MITSUNORI MIYAZAKI

Last Updated :2025/05/09

Affiliations, Positions
Hiroshima University
Web Site
https://integr-physiol.hiroshima-u.ac.jp
E-mail
mmiya4hiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5435 FAX : (+81)
Self-introduction
Department of Integrative Physiology, Associate Professor

Basic Information

Major Professional Backgrounds

  • 2005/04/01, 2006/03/31, Japan Society for the Promotion of Science, Research Fellow (DC2)
  • 2006/04/01, 2007/03/31, Japan Society for the Promotion of Science, Research Fellow (PD)
  • 2006/04/01, 2011/04/30, University of Kentucky, Department of Physiology, College of Medicine / Center for Muscle Biology, Postdoctoral Fellow
  • 2008/04/01, 2010/03/31, American Heart Association, Postdoctoral Fellow
  • 2010/04/01, 2012/03/31, Japan Society for the Promotion of Science, Research Fellow (PD)
  • 2012/04/01, 2015/03/31, Health Sciences University of Hokkaido, Department of Physical Therapy, School of Rehabilitation Sciences, Senior Assistant Professor
  • 2015/04, 2021/03, Health Sciences University of Hokkaido, School of Rehabilitation Sciences, Associate Professor
  • 2021/04, 9999, Hiroshima University, Department of Integrative Physiology, Graduate School of Biomedical and Health Sciences, Associate Professor
  • 2001/05, 2003/03, Ichihara　Hospital, Physical Therapist
  • 2003/04, 2004/08, Physical Therapist
  • 2004/09, 2005/03, Physical Therapist
  • 2013/04, 2014/08, Matsuda Orthopedic Hospital, Physical Therapist

Educational Backgrounds

  • Sapporo Medical University, School of Health Science, Department of Physical Therapy, Japan, 1997/04, 2001/03
  • University of Tsukuba, Master's Program in Health and Physical Education, Japan, 2001/04, 2003/03
  • University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan, 2003/04, 2006/03

Academic Degrees

  • University of Tsukuba

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Health Sciences : Occupational Therapy
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences

Research Fields

  • Complex systems;Biomedical engineering;Rehabilitation science / Welfare engineering
  • Complex systems;Health / Sports science;Sports science
  • Complex systems;Health / Sports science;Applied health science

Research Keywords

  • Skeletal Muscle, Hypertrophy, Atrophy, Exercise, Rehabilitation, Hibernation, Energy Metabolism

Affiliated Academic Societies

  • Japanese Society of Physical Fitness and Sports Medicine, 2002/04
    Related URL
  • Japan Society of Exercise and Sports Physiology, 2002/04
    Related URL
  • The Physiological Society of Japan, 2021/04
    Related URL
  • Japan Society of Physical Therapy Fundamentals, 2012
    Related URL

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 4Term, Human health and the society
  2. 2025, Undergraduate Education, 2Term, Physiology I
  3. 2025, Undergraduate Education, 2Term, Physiology I
  4. 2025, Undergraduate Education, Second Semester, Physiology II
  5. 2025, Undergraduate Education, Second Semester, Physiology II
  6. 2025, Undergraduate Education, First Semester, Anatomy and Physiology I
  7. 2025, Undergraduate Education, First Semester, Practice of Physiology
  8. 2025, Undergraduate Education, First Semester, Practice of Physiology
  9. 2025, Undergraduate Education, Intensive, Clinical practice I
  10. 2025, Undergraduate Education, Intensive, Clinical practice II
  11. 2025, Undergraduate Education, 3Term, Preliminary Research Practice
  12. 2025, Undergraduate Education, Second Semester, Intoroduction to research methods in occupational therapy II
  13. 2025, Graduate Education (Doctoral Program) , Second Semester, Methodology of Education for Health Promotion
  14. 2025, Graduate Education (Master's Program) , First Semester, Lecture on integrative Physiology
  15. 2025, Graduate Education (Master's Program) , First Semester, Seminar on integrative Physiology
  16. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on integrative Physiology
  17. 2025, Graduate Education (Master's Program) , Year, Research on integrative Physiology
  18. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on integrative Physiology
  19. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on integrative Physiology
  20. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on integrative Physiology
  21. 2025, Graduate Education (Master's Program) , First Semester, Research on Integrative Physiology
  22. 2025, Graduate Education (Master's Program) , Second Semester, Research on Integrative Physiology

