YUKIKO NAKANO

Last Updated :2021/04/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
nakanoyhiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi Minamiku Hiroshima, Japan, Japan
TEL : (+81)82-257-5540 FAX : (+81)82-257-1569
Self-introduction
On the research side, I have conducted clinical and molecular biological research on fatal arrhythmias to prevent sudden cardiac death. Atrial fibrillation is the most common arrhythmia,which causes strokes, heart failure, and dementia and increases mortality. I have conducted research for early detection of atrial fibrillation, aiming to extend healthy life expectancy. On the clinical side, I actively performe catheter ablation treatment for arrhythmia.

Basic Information

Major Professional Backgrounds

  • 1991/06/01, 1992/09/30, Hiroshima University, Medical Hospital, Clinical Resident
  • 1992/10/01, 1993/03/31
  • 1993/04/01, 1995/03/31, Hiroshima City Asa Hospital
  • 1999/04/01, 2003/09/30, Hiroshima University, Medical Hospital, Clinical Fellow
  • 2003/10/01, 2004/03/31, Hiroshima University, Hospital, Clinical Fellow
  • 2004/04/01, 2005/03/31, Hiroshima University Hospital, Clinical Fellow
  • 2005/04/01, 2007/03/31, Hiroshima University Hospital, Research Associate
  • 2007/04/01, 2014/07/31, Hiroshima University, Assistant Professor
  • 2014/08/01, 2017/03/31, Hiroshima University Hospital, Lecturer

Educational Backgrounds

  • Hiroshima University, Japan, 1995/04, 1999/03
  • Hiroshima University, Japan, 1985/04, 1991/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Cardiovascular medicine

Research Keywords

  • Arrhythmia

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2021, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2021, Undergraduate Education, First Semester, Internal Medicine Ⅱ
  3. 2021, Graduate Education (Doctoral Program) , 3Term, Advanced Lecture on Creation and Development of Biomedical Sciences
  4. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Creation and Development of Biomedical Sciences
  5. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cardiovascular Medicine
  6. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cardiovascular Medicine
  7. 2021, Graduate Education (Master's Program) , 3Term, Science for Healthy Life
  8. 2021, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B
  9. 2021, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  10. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cardiovascular Medicine
  11. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cardiovascular Medicine
  12. 2021, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cardiovascular Medicine
  13. 2021, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cardiovascular Medicine
  14. 2021, Graduate Education (Master's Program) , First Semester, Pathophysiology

Research Activities

Academic Papers

  1. Cardiac electrophysiological characteristics of silent paroxysmal atrial fibrillation: What causes asymptomaticity?, Journal of Cardiovascular Electrophysiology, 30(12), 2716-2723
  2. HotBalloon ablation of atrial fibrillation in patients with dextrocardia and situs inversus by "mirror image" approach, Journal of Arrhythmia, 35(6), 855-857
  3. In Paroxysmal Atrial Fibrillation Patients, the Neutrophil-to-lymphocyte Ratio Is Related to Thrombogenesis and More Closely Associated with Left Atrial Appendage Contraction than with the Left Atrial Body Function, INTERNAL MEDICINE, 57(5), 633-640, 2018
  4. Head-to-head comparison of the heart rate variability between the bisoprolol transdermal patch and bisoprolol fumarate tablet, CARDIOVASCULAR THERAPEUTICS, 36(3), JUN 2018
  5. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27(4), 1660-1666, 201704
