YUKIKO NAKANO

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
nakanoyhiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi Minamiku Hiroshima, Japan, Japan
TEL : (+81)82-257-1543 FAX : (+81)82-257-1569
Self-introduction
On the research side, I have conducted clinical and molecular biological research on fatal arrhythmias to prevent sudden cardiac death. Atrial fibrillation is the most common arrhythmia,which causes strokes, heart failure, and dementia and increases mortality. I have conducted research for early detection of atrial fibrillation, aiming to extend healthy life expectancy. On the clinical side, I actively performe catheter ablation treatment for arrhythmia.

Basic Information

Major Professional Backgrounds

  • 1991/06/01, 1992/09/30, Hiroshima University, Medical Hospital, Clinical Resident
  • 1992/10/01, 1993/03/31
  • 1993/04/01, 1995/03/31, Hiroshima City Asa Hospital
  • 1999/04/01, 2003/09/30, Hiroshima University, Medical Hospital, Clinical Fellow
  • 2003/10/01, 2004/03/31, Hiroshima University, Hospital, Clinical Fellow
  • 2004/04/01, 2005/03/31, Hiroshima University Hospital, Clinical Fellow
  • 2005/04/01, 2007/03/31, Hiroshima University Hospital, Research Associate
  • 2007/04/01, 2014/07/31, Hiroshima University, Assistant Professor
  • 2014/08/01, 2017/03/31, Hiroshima University Hospital, Lecturer

Educational Backgrounds

  • Hiroshima University, Japan, 1995/04, 1999/03
  • Hiroshima University, Japan, 1985/04, 1991/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Cardiovascular medicine

Research Keywords

  • Arrhythmia

Affiliated Academic Societies

  • Cardiovascular Stroke Society of Japan; CVSS
  • The Japanese Heart Failure Society
  • The Japanese Society of Hypertension
  • The Japan Society of Ultrasonics in Medicine
  • The Japanese Society of Internal Medicine
  • The Japanese Circulation Society
  • Japanese Heart Rhythm Society
  • Japanese College of Cardiology

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2022, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2022, Undergraduate Education, Intensive, Practice for medical research
  4. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  6. 2022, Undergraduate Education, First Semester, Internalz Medicine II
  7. 2022, Graduate Education (Doctoral Program) , 3Term, Advanced Lecture on Creation and Development of Biomedical Sciences
  8. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cardiovascular Medicine
  9. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cardiovascular Medicine
  10. 2022, Graduate Education (Master's Program) , 3Term, Science for Healthy Life
  11. 2022, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B
  12. 2022, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  13. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cardiovascular Medicine
  14. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cardiovascular Medicine
  15. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cardiovascular Medicine
  16. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cardiovascular Medicine