Research Activities

Academic Papers

  1. Akt1 deficiency does not affect fiber type composition or mitochondrial protein expression in skeletal muscle of male mice, PHYSIOLOGICAL REPORTS, 12(17), 202409
    Link to Paper Search Results by DOI
  2. ★, Decreased insulin-like growth factor-1 expression in response to mechanical loading is associated with skeletal muscle anabolic resistance in cancer cachexia, Growth Hormone & IGF Research, 69-70, 101536, 20230518
    Link to Paper Search Results by DOI
  3. ★, Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation, SCIENTIFIC REPORTS, 12(1), 19723-19723, 20221116
    Link to Paper Search Results by DOI
  4. The impact of visual cross-modal conflict with semantic and nonsemantic distractors on working memory task: A functional near-infrared spectroscopy study, MEDICINE, 101(36), 20220909
    Link to Paper Search Results by DOI
  5. The impact of visual cross-modal conflict with semantic and nonsemantic distractors on working memory task A functional near-infrared spectroscopy study, Medicine®, 101(36), e30330, 20220909
  6. ★, Supplementing cultured human myotubes with hibernating bear serum results in increased protein content by modulating Akt/FOXO3a signaling, PLOS ONE, 17(1), e0263085-e0263085, 20220125
    Link to Paper Search Results by DOI
  7. ★, Voluntary exercise prevents abnormal muscle mitochondrial morphology in cancer cachexia mice, PHYSIOLOGICAL REPORTS, 9(16), e15016-e15016, 202108
    Link to Paper Search Results by DOI
  8. Changes in liver microRNA expression and their possible regulatory role in energy metabolism-related genes in hibernating black bears, Journal of Comparative Physiology B, 191(2), 397-409, 202103
  9. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1, Autophagy, 17(1), 1-382, 20210102
  10. ★, Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation, Physiological Reports, 8(19), e14599, 20201010
  11. Personality Traits Modulate the Impact of Emotional Stimuli During a Working Memory Task: A Near-Infrared Spectroscopy Study., Frontiers in Behavioral Neuroscience, 14, 514414-514414, 202009
  12. ★, Skeletal muscles of hibernating black bears show minimal atrophy and phenotype shifting despite prolonged physical inactivity and starvation., PloS one, 14(4), e0215489, 20190418
  13. ★, Voluntary Wheel Running Prevents Skeletal Muscle Atrophy by Modulating Ubiquitin-proteasome-dependent Proteolysis in Cancer Cachexia Mice, Physical Therapy Japan, 46(2), 73-82, 20190201
  14. ★, Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation., American journal of physiology. Regulatory, integrative and comparative physiology, 314(5), R741-R751, 20180501
  15. High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice., PloS one, 13(6), e0199050, 20180612
  16. ★, TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts., FEBS open bio, 7(3), 424-433, 20170111
  17. Altered signaling pathway governing protein metabolism in skeletal muscle of the Japanese black bear during hibernation, FASEB JOURNAL, 29, 201504
  18. Growth factor-dependent and independent regulation of skeletal muscle mass -Is IGF-1 necessary for skeletal muscle hypertrophy?-, Journal of Physical Fitness and Sports Medicine, 2(1), 1-6, 201301
