TOMOHISA NEZU

Last Updated :2021/09/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
E-mail
tomonezuhiroshima-u.ac.jp
Self-introduction
My research topics are epidemiological research for stroke, especially, cerebraovascular metabolisim, neurosonology and biological marker. I am conducting research in collaboration with related departments, focusing on the development of blood biomarkers and medical devices.

Basic Information

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Research Keywords

  • Neurology, Stroke Medicine

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2021, Undergraduate Education, Intensive, Introduction to clinical clerkship

Research Activities

Academic Papers

  1. Increased serum alkaline phosphatase and functional outcome in patients with acute ischemic stroke presenting a low ankle-brachial index., J Atheroscler Thromb., 2021
  2. ★, Predictors of stroke outcome extracted from multivariate linear discriminant analysis or neural network analysis., J Atheroscler Thromb., 2021
  3. ★, Case of neuronal intranuclear inclusion disease with dynamic perfusion changes lacking typical signs on diffusion-weighted imaging, Neurol Genet., 7:e601, 2021
  4. ★, Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide, J Neurol Sci ., 15(396), 119-120, 2019
  5. Effects of Meteorological Conditions on the Risk of Ischemic Stroke Events in Patients Treated with Alteplase-HEWS-tPA, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(7), 1500-1505, 2015
  6. ★, Preserved acetazolamide reactivity in lacunar patients with severe white-matter lesions: O-15-labeled gas and H2O positron emission tomography studies, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 32(5), 844-850, 2012
  7. Association of Serum Anti-Periodontal Pathogen Antibody with Ischemic Stroke, CEREBROVASCULAR DISEASES, 34(5-6), 385-392, 2012
  8. ★, Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients, JOURNAL OF NEUROLOGY, 260(10), 2642-2649, 2013
  9. The Association between Hyperintense Vessel Sign and Final Ischemic Lesion Differ in Its Location, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1337-1343, 2014
  10. Safety Evaluation of Substituting Clopidogrel for Ticlopidine in Japanese Patients with Ischemic Stroke-Hiroshima Ticlopidine, Clopidogrel Safe Exchange Trial, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1485-1490, 2014
  11. CD34+/CD144+Circulating Endothelial Cells as an Indicator of Carotid Atherosclerosis, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(3), 583-590, 2015
  12. ★, Endothelial dysfunction is associated with the severity of cerebral small vessel disease, HYPERTENSION RESEARCH, 38(4), 291-297, 2015
  13. ★, A Case of Recurrent Ischemic Stroke Involving Subacute, Progressive Intracranial Cerebral Arterial Sclerosis Prior to Diagnosis with JAK2-mutated Polycythemia Vera, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(12), E4-E6, 2015
  14. ★, Greater Severity of Neurological Defects in Women Admitted With Atrial Fibrillation-Related Stroke, CIRCULATION JOURNAL, 80(1), 250-+, 2015
  15. ★, Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study., EBioMedicine, 2(8), 2015
  16. ★, Carotid Intima-Media Thickness for Atherosclerosis., Journal of atherosclerosis and thrombosis, 23(1), 2016
  17. The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study., EBioMedicine, 2(9), 2015
  18. Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases., Case reports in neurological medicine, 2015, 2015
  19. Intravenous alteplase at 0.6 mg/kg for acute stroke patients with basilar artery occlusion: the stroke acute management with urgent risk factor assessment and improvement (SAMURAI) Recombinant tissue plasminogen activator registry., Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 22(7), 2013
  20. CHADS2 score is associated with 3-month clinical outcomes after intravenous rt-PA therapy in stroke patients with atrial fibrillation: SAMURAI rt-PA Registry., Journal of the neurological sciences, 306(1-2), 2011
  21. Intravenous recombinant tissue plasminogen activator therapy for stroke patients receiving maintenance hemodialysis: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry., European neurology, 66(1), 2011
  22. ★, Early ischemic change on CT versus diffusion-weighted imaging for patients with stroke receiving intravenous recombinant tissue-type plasminogen activator therapy: stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry., Stroke; a journal of cerebral circulation, 42(8), 2011
  23. ★, Small-vessel disease in the basal ganglia: lacune or microbleed?, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 21(8), 2012
  24. Effects of hyperacute blood pressure and heart rate on stroke outcomes after intravenous tissue plasminogen activator., Journal of hypertension, 29(10), 2011
  25. Nationwide survey of neuro-specialists' opinions on anticoagulant therapy after intracerebral hemorrhage in patients with atrial fibrillation., Journal of the neurological sciences, 312(1-2), 2012
  26. ★, Pre-treatment ASPECTS-DWI score has a relation with functional outcome at 3 months following intravenous rt-PA therapy, 31(5), 366-373, 20090925
  27. ★, Central apnoea associated with subcortical haemorrhage in the left temporal lobe, J Neurol Neurosurg Psychiatry, 81, 299-301, 2010