Research Activities

Academic Papers

  1. Association of Flow Parameters and Diameter in the Common Carotid Artery with Impaired Glucose Metabolism, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(5), 654-666, 2022
  2. Use of preprocedural multidetector computed tomography to decrease atrial fibrillation recurrence following extensive encircling circumferential pulmonary vein isolation, JOURNAL OF CARDIOLOGY, 60(3-4), 236-241, 2012
  3. Non-dipper phenomenon in essential hypertension is related to blunted nocturnal riseand fall of sympatho-vagal nervous activity and progress in retinopathy, 88, 181-186, 20010401
  4. Calorie restriction reduced blood pressure in obesity hypertensives by improvement of Autonomic nerve activity and insulin sensitivity, Journal of Cardiovascular Pharmacology, 38, 69-74, 20010401
  5. Vitamine D receptor gene polymorpnism is associated with serum total and ionized calcium concentration, Journal of molecular Medicine, 78(10), 575-579, 20000401
  6. Abnormal magnesium status in patients with cardiovascular diseases, Clinical Science, 98, 175-181, 20000401
  7. Abnormal Ca2+ handling and increased Mg2+ permeability in platelets of hypertensive rats, Hypertension Research, 23, 651-657, 20000401
  8. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension, Hypertension, 32, 16-24, 19980401
  9. Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension, Hypertension, 29(1), 280-285, 19970401
  10. Lack of effect of transmembrane gradient of magunesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes, Biochimica et Biophysica Acta, 1329, 169-173, 19970401
  11. Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertension, American Journal of Hypertension, 10(9), 1064-1068, 19970401
  12. Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension (Noninvasive 24-hour ambulatory blood pressure monitoring), Hypertention, 30, 163-167, 19970401
  13. Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration, Journal of molecular Medicine, 78(10), 575-579, 20000401
  14. Increased cytosolic free Mg2+ and Ca2+ in platelets of patients with vasospastic angina, American Journal of Physiology, 274, R544-R548, 19980401
  15. Estrogen replacement suppresses function of thrombin stimulated platelets by inhibiting Ca2+ influx and raising cyclic adenosine monophosphate, Cardiovascular Research, 53, 634-641, 20020401
  16. Non-SCN5A Related Brugada Syndromes: Verification of Normal Splicing and Trafficking of SCN5A without Exonic Mutations, Annals of Human Genetics, 71, 8-17, 20070101
  17. A frameshift mutation of beta subunit of epithelial sodium channel in a case of isolated Liddle syndrome., Journal of Hypertension, 20(12), 2379-82, 20021201
  18. Coronary sinus Morphology in Patients with Posteroseptal Atrioventricular Accessory Pathways., J Arrthmia, 22(3), 149-154, 20060401
  19. Ablation of ventricular tachycardia originating from the right ventricle associated with scleroderma cardiomyopathy., J Arrhythmia, 21(5), 542-545, 20050401
  20. Ablation of indiopathic ventricular tachycardia with a left Bundle-Branch block morphology originating from the pulmonary artery., J Arrthmia, 22(3), 180-186, 20060401
  21. Successive, rapid recurrences on in-stent restenoses in a woman with angina pecteoris., Intern Med, 45, 1093-1096, 20060401
  22. Coronary sinus morphology in patients with posteroseptal atrioventricular pathways, J Arrhythmia, 22, 149-154, 20061201
  23. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet., Hypertension Research, 30(1), 85-91, 20070101
  24. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human gallbladder lesions, EUROPEAN JOURNAL OF CANCER, 36(2), 257-263, 200001
  25. Abnormal Ca2+ handling and increased Mg2+ permeability in platelets of hypertensive rats, HYPERTENSION RESEARCH, 23(6), 651-657, 200011
  26. Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(5), 818-825, 2004
  27. Improvement of atrial signal-averaged electrocardiographic abnormalities after radiofrequency catheter ablation in persistent atrial flutter, JAPANESE HEART JOURNAL, 45(5), 761-770, 200409
  28. Predictors and long-term prognostic implications of angiographic slow/no-flow during percutaneous coronary intervention for acute myocardial infarction, INTERNAL MEDICINE, 47(10), 899-906, 2008
  29. Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris, HYPERTENSION RESEARCH, 33(11), 1162-1166, 201011
  30. Long-Term Electrocardiographic Follow-up From Childhood of an Adult Patient With Brugada Syndrome Associated With Sick Sinus Syndrome - A Case Report, CIRCULATION JOURNAL, 73(3), 575-579, 200903
  31. A spontaneous Type 1 electrocardiogram pattern in lead V-2 is an independent predictor of ventricular fibrillation in Brugada syndrome, EUROPACE, 12(3), 410-416, 201003
  32. Clinical Course and Outcome of Heart Transplant Recipients Single Center Experience at the National Cardiovascular Center in Japan, INTERNATIONAL HEART JOURNAL, 51(4), 264-271, 201007
  33. Relationship Between Arrhythmogenic Pulmonary Veins and the Surrounding Atrial Substrate in Patients with Paroxysmal Atrial Fibrillation, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 22(4), 405-410, 201104
  34. Learning curve for ablation of atrial fibrillation in medium-volume centers, JOURNAL OF CARDIOLOGY, 57(3), 263-268, 201105
  35. Rapid hemostasis at the femoral venous access site using a novel hemostatic pad containing kaolin after atrial fibrillation ablation, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 31(2), 157-164, 201108
