Isao Hirata

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
isaohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2001/04/01, 2002/03/31, Foundation for Biomedical Research and Innovation, Part-Time Special Postdoctoral Researcher
  • 2002/04/01, 2007/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Research Associate
  • 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Kyoto University, Graduate School, Division of Engineering, Polymer Science, Japan, 1998/04, 2001/03
  • Kyoto University, Graduate School, Division of Engineering, Polymer Science, Japan, 1996/04, 1998/03
  • Kyoto University, Faculty of Engineering, Polymer Science, Japan, 1992/04, 1996/03

Academic Degrees

  • PhD (Engineering), Kyoto University
  • Master of Engineering, Kyoto University
  • Bachelor of Engineering, Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering

Research Keywords

  • nano-surface
  • biocompatibility
  • surface plasmon resonance
  • mesenchymal stem cell
  • Bone regeneration

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, General Chemistry
  2. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  3. 2025, Undergraduate Education, 1Term, Dental Materials and Devices I
  4. 2025, Undergraduate Education, 2Term, Dental Materials and Devices II
  5. 2025, Undergraduate Education, 3Term, Dental Materials and Devices Practice I
  6. 2025, Undergraduate Education, 4Term, Dental Materials and Devices Practice II
  7. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  8. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  9. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  10. 2025, Undergraduate Education, 2Term, Precision Casting Science
  11. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biomaterials
  12. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biomaterials
  13. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biomaterials
  14. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biomaterials