  6. Radiofrequency catheter ablation is effective for atrial fibrillation patients with hypertrophic cardiomyopathy by decreasing left atrial pressure, JOURNAL OF ARRHYTHMIA, 33(4), 256-261, 201708
  7. Syncope in patients with inherited arrhythmias, JOURNAL OF ARRHYTHMIA, 33(6), 572-578, 201712
  8. H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters, JOURNAL OF BIOMEDICAL SCIENCE, 24, 20171204
  9. Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands With Brugada Syndrome A Japanese Multicenter Registry, CIRCULATION, 135(23), 2255-+, 20170606
  10. Cardiac resynchronization therapy for patients with cardiac sarcoidosis, EUROPACE, 19(5), 824-830, 201705
  11. Arrhythmia risk and beta-blocker therapy in pregnant women with long QT syndrome, HEART, 103(17), 1374-1379, 201709
  12. ★, Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, Circulation. Arrhythmia and electrophysiology, 9(1), 201601
  13. Increased left atrial pressure in non-heart failure patients with subclinical hypothyroidism and atrial fibrillation, Endocr Connect, 5(3), 101-106, 201603
  14. Electrical remodeling of the atrioventricular node caused by persistent atrial fibrillation in humans, Journal of cardiovascular electrophysiology, 201604
  15. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, European Radiology, 201608
  16. Electrical Remodeling of the Atrioventricular Node Caused by Persistent Atrial Fibrillation in Humans, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 27(8), 918-922, AUG 2016
  17. Dexmedetomidine Depresses Sinoatrial and Atrioventricular Nodal Function Without Any Change in Atrial Fibrillation Inducibility, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 68(6), 473-478, DEC 2016
  18. Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese, JOURNAL OF BIOMEDICAL SCIENCE, 23, DEC 7 2016
  19. Genetics of long-QT syndrome, JOURNAL OF HUMAN GENETICS, 61(1), 51-55, JAN 2016
  20. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9(1), JAN 2016
  21. Increased left atrial pressure in non-heart failure patients with subclinical hypothyroidism and atrial fibrillation, ENDOCRINE CONNECTIONS, 5(3), 101-106, MAY 1 2016
  22. Don't expect left ventricular reverse remodeling after cardiac resynchronization therapy in patients with systolic heart failure and atrioventricular block: A multicenter study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 221, 597-600, OCT 15 2016
  23. ★, Risk stratification of ventricular fibrillation in Brugada syndrome using noninvasive scoring methods, HEART RHYTHM, 13(10), 1947-1954, OCT 2016
  24. Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 5(9), SEP 2016
  25. Who is the operator, that is the question: a multicentre study of catheter ablation of atrial fibrillation, EUROPACE, 18(9), 1352-1356, SEP 2016
  26. Increased urine output by ipragliflozin in a non-diabetic patient with a diuretic-resistant heart failure, Int J Cardiol, 180, 42-43, 201502
  27. Mechanical and substrate abnormalities of the left atrium assessed by 3-dimensional speckle-tracking echocardiography and electroanatomic mapping system in patients with paroxysmal atrial fibrillation, HEART RHYTHM, 12(3), 490-497, MAR 2015
  28. Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation, JOURNAL OF CARDIOLOGY, 64(2), 133-138, AUG 2014
  29. Prediction of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Using Preoperative Total Atrial Conduction Time Determined on Tissue Doppler Imaging, CIRCULATION JOURNAL, 78(2), 345-352, FEB 2014
  30. Don't move during ablation of atrial fibrillation!, INTERNATIONAL JOURNAL OF CARDIOLOGY, 171(1), 78-81, JAN 15 2014
  31. Procedural sedation with dexmedetomidine during ablation of atrial fibrillation: a randomized controlled trial, EUROPACE, 16(7), 994-999, JUL 2014