  36. The Origin and Clinical Significance of the Signal Opposite to the Mitral E-Wave: A Simple and Novel Indicator of Left Ventricular Filling Pressure, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 28(6), 606-611, 201107
  37. Prediction of sinus node dysfunction in patients with long-standing persistent atrial fibrillation using the atrial fibrillatory cycle length, JOURNAL OF ELECTROCARDIOLOGY, 45(2), 141-147, 2012
  38. How many electrical cardioversions should be applied for repetitive recurrences of atrial arrhythmias following ablation of persistent atrial fibrillation?, EUROPACE, 13(12), 1703-1708, 201112
  39. Prediction of sinus node dysfunction in patients with persistent atrial flutter using the flutter cycle length, EUROPACE, 14(3), 380-387, 201203
  40. Effects of Ivabradine on the Pulmonary Vein Electrical Activity and Modulation of Pacemaker Currents and Calcium Homeostasis, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 23(2), 200-206, 201202
  41. Atrioventricular conduction properties in patients with prolonged pauses undergoing ablation of longstanding persistent atrial fibrillation: do pauses during atrial fibrillation matter?, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 34(3), 277-285, 201209
  42. High-frequency stimulation of the atria increases early recurrence following pulmonary vein isolation in patients with persistent atrial fibrillation, HEART RHYTHM, 9(9), 1386-1392, 201209
  43. Sleep-disordered breathing predicts sinus node dysfunction in persistent atrial fibrillation patients undergoing pulmonary vein isolation, JOURNAL OF CARDIOLOGY, 60(3-4), 321-326, 2012
  44. Outcomes of Ablation of Paroxysmal Atrial Fibrillation in Patients on Chronic Hemodialysis, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 23(12), 1289-1294, 201212
  45. Pulmonary Artery Mapping for Differential Diagnosis of Left-Sided Atrial Tachycardia, CIRCULATION JOURNAL, 77(2), 345-351, 201302
  46. Left atrial thickness under the catheter ablation lines in patients with paroxysmal atrial fibrillation: insights from 64-slice multidetector computed tomography, HEART AND VESSELS, 28(3), 360-368, 201305
  47. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9(4), 201304
  48. Clinical significance of sleep-disordered breathing induced by sedatives during ablation of atrial fibrillation, SLEEP MEDICINE, 14(7), 622-627, 201307
  49. A Head-to-Head Comparison of Periprocedural Coagulability Under Anticoagulation with Rivaroxaban Versus Dabigatran in Patients Undergoing Ablation of Atrial Fibrillation, CLINICAL DRUG INVESTIGATION, 33(11), 847-853, 2013
  50. Ablation of atrial fibrillation in Brugada syndrome patients with an implantable cardioverter defibrillator to prevent inappropriate shocks resulting from rapid atrial fibrillation, INTERNATIONAL JOURNAL OF CARDIOLOGY, 168(6), 5273-5276, 2013
  51. Variable Procedural Strategies Adapted to Anatomical Characteristics in Catheter Ablation of the Cavotricuspid Isthmus Using a Preoperative Multidetector Computed Tomography Analysis, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 24(12), 1344-1351, 201312
  52. Prediction of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Using Preoperative Total Atrial Conduction Time Determined on Tissue Doppler Imaging, CIRCULATION JOURNAL, 78(2), 345-352, 201402
  53. Periprocedural coagulability in patients undergoing ablation of atrial fibrillation: lessons from a periablation anticoagulation strategy of a brief withdrawal of warfarin without heparin bridging, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 37(4), 393-399, 201405
  54. Procedural sedation with dexmedetomidine during ablation of atrial fibrillation: a randomized controlled trial, EUROPACE, 16(7), 994-999, 201407
  55. Time-Domain T-Wave Alternans is Strongly Associated with a History of Ventricular Fibrillation in Patients with Brugada Syndrome, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 25(9), 1021-1027, 201409
  56. Incomplete Cure of Tachycardia-Induced Cardiomyopathy Secondary to Rapid Atrial Fibrillation by Heart Rate Control Without Sinus Conversion, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 25(10), 1037-1043, 201410
  57. Impact of Pulmonary Vein Isolation on Fractionated Atrial Potentials and Ganglionated Plexi in Patients With Persistent Atrial Fibrillation, INTERNATIONAL HEART JOURNAL, 55(6), 494-498, 201411
  58. Mechanical and substrate abnormalities of the left atrium assessed by 3-dimensional speckle-tracking echocardiography and electroanatomic mapping system in patients with paroxysmal atrial fibrillation, HEART RHYTHM, 12(3), 490-497, 201503
  59. Don't move during ablation of atrial fibrillation!, INTERNATIONAL JOURNAL OF CARDIOLOGY, 171(1), 78-81, 2014
  60. Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation, JOURNAL OF CARDIOLOGY, 64(2), 133-138, 201408
  61. Genetics of long-QT syndrome, JOURNAL OF HUMAN GENETICS, 61(1), 51-55, 201601
  62. Is structural remodeling of fibrillated atria the consequence of tissue hypoxia?, Circulation Journal, 74(9), 1815-1821, 201009
  63. Platelet Function Measured Using a Whole Blood Aggregometer Can Predict Bleeding Events, Journal of atherosclerosis and thrombosis, 18(1), 18-23, 2011
  64. Impact of aldosterone-producing adenoma on cardiac structures in echocardiography, Journal of echocardiography, 11, 123-129, 201302
