Isao Hirata
Last Updated :2025/04/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
- E-mail
- isao
hiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 2001/04/01, 2002/03/31, Foundation for Biomedical Research and Innovation, Part-Time Special Postdoctoral Researcher
- 2002/04/01, 2007/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Research Associate
- 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
- 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
- 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
Educational Backgrounds
- Kyoto University, Graduate School, Division of Engineering, Polymer Science, Japan, 1998/04, 2001/03
- Kyoto University, Graduate School, Division of Engineering, Polymer Science, Japan, 1996/04, 1998/03
- Kyoto University, Faculty of Engineering, Polymer Science, Japan, 1992/04, 1996/03
Academic Degrees
- PhD (Engineering), Kyoto University
- Master of Engineering, Kyoto University
- Bachelor of Engineering, Kyoto University
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
In Charge of Primary Major Programs
Research Fields
- Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering
Research Keywords
- nano-surface
- biocompatibility
- surface plasmon resonance
- mesenchymal stem cell
- Bone regeneration
Educational Activity
Course in Charge
- 2025, Liberal Arts Education Program1, 2Term, General Chemistry
- 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
- 2025, Undergraduate Education, 1Term, Dental Materials and Devices I
- 2025, Undergraduate Education, 2Term, Dental Materials and Devices II
- 2025, Undergraduate Education, 3Term, Dental Materials and Devices Practice I
- 2025, Undergraduate Education, 4Term, Dental Materials and Devices Practice II
- 2025, Undergraduate Education, First Semester, Dental Research Practices I
- 2025, Undergraduate Education, Second Semester, Dental Research Practices II
- 2025, Undergraduate Education, First Semester, Dental Research Practices III
- 2025, Undergraduate Education, 2Term, Precision Casting Science
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biomaterials
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biomaterials
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biomaterials
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biomaterials
Research Activities
Academic Papers
- Structure and function of engineered stromal cell-derived factor-1a, Dental Materials Journal, 43(2), 286-293, 20240325
- Effect of laser engraving on shear bond strength of polyetheretherketone to indirect composite and denture-base resins, JOURNAL OF DENTAL SCIENCES, 19(1), 32-38, 202401
- Nd:YVO4 laser groove treatment can improve the shear bond strength between dental PEEK and adhesive resin cement with an adhesive system, DENTAL MATERIALS JOURNAL, 41(3), 382-391, 202206
- Mucoadhesion of polyamphoteric hydrogels synthesized from acrylic acid and N,N-dimethylaminopropyl acrylamide, INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, 104, 202101
- Evaluation of a peptide motif designed for protein tethering to polymer surfaces, JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 32(1), 76-92, 20210102
- Oriented immobilization of basic fibroblast growth factor: Bioengineered surface design for the expansion of human mesenchymal stromal cells, SCIENTIFIC REPORTS, 10(1), 2020
- Epidermal growth factor-immobilized surfaces for the selective expansion of neural progenitor cells derived from induced pluripotent stem cells, BIOTECHNOLOGY AND BIOENGINEERING, 117(9), 2741-2748, 202009
- Effect of laser groove treatment on shear bond strength of resin-based luting agent to polyetheretherketone (PEEK), JOURNAL OF PROSTHODONTIC RESEARCH, 63(1), 52-57, 201901
- Effect of microslit retention on the bond strength of zirconia to dental materials, DENTAL MATERIALS JOURNAL, 38(6), 1043-1052, 201912