  32. Periprocedural coagulability in patients undergoing ablation of atrial fibrillation: lessons from a periablation anticoagulation strategy of a brief withdrawal of warfarin without heparin bridging, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 37(4), 393-399, MAY 2014
  33. Impact of Pulmonary Vein Isolation on Fractionated Atrial Potentials and Ganglionated Plexi in Patients With Persistent Atrial Fibrillation, INTERNATIONAL HEART JOURNAL, 55(6), 494-498, NOV 2014
  34. Incomplete Cure of Tachycardia-Induced Cardiomyopathy Secondary to Rapid Atrial Fibrillation by Heart Rate Control Without Sinus Conversion, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 25(10), 1037-1043, OCT 2014
  35. Time-Domain T-Wave Alternans is Strongly Associated with a History of Ventricular Fibrillation in Patients with Brugada Syndrome, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 25(9), 1021-1027, SEP 2014
  36. A Head-to-Head Comparison of Periprocedural Coagulability Under Anticoagulation with Rivaroxaban Versus Dabigatran in Patients Undergoing Ablation of Atrial Fibrillation, CLINICAL DRUG INVESTIGATION, 33(11), 847-853, 2013
  37. Impact of aldosterone-producing adenoma on cardiac structures in echocardiography, Journal of echocardiography, 11, 123-129, 201302
  38. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9(4), APR 2013
  39. Variable Procedural Strategies Adapted to Anatomical Characteristics in Catheter Ablation of the Cavotricuspid Isthmus Using a Preoperative Multidetector Computed Tomography Analysis, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 24(12), 1344-1351, DEC 2013
  40. Pulmonary Artery Mapping for Differential Diagnosis of Left-Sided Atrial Tachycardia, CIRCULATION JOURNAL, 77(2), 345-351, FEB 2013
  41. Clinical significance of sleep-disordered breathing induced by sedatives during ablation of atrial fibrillation, SLEEP MEDICINE, 14(7), 622-627, JUL 2013
  42. Left atrial thickness under the catheter ablation lines in patients with paroxysmal atrial fibrillation: insights from 64-slice multidetector computed tomography, HEART AND VESSELS, 28(3), 360-368, MAY 2013
  43. Ablation of atrial fibrillation in Brugada syndrome patients with an implantable cardioverter defibrillator to prevent inappropriate shocks resulting from rapid atrial fibrillation, INTERNATIONAL JOURNAL OF CARDIOLOGY, 168(6), 5273-5276, OCT 15 2013
  44. Outcomes of Ablation of Paroxysmal Atrial Fibrillation in Patients on Chronic Hemodialysis, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 23(12), 1289-1294, DEC 2012
  45. Effects of Ivabradine on the Pulmonary Vein Electrical Activity and Modulation of Pacemaker Currents and Calcium Homeostasis, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 23(2), 200-206, FEB 2012
  46. Prediction of sinus node dysfunction in patients with persistent atrial flutter using the flutter cycle length, EUROPACE, 14(3), 380-387, MAR 2012
  47. Prediction of sinus node dysfunction in patients with long-standing persistent atrial fibrillation using the atrial fibrillatory cycle length, JOURNAL OF ELECTROCARDIOLOGY, 45(2), 141-147, MAR-APR 2012
  48. Atrioventricular conduction properties in patients with prolonged pauses undergoing ablation of longstanding persistent atrial fibrillation: do pauses during atrial fibrillation matter?, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 34(3), 277-285, SEP 2012
  49. High-frequency stimulation of the atria increases early recurrence following pulmonary vein isolation in patients with persistent atrial fibrillation, HEART RHYTHM, 9(9), 1386-1392, SEP 2012