  65. ★, Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, Circulation. Arrhythmia and electrophysiology, 9(1), 201601
  66. Increased left atrial pressure in non-heart failure patients with subclinical hypothyroidism and atrial fibrillation, Endocr Connect, 5(3), 101-106, 201603
  67. Electrical remodeling of the atrioventricular node caused by persistent atrial fibrillation in humans, Journal of cardiovascular electrophysiology, 201604
  68. Electrical Remodeling of the Atrioventricular Node Caused by Persistent Atrial Fibrillation in Humans, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 27(8), 918-922, 201608
  69. Increased left atrial pressure in non-heart failure patients with subclinical hypothyroidism and atrial fibrillation, ENDOCRINE CONNECTIONS, 5(3), 101-106, 2016
  70. Increased urine output by ipragliflozin in a non-diabetic patient with a diuretic-resistant heart failure, Int J Cardiol, 180, 42-43, 201502
  71. Don't expect left ventricular reverse remodeling after cardiac resynchronization therapy in patients with systolic heart failure and atrioventricular block: A multicenter study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 221, 597-600, 2016
  72. Who is the operator, that is the question: a multicentre study of catheter ablation of atrial fibrillation, EUROPACE, 18(9), 1352-1356, 201609
  73. Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 5(9), 201609
  74. ★, Risk stratification of ventricular fibrillation in Brugada syndrome using noninvasive scoring methods, HEART RHYTHM, 13(10), 1947-1954, 201610
  75. Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese, JOURNAL OF BIOMEDICAL SCIENCE, 23, 2016
  76. Dexmedetomidine Depresses Sinoatrial and Atrioventricular Nodal Function Without Any Change in Atrial Fibrillation Inducibility, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 68(6), 473-478, 201612
  77. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, European Radiology, 201608
  78. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 9(1), 201601
  79. DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters, EUROPEAN RADIOLOGY, 27(4), 1660-1666, 201704
  80. Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands With Brugada Syndrome A Japanese Multicenter Registry, CIRCULATION, 135(23), 2255-+, 20170606
  81. Cardiac resynchronization therapy for patients with cardiac sarcoidosis, EUROPACE, 19(5), 824-830, 201705
  82. Arrhythmia risk and beta-blocker therapy in pregnant women with long QT syndrome, HEART, 103(17), 1374-1379, 201709
  83. Syncope in patients with inherited arrhythmias, JOURNAL OF ARRHYTHMIA, 33(6), 572-578, 201712
  84. H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters, JOURNAL OF BIOMEDICAL SCIENCE, 24, 20171204
  85. In Paroxysmal Atrial Fibrillation Patients, the Neutrophil-to-lymphocyte Ratio Is Related to Thrombogenesis and More Closely Associated with Left Atrial Appendage Contraction than with the Left Atrial Body Function, INTERNAL MEDICINE, 57(5), 633-640, 2018
  86. Radiofrequency catheter ablation is effective for atrial fibrillation patients with hypertrophic cardiomyopathy by decreasing left atrial pressure, JOURNAL OF ARRHYTHMIA, 33(4), 256-261, 201708
  87. Head-to-head comparison of the heart rate variability between the bisoprolol transdermal patch and bisoprolol fumarate tablet, CARDIOVASCULAR THERAPEUTICS, 36(3), 201806
  88. Effect of fibrillatory wave amplitude on coronary blood flow as assessed by thrombolysis in myocardial infarction frame count in patients with atrial fibrillation, HEART AND VESSELS, 33(7), 786-792, 201807
  89. Maintenance of low inflammation level by the ZFHX3 SNP rs2106261 minor allele contributes to reduced atrial fibrillation recurrence after pulmonary vein isolation, PLOS ONE, 13(9), 2018
  90. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement, SCIENTIFIC REPORTS, 8, 2018
  91. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190(4), 424-432, 201810
  92. ★, HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation, CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11(7), 201807
  93. Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation, PLOS ONE, 14(3), 20190306
  94. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, EUROPEAN JOURNAL OF NUTRITION, 58(3), 989-996, 201904
  95. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9(1), 10206-10206, 20190715
  96. Safety and Efficacy of Minimally Interrupted Dabigatran vs Uninterrupted Warfarin Therapy in Adults Undergoing Atrial Fibrillation Catheter Ablation A Randomized Clinical Trial, JAMA NETWORK OPEN, 2(4), 201904
  97. Diagnostic performance of the N-terminal pro-brain natriuretic peptide to detect an increased left atrial pressure in patients with persistent atrial fibrillation, Clin Chem Lab Med., 56(6), e147-e149, 201805
  98. Residual anticoagulation activity in atrial fibrillation patients with temporary interrupted direct oral anticoagulants: Comparisons across 4 drugs, THROMBOSIS RESEARCH, 183, 119-123, 201911
  99. Successful catheter ablation of persistent atrial fibrillation is associated with improvement in functional tricuspid regurgitation and right heart reverse remodeling, HEART AND VESSELS, 35(6), 842-851, 202006
  100. Predicting atrial fibrillation using a combination of genetic risk score and clinical risk factors, HEART RHYTHM, 17(5), 699-705, 202005
  101. Remaining activity of temporary interrupted direct oral anticoagulants and its impact on intra-ablation heparinization in patients with atrial fibrillation: Comparisons across four drugs and two dose regimens, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 31(8), 1996-2004, 202008