  19. Effective fiber hypertrophy in satellite cell-depleted skeletal muscle., Development (Cambridge, England), 138(17), 3657-66, 201109
  20. ★, Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling., The Journal of physiology, 589(Pt 7), 1831-46, 20110401
  21. Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat., PloS one, 6(11), e27168, 2011
  22. Molecular Mechanisms regulating Skeletal Muscle Hypertrophy, Journal of Health, Physical Education and Recreation, 60(10), 713-718, 201010
  23. Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 is not key for adult skeletal muscle hypertrophy., Journal of applied physiology (Bethesda, Md. : 1985), 108(6), 1830-1830, 201006
  24. Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes., The FEBS journal, 277(9), 2180-91, 201005
  25. The circadian clock and skeletal muscle function, Japanese Journal of Physical Fitness and Sports Medicine, 59(2), 233-242, 2010
  26. Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis., Journal of applied physiology (Bethesda, Md. : 1985), 106(4), 1403-11, 200904
  27. Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals., Journal of applied physiology (Bethesda, Md. : 1985), 106(4), 1367-73, 200904
  28. REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch., American journal of physiology. Cell physiology, 296(3), C583-92-92, 200903
  29. Intermittent reloading attenuates muscle atrophy through modulating Akt/mTOR pathway., Medicine and science in sports and exercise, 40(5), 848-55, 200805
  30. Calcineurin-mediated slow-type fiber expression and growth in reloading condition., Medicine and science in sports and exercise, 38(6), 1065-72, 200606
  31. Effects of intensity and duration of endurance exercise on skeletal muscle fiber type transition in mice., Adv. Exerc. Sports Physiol, 11, 15-20, 200501
  32. Contribution of the calcineurin signaling pathway to overload-induced skeletal muscle fiber-type transition, JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 55(4), 751-764, 200412
  33. Simple method for the identification of oxidative fibers in skeletal muscle., European journal of applied physiology, 91(2-3), 357-9, 200403
  34. 骨格筋線維タイプの変化におよぼす負荷量の影響 : カルシニューリンシグナル経路の関与(日本体力医学会プロジェクト研究:ヒトの骨格筋における遺伝子発現とその変化に対する運動の影響,第61回日本体力医学会大会), Japanese Journal of Physical Fitness and Sports Medicine, 55(1), 15-16, 200602
  35. 76.NFkB系シグナル経路の阻害による廃用性骨格筋萎縮の抑制効果(運動器,一般口演,第60回 日本体力医学会大会), Japanese Journal of Physical Fitness and Sports Medicine, 54(6), 456, 200512
  36. 1P14 Effects on muscle oxygenation of exercise program in older persons, Advances in exercise and sports physiology, 9(4), 171, 200312
  37. 1Q07 Effect on blood adipose tissue and MDA-LDL with combined exercise training in middle-aged and older persons, Advances in exercise and sports physiology, 9(4), 199, 200312
  38. 1C01 Nobel method for the identification of oxidative fibers in skeletal muscle, Advances in exercise and sports physiology, 9(4), 148, 200312
  39. 1C04 Contribution of calcineurie pathway to overload-induced skeletal muscle fiber tpe alteration, Advances in exercise and sports physiology, 9(4), 150, 200312
  40. 3P17 Effects of endurance exercise intensity and duration on skeletal muscle fiber type in mice :, Advances in exercise and sports physiology, 8(4), 201-201, 2002