  50. Use of preprocedural multidetector computed tomography to decrease atrial fibrillation recurrence following extensive encircling circumferential pulmonary vein isolation, JOURNAL OF CARDIOLOGY, 60(3-4), 236-241, SEP-OCT 2012
  51. Sleep-disordered breathing predicts sinus node dysfunction in persistent atrial fibrillation patients undergoing pulmonary vein isolation, JOURNAL OF CARDIOLOGY, 60(3-4), 321-326, SEP-OCT 2012
  52. Platelet Function Measured Using a Whole Blood Aggregometer Can Predict Bleeding Events, Journal of atherosclerosis and thrombosis, 18(1), 18-23, 2011
  53. Relationship Between Arrhythmogenic Pulmonary Veins and the Surrounding Atrial Substrate in Patients with Paroxysmal Atrial Fibrillation, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 22(4), 405-410, APR 2011
  54. Rapid hemostasis at the femoral venous access site using a novel hemostatic pad containing kaolin after atrial fibrillation ablation, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 31(2), 157-164, AUG 2011
  55. How many electrical cardioversions should be applied for repetitive recurrences of atrial arrhythmias following ablation of persistent atrial fibrillation?, EUROPACE, 13(12), 1703-1708, DEC 2011
  56. The Origin and Clinical Significance of the Signal Opposite to the Mitral E-Wave: A Simple and Novel Indicator of Left Ventricular Filling Pressure, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 28(6), 606-611, JUL 2011
  57. Learning curve for ablation of atrial fibrillation in medium-volume centers, JOURNAL OF CARDIOLOGY, 57(3), 263-268, MAY 2011
  58. Is structural remodeling of fibrillated atria the consequence of tissue hypoxia?, Circulation Journal, 74(9), 1815-1821, 201009
  59. Clinical Course and Outcome of Heart Transplant Recipients Single Center Experience at the National Cardiovascular Center in Japan, INTERNATIONAL HEART JOURNAL, 51(4), 264-271, JUL 2010
  60. A spontaneous Type 1 electrocardiogram pattern in lead V-2 is an independent predictor of ventricular fibrillation in Brugada syndrome, EUROPACE, 12(3), 410-416, MAR 2010
  61. Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris, HYPERTENSION RESEARCH, 33(11), 1162-1166, NOV 2010
  62. Long-Term Electrocardiographic Follow-up From Childhood of an Adult Patient With Brugada Syndrome Associated With Sick Sinus Syndrome - A Case Report, CIRCULATION JOURNAL, 73(3), 575-579, MAR 2009
  63. Predictors and long-term prognostic implications of angiographic slow/no-flow during percutaneous coronary intervention for acute myocardial infarction, INTERNAL MEDICINE, 47(10), 899-906, 2008
  64. Non-SCN5A Related Brugada Syndromes: Verification of Normal Splicing and Trafficking of SCN5A without Exonic Mutations, Annals of Human Genetics, 71, 8-17, 20070101
  65. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet., Hypertension Research, 30(1), 85-91, 20070101
  66. Coronary sinus Morphology in Patients with Posteroseptal Atrioventricular Accessory Pathways., J Arrthmia, 22(3), 149-154, 20060401
  67. Ablation of indiopathic ventricular tachycardia with a left Bundle-Branch block morphology originating from the pulmonary artery., J Arrthmia, 22(3), 180-186, 20060401
  68. Successive, rapid recurrences on in-stent restenoses in a woman with angina pecteoris., Intern Med, 45, 1093-1096, 20060401
  69. Coronary sinus morphology in patients with posteroseptal atrioventricular pathways, J Arrhythmia, 22, 149-154, 20061201
  70. Ablation of ventricular tachycardia originating from the right ventricle associated with scleroderma cardiomyopathy., J Arrhythmia, 21(5), 542-545, 20050401
  71. Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(5), 818-825, MAR 3 2004