  102. HotBalloon ablation of atrial fibrillation in patients with dextrocardia and situs inversus by "mirror image" approach, Journal of Arrhythmia, 35(6), 855-857, 201910
  103. Cardiac electrophysiological characteristics of silent paroxysmal atrial fibrillation: What causes asymptomaticity?, Journal of Cardiovascular Electrophysiology, 30(12), 2716-2723, 201912
  104. Increased Urinary Liver-Type Fatty Acid-Binding Protein Level Predicts Major Adverse Cardiovascular Events in Patients With Hypertension, AMERICAN JOURNAL OF HYPERTENSION, 33(7), 604-609, 202007
  105. Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality, HEART AND VESSELS, 35(12), 1633-1639, 202012
  106. Effects of upright T-wave in lead aVR on left ventricular volume and function derived from ECG-gated SPECT in patients with advanced chronic kidney disease, ANNALS OF NUCLEAR MEDICINE, 35(1), 1-7, 202101
  107. Tricuspid valve geometry and right heart remodelling: insights into the mechanism of atrial functional tricuspid regurgitation, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 21(10), 1068-1078, 202010
  108. Effects of Newly Developed Right Versus Left Bundle Branch Block on the QRS Axis, T-wave Axis and Frontal QRS-T Angle in Patients with a Narrow QRS, INTERNAL MEDICINE, 60(1), 25-30, 2021
  109. Impact of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement on Changes in Cardiac Sympathetic Nervous Function Assessment by 123I-Metaiodobenzylguanidine Myocardial Scintigraphy, INTERNATIONAL HEART JOURNAL, 61(6), 1188-1195, 202011
  110. Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation, SCIENTIFIC REPORTS, 11(1), 20210128
  111. Relationship between interleukin-1 beta gene expression in epicardial adipose tissue and coronary atherosclerosis based on computed tomographic analysis, JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 15(2), 175-179, 2021
  112. Associations of frontal QRS-T angle with left ventricular volume and function derived from ECG-gated SPECT in patients with advanced chronic kidney disease, ANNALS OF NUCLEAR MEDICINE, 35(6), 662-668, 202106
  113. Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 32(5), 1240-1250, 202105
  114. Determinants of Exercise-Induced Mitral Regurgitation Using Three-Dimensional Transesophageal Echocardiography Combined With Isometric Handgrip, AMERICAN JOURNAL OF CARDIOLOGY, 151, 78-85, 20210715
  115. Diversity in the risk of type 2 diabetes associated with age, sex, and 1-h post-load plasma glucose levels in the Japanese population with prediabetes, DIABETES RESEARCH AND CLINICAL PRACTICE, 175, 202105
  116. Intra-procedural anticoagulation and post-procedural hemoglobin fall in atrial fibrillation ablation with minimally interrupted direct oral anticoagulants: comparisons across 4 drugs, JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 61(3), 551-557, 202109
  117. Functionally validated SCN5A variants allow interpretation of pathogenicity and prediction of lethal events in Brugada syndrome, EUROPEAN HEART JOURNAL, 42(29), 2854-2863, 20210801
  118. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 28(9), 963-973, 2021
  119. Prevalence, distribution, and determinants of pulmonary venous systolic flow reversal in severe mitral regurgitation, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 22(9), 964-973, 202109
  120. The Monocyte to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography, INTERNATIONAL HEART JOURNAL, 62(4), 866-871, 202107
  121. Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates, HEART AND VESSELS, 36(11), 1721-1729, 202111
  122. Stair climbing activity and vascular function in patients with hypertension, HYPERTENSION RESEARCH, 44(10), 1274-1282, 202110
  123. Does atrial fibrillation ablation worsen preexisting anemia? Another anemia paradox in DOAC era, JOURNAL OF CARDIOLOGY, 78(5), 382-387, 202111
  124. Upstroke time as a marker of atherosclerosis in patients with diabetes mellitus who have a normal ankle-brachial index, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35(11), 202111
  125. Common Carotid Artery Flow Parameters Predict the Incidence of Hypertension, HYPERTENSION, 78(6), 1711-1718, 202112
  126. Peripheral arterial tone during active standing, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 473(12), 1939-1946, 202112
  127. Association of obesity with serum free fatty acid levels in individuals at different stages of prediabetes, CLINICAL OBESITY, 12(1), 202202
  128. The International Classification of Functioning, Disabilities, and Health categories rated as necessary for care planning for older patients with heart failure: a survey of care managers in Japan, BMC GERIATRICS, 21(1), 20211215
  129. Vascular Dysfunction Predicts Future Deterioration of Left Ventricular Ejection Fraction in Patients with Heart Failure with Mildly Reduced Ejection Fraction, JOURNAL OF CLINICAL MEDICINE, 10(24), 202112
  130. Impact of the distribution of epicardial and visceral adipose tissue on left ventricular diastolic function, HEART AND VESSELS, 37(2), 250-261, 202202
  131. Short stature is associated with low flow-mediated vasodilation in Japanese men, HYPERTENSION RESEARCH, 45(2), 308-314, 202202
  132. Evaluation of the Feasibility and Efficacy of a Novel Device for Screening Silent Atrial Fibrillation (MYBEAT Trial), CIRCULATION JOURNAL, 86(2), 182-+, 202202