Publications such as books

  1. 2023/01/02, Physical Therapy and Research in Patients with Cancer, This collection of chapters describes in detail the physical therapy research in patients with various types of cancers to help medical professionals and physical therapists help improve the physical function, activity of daily living, quality of life, the survival rate in cancer patients and cancer survivors. It provides not only information on rehabilitation but details on physical therapy cancer research and research methods. The book provides practical skills to treat the patients and to create useful and effective physical therapy programs by giving step-by-step tutorials to help readers learn various techniques. Along with presenting an introduction to physical therapy of cance and new findings, the authors provide recommendations on each cancer therapy. Physical Therapy and Research in Patients with Cancer is aimed at physical therapists and student physical therapists. Undergraduate and postgraduate students also can use our book to understand the basics and get up-to-date information. By sharing the latest research with our readers, the book creates a foundation for further development in this field of study., Physical Exercise and Skeletal Muscle Adaptation in Cancer Cachexia, Springer Nature, 2023, 01, Scholarly Book, Joint work, Mitsunori Miyazaki, 978-981-19-6709-2, 578
  2. 2012, Current Research Trends on Skeletal Muscle, Molecular mechanisms regulating protein synthesis and skeletal muscle hypertrophy through mTOR signaling, Research Signpost, 2012, 2012, Scholarly Book, Joint work, Mitsunori Miyazaki
  3. 2013/08/31, Basic Biology and Current Understanding of Skeletal Muscle, Skeletal muscle is a highly plastic tissue that constitutes approximately thirty percent of total body mass and adapts rapidly to changing functional demands. Skeletal muscle is not only the generator of force production, but also plays a crucial role in whole body metabolism and energy consumption. In this book, leading experts in the area of exercise biochemistry and molecular biology in skeletal muscle provide an up-to-date view of the molecular basis of various adaptations of skeletal muscle, with emphasis on new biological concepts (muscle stem cells, muscle steroidogenesis, etc). This book deals with the recent intriguing role of heat shock protein (HSP), AMPK and reactive oxygen species (ROS) for muscle morphology, function and metabolism. Discussed also is the molecular mechanism for protein metabolism and therapeutic application for sarcopenia. The deeper understanding of the signal transduction and modification in skeletal muscle will develop new therapeutic strategies for preventing physical disability and increased risk of morbidity/mortality due to the loss of muscle mass., Cellular mechanisms regulating protein metabolism in skeletal muscle cell -Age-associated alteration of intracellular signaling governing protein synthesis and degradation-, Nova Science Pub Inc., 2013, 8, Scholarly Book, Joint work, English, Yusuke Ono, Mitsunori Miyazaki, Akihiko Yamaguchi, Kunihiro Sakuma and Isao Morita, Kunihiro Sakuma and Akihiko Yamaguchi, Wataru Aoi, Tomonori Ogata, Fuminori Kawano, Masataka Suwa, Akira Wagatsuma, Katsuji Aizawa, 78-1-62808-367-5, 330