  72. Improvement of atrial signal-averaged electrocardiographic abnormalities after radiofrequency catheter ablation in persistent atrial flutter, JAPANESE HEART JOURNAL, 45(5), 761-770, SEP 2004
  73. Estrogen replacement suppresses function of thrombin stimulated platelets by inhibiting Ca2+ influx and raising cyclic adenosine monophosphate, Cardiovascular Research, 53, 634-641, 20020401
  74. A frameshift mutation of beta subunit of epithelial sodium channel in a case of isolated Liddle syndrome., Journal of Hypertension, 20(12), 2379-82, 20021201
  75. Non-dipper phenomenon in essential hypertension is related to blunted nocturnal riseand fall of sympatho-vagal nervous activity and progress in retinopathy, 88, 181-186, 20010401
  76. Calorie restriction reduced blood pressure in obesity hypertensives by improvement of Autonomic nerve activity and insulin sensitivity, Journal of Cardiovascular Pharmacology, 38, 69-74, 20010401
  77. Vitamine D receptor gene polymorpnism is associated with serum total and ionized calcium concentration, Journal of molecular Medicine, 78(10), 575-579, 20000401
  78. Abnormal magnesium status in patients with cardiovascular diseases, Clinical Science, 98, 175-181, 20000401
  79. Abnormal Ca2+ handling and increased Mg2+ permeability in platelets of hypertensive rats, Hypertension Research, 23, 651-657, 20000401
  80. Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration, Journal of molecular Medicine, 78(10), 575-579, 20000401
  81. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human gallbladder lesions, EUROPEAN JOURNAL OF CANCER, 36(2), 257-263, JAN 2000
  82. Abnormal Ca2+ handling and increased Mg2+ permeability in platelets of hypertensive rats, HYPERTENSION RESEARCH, 23(6), 651-657, NOV 2000
  83. Increased cytosolic free Mg2+ and Ca2+ in platelets of patients with vasospastic angina, American Journal of Physiology, 274, R544-R548, 19980401
  84. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension, Hypertension, 32, 16-24, 19980401
  85. Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension, Hypertension, 29(1), 280-285, 19970401
  86. Lack of effect of transmembrane gradient of magunesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes, Biochimica et Biophysica Acta, 1329, 169-173, 19970401
  87. Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertension, American Journal of Hypertension, 10(9), 1064-1068, 19970401
  88. Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension (Noninvasive 24-hour ambulatory blood pressure monitoring), Hypertention, 30, 163-167, 19970401
  89. Effect of fibrillatory wave amplitude on coronary blood flow as assessed by thrombolysis in myocardial infarction frame count in patients with atrial fibrillation, HEART AND VESSELS, 33(7), 786-792, JUL 2018
  90. Maintenance of low inflammation level by the ZFHX3 SNP rs2106261 minor allele contributes to reduced atrial fibrillation recurrence after pulmonary vein isolation, PLOS ONE, 13(9), SEP 4 2018
  91. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement, SCIENTIFIC REPORTS, 8, OCT 1 2018
  92. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190(4), 424-432, OCT 2018
  93. ★, HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation, CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11(7), 201807
  94. Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation, PLOS ONE, 14(3), 20190306
  95. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, EUROPEAN JOURNAL OF NUTRITION, 58(3), 989-996, 201904
  96. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9(1), 10206-10206, 20190715
  97. Safety and Efficacy of Minimally Interrupted Dabigatran vs Uninterrupted Warfarin Therapy in Adults Undergoing Atrial Fibrillation Catheter Ablation A Randomized Clinical Trial, JAMA NETWORK OPEN, 2(4), 201904