Invited Lecture, Oral Presentation, Poster Presentation

  1. Vena Contracta Related to Isolated Annular Dilatation: Insights Into the Pathophysiology and Mechanisms of Atrial Functional Tricuspid Regurgitation, Utsunomiya H, Takahari K, Takemoto H, Ueda Y, Izumi K, Itakura K, Hidaka T, Nakano Y, The 32nd Annual Scientific Sessions of the American Society of Echocardiography, 2021/06/19, Without Invitation, English
  2. Tricuspid Valve Geometry and Right Heart Remodeling: Insights Into the Mechanism of Atrial Functional Tricuspid Regurgitation, Utsunomiya H, Harada Y, Susawa H, Ueda Y, Izumi K, Itakura K, Hidaka T, Shiota T, Nakano Y, Kihara Y, The 93rd Scientific Sessions of the American Heart Association, 2020/11, Without Invitation, English, Web
  3. Uninterrupted vs. Interrupted Dabigatran. Uninterrupted Dabigatran is Associate with Optimal ACT Control During Catheter Ablation, Shunsuke Miyauchi, Yukiko Nakano Y, Yoshihiro Ikeuchi, Sho Okamura, Yosaku Okubo, Naoya Hironobe, Takehito Tokuyama, Yasuki Kihara, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/18, Without Invitation, English, Pennsylvania, PA
  4. Circulating Mir-223-3p As A Novel Biomarker And Pathogenesis Of Brugada Syndrome, Yukiko Nakano, Onohara Y, Motoda C, Tokuyama T, Hironobe N, Okubo Y, Okamura S, Miyauchi S, Ikeuchi Y, Nishiyama O, Ochi H, Chayama K, Kihara Y, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/18, Without Invitation, English, Pennsylvania, PA
  5. Left Atrial Dimension Reduction Rate After Blanking Period Predicts Late Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation, Shunsuke Miyauchi, Yukiko Nakano, Yoshihiro Ikeuchi, Sho Okamura, Yosaku Okubo, Naoya Hironobe, Takehito Tokuyama, Yasuki Kihara, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/17, Without Invitation, English, Pennsylvania, PA
  6. Inconsistency Between Epinephrine Provocation Test And Genetic Test In Type 2 Long QT Syndrome, Yukiko Nakano, Onohara Y, Tokuyama T, Hironobe N, Okubo Y, Okamura S, Miyauchi S, Ikeuchi Y, Yamada T, Ochi H, Chayama K, Kihara Y, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/17, Without Invitation, English, Pennsylvania, PA
  7. Predicting Atrial Fibrillation using a Combination of Genetic Risk Score and Clinical Risk Factors, Yosaku Okubo, Yukiko Nakano, Takehito Tokuyama, Naoya Hironobe, Sho Okamura, Shunsuke Miyauchi, Yoshihiro Ikeuchi, Yasuki Kihara, American Heart Association (AHA) 2019 Scientific Sessions, 2019/11/16, Without Invitation, English, Pennsylvania, PA
  8. Gene polymorphisms associated with tachycardia induced cardiomyopathy in patients with AF, Yukiko Nakano, APHRS2019 Asia Pacific Heart Rhythm Society, 2019/10/24, With Invitation, English, Bangkok, Thailand
  9. Uninterrupted vs. Interrupted Dabigatran. Uninterrupted Dabigatran is Associated with Optimal ACT Control During Catheter Ablation, Shunsuke Miyauchi, Yukiko Nakano, Yoshihiro Ikeuchi, Sho Okamura, Yosaku Okubo, Naoya Hironobe, Takehito Tokuyama, Yasuki Kihara, APHRS2019 Asia Pacific Heart Rhythm Society, 2019/10/24, Without Invitation, English, Bangkok, Thailand
  10. Role of microRNA in genetic regulation of cardiac arrhythmias, Yukiko Nakano, APHRS2019 Asia Pacific Heart Rhythm Society, 2019/10/24, With Invitation, English, Bangkok, Thailand
  11. Genetics of Atrial Fibrillation, Yukiko Nakano, Asian-Pacific Society of Atherosclerosis and Vascular Diseases 2019 (APSAVD), 2019/09/21, With Invitation, English, Taipei, Taiwan
