Keiei Son

Last Updated :2022/06/30

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
jysunhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, TOHOKU UNIVERSITY

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry

Research Keywords

  • chromosomal translocation
  • DNA repair
  • heme Bach1

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Intensive, Practice for medical research
  2. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  3. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  4. 2022, Graduate Education (Master's Program) , First Semester, Research
  5. 2022, Graduate Education (Master's Program) , Second Semester, Research
  6. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  7. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  8. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  9. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  10. 2022, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
  11. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular Biology
  12. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular Biology
  13. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular Biology
  14. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular Biology
  15. 2022, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology
  16. 2022, Undergraduate Education, Intensive, Practice for medical research
  17. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  18. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  19. 2022, Graduate Education (Master's Program) , First Semester, Research
  20. 2022, Graduate Education (Master's Program) , Second Semester, Research
  21. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  22. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  23. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  24. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  25. 2022, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
  26. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular Biology
  27. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular Biology
  28. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular Biology
  29. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular Biology
  30. 2022, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

  1. [Ionizing radiation-induced DNA damage and repair]., Nihon rinsho. Japanese journal of clinical medicine, 70(3), 2012
  2. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene., The EMBO journal, 21(19), 2002
  3. Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice., Oxidative medicine and cellular longevity, 2014, 2014
  4. ★, Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2015
  5. Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T., Biochemistry, 55(4), 2016
  6. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1., The EMBO journal, 23(13), 2004
  7. Heme oxygenase-1 gene enhancer manifests silencing activity in a chromatin environment prior to oxidative stress., Antioxidants & redox signaling, 8(1-2), 2006
  8. Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells., Genes, chromosomes & cancer, 46(1), 2007
  9. [Genomic instability in leukemia]., Nihon rinsho. Japanese journal of clinical medicine, 65 Suppl 1, 2007
  10. Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain., Neuroscience letters, 440(2), 2008
  11. ★, ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot., PloS one, 5(10), 2010
  12. A modified system for analyzing ionizing radiation-induced chromosome abnormalities., Radiation research, 177(5), 2012
  13. [Genomic instability in leukemia]., Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 2, 2012
  14. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil‑induced DNA damage in esophageal cancer cell lines., International journal of oncology, 42(6), 2013
  15. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition., Cancer science, 104(12), 2013
  16. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage., Journal of cell science, 126(Pt 22), 2013
  17. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1., Scientific reports, 4, 2014
  18. Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2., International journal of radiation oncology, biology, physics, 89(4), 2014
  19. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program., Nature immunology, 15(12), 2014
  20. ★, hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair., Genes to cells : devoted to molecular & cellular mechanisms, 20(9), 2015
  21. Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells., Cancer science, 107(4), 2016
  22. SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites., Nucleus (Austin, Tex.), 9(1), 87-94, 201801
  23. ★, Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations., eLife, 7, e32222, 20180508
  24. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure., Radiation research, 190(4), 424-432, 201810
  25. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene., The Journal of biological chemistry, 278(49), 2003
  26. ★, Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network., Proceedings of the National Academy of Sciences of the United States of America, 101(6), 2004
  27. Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells., The Journal of biological chemistry, 278(11), 2003
  28. Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment., Blood, 105(8), 2005
  29. Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes., Biochemical and biophysical research communications, 340(1), 2006
  30. Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2., EMBO reports, 13(1), 2011
  31. Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1, EMBO J., 20(11), 2001
  32. ★, The promoter of mouse transcription repressor bach1 is regulated by Sp1 and trans-activated by Bach1., J Biochem, 130(3), 2001
  33. Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthase., J Biochem, 136(2), 2004
  34. Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells, J Biol Chem., 279(7), 2004
  35. The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation., Antioxidants & redox signaling, 8(1-2)
  36. Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome., Nucleic Acids Res., 46(19), 10007-10018, 20181102
  37. Matrin3 promotes homologous recombinational repair by regulation of RAD51, J Biochem., 20190523
  38. Matrin3 promotes homologous recombinational repair by regulation of RAD51, JOURNAL OF BIOCHEMISTRY, 166(4), 343-351, 201910
  39. The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation., Antioxidants & redox signaling, 8(1-2)
  40. Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients, RADIATION RESEARCH, 195(3), 244-252, 202103