  98. Diagnostic performance of the N-terminal pro-brain natriuretic peptide to detect an increased left atrial pressure in patients with persistent atrial fibrillation, Clin Chem Lab Med., 56(6), e147-e149, 201805
  99. Residual anticoagulation activity in atrial fibrillation patients with temporary interrupted direct oral anticoagulants: Comparisons across 4 drugs, THROMBOSIS RESEARCH, 183, 119-123, 201911
  100. Successful catheter ablation of persistent atrial fibrillation is associated with improvement in functional tricuspid regurgitation and right heart reverse remodeling, HEART AND VESSELS, 35(6), 842-851, 202006
  101. Predicting atrial fibrillation using a combination of genetic risk score and clinical risk factors, HEART RHYTHM, 17(5), 699-705, 202005
  102. Remaining activity of temporary interrupted direct oral anticoagulants and its impact on intra-ablation heparinization in patients with atrial fibrillation: Comparisons across four drugs and two dose regimens, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 31(8), 1996-2004, 202008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Uninterrupted vs. Interrupted Dabigatran. Uninterrupted Dabigatran is Associate with Optimal ACT Control During Catheter Ablation, Shunsuke Miyauchi, Yukiko Nakano Y, Yoshihiro Ikeuchi, Sho Okamura, Yosaku Okubo, Naoya Hironobe, Takehito Tokuyama, Yasuki Kihara, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/18, Without Invitation, English, Pennsylvania, PA
  2. Circulating Mir-223-3p As A Novel Biomarker And Pathogenesis Of Brugada Syndrome, Yukiko Nakano, Onohara Y, Motoda C, Tokuyama T, Hironobe N, Okubo Y, Okamura S, Miyauchi S, Ikeuchi Y, Nishiyama O, Ochi H, Chayama K, Kihara Y, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/18, Without Invitation, English, Pennsylvania, PA
  3. Left Atrial Dimension Reduction Rate After Blanking Period Predicts Late Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation, Shunsuke Miyauchi, Yukiko Nakano, Yoshihiro Ikeuchi, Sho Okamura, Yosaku Okubo, Naoya Hironobe, Takehito Tokuyama, Yasuki Kihara, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/17, Without Invitation, English, Pennsylvania, PA
  4. Inconsistency Between Epinephrine Provocation Test And Genetic Test In Type 2 Long QT Syndrome, Yukiko Nakano, Onohara Y, Tokuyama T, Hironobe N, Okubo Y, Okamura S, Miyauchi S, Ikeuchi Y, Yamada T, Ochi H, Chayama K, Kihara Y, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/17, Without Invitation, English, Pennsylvania, PA
  5. Predicting Atrial Fibrillation using a Combination of Genetic Risk Score and Clinical Risk Factors, Yosaku Okubo, Yukiko Nakano, Takehito Tokuyama, Naoya Hironobe, Sho Okamura, Shunsuke Miyauchi, Yoshihiro Ikeuchi, Yasuki Kihara, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/16, Without Invitation, English, Pennsylvania, PA
  6. Gene polymorphisms associated with tachycardia induced cardiomyopathy in patients with AF, Yukiko Nakano, APHRS2019 Asia Pacific Heart Rhythm Society, 2019/10/24, With Invitation, English, Bangkok, Thailand
  7. Uninterrupted vs. Interrupted Dabigatran. Uninterrupted Dabigatran is Associated with Optimal ACT Control During Catheter Ablation, Shunsuke Miyauchi, Yukiko Nakano, Yoshihiro Ikeuchi, Sho Okamura, Yosaku Okubo, Naoya Hironobe, Takehito Tokuyama, Yasuki Kihara, APHRS2019 Asia Pacific Heart Rhythm Society, 2019/10/24, Without Invitation, English, Bangkok, Thailand
  8. Role of microRNA in genetic regulation of cardiac arrhythmias, Yukiko Nakano, APHRS2019 Asia Pacific Heart Rhythm Society, 2019/10/24, With Invitation, English, Bangkok, Thailand
  9. Genetics of Atrial Fibrillation, Yukiko Nakano, Asian-Pacific Society of Atherosclerosis and Vascular Diseases 2019 (APSAVD), 2019/09/21, With Invitation, English, Taipei, Taiwan
