KAZUNORI KUME

Last Updated :2023/12/04

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
kume513hiroshima-u.ac.jp
Self-introduction
Our research goal is to understand the control mechanisms of cell structure that guarantees the functions of eukaryotic cells. Research topics we focus on are the control mechanism of nuclear size and the control mechanism of cell morphology.

Basic Information

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Engineering : Cluster 3(Applied Chemistry, Biotechnology and Chemical Engineering) : Program of Biotechnology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Cell biology
  • Agricultural sciences;Agricultural chemistry;Applied biochemistry

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  2. 2023, Undergraduate Education, Second Semester, Experiments on Biotechnology II
  3. 2023, Undergraduate Education, 4Term, Molecular BiologyIII
  4. 2023, Graduate Education (Master's Program) , 1Term, English Presentation Methods in Science and Technology
  5. 2023, Graduate Education (Master's Program) , 2Term, Lecture on Developing Communication Skill
  6. 2023, Graduate Education (Master's Program) , 2Term, Integrated Genome Science B
  7. 2023, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  8. 2023, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  9. 2023, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  10. 2023, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  11. 2023, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  12. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  13. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  14. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  15. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  16. 2023, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  17. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  18. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  19. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  20. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Fission Yeast Germinal Center (GC) Kinase Ppk11 Interacts with Pmo25 and Plays an Auxiliary Role in Concert with the Morphogenesis Orb6 Network (MOR) in Cell Morphogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(45), 35196-35205, 20101105
  2. The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe, JOURNAL OF CELL BIOLOGY, 190(5), 793-805, 20100906
  3. Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth., Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth., 13(3), 234-U357, 2011
  4. Effect of ethanol on cell growth of budding yeast: Genes that are important for cell growth in the presence of ethanol, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(4), 968-972, 200404
  5. Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis, EMBO JOURNAL, 24(17), 3012-3025, 20050907
  6. Mal3, the fission yeast EB1 homologue, cooperates with Bub1 spindle checkpoint to prevent monopolar attachment, EMBO REPORTS, 6(12), 1194-1200, 200512
  7. The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint, MOLECULAR BIOLOGY OF THE CELL, 17(3), 1421-1435, 200603
  8. A method for Pmo25-associated kinase assay in fission yeast: The activity is dependent on two GC kinases Nak1 and Sid1, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(2), 615-617, 200702
  9. Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75(1), 140-144, 201101
  10. Implication of Ca2+ in the Regulation of Replicative Life Span of Budding Yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(33), 28681-28687, 20110819
  11. Ras/cAMP-dependent Protein Kinase (PKA) Regulates Multiple Aspects of Cellular Events by Phosphorylating the Whi3 Cell Cycle Regulator in Budding Yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(15), 10558-10566, 20130412
  12. Fission Yeast Leucine-Rich Repeat Protein Lrp1 Is Essential for Cell Morphogenesis as a Component of the Morphogenesis Orb6 Network (MOR), BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(5), 1086-1091, 201305
  13. Evidence of Antagonistic Regulation of Restart from G(1) Delay in Response to Osmotic Stress by the Hog1 and Whi3 in Budding Yeast, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(10), 2002-2007, 201310
  14. Polishing Properties of Sake Rice Koshitanrei for High-Quality Sake Brewing, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(10), 2160-2165, 201310
  15. Isolation of a Non-Urea-Producing Sake Yeast Strain Carrying a Discriminable Molecular Marker, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(12), 2505-2509, 201312
  16. Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78(11), 1954-1962, 20141102
  17. Casein Kinase 1 gamma Ensures Monopolar Growth Polarity under Incomplete DNA Replication Downstream of Cds1 and Calcineurin in Fission Yeast, MOLECULAR AND CELLULAR BIOLOGY, 35(9), 1533-1542, 201505
  18. Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(5), 790-794, 20150504
  19. Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(7), 1191-1199, 20150703
  20. Search for kinases related to transition of growth polarity in fission yeast., BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(5), 2010
  21. The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, YEAST, 32(9), 607-614, 201509
  22. Casein kinase 1 gamma acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast, GENES TO CELLS, 20(12), 1046-1058, 201512
  23. Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(8), 1657-1662, 201608
  24. Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5, ELIFE, 5, 20160730
  25. Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(42), 11913-11918, 20161018
  26. A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control, PLOS GENETICS, 13(5), 201705
  27. Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 491(4), 883-889, 20170930
  28. A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast, MOLECULAR BIOLOGY OF THE CELL, 28(25), 3647-3659, 20171201
  29. Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503(2), 1160-1167, 20180905
  30. Nuclear membrane protein Lem2 regulates nuclear size through membrane flow, NATURE COMMUNICATIONS, 10, 20190423
  31. SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 83(8), 1473-1476, 20190803
  32. Control of cellular organization and its coordination with the cell cycle, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84(5), 869-875, 20200503
  33. Cellulose Nanofiber and Magnetic Nanoparticles as Building Blocks Constructing Biomass-Based Porous Structured Particles and Their Protein Adsorption Performance, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8(50), 18686-18695, 20201221
  34. Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast, JOURNAL OF CELL SCIENCE, 134(3), 202102

Invited Lecture, Oral Presentation, Poster Presentation

  1. Inner nuclear membrane protein Lem2 regulates nuclear size in fission yeast, Kazunori Kume, Paul Nurse, 10th International Pombe Meeting, 2019/07/15, With Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2020, 2022
  2. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2020, 2023
  3. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  4. KAKENHI, 2014, 2016
  5. KAKENHI, Cell morphogenesis network regulates coordination between cell morphogenesis and cell growth, 2009, 2011
  6. KAKENHI, Basic and applied research on cell polarity control yeast, 2008, 2011
  7. KAKENHI, 2007, 2008

Social Activities

Organizing Academic Conferences, etc.

  1. 2019/03, 2019/03
  2. 2018/03, 2018/03
  3. 2017/03, 2017/03
  4. 2016/03, 2016/03
  5. 2015/08, 2015/08
  6. 2015/03, 2015/03
  7. 2015/03, 2015/03