Research Activities

Academic Papers

  1. Structure and function of engineered stromal cell-derived factor-1a, Dental Materials Journal, 43(2), 286-293, 20240325
    Link to Paper Search Results by DOI
  2. Effect of laser engraving on shear bond strength of polyetheretherketone to indirect composite and denture-base resins, JOURNAL OF DENTAL SCIENCES, 19(1), 32-38, 202401
    Link to Paper Search Results by DOI
  3. Nd:YVO4 laser groove treatment can improve the shear bond strength between dental PEEK and adhesive resin cement with an adhesive system, DENTAL MATERIALS JOURNAL, 41(3), 382-391, 202206
    Link to Paper Search Results by DOI
  4. Mucoadhesion of polyamphoteric hydrogels synthesized from acrylic acid and N,N-dimethylaminopropyl acrylamide, INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, 104, 202101
    Link to Paper Search Results by DOI
  5. Evaluation of a peptide motif designed for protein tethering to polymer surfaces, JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 32(1), 76-92, 20210102
    Link to Paper Search Results by DOI
  6. Oriented immobilization of basic fibroblast growth factor: Bioengineered surface design for the expansion of human mesenchymal stromal cells, SCIENTIFIC REPORTS, 10(1), 2020
  7. Epidermal growth factor-immobilized surfaces for the selective expansion of neural progenitor cells derived from induced pluripotent stem cells, BIOTECHNOLOGY AND BIOENGINEERING, 117(9), 2741-2748, 202009
    Link to Paper Search Results by DOI
  8. Effect of laser groove treatment on shear bond strength of resin-based luting agent to polyetheretherketone (PEEK), JOURNAL OF PROSTHODONTIC RESEARCH, 63(1), 52-57, 201901
    Link to Paper Search Results by DOI
  9. Effect of microslit retention on the bond strength of zirconia to dental materials, DENTAL MATERIALS JOURNAL, 38(6), 1043-1052, 201912
    Link to Paper Search Results by DOI
  10. Enhancement of calcification by osteoblasts cultured on hydroxyapatite surfaces with adsorbed inorganic polyphosphate, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 54(6), 449-457, 201806
    Link to Paper Search Results by DOI
  11. Formation of chemical bonds on zirconia surfaces with acidic functional monomers, JOURNAL OF ORAL SCIENCE, 60(2), 187-193, 201806
    Link to Paper Search Results by DOI
  12. Effect of ozonated water on the surface roughness of dental stone casts, DENTAL MATERIALS JOURNAL, 37(5), 740-745, 201810
    Link to Paper Search Results by DOI
  13. Molecular level analyses of mechanical properties of PTFE sterilized by Co-​60 gamma-​ray irradiation for clinical use, Radiation Physics and Chemistry, 139, 126-131, 2017
    Link to Paper Search Results by DOI
  14. Effect of wettability by surface treatment for zirconia on bonding between zirconia material and indirect composite resin, Journal of Nippon Academy of Dental Technology, 37(2), 89-96, 2016
  15. The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity, DENTAL MATERIALS JOURNAL, 34(1), 31-40, 201502
    Link to Paper Search Results by DOI
  16. Effect of thione primers on adhesive bonding between an indirect composite material and Ag-Pd-Cu-Au alloy, DENTAL MATERIALS JOURNAL, 33(5), 681-688, 201410
    Link to Paper Search Results by DOI
  17. Osteoclast Response to Bioactive Surface Modification of Hydroxyapatite, Open Journal of Stomatology, 4(7), 340-344, 201407
  18. Influence of alkyl chain length on calcium phosphate deposition onto titanium surfaces modified with alkylphosphonic acid monolayers, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 101(8), 2267-2272, 201308
    Link to Paper Search Results by DOI
  19. New development of carbonate apatite-chitosan scaffold based on lyophilization technique for bone tissue engineering, DENTAL MATERIALS JOURNAL, 32(2), 317-325, 201304
    Link to Paper Search Results by DOI
  20. Bioactive Surface Modification of Hydroxyapatite, BIOMED RESEARCH INTERNATIONAL, 2013
    Link to Paper Search Results by DOI
  21. Real time assessment of surface interactions with a titanium passivation layer by surface plasmon resonance, ACTA BIOMATERIALIA, 8(3), 1260-1266, 201203
    Link to Paper Search Results by DOI
  22. A novel glass ionomer cement containing MgCO3 apatite induced the increased proliferation and differentiation of human pulp cells in vitro, DENTAL MATERIALS JOURNAL, 31(5), 772-778, 201209
    Link to Paper Search Results by DOI
  23. Fabrication of a highly deacetylated chitosan scaffold for tissue engineering, Hiroshima Daigaku Shigaku Zasshi, 44(1), 10-15, 2012
  24. High-​throughput study of protein-​surface interactions using a surface plasmon resonance imaging apparatus, ACS Symposium Series, 1120, 695-708, 2012
  25. Detection of synthetic RGDS(PO3H2)PA peptide adsorption using a titanium surface plasmon resonance biosensor, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 22(3), 657-661, 201103
    Link to Paper Search Results by DOI
  26. Chemical analyses of hydroxyapatite formation on SAM surfaces modified with COOH, NH2, CH3, and OH functions, DENTAL MATERIALS JOURNAL, 29(4), 438-445, 201007
    Link to Paper Search Results by DOI
  27. Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces, DENTAL MATERIALS JOURNAL, 29(6), 668-672, 201011
    Link to Paper Search Results by DOI
  28. Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents, DENTAL MATERIALS JOURNAL, 28(2), 234-242, 200903