- Enhancement of calcification by osteoblasts cultured on hydroxyapatite surfaces with adsorbed inorganic polyphosphate, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 54(6), 449-457, 201806
- Formation of chemical bonds on zirconia surfaces with acidic functional monomers, JOURNAL OF ORAL SCIENCE, 60(2), 187-193, 201806
- Effect of ozonated water on the surface roughness of dental stone casts, DENTAL MATERIALS JOURNAL, 37(5), 740-745, 201810
- Molecular level analyses of mechanical properties of PTFE sterilized by Co-60 gamma-ray irradiation for clinical use, Radiation Physics and Chemistry, 139, 126-131, 2017
- Effect of wettability by surface treatment for zirconia on bonding between zirconia material and indirect composite resin, Journal of Nippon Academy of Dental Technology, 37(2), 89-96, 2016
- The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity, DENTAL MATERIALS JOURNAL, 34(1), 31-40, 201502
- Effect of thione primers on adhesive bonding between an indirect composite material and Ag-Pd-Cu-Au alloy, DENTAL MATERIALS JOURNAL, 33(5), 681-688, 201410
- Osteoclast Response to Bioactive Surface Modification of Hydroxyapatite, Open Journal of Stomatology, 4(7), 340-344, 201407
- Influence of alkyl chain length on calcium phosphate deposition onto titanium surfaces modified with alkylphosphonic acid monolayers, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 101(8), 2267-2272, 201308
- New development of carbonate apatite-chitosan scaffold based on lyophilization technique for bone tissue engineering, DENTAL MATERIALS JOURNAL, 32(2), 317-325, 201304
- Bioactive Surface Modification of Hydroxyapatite, BIOMED RESEARCH INTERNATIONAL, 2013
- Real time assessment of surface interactions with a titanium passivation layer by surface plasmon resonance, ACTA BIOMATERIALIA, 8(3), 1260-1266, 201203
- A novel glass ionomer cement containing MgCO3 apatite induced the increased proliferation and differentiation of human pulp cells in vitro, DENTAL MATERIALS JOURNAL, 31(5), 772-778, 201209
- Fabrication of a highly deacetylated chitosan scaffold for tissue engineering, Hiroshima Daigaku Shigaku Zasshi, 44(1), 10-15, 2012
- High-throughput study of protein-surface interactions using a surface plasmon resonance imaging apparatus, ACS Symposium Series, 1120, 695-708, 2012
- Detection of synthetic RGDS(PO3H2)PA peptide adsorption using a titanium surface plasmon resonance biosensor, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 22(3), 657-661, 201103
- Chemical analyses of hydroxyapatite formation on SAM surfaces modified with COOH, NH2, CH3, and OH functions, DENTAL MATERIALS JOURNAL, 29(4), 438-445, 201007
- Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces, DENTAL MATERIALS JOURNAL, 29(6), 668-672, 201011
- Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents, DENTAL MATERIALS JOURNAL, 28(2), 234-242, 200903
- Complement activation on surfaces carrying amino groups, BIOMATERIALS, 29(4), 407-417, 200802
- Influence of the chemical structure of functional monomers on their adhesive performance., J Dent Res, 87, 757-761, 20081101
- Higher Concentrations of Fluoride Ions Dramatically Inhibit the Survival of Osteoblasts., J Oral Tissue Engin, 6, 3-8, 20081101
- Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts, JOURNAL OF DENTISTRY, 36(12), 993-998, 200812
- High-throughput immunophenotyping by surface plasmon resonance imaging, ANALYTICAL CHEMISTRY, 79(22), 8616-8623, 20071115
- ★, Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds, JOURNAL OF ARTIFICIAL ORGANS, 10(4), 212-217, 2007
- Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups, Dental Materials Journal, 26(6), 814-819, 20071101
- Immobilization of simulated reducing agent at the surface of SiO2 fillers in dental composite resins, Dental Materials Journal, 26(4), 568-574, 20070701
