Keiei Son
Last Updated :2024/05/07
- Affiliations, Positions
- Research Institute for Radiation Biology and Medicine, Associate Professor
- E-mail
- jysunhiroshima-u.ac.jp
Basic Information
Academic Degrees
- Doctor of Philosophy in Medical Science, TOHOKU UNIVERSITY
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine
Research Fields
- Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
Research Keywords
- chromosomal translocation
- DNA repair
- heme Bach1
Educational Activity
Course in Charge
- 2024, Undergraduate Education, Intensive, Practice for medical research
- 2024, Graduate Education (Master's Program) , First Semester, Seminar
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar
- 2024, Graduate Education (Master's Program) , First Semester, Research
- 2024, Graduate Education (Master's Program) , Second Semester, Research
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2024, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular Biology
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular Biology
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular Biology
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular Biology
- 2024, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology
Research Activities
Academic Papers
- Klotho protects chromosomal DNA from radiation-induced damage, JOURNAL OF BIOCHEMISTRY, 173(5), 375-382, 20230426
- A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage, Radiat Res, 197(4), 38-395, 20220401
- Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients, Radiat Res, 195(3), 244-252, 20210301
- A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage, RADIATION RESEARCH, 197(4), 384-395, 202204
- [Ionizing radiation-induced DNA damage and repair]., Nihon rinsho. Japanese journal of clinical medicine, 70(3), 2012
- Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene., The EMBO journal, 21(19), 2002
- Bach1 deficiency and accompanying overexpression of heme oxygenase-1 do not influence aging or tumorigenesis in mice., Oxidative medicine and cellular longevity, 2014, 2014
- ★, Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2015
- Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T., Biochemistry, 55(4), 2016
- Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1., The EMBO journal, 23(13), 2004
- Heme oxygenase-1 gene enhancer manifests silencing activity in a chromatin environment prior to oxidative stress., Antioxidants & redox signaling, 8(1-2), 2006
- Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells., Genes, chromosomes & cancer, 46(1), 2007
- [Genomic instability in leukemia]., Nihon rinsho. Japanese journal of clinical medicine, 65 Suppl 1, 2007
- Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain., Neuroscience letters, 440(2), 2008
- ★, ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot., PloS one, 5(10), 2010
- A modified system for analyzing ionizing radiation-induced chromosome abnormalities., Radiation research, 177(5), 2012
- [Genomic instability in leukemia]., Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 2, 2012
- Involvement of ribonucleotide reductase-M1 in 5-fluorouracil‑induced DNA damage in esophageal cancer cell lines., International journal of oncology, 42(6), 2013
- Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition., Cancer science, 104(12), 2013
- Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage., Journal of cell science, 126(Pt 22), 2013
- Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1., Scientific reports, 4, 2014
- Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2., International journal of radiation oncology, biology, physics, 89(4), 2014
- The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program., Nature immunology, 15(12), 2014
- ★, hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair., Genes to cells : devoted to molecular & cellular mechanisms, 20(9), 2015
- Enhanced gefitinib-induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia-mutated kinase inhibition in non-small-cell lung cancer cells., Cancer science, 107(4), 2016
- SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites., Nucleus (Austin, Tex.), 9(1), 87-94, 201801
- ★, Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations., eLife, 7, e32222, 20180508
- Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure., Radiation research, 190(4), 424-432, 201810
- Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene., The Journal of biological chemistry, 278(49), 2003
- ★, Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network., Proceedings of the National Academy of Sciences of the United States of America, 101(6), 2004
- Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells., The Journal of biological chemistry, 278(11), 2003
- Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment., Blood, 105(8), 2005
- Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes., Biochemical and biophysical research communications, 340(1), 2006
- Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2., EMBO reports, 13(1), 2011
- Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1, EMBO J., 20(11), 2001
- ★, The promoter of mouse transcription repressor bach1 is regulated by Sp1 and trans-activated by Bach1., J Biochem, 130(3), 2001
- Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthase., J Biochem, 136(2), 2004
- Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells, J Biol Chem., 279(7), 2004
- The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation., Antioxidants & redox signaling, 8(1-2)
- Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome., Nucleic Acids Res., 46(19), 10007-10018, 20181102
- Matrin3 promotes homologous recombinational repair by regulation of RAD51, J Biochem., 166(4), 343-351, 20190523
- Matrin3 promotes homologous recombinational repair by regulation of RAD51, JOURNAL OF BIOCHEMISTRY, 166(4), 343-351, 201910
- The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation., Antioxidants & redox signaling, 8(1-2)
- Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients, RADIATION RESEARCH, 195(3), 244-252, 202103
Invited Lecture, Oral Presentation, Poster Presentation
- Involvement of ARP8 phosphorylation in the regulation of replication stress response, Jiying Sun, Satoshi Tashiro, 2022/09/29, Without Invitation, English
- A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage, Jiying SUN , Shu FUJINO, Shinya NAKAYAMA , Yasunori HORIKOSHI , Yasuha KINUGASA , Mari ISHIDA , Chiemi SAKAI , Shigehiro DOI , Takao MASAKI , Satoshi TASHIRO, 2022/09/15, Without Invitation, English
- Prevention of chromosomal translocations by ATM- regulated phosphorylation of INO80 chromatin remodeling complex, Sun jiying, 2021/09/21, With Invitation, Japanese
- INO80 chromatin remodeling complex phosphorylation regulated by ATM prevents etoposide-induced chromosomal translocations, Jiying, 2020/10/15, With Invitation, Japanese
- The molecular mechanism of ARP8 phosphorylation in preventing 11q23 chromosomal translocations, Sun jiyng, Tashiro Satoshi, The 79th Annual Meeting of Japanese Cancer Association, 2020/10/01, With Invitation, English, Hiroshima
- Phosphorylated ARP8, a subunit of INO80 chromatin remodeling complex prevents etoposide-induced chromosomal translocations, Jiying Sun, The 42nd annual meeting of the molecular biology Society of Japan, 2019/12/04, With Invitation, Japanese
- Prevention of 11q23 chromosomal translocations by ATM and ATR through the phosphorylation of ARP8., Jiying Sun, The 78th Annual Meeting of Japanese Cancer Association, 2019/09/26, Without Invitation, Japanese
- Prevention of 11q23 chromosomal translocations through ARP8 phosphorylation by ATM., Sun jiying, The 3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2019/01/13, Without Invitation, Japanese
- ATM regulates ARP8 phosphorylation to prevent etoposide-induced chromosomal translocations, Sun Jiying, Lin Shi, Aiko Kinomura, Atsuhiko Fukuto, 5, Yasunori Horikoshi
Yukako Oma, Masahiko Harata, Masae Ikura, Tsuyoshi Ikura, Roland Kanaar , Satoshi Tashiro, The 41st Annual Meeting of the Molecular Biology Society of Japan, 2018/11/28, Without Invitation, English
- ATM regulates INO80 chromatin remodeling complex phosphorylation to prevent chromosomal translocations, 2018/09/27, Without Invitation, English
- INO80 chromatin remodeling complex prevents 11q23 chromosomal translocations, Satoshi Tashiro, The 76th Annual Meeting of Japanese Cancer Association, 2017/09/28, Without Invitation, English