  12. A common SCN10A variant may promote DNA methylation of SCN5A Promoter and decrease SCN5A expression in Brugada syndrome patients without SCN5A exonic mutation, Okamura S, Nakano Y, Okubo Y, Hironobe N, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y, American Heart Association Scientific Sessions 2017, 2017/11, Without Invitation, English, Anaheim, USA
  13. Studying Progression Cardiac Conduction Disturbance with patient-specific iPSCs, Motoda C, Yuasa S, Nakano Y, Fukuda K, Kihara Y, American Heart Association Scientific Sessions 2017, 2017/11, Without Invitation, English, Anaheim, USA
  14. Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Logistic Models of Noninvasive Parameters, Nakano Y, Kawazoe H, Ochi H, Takagi M, Tokuyama T, Sairaku A, Matsumura H, Tomomori S, Amioka M, Kihara Y, American Heart Association 2016, 2016/11/14, Without Invitation, English, New Orleans,USA
  15. Variants Of Aldehyde Dehydrogenase 2 And Alcohol Dehydrogenase Genes Are Associated With Atrial Fibrillation, Nakano Y, Ochi H, Tomomori S, Matsumura H, Tokuyama T, Sairaku A, Motoda C, Chayama K, Chen C, Mochly-Rosen D, Kihara Y, American Heart Association 2016, 2016/11/13, Without Invitation, Japanese, New Orleans,USA
  16. A Common Genetic Variant within SCN10A Modulates DNAMethylation of SCN5A Promoters, Nakano Y, Ochi H, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Suenari K, Onohara Y, Chayama K, Kihara Y, The 80th Annual Scientific Meeting of the Japanese Circulation Society, 2016/03/18, Without Invitation, English, Miyagi
  17. Common Variant near HEY2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome, Nakano Y, Ochi H, Toshishige M, Ikenaga H, Oda N, Tokuyama T, Sairaku A, Watanabe Y, Kawazoe H, Matsumura H, Tomomori S, Oda N, Kishimoto S, Uchimura-Makita Y, Motoda C, Fujiwara M, Kajihara K, Itakura K, Chayama K, Kihara Y, The 77th Annual Scientific Meeting of the Japanese Circulation Society, 2015/04/24, With Invitation, English, Oasaka
  18. Atrial fibrillation ablation in patients with advanced congestive heart failure, Nakano Y, The XVI International Symposium on Progress in Clinical Pacing, 2014/12/03, With Invitation, English, Rome,Italy
  19. Common Variant Near Hey2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome by Modurating QTc Interval, Nakano Y, Ochi H, Toshishige M, Tokuyama T, Kawazoe H, Watanabe Y, Matsumura M, Tomomori S, Kishimoto S, Ikenaga H, Oda N, Chayama K, Kihara Y, The 87th Scientific Sessions of the American Heart Association 2014, 2014/11/18, Without Invitation, English
  20. Nonsynonymous Polymorphism in Semaphorin 3A is a New Genetic Risk Factor for Human Idiopathic Ventricular Fibrillation, Nakano Y, Toshisige M, Ochi H, Tokuyama T, Sairaku A, Oda N, Kajiahara K, Uchimura Y, Fujiwara M, Watanabe Y, Kawazoe H, Motoda C, Matumura H, Oda N, Aiba T, Watanabe H, Schimizu W, Horie M, Makita N, Chayama K, Kihara Y, The 78th Annual Scientific Meeting of the Japanese Circulation Society, 2014/03/22, Without Invitation, English, Tokyo
  21. Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest With Documented Ventricular Fibrillation, Nakano Y, Chayama K, Ochi H, Toshishige M, Tokuyama T, Oda N, Uchimura(Makita) Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Kawazoe H, Ikenaga H, Matsumoto S, Oda N, Suenari K, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Watanabe H, Hasegawa K, Aiba T, Ohno S, Shimizu W, Horie M, Tashiro S, Makita N, Kihara Y, The 86th Scientific Sessions of the American Heart Association 2013, 2013/11/18, Without Invitation, English, Dallas,USA
  22. 1141-3C>A Polymorphism is Linked to H558R Polymorphism: Genetic Modulators of Brugada Syndrome, Nakano Y, Toshisige M, Tokuyama T, Oda N, Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Kazuyoshi S, Ochi H, Chayama K, Kihara Y, The 77th Annual Scientific Meeting of the Japanese Circulation Society, 2013/03/17, Without Invitation, English, Kanagawa