    Link to Paper Search Results by DOI
  29. Complement activation on surfaces carrying amino groups, BIOMATERIALS, 29(4), 407-417, 200802
    Link to Paper Search Results by DOI
  30. Influence of the chemical structure of functional monomers on their adhesive performance., J Dent Res, 87, 757-761, 20081101
  31. Higher Concentrations of Fluoride Ions Dramatically Inhibit the Survival of Osteoblasts., J Oral Tissue Engin, 6, 3-8, 20081101
  32. Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts, JOURNAL OF DENTISTRY, 36(12), 993-998, 200812
    Link to Paper Search Results by DOI
  33. High-throughput immunophenotyping by surface plasmon resonance imaging, ANALYTICAL CHEMISTRY, 79(22), 8616-8623, 20071115
    Link to Paper Search Results by DOI
  34. ★, Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds, JOURNAL OF ARTIFICIAL ORGANS, 10(4), 212-217, 2007
    Link to Paper Search Results by DOI
  35. Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups, Dental Materials Journal, 26(6), 814-819, 20071101
  36. Immobilization of simulated reducing agent at the surface of SiO2 fillers in dental composite resins, Dental Materials Journal, 26(4), 568-574, 20070701
  37. Osteoblastactivity on the CO3Ap-collagen sponge scaffolds with different carbonate contents in apatite crystals., Arch. BioCeramics Res., 7, 25-28, 20070101
  38. Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation, BIOMATERIALS, 28(6), 1048-1060, 200702
    Link to Paper Search Results by DOI
  39. Apoptotic and necrotic influence of dental resin polymerization initiators in human gingival fibroblast cultures, DENTAL MATERIALS JOURNAL, 26(6), 861-869, 200711
    Link to Paper Search Results by DOI
  40. Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold bioniaterials, DENTAL MATERIALS JOURNAL, 26(4), 487-492, 200707
    Link to Paper Search Results by DOI
  41. Development of surface plasmon resonance imaging apparatus for high-throughput study of protein-surface interactions, e-Journal of Surface Science and Nanotech, 4, 201-207, 20060201
  42. Nano-biochemical surface modification of titanium implant with phospho-amino acid., the 2006 Spring Scientific Meeting of the Korean Academy of Prosthodontics & the 3rd international joint meeting with Japan Prosthodontic Society, 20060428
  43. Osteoblast Behavior at the surface of CO(3)Ap-collagen sponges, BIOCERAMICS 18, PTS 1 AND 2, 309-311, 989-992, 2006
    Link to Paper Search Results by DOI
  44. Detailed consideration of physicochemical properties of CO(3)apatites as biomaterials in relation to carbonate content using ICP, X-ray diffraction, FT-IR, SEM, and HR-TEM, DENTAL MATERIALS JOURNAL, 25(3), 597-603, 200609
    Link to Paper Search Results by DOI
  45. Analysis of chemical interaction of 4-MET with hydroxyapatite using XPS, DENTAL MATERIALS JOURNAL, 25(4), 645-649, 200612
    Link to Paper Search Results by DOI
  46. Advantages of TOF-SIMS analysis of hydroxyapatite and fluorapatite in comparison with XRD, HR-TEM and FT-IR, DENTAL MATERIALS JOURNAL, 24(4), 508-514, 200512
    Link to Paper Search Results by DOI
  47. SEM observation of collagen fibrils secreted from the body surface of osteoblasts on a CO(3)apatite-collagen sponge, DENTAL MATERIALS JOURNAL, 24(3), 460-464, 200509
    Link to Paper Search Results by DOI
  48. ★, Simple method for preparation of ultra-thin poly(N-isopropylacrylamide) hydrogel layers and characterization of their thermo-responsive properties, Polymer, 45(16), 5569-5578, 20040701
  49. Characterization of CO(3)Ap-collagen sponges using x-ray high-resolution microtomography, BIOMATERIALS, 25(13), 2577-2583, 200406
    Link to Paper Search Results by DOI
  50. Osteoblast proliferation behavior and bone formation on and in CO(3)apatite-collagen sponges with a porous hydroxyapatite frame, DENTAL MATERIALS JOURNAL, 23(3), 258-264, 200409
    Link to Paper Search Results by DOI
  51. Deposition of Complement Protein, C3b, on Mixed Self-Assembled Monolayers carrying Surface Hydroxyl and Methyl Groups studied by Surface Plasmon Resonance, Journal of Biomedical Material Research, 66A, 669-676, 20030401
  52. Investigation on light-addressable potentiometric sensor as a possible cell-semiconductor hybrid, 18, 1509-1514, 20030401
  53. Hydrophilic modification of a polyimide film surface, Transactions of Fusion Science and Technology, 14(3), 351-361, 20000401
  54. Study of complement activation on well-defined surfaces using surface plasmon resonance, Elsevier= Colloid and Surface= B:Biointerface, 18(3,4), 285-292, 20000401
  55. Surface modification of Si3N4-coated silicon plate for investigation of living cells, Japanese Journal of Applied Physics, 39(11), 6441-6442, 20000401
  56. Atomic Force Microscopic Analysis of a Porous Membrane with pH-Sensitive Molecular Valves, Macromolecules, 31(11), 3671-3678, 19980401
  57. Photolysis of a Fluorinated Polymer Film by Vacuum Ultraviolet Radiation, Journal of Polymer Science, 36(13), 2215-2222, 19980401
  58. Atomic Force Microscopic Images of Solvated Polymer Brushes, Langmuir, 13(11), 3063-3066, 19970401
  59. TEM/EDX Observation of Micro-beads of Magnetically Activated Cell Sorting (MACS) System and Separation Trial of Mouse Mesenchymal Stem Cells from Bone Marrow Cells by MACS System, J Oral Tissue Engin, 6, 33-40, 20081101