- Osteoblastactivity on the CO3Ap-collagen sponge scaffolds with different carbonate contents in apatite crystals., Arch. BioCeramics Res., 7, 25-28, 20070101
- Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation, BIOMATERIALS, 28(6), 1048-1060, 200702
- Apoptotic and necrotic influence of dental resin polymerization initiators in human gingival fibroblast cultures, DENTAL MATERIALS JOURNAL, 26(6), 861-869, 200711
- Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold bioniaterials, DENTAL MATERIALS JOURNAL, 26(4), 487-492, 200707
- Development of surface plasmon resonance imaging apparatus for high-throughput study of protein-surface interactions, e-Journal of Surface Science and Nanotech, 4, 201-207, 20060201
- Nano-biochemical surface modification of titanium implant with phospho-amino acid., the 2006 Spring Scientific Meeting of the Korean Academy of Prosthodontics & the 3rd international joint meeting with Japan Prosthodontic Society, 20060428
- Osteoblast Behavior at the surface of CO(3)Ap-collagen sponges, BIOCERAMICS 18, PTS 1 AND 2, 309-311, 989-992, 2006
- Detailed consideration of physicochemical properties of CO(3)apatites as biomaterials in relation to carbonate content using ICP, X-ray diffraction, FT-IR, SEM, and HR-TEM, DENTAL MATERIALS JOURNAL, 25(3), 597-603, 200609
- Analysis of chemical interaction of 4-MET with hydroxyapatite using XPS, DENTAL MATERIALS JOURNAL, 25(4), 645-649, 200612
- Advantages of TOF-SIMS analysis of hydroxyapatite and fluorapatite in comparison with XRD, HR-TEM and FT-IR, DENTAL MATERIALS JOURNAL, 24(4), 508-514, 200512
- SEM observation of collagen fibrils secreted from the body surface of osteoblasts on a CO(3)apatite-collagen sponge, DENTAL MATERIALS JOURNAL, 24(3), 460-464, 200509
- ★, Simple method for preparation of ultra-thin poly(N-isopropylacrylamide) hydrogel layers and characterization of their thermo-responsive properties, Polymer, 45(16), 5569-5578, 20040701
- Characterization of CO(3)Ap-collagen sponges using x-ray high-resolution microtomography, BIOMATERIALS, 25(13), 2577-2583, 200406
- Osteoblast proliferation behavior and bone formation on and in CO(3)apatite-collagen sponges with a porous hydroxyapatite frame, DENTAL MATERIALS JOURNAL, 23(3), 258-264, 200409
- Deposition of Complement Protein, C3b, on Mixed Self-Assembled Monolayers carrying Surface Hydroxyl and Methyl Groups studied by Surface Plasmon Resonance, Journal of Biomedical Material Research, 66A, 669-676, 20030401
- Investigation on light-addressable potentiometric sensor as a possible cell-semiconductor hybrid, 18, 1509-1514, 20030401
- Hydrophilic modification of a polyimide film surface, Transactions of Fusion Science and Technology, 14(3), 351-361, 20000401
- Study of complement activation on well-defined surfaces using surface plasmon resonance, Elsevier= Colloid and Surface= B:Biointerface, 18(3,4), 285-292, 20000401
- Surface modification of Si3N4-coated silicon plate for investigation of living cells, Japanese Journal of Applied Physics, 39(11), 6441-6442, 20000401
- Atomic Force Microscopic Analysis of a Porous Membrane with pH-Sensitive Molecular Valves, Macromolecules, 31(11), 3671-3678, 19980401
- Photolysis of a Fluorinated Polymer Film by Vacuum Ultraviolet Radiation, Journal of Polymer Science, 36(13), 2215-2222, 19980401
- Atomic Force Microscopic Images of Solvated Polymer Brushes, Langmuir, 13(11), 3063-3066, 19970401
- TEM/EDX Observation of Micro-beads of Magnetically Activated Cell Sorting (MACS) System and Separation Trial of Mouse Mesenchymal Stem Cells from Bone Marrow Cells by MACS System, J Oral Tissue Engin, 6, 33-40, 20081101
Invited Lecture, Oral Presentation, Poster Presentation
