, JSPS postdoctoral fellow for research abroad
  • 2016/01/01, 2018/03/31, The University of Tokyo, Institute of Industrial Science, Assistant Professor (Special Appointment)
  • 2018/04/01, 2019/03/31, Hiroshima University, Graduate School of Science, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor

Academic Degrees

  • Master (Medical science), Tokyo Medical and Dental University
  • Ph.D (Philosophy), Tokyo Medical and Dental University

In Charge of Primary Major Programs

  • Biology

Research Fields

  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering
  • Interdisciplinary science and engineering;Nano / Micro science;Nano / Microsystems
  • Biological Sciences;Oncology;Tumor biology

Research Keywords

  • Molecular Biology, Tumor Model, Biomaterial Science, Biomedical Engineering

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 3Term, Introduction to Biology
  2. 2024, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  3. 2024, Undergraduate Education, 2Term, Developmental Biology B
  4. 2024, Undergraduate Education, Second Semester, Seminar for Developmental Biology
  5. 2024, Undergraduate Education, First Semester, Special Study for Graduation
  6. 2024, Undergraduate Education, Second Semester, Special Study for Graduation
  7. 2024, Undergraduate Education, First Semester, Practice for Fundamental Biology III
  8. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  9. 2024, Undergraduate Education, 4Term, Biological Informatics
  10. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  11. 2024, Graduate Education (Master's Program) , 4Term, Cell Dynamics and Genomics
  12. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
  13. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
  14. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  15. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  16. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  17. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  18. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  19. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. CHRNA1 and its correlated-myogenesis/cell cycle genes are prognosis-related markers of metastatic melanoma, Biochemistry and Biophysics Reports, 33, 2023
  2. Microarray transcriptome datasets of maternal-zygotic DNA methyltransferase 3aa-/- zebrafish during early developmental stages, Data in Brief, 47, 2023
  3. Biomimetic antimicrobial polymers – Design, characterization, antimicrobial and novel applications, WIREs Nanomedicine & Nanobiotechnology, 15, e1866, 2023
  4. Radiomic analysis for pretreatment prediction of recurrence post-radiotherapy in cervical squamous cell carcinoma cancer, Diagnostics, 12, 2346, 2022
  5. Understanding Breast cancers through spatial and high-resolution visualization using imaging technologies, Cancers, 14, 4080, 2022
  6. Methylome data derived from maternal-zygotic DNA methyltransferase 3aa-/- zebrafish, Data in Brief, 44, 108514, 2022
  7. Identification of aberrant transcription termination at specific gene loci with DNA hypomethylated transcription termination sites caused by DNA methyltransferase deficiency, Genes & Genetic Systems, 2022
  8. ★, Analysis of melanoma gene expression signatures at the single-cell level uncovers 45-gene signature related to prognosis, Biomedicines, 10(7), 1478, 2022
  9. ★, 3D in vitro co-culture disc for spatiotemporal image analysis of cancer-stromal cell interaction, Biomaterials Science, 9, 4448-4458, 2021
  10. Amphiphilic Polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria, Biomaterials Science, 9, 2758-2767, 2021
  11. Synthetic Biomimetic polymethacrylates: Promising platform for the design of anti-cyanobacterial and anti-algal agents, Polymers, 13, 1025, 2021
  12. ★, Anticancer polymers designed for killing dormant prostate cancer cells, Scientific Reports, 9, 1096, 2019
  13. Branched Poly(ethylene imine)s as Anti-algal and Anti-cyanobacterial Agents with Selective Flocculation Behavior to Cyanobacteria over Algae, Macromolecular Bioscience, 18, 1800187, 2018
  14. A 3D in vitro pericyte-supported microvessel model: visualisation and quantitative characterisation of multistep angiogenesis, Journal of Materials Chemistry B, 6, 1085-1094, 2018
  15. A vascular endothelial growth factor-dependent sprouting angiogenesis assay based on an in vitro human blood vessel model for the study of anti-angiogenic drugs, EBioMedicine, 27, 225-236, 2018
  16. Synthetic random copolymers as a molecular platform to mimic host-defense antimicrobial peptides, Bioconjugate Chemistry, 28, 1340-1350, 2017
  17. Bundle gel fibers with tunable microenvironment for in vitro neuron cell guiding, ACS Applied Materials and Interfaces, 9, 43250-43257, 2017
  18. A vascular permeability assay using an in vitro human microvessel model mimicking the inflammatory condition, Nanotheranostics, 1, 103-113, 2017
  19. ★, Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography, Scientific Reports, 7, 42426, 2017
  20. Cationic amphiphilic polymers with antimicrobial activity for oral care applications: Eradication of S. mutans biofilm, Biomacromolecules, 18, 257-265, 2017
  21. A cationic amphiphilic random copolymer with pH-responsive activity against methicillin-resistant Staphylococcus aureus, PLoS ONE, 12, e0169262, 2017
  22. Radical-medicated end-group transformation of amphiphilic methacrylate random copolymers for modulation of antimicrobial and hemolytic activities, Journal of Polymer Science Part A: Polymer Chemistry, 55, 304-312, 2017
  23. Multiwalled carbon nanotube reinforced biomimetic bundled gel fibres, Biomaterials Science, 4, 1197-1201, 2016
  24. Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity, Chemical Communications, 51, 12597-12600, 2015
  25. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques, Mucosal Immunology, 8, 1144-1153, 2015
  26. Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers, Macromolecular Bioscience, 13, 1285-1299, 2013
  27. Nanogel-based antigen-delivery system for nasal vaccines, Biotechnology and Genetic Engineering Reviews, 29, 61-72, 2013
  28. Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effectcive protein refolding, RSC Advences, 3, 25716-25718, 2013
  29. Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation, Biomaterials Science, 1, 842-849, 2013
  30. Activation of platelets upon contact with a vitamin E-coated/non-coated surface, Journal of Artificial Organs, 16, 193-205, 2013
  31. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae, Infection and Immunity, 81, 1625-1634, 2013
  32. Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle, Biomacromolecules, 14, 56-63, 2013
  33. Artificial chaperone polysaccharide nanogels for protein delivery: a thermodynamic study of protein-nanogel interactions using fluorescence correlation spectroscopy, Current Drug Discovery Technologies, 8, 308-313, 2011
  34. Amphiphilic polysaccharide nanoballs: a new building block for nanogel biomedical engineering and artificial chaperones, ACS nano, 5, 337-345, 2011
  35. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines, Nature materials, 9, 572-578, 2010
  36. The binding of pullulan modified cholesteryl nanogels to AB oligomers and their suppression of cytotoxicity, Biomaterials, 30, 5583-5591, 2009

