Kenji Kitamura

Last Updated :2024/07/05

Affiliations, Positions
Natural Science Center for Basic Research and Development, Associate Professor
Studies on the regulation of yeast physiology by amino acids and oligopeptides. 1) functional regulation and substrate specificity of membrane transporters, 2) exploration of novel physiological role of amino acids/oligopeptides and its action mechanism.

Basic Information

Academic Degrees

  • Doctor of Science, Osaka City University
  • Master of Science, Osaka City University

Educational Activity

  • [Bachelor Degree Program] School of Engineering : Cluster 3(Applied Chemistry, Biotechnology and Chemical Engineering) : Program of Biotechnology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology

Research Fields

  • Agricultural sciences;Agricultural chemistry;Applied microbiology

Research Keywords

  • peptide transporter
  • dipeptide
  • ubiquitin ligase
  • cell cycle
  • yeast

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Ethics and regulations in natural science research
  2. 2024, Undergraduate Education, Second Semester, Basic Experiments in Chemistry
  3. 2024, Undergraduate Education, Second Semester, Experiments on Biotechnology II
  4. 2024, Undergraduate Education, 1Term, BiochemistryIII
  5. 2024, Undergraduate Education, Year, Graduation Thesis
  6. 2024, Graduate Education (Master's Program) , 3Term, Research Methods in Life Science
  7. 2024, Graduate Education (Master's Program) , 2Term, Lecture on Developing Communication Skill
  8. 2024, Graduate Education (Master's Program) , 1Term, Integrated Genome Science A
  9. 2024, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  10. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  11. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  12. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  13. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  14. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  15. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. ★, The Ubiquitin Ligase Ubr11 Is Essential for Oligopeptide Utilization in the Fission Yeast Schizosaccharomyces pombe, EUKARYOTIC CELL, 11(3), 302-310, 201203
  2. The type-2 N-end rule peptide recognition activity of Ubr11 ubiquitin ligase is required for the expression of peptide transporters, FEBS LETTERS, 587(2), 214-219, 20130116
  3. Essential role of Ubr11, but not Ubr1, as an N-end rule ubiquitin ligase in Schizosaccharomyces pombe, YEAST, 30(1), 1-11, 201301
  4. Analysis of yeast genome by Southern blotting, 38-45, 19980401
  5. ★, Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiaion via ubiquitin proteolysis and 14-3-3 protein in fission yeast., Dev. Cell, 1(1), 389-399, 20010901
  6. A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe., Mol. Gen. Genomics, 265, 424-435, 20010101
  7. ★, The spike of S-phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases., Mol. Cell, 6, 1377-1387, 20000401
  8. ★, Fission yeast Ste9, a homologue of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase., Mol Biol Cell, 9, 1065-1080, 19980401
  9. Identification of a novel casein kinase-1 homologue in fission yeast Schizosaccharomyces pombe, Gene, 214, 131-137, 19980401
  10. The Ste16 WD-repeat protein regulates cell-cycle progression under starvation therough the Rum1 protein in Schizosaccharomyces pombe., Curr. Genet., 33, 29-37, 19980401
  11. Autocrine response of S. pombe haploid cells to mating pheromones., FEMS Microbiol. Lett., 143, 41-45, 19960401
  12. The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe., Mol. Gen. Genet., 244, 456-464, 19940401
  13. The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein., EMBO J., 10(12), 3743-3751, 19910401
  14. The novel gene trs1 encodes an essential protein for the transition from mitotic cell cycle to resting state in Schizosaccharomyces pombe., FEMS Microbiol. Lett., 84, 1-6, 19910401
  15. Novel sterile mutants of the fission yeast Schizosaccharomyces pombe which are defective in their response to starvation., Curr. Genet., 18, 315-321, 19900401