  10. A common SCN10A variant may promote DNA methylation of SCN5A Promoter and decrease SCN5A expression in Brugada syndrome patients without SCN5A exonic mutation, Okamura S, Nakano Y, Okubo Y, Hironobe N, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y, American Heart Association Scientific Sessions 2017, 2017/11, Without Invitation, English, Anaheim, USA
  11. Studying Progression Cardiac Conduction Disturbance with patient-specific iPSCs, Motoda C, Yuasa S, Nakano Y, Fukuda K, Kihara Y, American Heart Association Scientific Sessions 2017, 2017/11, Without Invitation, English, Anaheim, USA
  12. Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Logistic Models of Noninvasive Parameters, Nakano Y, Kawazoe H, Ochi H, Takagi M, Tokuyama T, Sairaku A, Matsumura H, Tomomori S, Amioka M, Kihara Y, American Heart Association 2016, 2016/11/14, Without Invitation, English, New Orleans,USA
  13. Variants Of Aldehyde Dehydrogenase 2 And Alcohol Dehydrogenase Genes Are Associated With Atrial Fibrillation, Nakano Y, Ochi H, Tomomori S, Matsumura H, Tokuyama T, Sairaku A, Motoda C, Chayama K, Chen C, Mochly-Rosen D, Kihara Y, American Heart Association 2016, 2016/11/13, Without Invitation, Japanese, New Orleans,USA
  14. A Common Genetic Variant within SCN10A Modulates DNAMethylation of SCN5A Promoters, Nakano Y, Ochi H, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Suenari K, Onohara Y, Chayama K, Kihara Y, The 80th Annual Scientific Meeting of the Japanese Circulation Society, 2016/03/18, Without Invitation, English, Miyagi
  15. Common Variant near HEY2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome, Nakano Y, Ochi H, Toshishige M, Ikenaga H, Oda N, Tokuyama T, Sairaku A, Watanabe Y, Kawazoe H, Matsumura H, Tomomori S, Oda N, Kishimoto S, Uchimura-Makita Y, Motoda C, Fujiwara M, Kajihara K, Itakura K, Chayama K, Kihara Y, The 77th Annual Scientific Meeting of the Japanese Circulation Society, 2015/04/24, With Invitation, English, Oasaka
  16. Atrial fibrillation ablation in patients with advanced congestive heart failure, Nakano Y, The XVI International Symposium on Progress in Clinical Pacing, 2014/12/03, With Invitation, English, Rome,Italy
  17. Common Variant Near Hey2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome by Modurating QTc Interval, Nakano Y, Ochi H, Toshishige M, Tokuyama T, Kawazoe H, Watanabe Y, Matsumura M, Tomomori S, Kishimoto S, Ikenaga H, Oda N, Chayama K, Kihara Y, The 87th Scientific Sessions of the American Heart Association 2014, 2014/11/18, Without Invitation, English
  18. Nonsynonymous Polymorphism in Semaphorin 3A is a New Genetic Risk Factor for Human Idiopathic Ventricular Fibrillation, Nakano Y, Toshisige M, Ochi H, Tokuyama T, Sairaku A, Oda N, Kajiahara K, Uchimura Y, Fujiwara M, Watanabe Y, Kawazoe H, Motoda C, Matumura H, Oda N, Aiba T, Watanabe H, Schimizu W, Horie M, Makita N, Chayama K, Kihara Y, The 78th Annual Scientific Meeting of the Japanese Circulation Society, 2014/03/22, Without Invitation, English, Tokyo
  19. Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest With Documented Ventricular Fibrillation, Nakano Y, Chayama K, Ochi H, Toshishige M, Tokuyama T, Oda N, Uchimura(Makita) Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Kawazoe H, Ikenaga H, Matsumoto S, Oda N, Suenari K, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Watanabe H, Hasegawa K, Aiba T, Ohno S, Shimizu W, Horie M, Tashiro S, Makita N, Kihara Y, The 86th Scientific Sessions of the American Heart Association 2013, 2013/11/18, Without Invitation, English, Dallas,USA