Invited Lecture, Oral Presentation, Poster Presentation

  1. Development of micropore-forming polylactide filaments for use in 3D printing, Isao Hirata, Koichi Kato, The 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English, UNIVERSITAS AIRLANGGA, Indonesia, Online(Host: Indonesia)
  2. Development of biodegradable composite filament for 3D printer -Micropore formation on 3D printed scaffold-, Hirata Isao, Kato Koichi, 2020/04/18, Without Invitation, Japanese, The Japanese Society for Dental Materials and Devices, Shiojiri
  3. Oriented immobilization of basic fibroblast growth factor: A novel bioengineered surface design for the expansion of mesenchymal stem cells, Ajay Shakya, Eiji Imado, Nguyen Kim Phuong, Tamamo Matsuyama, Kotaro Horimoto, Isao Hirata, Koichi Kato, Society for Biomaterials 2019, 2019/04/03, Without Invitation, English
  4. An approach to selectively expand stem cells: Oriented immobilization of growth factors onto solid surfaces, Koichi Kato, Ajay Shakya, Isao Hirata, APAN Deantal Telemedicine, 2019/02/19, Without Invitation, English
  5. Development of micropore-forming polylactide filaments for use in 3D printing, Isao Hirata, Koichi Kato, The 40th annual meeting of the Japanese Society for Biomaterials, 2018/11/12, Without Invitation, Japanese, the Japanese Society for Biomaterials, Kobe, Japan
  6. Surface-immobilization of neurotrophin-4 mimetic peptide for the selective binding of a TrkB-expressing cell population from iPS cells, Haruhisa Watanabe, Haruhisa Watanabe, Aimi N. Abdullah, Yuuka Yamauchi, Isao Hirata, Koichi Kato, THE 6TH JAPAN-CHINA SYMPOSIUM ON NANOMEDICINE, 2018/05/25, Without Invitation, English
  7. Oriented immobilization of basic fibroblast growth facor on alkanethiol monolayers for stem cell expansion, AJAY SHAKYA, AJAY SHAKYA, ISAO HIRATA, KOICHI KATO, THE 6TH JAPAN-CHINA SYMPOSIUM ON NANOMEDICINE, 2018/05/25, Without Invitation, English
  8. Immobilization of basic fibroblast growth factor onto bioengineered surfaces: A novel approach for the efficient expansion of mesenchymal stem cells, AJAY SHAKYA, AJAY SHAKYA, ISAO HIRATA, KOICHI KATO, 7th Hiroshima Conference, 2018/03/29, Without Invitation, English, Hiroshima,Japan
  9. Evaluation of acid-corrosion and molecule-adhesion of titanium passivation layer by surface plasmon resonance analysis, Isao Hirata, Pacific Rim Nano Medicine Symposium 2018 -The 9th Japan-Taiwan Symposium on Nanomedicine-, 2018/01/25, With Invitation, English, Riken, Compass to Healthy Life Research Complex Program (RCH), Kobe, Japan
  10. Bioengineered Surface Design for Mesenchymal Stem Cell Culture, Isao Hirata, Ajay Shakya, Nguyen Kim Phuong, and Koichi Kato, The 5th China-Japan Symposium on Nanomedicine, 2017/09/16, With Invitation, English, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou, China
  11. Effect of Molecular Crowding on the Dynamics of Antigen-antibody Interactions at Solid/Liquid Interface, Koichi Kato, Isao Hirata, International Workshop on Nanodevice Technologies 2017 (IWNT2017), 2017/03/02, Without Invitation, English, Research Institute for Nanodevice and Bio Systems, Hiroshima University, Higashi-Hiroshima, Japan
  12. Effect of Mesenchymal Stem Cells from Surface Functional Groups on Mixed Self Assembled Monolayer, Hirata I, Veronica SR, Tania S, Yamauchi Y, Kanawa M, Kato Y, Kato K, International Dental Materials Congress 2016, 2016/11/04, Without Invitation, English, The Japanese Society for Dental Materials and Devices The Indonesian Society for Dental Materials Science and Technology Universitas Airlangga, Bali, Indonesia
  13. Proliferation of mesenchymal stem cells seeded on biodegradable hydroxyapatite-chitosan porous scaffolds, Ariani MD, Salim S, Hirata I, Kato K, The International Dental Materials Congress 2016, 2016/11/04, Without Invitation, English, The Japanese Society for Dental Materials and Devices The Indonesian Society for Dental Materials Science and Technology Universitas Airlangga, Bali, Indonesia
  14. Designed SDF-1 chimeric protein for bone tissue regeneration, Date T, Hirata I, Hattori S, Matsuda C, Nakano A, Yamakado N, Tanimoto K, Kato K, The International Dental Materials Congress 2016, 2016/11/04, Without Invitation, English, The Japanese Society for Dental Materials and Devices The Indonesian Society for Dental Materials Science and Technology Universitas Airlangga, Bali, Indonesia
  15. Analysis of chemical interaction between alumina blasted zirconia and functional monomers, Otaku Mai, Shimoe S, Hirata I, Iwaguro S, Kawamura M, Satoda T, Nippon Academy of Dental Technology 38th Congress, 2016/09/10, Without Invitation, Japanese, Nippon Academy of Dental Technology, Nara, Japan
  16. Development of Mesenchymal Stem Cell Culture Substrates Used in Serum-Free Medium, Hirata I, Yamauchi Y, Kanawa M, Kato Y, Kato K, The 88th Annual Meeting of Japanese Tissue Culture Association, 2015/05/26, Without Invitation, Japanese, The Japanese Tissue Culture Association, Hiroshima, Japan