  23. 1291-3 C>A Polymorphism is Linked to H558R Polymorphism: Genetic Modulators of Brugada Syndrome, Nakano Y, Toshisige M, Ochi H, Oda N, Uchimura-Makita Y, Kajihara K, Tokuyama T, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Suenari K, Chayama K, Kihar Y, The 85th Scientific Sessions of the American Heart Association 2012, 2012/11/07, Without Invitation, English, Los Angeles,USA
  24. Abnormal Cardiac Innervation in Ventricular Fibrillation Patients with and Without Brugada Syndrome, Nakano Y, Oda N, Suenari K, Makita Y, Kajihara K, Sairaku A, Tokuyama T, Motoda C, Fujiwara M, Toshitaka I, Watanabe Y, Yamazato R, Sumida H, Kihara Y, The 84th Scientific Sessions of the American Heart Association 2011, 2011/11/15, Without Invitation, English, Orlando,USA
  25. Abnormal Cardiac Innervation in Ventricular Fibrillation Patients With and Without Brugada Syndrome, Nakano Y, Oda N, Makita Y, Kajihara K, Sairaku A, Tokuyama T, Motoda C, Fujiwara M, Hamada M, Kihara Y, The 75th Annual Scientific Meeting of the Japanese Circulation Society, 2011/08/04, Without Invitation, Japanese, Kanagawa
  26. Dose Histological Cardiac Abnormalities in Patients with Brugada Syndrome Relate to Conduction Properties and Episodes of Ventricular Fibrillation?, Nakano Y, The 74th Annual Scientific Meeting of the Japanese Circulation Society, 2010/03, Without Invitation, English, Kyoto
  27. Prospective and Retrospective Predictors of Ventricular Fibrillation in Brugada Syndrome, Nakano Y, Ogi H, Suenari K, Hirai Y, Oda N, Makita Y, Kajihara K, Tonouchi Y, Imai K, Sueda T, Chayama K, Shimizu W, Kihara Y, 2009/03, Without Invitation, Japanese
  28. Type1 ECG in V2 Lead is an Independent Predictor of Ventricular Fibrillation in Brugada Syndrome, Nakano Y, Ogi H, Suenari K, Hirai Y, Oda N, Makita Y, Kajihara K, Tonouchi Y, Imai K, Sueda T, Chayama K, Kihara Y, The 81th Scientific Sessions of the American Heart Association 2008, 2008/11, Without Invitation, Japanese
  29. The genetic defect and the structural heart disease independently contribute to the clinical phenotype of Brugada syndrome, Nakano Y, The 72th Annual Scientific Meeting of the Japanese Circulation Society, 2008/03, Without Invitation, English, Fukuoka
  30. Independent Predictor of Ventricular Fibrillation in Brugada Syndrome is Coved Type ST Change in V2 Lead, Nakano Y, The 72th Annual Scientific Meeting of the Japanese Circulation Society, 2008/03, Without Invitation, English, Fukuoka
  31. A De Novo Semapholin 3A Gene Polymorphism Associated with Atrial Fibrillation, Hironobe N, Nakano Y, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y, 2018/03, Without Invitation, English
  32. Diagnostic Sensitivity Of Single Holter Monitoring To Detect Paroxysmal Atrial Fibrillation: Is Once Enough?, Hironobe N, Sairaku A, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Nakano Y, Kihara Y, 2018/03, Without Invitation, English
  33. Semaphorin 3A Polymorphism Modifies Autonomic Function in Brugada Syndrome, Tokuyama T, Nakano Y, Okamura S, Okubo Y, Hironobe N, Amioka M, Tomomori S, Matsumura H, Motoda C, Sairaku A, Kihara Y, 2018/03, Without Invitation, English
  34. A common SCN10A variant may contribute to decrease SCN5A expression by promoting SCN5A promoter methylation in Brugada syndrome patients, Okamura S, Nakano Y, Okubo Y, Hironobe N, Amioka M, Tomomori S, Matsumura H, Motoda C, Tokuyama T, Sairaku A, Kihara Y, 2018/03, Without Invitation, English