  28. ★, Pretreatment ASPECTS on DWI predicts 3-month outcome following rt-PA: SAMURAI rt-PA Registry., Neurology, 75, 555-561, 2010
  29. The Multidisciplinary Swallowing Team Approach Decreases Pneumonia Onset in Acute Stroke Patients, PLOS ONE, 11(5), 2016
  30. ★, Carotid Intima-Media Thickness for Atherosclerosis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 23(1), 18-31, 2016
  31. ★, Temporal Trends in Stroke Severity and Prior Antithrombotic Use Among Acute Ischemic Stroke Patients in Japan, CIRCULATION JOURNAL, 80(9), 2033-2036, 201609
  32. ★, Multiple Infarcts Are Associated With Long-Term Stroke Recurrence and All-Cause Mortality in Cryptogenic Stroke Patients, STROKE, 47(9), 2209-2215, 201609
  33. Association Between Absolute Eosinophil Count and Complex Aortic Arch Plaque in Patients With Acute Ischemic Stroke, STROKE, 48(4), 1074-1076, 2017
  34. Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study, CLINICAL AND EXPERIMENTAL HYPERTENSION, 39(3), 225-234, 2017
  35. Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events: The HEWS-stroke study, PLOS ONE, 12(5), 2017
  36. A case of hypertensive encephalopathy with enlarged optic nerve sheath measured by transorbital sonography., J Stroke Cerebrovasc Dis, 26, e20-e21, 2017
  37. Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(1), 107-+, 2018
  38. Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(3), 262-268, 2018
  39. ★, Impact of D-dimer levels for short-term or long-term outcomes in cryptogenic stroke patients, JOURNAL OF NEUROLOGY, 265(3), 628-636, 2018
  40. Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex, EUROPEAN NEUROLOGY, 79(1-2), 90-99, 2018
  41. ★, Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 350-358, 2018
  42. Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 359-373, 2018
  43. Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence A Post Hoc Analysis of the J-STARS Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(4), 865-+, 2018
  44. Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases, CASE REPORTS IN NEUROLOGICAL MEDICINE, 2015
  45. ★, Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(6), 490-504, 2018
  46. ★, Antithrombotic Therapy Strategy for Cancer-Associated Ischemic Stroke: A Case Series of 26 Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(9), E206-E211, 2018
  47. ★, Controlling nutritional status score for predicting 3-mo functional outcome in acute ischemic stroke, NUTRITION, 55-56, 1-6, 2018
  48. Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring alpha-Galactosidase A and Globotriaosylsphingosine, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(12), 3563-3569, 201812
  49. Warm Front Passage on the Previous Day Increased Ischemic Stroke Events, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 28(7), 1873-1878, 201907
  50. Baseline Carotid Intima-Media Thickness and Stroke Recurrence During Secondary Prevention With Pravastatin, STROKE, 50(6), 1586-1589, 201906
  51. ★, Steroid-responsive Nivolumab-induced Involuntary Movement with Anti-thyroid Antibodies, INTERNAL MEDICINE, 58(24), 3577-3581, 2019
  52. Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months, SCIENTIFIC REPORTS, 10(1), 20200121
  53. ★, Effect of tooth loss and nutritional status on outcomes after ischemic stroke, NUTRITION, 71, 202003
  54. Increased blood pressure variability during the subacute phase in patients with ischemic stroke presenting with a low ankle-brachial index, GERIATRICS & GERONTOLOGY INTERNATIONAL, 20(5), 448-454, 202005
  55. Different Influences of Statin Treat en in Preventing At-Risk Stroke Subtypes A Post Hoc Analysis of J-STARS, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(5), 449-460, 2020
  56. Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 200(3), 302-309, 202006
  57. ★, Effect of Statin on Stroke Recurrence Prevention at Different Infarction Locations: A Post Hoc Analysis of The J-STARS Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(6), 524-533, 2020
  58. ★, Conus Medullaris Infarction Involving the Paraspinal Muscles and Nerve Roots, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 29(8), 202008
  59. Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients, PLOS ONE, 15(8), 20200806
  60. ★, Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(10), 1023-1035, 2020
  61. ★, Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients, PLOS ONE, 15(10), 20201008
  62. Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome, PLOS ONE, 15(10), 20201028
  63. ★, Effects of vascular compression on the rostral ventrolateral medulla for blood pressure variability in stroke patients, JOURNAL OF HYPERTENSION, 38(12), 2443-2450, 202012
  64. ★, Prognostic role of the controlling nutritional status score in acute ischemic stroke among stroke subtypes, JOURNAL OF THE NEUROLOGICAL SCIENCES, 416, 20200915
  65. cnm-Positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage, EUROPEAN JOURNAL OF NEUROLOGY, 28(5), 1581-1589, 202105
  66. Impact of anatomical variations on ultrasonographic reference values of lower extremity peripheral nerves, MUSCLE & NERVE, 63(6), 890-896, 202106
  67. Giant Cell Arteritis with Internal Carotid Artery Occlusion in the Absence of Typical Clinical Features, INTERNAL MEDICINE, 60(8), 1293-1297, 202104