Patented

  1. Patent, 2695934, 2019/01/09

External Funds

Acceptance Results of Competitive Funds

  1. JSPS KAKENHI(Grant-in-Aid for Scientific Research (C)), Designing biomaterials for in situ tongue regeneration, 2023/04/01, 2026/03/31
  2. JSPS KAKENHI(Grant-in-Aid for Scientific Research (C)), Three-dimensional molding and functional control of carbonate-apatite composite scaffolds, 2023/04/01, 2027/03/31
  3. 2021/04/01, 2025/03/31
  4. 2021/04/01, 2024/03/31
  5. 2020/04/01, 2023/03/31
  6. 2020/04/01, 2024/03/31
  7. Fund for the Promotion of Joint International Research, Fostering Joint International Research (B), Grants-in-Aid for Scientific Research, Strategy for spatially-controlled tissue regeneration, 2019/10, 2023/03
  8. 2017/04/01, 2020/03/31
  9. KAKENHI, Development of Resin and Powder mixed biodegradable filament for 3D printing system, 2016/04/01, 2018/03/31
  10. KAKENHI, Development of new micro-maintenance for expansion of application area of zirconia, 2016/04/01, 2019/03/31
  11. Grant-in-Aid for Scientific Research (B), Design of culture substrate for large-scale preparation of epithelial cell derived from iPS cell, 2016/04/01, 2019/03/31
  12. KAKENHI, 2013, 2015
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  13. KAKENHI, 2013, 2015
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  14. KAKENHI, 2012, 2014
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  15. KAKENHI, 2012, 2014
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  16. KAKENHI, Effect of messencymal stem cells proliferation and differentiationon self-assembled monolayer using serum-free medium, 2011, 2012
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  17. KAKENHI, Higher biofunctional nano-surface modification for development of histocompatibility typed titanium implants, 2009, 2011
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  18. KAKENHI, Development of functional titanium implant for bone attachment, 2008, 2009
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  19. KAKENHI, Affinity chemical modification and functional control onto carbonate-apatite composite scaffolds, 2006, 2009
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  20. 2006
  21. KAKENHI, 2006, 2007
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  22. KAKENHI, High functional nanobio surface modification of titanium implant with bone morphogenetic protein, 2006, 2007
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  23. KAKENHI, 2004, 2005
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  24. KAKENHI, 2004, 2005
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  25. 2004
  26. KAKENHI, Development of functional Ti implants with release of growth factors, 2004, 2005
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  27. KAKENHI, 2003, 2005
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  28. KAKENHI, Creation of high-quality COaAp-collagen composites for reconstruction and regeneration of alveolar bone, 2002, 2005
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Social Activities

Organizing Academic Conferences, etc.

  1. The 4th Japan-China Symposium on Nanomedicine, Local Secretariat, 2016/05, 2016/05
  2. The 2nd Japan-China Symposium on Nanomedicine, Local Secretariat, 2014/05, 2014/05
  3. 2011/05

History as Peer Reviews of Academic Papers

  1. 2020, Dental Materials Journal, 1
  2. 2019, Journal of Biomaterials Applications, 1
  3. 2018, Dental Materials Journal, 2
  4. 2018, Journal of Artificial Organs, 1
  5. 2017, Dental Materials Journal, 1
  6. 2017, Journal of Biomaterials Applications, 1
  7. 2016, PLOS ONE, 1
  8. 2015, Dental Materials Journal, 1
  9. 2013, Dental Materials Journal, 1
  10. 2011, Journal of Artificial Organs, 1
  11. 2011, Dental Materials Journal, 2
  12. 2010, Langmuir, 1