Invited Lecture, Oral Presentation, Poster Presentation

  1. INO80 chromatin remodeling complex phosphorylation regulated by ATM prevents etoposide-induced chromosomal translocations, Jiying, 2020/10/15, With Invitation, Japanese
  2. The molecular mechanism of ARP8 phosphorylation in preventing 11q23 chromosomal translocations, Sun jiyng, Tashiro Satoshi, The 79th Annual Meeting of Japanese Cancer Association, 2020/10/01, Without Invitation, English, Hiroshima
  3. Phosphorylated ARP8, a subunit of INO80 chromatin remodeling complex prevents etoposide-induced chromosomal translocations, Jiying Sun, The 42nd annual meeting of the molecular biology Society of Japan, 2019/12/04, With Invitation, Japanese
  4. Prevention of 11q23 chromosomal translocations by ATM and ATR through the phosphorylation of ARP8., Jiying Sun, The 78th Annual Meeting of Japanese Cancer Association, 2019/09/26, Without Invitation, Japanese
  5. Prevention of 11q23 chromosomal translocations through ARP8 phosphorylation by ATM., Sun jiying, The 3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2019/01/13, Without Invitation, Japanese
  6. ATM regulates ARP8 phosphorylation to prevent etoposide-induced chromosomal translocations, Sun Jiying, Lin Shi, Aiko Kinomura, Atsuhiko Fukuto, 5, Yasunori Horikoshi Yukako Oma, Masahiko Harata, Masae Ikura, Tsuyoshi Ikura, Roland Kanaar , Satoshi Tashiro, The 41st Annual Meeting of the Molecular Biology Society of Japan, 2018/11/28, Without Invitation, English
  7. ATM regulates INO80 chromatin remodeling complex phosphorylation to prevent chromosomal translocations, 2018/09/27, Without Invitation, English
  8. INO80 chromatin remodeling complex prevents 11q23 chromosomal translocations, Satoshi Tashiro, The 76th Annual Meeting of Japanese Cancer Association, 2017/09/28, Without Invitation, English
  9. Molecular mechanism of etoposide induced 11q23 chromosome translocations, Jiying Sun, Aiko Kinomura, Tsuyoshi Ikura, and Satoshi Tashiro, 5th international symposium of the mathematics on chromatin live dynamics, 2017/03/07, Without Invitation, English
  10. Involvement of a chromatin remodeling factor in chromosomal translocations, Sun Jiying, 2017/01/11, Without Invitation, English
  11. Involvement of a chromatin remodeling factor in chromosomal translocations, Tsuyoshi Ikura, and Satoshi Tashiro, 2016/10/08, Without Invitation, English
  12. Molecular mechanism of etoposide induced 11q23 chromosome translocations, Jiying Sun, Aiko Kinomura1, Masahiko Harata2, Tsuyoshi Ikura3, and Satoshi Tashiro, 2016/09/25, Without Invitation, English
  13. Involvement of a chromatin remodeling factor in chromosomal translocations, Jiying Sun, Aiko Kinomura, Masahiko Harata, Tsuyoshi Ikura, andSatoshi Tashiro, 2016/03/25, Without Invitation, Japanese
  14. Involvement of a chromatin remodeling factor in chromosomal translocations, Jiying Sun, Aiko Kinomura, Masahiko Harata, Tsuyoshi Ikura, and Satoshi Tashiro, 2015/12/01, Without Invitation, English
  15. Molecular mechanism of etoposide induced 11q23 chromosome translocations, Jiying Sun, Tsuyoshi Ikura, Satoshi Tashiro, 2015/10/08, Without Invitation, English
  16. Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Aiko Kinomura, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 15th international congress of radiation research, 2015/05/25, Without Invitation, English
  17. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, Ning-Ang Liu, Jiying Sun, Kazuteru Kono, Yasunori Horikoshi, Tsuyoshi Ikura, Xing Tong, Tokuko Haraguchi and Satoshi Tashiro, 15th international congress of radiation research, 2015/05/25, Without Invitation, English
  18. Involvement of recombination repair proteins in 11q23 chromosome translocation, 2014/10/17, Without Invitation, Japanese
  19. Involvement of recombination repair proteins in 11q23 chromosome translocation, 2014/10/01, Without Invitation, Japanese
  20. Involvement of chromatin remodeling factor in chromosomal translocation, Jiying Sun, Aiko Kinomura, Masayuki Harata, Tsuyoshi Ikura, and Satoshi Tashiro, 2014/02/13, Without Invitation, English
  21. Involvement of chromatin remodeling factor in chromosomal translocation, Jiying Sun, Aiko Kinomura, Masayuki Harata, Tsuyoshi Ikura, and Satoshi Tashiro,, 2013/12/03, Without Invitation, English
  22. Molecular mechanism of etoposide induced 11q23 chromosome translocation,, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura and Satoshi Tashiro, 2013/12/03, Without Invitation, English
  23. Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Tsuyoshi Ikura, Satoshi Tashiro, 2013/10/03, Without Invitation, Japanese
  24. Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 3rd RIRBM International Symposium, 2013/02, Without Invitation, English
  25. Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 2012/12/11, Without Invitation, Japanese
  26. Mechanism of 11q23 chromosomal translocation after etoposide treatment, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 2012/09/06, Without Invitation, Japanese
  27. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Dipanjan Chowdhury and Satoshi Tashiro, 2nd RIRBM International Symposium, 2012/02/20, Without Invitation, English
  28. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki, Shuki Mizutani, Roland Kanaar and Satoshi Tashiro, 2011/11/17, Without Invitation, Japanese
  29. Mechanism of 11q23 chromosomal translocation after etoposide treatment, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 2011/09/21, Without Invitation, English
  30. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki and Satoshi Tashiro, 2011/03/03, Without Invitation, English
  31. ATM modulates the loading of recombination proteins onto MLL BCR, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki and Satoshi Tashiro, 2010/12/07, Without Invitation, English
  32. INO80 chromatin remodeling complex prevents 11q23 chromosomal translocations, Jiying Sun and Satoshi Tashiro, Without Invitation, Japanese
  33. Prevention of 11q23 chromosomal translocations by ATM and ATR through the phosphorylation of ARP8., Jiying Sun and Satoshi Tashiro, Without Invitation, Japanese