- Development of micropore-forming polylactide filaments for use in 3D printing, Isao Hirata, Koichi Kato, The 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English, UNIVERSITAS AIRLANGGA, Indonesia, Online(Host: Indonesia)
- Development of biodegradable composite filament for 3D printer -Micropore formation on 3D printed scaffold-, Hirata Isao, Kato Koichi, 2020/04/18, Without Invitation, Japanese, The Japanese Society for Dental Materials and Devices, Shiojiri
- Oriented immobilization of basic fibroblast growth factor: A novel bioengineered surface design for the expansion of mesenchymal stem cells, Ajay Shakya, Eiji Imado, Nguyen Kim Phuong, Tamamo Matsuyama, Kotaro Horimoto, Isao Hirata, Koichi Kato, Society for Biomaterials 2019, 2019/04/03, Without Invitation, English
- An approach to selectively expand stem cells: Oriented immobilization of growth factors onto solid surfaces, Koichi Kato, Ajay Shakya, Isao Hirata, APAN Deantal Telemedicine, 2019/02/19, Without Invitation, English
- Development of micropore-forming polylactide filaments for use in 3D printing, Isao Hirata, Koichi Kato, The 40th annual meeting of the Japanese Society for Biomaterials, 2018/11/12, Without Invitation, Japanese, the Japanese Society for Biomaterials, Kobe, Japan
- Surface-immobilization of neurotrophin-4 mimetic peptide for the selective binding of a TrkB-expressing cell population from iPS cells, Haruhisa Watanabe, Haruhisa Watanabe, Aimi N. Abdullah, Yuuka Yamauchi, Isao Hirata, Koichi Kato, THE 6TH JAPAN-CHINA SYMPOSIUM ON NANOMEDICINE, 2018/05/25, Without Invitation, English
- Oriented immobilization of basic fibroblast growth facor on alkanethiol monolayers for stem cell expansion, AJAY SHAKYA, AJAY SHAKYA, ISAO HIRATA, KOICHI KATO, THE 6TH JAPAN-CHINA SYMPOSIUM ON NANOMEDICINE, 2018/05/25, Without Invitation, English
- Immobilization of basic fibroblast growth factor onto bioengineered surfaces: A novel approach for the efficient expansion of mesenchymal stem cells, AJAY SHAKYA, AJAY SHAKYA, ISAO HIRATA, KOICHI KATO, 7th Hiroshima Conference, 2018/03/29, Without Invitation, English, Hiroshima,Japan
- Evaluation of acid-corrosion and molecule-adhesion of titanium passivation layer by surface plasmon resonance analysis, Isao Hirata, Pacific Rim Nano Medicine Symposium 2018
-The 9th Japan-Taiwan Symposium on Nanomedicine-, 2018/01/25, With Invitation, English, Riken, Compass to Healthy Life Research Complex Program (RCH), Kobe, Japan
- Bioengineered Surface Design for Mesenchymal Stem Cell Culture, Isao Hirata, Ajay Shakya, Nguyen Kim Phuong, and Koichi Kato, The 5th China-Japan Symposium on Nanomedicine, 2017/09/16, With Invitation, English, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences, Suzhou, China
- Effect of Molecular Crowding on the Dynamics of Antigen-antibody Interactions at Solid/Liquid Interface, Koichi Kato, Isao Hirata, International Workshop on Nanodevice Technologies 2017 (IWNT2017), 2017/03/02, Without Invitation, English, Research Institute for Nanodevice and Bio Systems, Hiroshima University, Higashi-Hiroshima, Japan
- Effect of Mesenchymal Stem Cells from Surface Functional Groups on Mixed Self Assembled Monolayer, Hirata I, Veronica SR, Tania S, Yamauchi Y, Kanawa M, Kato Y, Kato K, International Dental Materials Congress 2016, 2016/11/04, Without Invitation, English, The Japanese Society for Dental Materials and Devices
The Indonesian Society for Dental Materials Science and Technology
Universitas Airlangga, Bali, Indonesia
- Proliferation of mesenchymal stem cells seeded on biodegradable hydroxyapatite-chitosan porous scaffolds, Ariani MD, Salim S, Hirata I, Kato K, The International Dental Materials Congress 2016, 2016/11/04, Without Invitation, English, The Japanese Society for Dental Materials and Devices
The Indonesian Society for Dental Materials Science and Technology
Universitas Airlangga, Bali, Indonesia