  20. 1141-3C>A Polymorphism is Linked to H558R Polymorphism: Genetic Modulators of Brugada Syndrome, Nakano Y, Toshisige M, Tokuyama T, Oda N, Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Kazuyoshi S, Ochi H, Chayama K, Kihara Y, The 77th Annual Scientific Meeting of the Japanese Circulation Society, 2013/03/17, Without Invitation, English, Kanagawa
  21. 1291-3 C>A Polymorphism is Linked to H558R Polymorphism: Genetic Modulators of Brugada Syndrome, Nakano Y, Toshisige M, Ochi H, Oda N, Uchimura-Makita Y, Kajihara K, Tokuyama T, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Suenari K, Chayama K, Kihar Y, The 85th Scientific Sessions of the American Heart Association 2012, 2012/11/07, Without Invitation, English, Los Angeles,USA
  22. Abnormal Cardiac Innervation in Ventricular Fibrillation Patients with and Without Brugada Syndrome, Nakano Y, Oda N, Suenari K, Makita Y, Kajihara K, Sairaku A, Tokuyama T, Motoda C, Fujiwara M, Toshitaka I, Watanabe Y, Yamazato R, Sumida H, Kihara Y, The 84th Scientific Sessions of the American Heart Association 2011, 2011/11/15, Without Invitation, English, Orlando,USA
  23. Abnormal Cardiac Innervation in Ventricular Fibrillation Patients With and Without Brugada Syndrome, Nakano Y, Oda N, Makita Y, Kajihara K, Sairaku A, Tokuyama T, Motoda C, Fujiwara M, Hamada M, Kihara Y, The 75th Annual Scientific Meeting of the Japanese Circulation Society, 2011/08/04, Without Invitation, Japanese, Kanagawa
  24. Dose Histological Cardiac Abnormalities in Patients with Brugada Syndrome Relate to Conduction Properties and Episodes of Ventricular Fibrillation?, Nakano Y, The 74th Annual Scientific Meeting of the Japanese Circulation Society, 2010/03, Without Invitation, English, Kyoto
  25. Prospective and Retrospective Predictors of Ventricular Fibrillation in Brugada Syndrome, Nakano Y, Ogi H, Suenari K, Hirai Y, Oda N, Makita Y, Kajihara K, Tonouchi Y, Imai K, Sueda T, Chayama K, Shimizu W, Kihara Y, 2009/03, Without Invitation, Japanese
  26. Type1 ECG in V2 Lead is an Independent Predictor of Ventricular Fibrillation in Brugada Syndrome, Nakano Y, Ogi H, Suenari K, Hirai Y, Oda N, Makita Y, Kajihara K, Tonouchi Y, Imai K, Sueda T, Chayama K, Kihara Y, The 81th Scientific Sessions of the American Heart Association 2008, 2008/11, Without Invitation, Japanese
  27. The genetic defect and the structural heart disease independently contribute to the clinical phenotype of Brugada syndrome, Nakano Y, The 72th Annual Scientific Meeting of the Japanese Circulation Society, 2008/03, Without Invitation, English, Fukuoka
  28. Independent Predictor of Ventricular Fibrillation in Brugada Syndrome is Coved Type ST Change in V2 Lead, Nakano Y, The 72th Annual Scientific Meeting of the Japanese Circulation Society, 2008/03, Without Invitation, English, Fukuoka
  29. A De Novo Semapholin 3A Gene Polymorphism Associated with Atrial Fibrillation, Hironobe N, Nakano Y, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y, 2018/03, Without Invitation, English
  30. Diagnostic Sensitivity Of Single Holter Monitoring To Detect Paroxysmal Atrial Fibrillation: Is Once Enough?, Hironobe N, Sairaku A, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Nakano Y, Kihara Y, 2018/03, Without Invitation, English
  31. Semaphorin 3A Polymorphism Modifies Autonomic Function in Brugada Syndrome, Tokuyama T, Nakano Y, Okamura S, Okubo Y, Hironobe N, Amioka M, Tomomori S, Matsumura H, Motoda C, Sairaku A, Kihara Y, 2018/03, Without Invitation, English
  32. A common SCN10A variant may contribute to decrease SCN5A expression by promoting SCN5A promoter methylation in Brugada syndrome patients, Okamura S, Nakano Y, Okubo Y, Hironobe N, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y, 2018/03, Without Invitation, English