- Molecular mechanism of etoposide induced 11q23 chromosome translocations, Jiying Sun, Aiko Kinomura, Tsuyoshi Ikura, and Satoshi Tashiro, 5th international symposium of the mathematics on chromatin live dynamics, 2017/03/07, Without Invitation, English
- Involvement of a chromatin remodeling factor in chromosomal translocations, Sun Jiying, 2017/01/11, Without Invitation, English
- Involvement of a chromatin remodeling factor in chromosomal translocations, Tsuyoshi Ikura, and Satoshi Tashiro, 2016/10/08, Without Invitation, English
- Molecular mechanism of etoposide induced 11q23 chromosome translocations, Jiying Sun, Aiko Kinomura1, Masahiko Harata2, Tsuyoshi Ikura3, and Satoshi Tashiro, 2016/09/25, Without Invitation, English
- Involvement of a chromatin remodeling factor in chromosomal translocations, Jiying Sun, Aiko Kinomura, Masahiko Harata, Tsuyoshi Ikura, andSatoshi Tashiro, 2016/03/25, Without Invitation, Japanese
- Involvement of a chromatin remodeling factor in chromosomal translocations, Jiying Sun, Aiko Kinomura, Masahiko Harata, Tsuyoshi Ikura, and Satoshi Tashiro, 2015/12/01, Without Invitation, English
- Molecular mechanism of etoposide induced 11q23 chromosome translocations, Jiying Sun, Tsuyoshi Ikura, Satoshi Tashiro, 2015/10/08, Without Invitation, English
- Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Aiko Kinomura, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 15th international congress of radiation research, 2015/05/25, Without Invitation, English
- Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage, Ning-Ang Liu, Jiying Sun, Kazuteru Kono, Yasunori Horikoshi, Tsuyoshi Ikura, Xing Tong, Tokuko Haraguchi and Satoshi Tashiro, 15th international congress of radiation research, 2015/05/25, Without Invitation, English
- Involvement of recombination repair proteins in 11q23 chromosome translocation, 2014/10/17, Without Invitation, Japanese
- Involvement of recombination repair proteins in 11q23 chromosome translocation, 2014/10/01, Without Invitation, Japanese
- Involvement of chromatin remodeling factor in chromosomal translocation, Jiying Sun, Aiko Kinomura, Masayuki Harata, Tsuyoshi Ikura, and Satoshi Tashiro, 2014/02/13, Without Invitation, English
- Involvement of chromatin remodeling factor in chromosomal translocation, Jiying Sun, Aiko Kinomura, Masayuki Harata, Tsuyoshi Ikura, and Satoshi Tashiro,, 2013/12/03, Without Invitation, English
- Molecular mechanism of etoposide induced 11q23 chromosome translocation,, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura and Satoshi Tashiro, 2013/12/03, Without Invitation, English
- Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Tsuyoshi Ikura, Satoshi Tashiro, 2013/10/03, Without Invitation, Japanese
- Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 3rd RIRBM International Symposium, 2013/02, Without Invitation, English
- Involvement of recombination repair proteins in 11q23 chromosome translocation, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 2012/12/11, Without Invitation, Japanese
- Mechanism of 11q23 chromosomal translocation after etoposide treatment, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 2012/09/06, Without Invitation, Japanese
- ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Dipanjan Chowdhury and Satoshi Tashiro, 2nd RIRBM International Symposium, 2012/02/20, Without Invitation, English
- ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Hidekazu Suzuki, Shuki Mizutani, Roland Kanaar and Satoshi Tashiro, 2011/11/17, Without Invitation, Japanese
- Mechanism of 11q23 chromosomal translocation after etoposide treatment, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Dipanjan Chowdhury and Satoshi Tashiro, 2011/09/21, Without Invitation, English
- ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki and Satoshi Tashiro, 2011/03/03, Without Invitation, English
- ATM modulates the loading of recombination proteins onto MLL BCR, Jiying Sun, Aiko Kinomura, Hidekazu Suzuki and Satoshi Tashiro, 2010/12/07, Without Invitation, English
- INO80 chromatin remodeling complex prevents 11q23 chromosomal translocations, Jiying Sun and Satoshi Tashiro, Without Invitation, Japanese
- Prevention of 11q23 chromosomal translocations by ATM and ATR through the phosphorylation of ARP8., Jiying Sun and Satoshi Tashiro, Without Invitation, Japanese