- Designed SDF-1 chimeric protein for bone tissue regeneration, Date T, Hirata I, Hattori S, Matsuda C, Nakano A, Yamakado N, Tanimoto K, Kato K, The International Dental Materials Congress 2016, 2016/11/04, Without Invitation, English, The Japanese Society for Dental Materials and Devices
The Indonesian Society for Dental Materials Science and Technology
Universitas Airlangga, Bali, Indonesia
- Analysis of chemical interaction between alumina blasted zirconia and functional monomers, Otaku Mai, Shimoe S, Hirata I, Iwaguro S, Kawamura M, Satoda T, Nippon Academy of Dental Technology 38th Congress, 2016/09/10, Without Invitation, Japanese, Nippon Academy of Dental Technology, Nara, Japan
- Development of Mesenchymal Stem Cell Culture Substrates Used in Serum-Free Medium, Hirata I, Yamauchi Y, Kanawa M, Kato Y, Kato K, The 88th Annual Meeting of Japanese Tissue Culture Association, 2015/05/26, Without Invitation, Japanese, The Japanese Tissue Culture Association, Hiroshima, Japan
Patented
- Patent, 2695934, 2019/01/09
External Funds
Acceptance Results of Competitive Funds
- JSPS KAKENHI(Grant-in-Aid for Scientific Research (C)), Designing biomaterials for in situ tongue regeneration, 2023/04/01, 2026/03/31
- JSPS KAKENHI(Grant-in-Aid for Scientific Research (C)), Three-dimensional molding and functional control of carbonate-apatite composite scaffolds, 2023/04/01, 2027/03/31
- 2021/04/01, 2025/03/31
- 2021/04/01, 2024/03/31
- 2020/04/01, 2023/03/31
- 2020/04/01, 2024/03/31
- Fund for the Promotion of Joint International Research, Fostering Joint International Research (B), Grants-in-Aid for Scientific Research, Strategy for spatially-controlled tissue regeneration, 2019/10, 2023/03
- 2017/04/01, 2020/03/31
- KAKENHI, Development of Resin and Powder mixed biodegradable filament for 3D printing system, 2016/04/01, 2018/03/31
- KAKENHI, Development of new micro-maintenance for expansion of application area of zirconia, 2016/04/01, 2019/03/31
- Grant-in-Aid for Scientific Research (B), Design of culture substrate for large-scale preparation of epithelial cell derived from iPS cell, 2016/04/01, 2019/03/31
- KAKENHI, 2013, 2015
- KAKENHI, 2013, 2015
- KAKENHI, 2012, 2014
- KAKENHI, 2012, 2014
- KAKENHI, Effect of messencymal stem cells proliferation and differentiationon self-assembled monolayer using serum-free medium, 2011, 2012
- KAKENHI, Higher biofunctional nano-surface modification for development of histocompatibility typed titanium implants, 2009, 2011
- KAKENHI, Development of functional titanium implant for bone attachment, 2008, 2009
- KAKENHI, Affinity chemical modification and functional control onto carbonate-apatite composite scaffolds, 2006, 2009
- 2006
- KAKENHI, 2006, 2007
- KAKENHI, High functional nanobio surface modification of titanium implant with bone morphogenetic protein, 2006, 2007
- KAKENHI, 2004, 2005
- KAKENHI, 2004, 2005
- 2004
- KAKENHI, Development of functional Ti implants with release of growth factors, 2004, 2005
- KAKENHI, 2003, 2005
- KAKENHI, Creation of high-quality COaAp-collagen composites for reconstruction and regeneration of alveolar bone, 2002, 2005
Social Activities
Organizing Academic Conferences, etc.
- The 4th Japan-China Symposium on Nanomedicine, Local Secretariat, 2016/05, 2016/05
- The 2nd Japan-China Symposium on Nanomedicine, Local Secretariat, 2014/05, 2014/05
- 2011/05
History as Peer Reviews of Academic Papers
- 2020, Dental Materials Journal, 1
- 2019, Journal of Biomaterials Applications, 1
- 2018, Dental Materials Journal, 2
- 2018, Journal of Artificial Organs, 1
- 2017, Dental Materials Journal, 1
- 2017, Journal of Biomaterials Applications, 1
- 2016, PLOS ONE, 1
- 2015, Dental Materials Journal, 1
- 2013, Dental Materials Journal, 1
- 2011, Journal of Artificial Organs, 1
- 2011, Dental Materials Journal, 2
- 2010, Langmuir, 1