Publications such as books

  1. 2017, Treatment of Non-vitamin K Antagonist Oral Anticoagulants, New Approaches for the Secondary Prevention of Cryptogenic Stroke Using Non-vitamin K Antagonist Oral Anticoagulants., Springer, 2017, Scholarly Book, Joint work, Tomohisa Nezu, Yoshiki Yagita
  2. 2017, Stroke Revisited: Diagnosis and Treatment of Ischemic Stroke, Selections of Antithrombotic Agents During Acute Stage., Springer, 2017, Textbook, Joint work, Tomohisa Nezu, Naohisa Hosomi, Masayasu Matsumoto, 135-143

Invited Lecture, Oral Presentation, Poster Presentation

  1. Current issues and perspective of cancer-associated stroke, Tomohisa Nezu, Naohisa Hosomi, Hiroyuki Naito, Shiro Aoki, Hirofumi Maruyma, 2020, With Invitation, Japanese
  2. Biological markers of cancer-associated stroke and its clinical outcomes, Tomohisa Nezu, Naohisa Hosomi, Hiroyuki Naito, Shiro Aoki, Tsuyoshi Torii , Takashi Kurashige , Tomohito Sugiura , Daisuke Kuzume , Yuko Morimoto , Yoshiki Yagita , Naoki Oyama , Yuji Shiga , Naoto Kinoshita , Hiroki Ueno, Hirofumi Maruyama, ESO-WSO CONFERENCE 2020, 2020/11/07, Without Invitation, English, published
  3. Biological markers of cancer-associated stroke and its clinical outcomes, 2020/08/23, Without Invitation, Japanese, published
  4. Relationships between telomere G-tail lengths, inflammation, oxidative stress and endothelial function in the patients with carotid atherosclerosis, 2015/02/12, Without Invitation, English, published
  5. Endothelial dysfunction is associated with the severity of white matter lesions in patients with chronic cerebrovascular disease and comorbidity., Asia Pacific Stroke Conference 2014, 2014, Without Invitation, English, Taipei
  6. Relationships between endothelial function, biological markers and cerebral small vessel disease in patients with chronic cerebrovascular disease and comorbidity, International Stroke Conference 2014, 2014, Without Invitation, English, San Diego, USA
  7. Telomere G-tail length shortening is associated with endothelial dysfunction in patients with chronic cerebrovascular disease and comorbidity, International Stroke Conference 2014, 2014, Without Invitation, English
  8. High levels of serum alpha2-macroglobulin are associated with white matter lesions but not with IL-6 in acute ischemic stroke patients, Asia Pacific Stroke Conference2013, 2013, Without Invitation, English
  9. Association of alpha2-macroglobulin as a novel biomarker with acute ischemic stroke, International Stroke Conference 2013, 2013, Without Invitation, English, Honolulu, USA
  10. Acetazolamide reactivity and oxygen metabolism in lacunar patients with white matter lesions, International Symposium on Cerebral flow, Metabolism, and Function., 2011, Without Invitation, English, Barcelona, Spain
  11. Female sex is associated with unfavorable outcomes following low-dose intravenous rt-PA therapy: the SAMURAI rt-PA Registry, International Stroke Conference 2011, 2011, Without Invitation, English
  12. Pre-treatment DWI-ASPECTS is superior to CT-ASPECTS in detecting excellent to fairly good outcome after intravenous rt-PA therapy, International Stroke Conference 2010, 2010, Without Invitation, English, San Antonio, USA
  13. Pre-treatment DWI-ASPECTS has a relation with functional outcome at 3 months following intravenous rt-PA therapy, International Stroke Conference 2010, 2010, Without Invitation, English
  14. Overview: Carotid intima-media thickness, 2017/07/07, With Invitation, English
  15. Microbleeds evaluation study for prevention of brain hemorrhage in ischemic stroke (MB-evidence): pilot analysis for multicenter longitudinal study., Nezu T, Naka H, Hosomi N, Takamatsu K, Nomura E, Kitamura T, Torii T, Oshita T, Nakamori M, Imamura E, shimomura R, Aoki S, Maruyama H, Matsumoto M., XXIII World Congress of Neurology, 2017/09/18, Without Invitation, English, published
  16. Controlling Nutritional Status Score Predicts 3-Month Functional Outcome in Patients With Acute Ischemic Stroke., Naito H, Nezu T, Hosomi N, et al., International Stroke Conference 2018, 2018/01/24, Without Invitation, English, Los Angeles,, published

Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, Front. Neurol., Editor
  2. 2019, Journal of Neurology, Neurosurgery, and Psychiatry, Others, 1