  16. Mapping of the ras1 gene of Schizosaccharomyces pombe., Mol. Gen. Genet., 209, 627-629, 19870401
  17. Fission yeast F-box protein Pof3 is required for genome integrity and telomere function, Mol. Bio. Cell, 13, 211-224, 20020101
  18. Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint, Genes to Cells, 9, 367-382, 20040401
  19. Requirement of the SCFPop1/Pop2 ubiquitin ligase for degradation of the fission yeast S phase cyclin Cig2, J. Biol. Chem., 279(18), 18974-18980, 20040401
  20. Spindle checkpoint activation at meiosis I advances anaphase II onset via meiosis-specific APC/C regulation, J. Cell Biol., 182(2), 277, 20080623
  21. Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe, GENES TO CELLS, 7(2), 199-215, 200202
  22. Nuclear Protein Quality Is Regulated by the Ubiquitin-Proteasome System through the Activity of Ubc4 and San1 in Fission Yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(15), 13775-13790, 20110415
  23. ★, Fission yeast Ubr1 ubiquitin ligase influences the oxidative stress response via degradation of active Pap1 bZIP transcription factor in the nucleus, MOLECULAR MICROBIOLOGY, 80(3), 739-755, 201105
  24. The Oxidative Stress Responsive Transcription Factor Pap1 Confers DNA Damage Resistance on Checkpoint-Deficient Fission Yeast Cells, PLOS ONE, 9(2), 20140225
  25. Application of a phosphite dehydrogenase gene as a novel dominant selection marker for yeasts, JOURNAL OF BIOTECHNOLOGY, 182, 68-73, 20140720
  26. 1P-112 The selection system for the transgenic yeasts with phosphite dehydorogenase, 65, 20130825
  27. Spindle checkpoint activation at meiosis I advances anaphase II onset via meiosis-specific APC/C regulation, JOURNAL OF CELL BIOLOGY, 182(2), 277-288, 2008
  28. Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast, MOLECULAR BIOLOGY OF THE CELL, 22(9), 1486-1494, 2011
  29. NBRP-Yeast Genetic Resource Center goes on to the third phase, YEAST, 30, 213-213, 2013
  30. The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, YEAST, 32(9), 607-614, 201509
  31. The ClpS-like N-domain is essential for the functioning of Ubr11, an N-recognin in Schizosaccharomyces pombe, SPRINGERPLUS, 3, 20140520
  32. Inhibition of the Arg/N-end rule pathway-mediated proteolysis by dipeptide-mimetic molecules, AMINO ACIDS, 48(1), 235-243, 201601
  33. UDP-galactose transporter gene hUGT1 expression in tobacco plants leads to hyper-galactosylated cell wall components, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 121(5), 573-583, 201605
  34. ★, Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1864(2), 393-398, 201702
  35. The benefits and risks of expressing the POT and FOT family of oligopeptide transporters in Saccharomyces cerevisiae, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 82(3), 540-546, 2018
  36. Expression of the human UDP-galactose transporter gene hUGT1 in tobacco plants' enhanced plant hardness, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 126(2), 241-248, 201808
  37. Spindle pole body movement is affected by glucose and ammonium chloride in fission yeast, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 511(4), 820-825, 20190416
  38. Reliable imaging of ATP in living budding and fission yeast, JOURNAL OF CELL SCIENCE, 132(8), 201904
  39. Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1, REDOX BIOLOGY, 28, 202001

Invited Lecture, Oral Presentation, Poster Presentation

  1. Regulation of oligopeptide and amino acid utilization by transcriptional network, Kenji Kitamura, 9th international fission yeast meeting, 2017/05/14, Without Invitation, English
  2. Ubr11 regulates uptake of dipeptides via degradation of Upa1, Kenji Kitamura, 8th international fission yeast meeting, 2015/06/21, Without Invitation, English
  3. UBR11 UBIQUITIN LIGASE REGULATES MODULATION OF CELL GROWTH BY EXTRCELLULAR OLIGOPEPTIDES AND AMINO ACIDS, Kenji Kitamura, 7th international fission yeast meeting, 2013/06/24, Without Invitation, English