Publications such as books

  1. 2015, Encyclopedia of Polymeric Nanomaterials, Vaccine, Springer, 2015, English, Haruko Takahashi, Kazunari Akiyoshi

Invited Lecture, Oral Presentation, Poster Presentation

  1. Disc-type 3D in vitro cancer modeling system for spatiotemporal visualization of cell-cell interaction, Haruko Takahashi, 2nd International Congress of Asian Oncology Society, 2022/06, With Invitation, English
  2. Synthetic anti-cancer polymer therapeutics to target cancer cell membrane, Haruko Takahashi, 3rd International Conference on Materials Science & Engineering (Materials2022), 2022/04, With Invitation, English
  3. Engineering-assisted muscle-tendon assemble organoids (assembloids) for analysis of musculotendinous junction formation mechanism, Haruko Takahashi, Shin-Yu Lee, Ikkei Kumoyama, Ruolin Hao, Hikaru Ikeda, Mingcong Xu, Mototsugu Eiraku, Yutaka Kikuchi, 44th Annual Meeting of the Molecular Biology Society of Japan, 2021/12, With Invitation, English
  4. 3D in vitro cancer and stromal cell co-culture disc for spatiotemporal image analysis, Haruko Takahashi, Yutaka Kikuchi, 1st JCA-AACR Precision Cancer Medicine International Conference, 2021/09, Without Invitation, English
  5. Integrative understanding of musculotendinous junction formation and maturation during musculoskeletal system development in mammals, Haruko Takahashi, Yasuhisa Yamamoto, Ikkei Kumoyama, Hikaru Ikeda, Mingcong Xu, Yutaka Kikuchi, 43rd Annual Meeting of the Molecular Biology Society of Japan, 2020/12, With Invitation, English
  6. Molecular engineering of antimicrobial polymers to target biofilms, Haruko Takahashi, ACS 257th National Meeting & Exposition, 2019/04, With Invitation, English

Social Activities

Other Social Contributions

  1. Interview in "Female Researchers", Science Communication Fellowship Program, 2019/05, Interviewee