CHIHO WATANABE

Last Updated :2021/04/05

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
Web Site
E-mail
cwatanhiroshima-u.ac.jp
Self-introduction
I am working on wet experiments using artificial cell models like lipid bilayers (liposomes, vesicles) and polymer microdroplets. I am aiming to understand life from a physicochemical viewpoint. Currently, I am interested in lipid diversity, liquid-liquid phase separation(LLPS), and neurodegenerative diseases such as Alzheimer's disease.

Basic Information

Major Professional Backgrounds

  • 2019/01/01, 2020/06/30, The University of Tokyo, Assistant Professor (Special Appointment)
  • 2016/04/01, 2018/12/31, Tokyo University of Agriculture and Technology, Engineering Department, Postdoctoral Researcher

Educational Backgrounds

  • University Paris Diderot, Paris 7, L'Ecole Doctorale 564 Physique en Ile-de-France, Doctoral course, France, 2012/09, 2015/09
  • Tokyo University of Agriculture and Technology, Graduate School of Bio-Applications and Systems, Master course, Japan, 2010/04, 2012/03
  • Tokyo University of Agriculture and Technology, Faculty of Engineering, Department of Organic and Polymer Materials Chemistry, Japan, 2006/04, 2010/03

Academic Degrees

  • Master of Engineering, Tokyo University of Agriculture and Technology
  • PhD, Universite Paris Diderot Paris 7

Affiliated Academic Societies

  • The Physical Society of Japan
  • The Biophysical Society of Japan
  • The Chemical Society of Japan; Division of Colloid and Surface Chemistry

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Chemistry I
  2. 2021, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Chemistry I
  3. 2021, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Chemistry II
  4. 2021, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Chemistry II
  5. 2021, Undergraduate Education, 3Term, Functional Biochemistry II
  6. 2021, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  7. 2021, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  8. 2021, Undergraduate Education, 4Term, Functional Biochemistry III
  9. 2021, Undergraduate Education, 1Term, Fundamentals of Biochemistry I
  10. 2021, Undergraduate Education, 2Term, Fundamentals of Biochemistry II
  11. 2021, Undergraduate Education, 2Term, Experimental Methods and Laboratory Work in Science for IGS I
  12. 2021, Undergraduate Education, 2Term, Experimental Methods and Laboratory Work in Science for IGS II

Research Activities

Academic Papers

  1. Membrane Surface Modulates Slow Diffusion in Small Crowded Droplets, Langmuir, 37(1), 437-444, 20201222
  2. Amyloid-beta Interactions with Lipid Rafts in Biomimetic Systems: A Review of Laboratory Methods, Methods in molecular biology (Clifton, N.J.), 2187, 47-86, 20200809
  3. Microfluidic Formation of Honeycomb-Patterned Droplets Bounded by Interface Bilayers via Bimodal Molecular Adsorption, MICROMACHINES, 11(7), 20200720
  4. Liposomal adhesion via electrostatic interactions and osmotic deflation increases membrane tension and lipid diffusion coefficient, Soft Matter, 16(18), 4549-4554, 20200423
  5. Unique phase behavior in cell size space: synergistic effect of molecular crowding and confinement., Biophysical reviews, 20, 385-386, 20200410
  6. ★, Quantitative Analysis of Membrane Surface and Small Confinement Effects on Molecular Diffusion., The journal of physical chemistry B, 124(6), 1090-1098, 20200213
  7. Single Micrometer-Sized Gels: Unique Mechanics and Characters for Applications., Gels (Basel, Switzerland), 4(2), 29-29, 20180328
  8. ★, Cell-size confinement effect on protein diffusion in crowded poly(ethylene)glycol solution, Physical Chemistry Chemical Physics, 20(13), 8842-8847, 20180309
  9. ★, On the possible structural role of single chain sphingolipids Sphingosine and Sphingosine 1-phosphate in the amyloid-beta peptide interactions with membranes. Consequences for Alzheimer's disease development, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 510, 317-327, 20161205
  10. Tuning of membrane electrostatic properties by single chain sphingolipids sphingosine and sphingosine-1-phosphate: The effect on bilayer dipole potential, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 483, 181-186, 20151020
  11. ★, Antagonism and Synergy of Single Chain Sphingolipids Sphingosine and Sphingosine-1-phosphate toward Lipid Bilayer Properties. Consequences for Their Role as Cell Fate Regulators, Langmuir, 30(46), 13956-13963, 20141128
  12. Lo/Ld phase coexistence modulation induced by GM1, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1838(8), 2105-2114, 201408

Awards

  1. 2020/09, The emerging science lecture prize at the 17th Australia-Japan Colloids Symposium, The 17th Australia-Japan Colloids Symposium organizing committees

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Grant-in-Aid for Early-Career Scientists, Characteristic phase separation dynamics guided by interfacial properties and its visualization, 2020, 2024
  2. ACT-X, Spatiotemporal design of diseases seen from cell models, 2019, 2022