Invited Lecture, Oral Presentation, Poster Presentation

  1. Cold resistance of skeletal muscle tissue stem cells in hibernating animals, Mitsunori Miyazaki, Tatsuya Miyaji, Ryuichi Kasuya, Guangyuan Li, Michito Shimozuru, Toshio Tsubota, 2024/08/22, Without Invitation, Japanese
  2. Diminished regenerative capacity of skeletal muscle in the Syrian hamster during hibernation., Ryuichi Kasuya, Tatsuya Miyaji, Mitsunori Miyazaki, 2024/07/08, Without Invitation, Japanese
  3. Cold-Induced Modulation of Myogenic Program in Muscle Stem Cells of the Mammalian Hibernator Syrian Hamster, Tatsuya Miyaji, Ryuichi Kasuya, Mitsunori Miyazaki, 2024/07/08, Without Invitation, Japanese
  4. Maintenance Of Skeletal Muscle Homeostasis In Hibernating Mammals, Mitsunori Miyazaki, 2024/07/08, Without Invitation, Japanese
  5. Regulation of Skeletal Muscle Size and Protein Metabolisms in Hibernating Animals, Mitsunori Miyazaki, 2023 RIKEN BDR QMIN Project Annual Meeting, 2023/12/18, With Invitation, English, RIKEN BDR
  6. Isolation of Skeletal Muscle Stem Cells from a Mammalian Hibernator Syrian hamster, Tatsuya Miyaji, Ryuichi Kasuya, Masatomo Watanabe, Mayuko Monden, Yutaka Tamura, Hitoshi Okamura, Mitsunori Miyazaki, The 10th Federation of the Asian and Oceanian Physiological Societies Congress, 2023/11/01, Without Invitation, English, Federation of the Asian and Oceanian Physiological Societies, EXCO, Daegu, Korea
  7. Hibernation delays the regenerative processes in the skeletal muscle of the mammalian hibernator Syrian hamster, Ryuichi Kasuya, Tatsuya Miyaji, Masatomo Watanabe, Mayuko Monden, Yutaka Tamura, Hitoshi Okamura, Mitsunori Miyazaki , The 10th Federation of the Asian and Oceanian Physiological Societies Congress, 2023/11/01, Without Invitation, English, Federation of the Asian and Oceanian Physiological Societies, EXCO, Daegu, Korea
  8. Hibernation-Induced Muscle Atrophy Resistance in the Skeletal Muscles of the Syrian Hamster, Mitsunori Miyazaki, Masatomo Watanabe, Mayuko Monden, Ryuichi Kasuya, Tatsuya Miyaji, Yutaka Tamura, The 10th Federation of the Asian and Oceanian Physiological Societies Congress, 2023/11/01, Without Invitation, English, Federation of the Asian and Oceanian Physiological Societies, EXCO, Daegu, Korea
  9. Molecular mechanism of "non-wasting muscles" induced by hibernation., Mitsunori Miyazaki, 2023/08/18, With Invitation, Japanese
  10. Basic research on the effect of therapeutic exercise on cancer cachexia, Mitsunori Miyazaki, 2022/10/02, With Invitation, Japanese, Osaka
  11. Muscle Mass Maintenance in Hibernating Animals, Mitsunori Miyazaki, 2023 Myology Institute Seminar, 2023/04/05, With Invitation, English, MYOLOGY Institute, UNIVERSITY of FLORIDA
  12. Unpleasant emotions induced by olfactory stimulation decreases cognitive performance with the Stroop color-word test, Kana Endo, Arisa Takeuchi, Kaede Morimoto, Miu Fujioka Tatsuya Miyaji, Ryuichi Kasuya, Mitsunori Miyazaki, The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 2023/03/14, Without Invitation, English
  13. Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation, Mitsunori Miyazaki, Michito Shimozuru, Yu Kitaoka, Kenya Takahashi, Toshio Tsubota, The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 2023/03/14, Without Invitation, English, The Physiological Society of Japan
  14. Muscle Atrophy Resistance to Prolonged Physical Inactivity in Hibernating Animals, Mitsunori Miyazaki, The 99th Annual Meeting of the Physiological Society of Japan, 2022/03/16, With Invitation, English, The Physiological Society of Japan
  15. Hibernating bear serum leads to increased protein content in human skeletal muscle cells, Mitsunori Miyazaki, Michito Shimozuru, Toshio Tsubota, 16th International Hibernation Symposium, 2021/08/02, Without Invitation, English, International Hibernation Society, Groningen, Netherland

Awards

  1. 2022/07/24, Best Research Award, 6th Physical Therapy Fundamentals Young Investigator Network Symposium

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Challenging Research (Pioneering)), 2023, 2024
  2. Grant-in-Aid for Transformative Research Areas (A), 2024, 2026
  3. 2023, 2028
  4. 2023, 2023
  5. 2023, 2025
  6. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2022, 2025
  7. 2022, 2022
  8. 2021, 2022
  9. Grants-in-Aid for Scientific Research, 2022/04/01, 2026/03/31
  10. Grants-in-Aid for Scientific Research, Exploration of hibernation-induced biologically active substances that promote skeletal muscle atrophy resistance., 2020/07/30, 2023/03/31

Social Activities

Organizing Academic Conferences, etc.

  1. The 31st annual meeting of Japan Society of Exercise and Sports Physiology, 2023/08, 2023/08

Other Social Contributions

  1. WISE/LP Special Lecture, Hokkaido University, Regulation of Skeletal Muscle Size and Protein Metabolisms in Hibernating Animals, Hokkaido University, WISE/LP Special Lecture, 2023/02/03, 2023/02/03, Lecturer, Lecture, Graduate students