TAKUSHI SHIMOMURA

Last Updated :2026/09/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor/Lecturer
E-mail
shimothiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2026/03/01, Hiroshima University, Department of Physiology and Biophysics, Graduate School of Biomedical and Health Sciences, Lecturer
  • 2015/04, 2026/02, National Institute for Physiological Sciences, Division of Biophysics and Neurobiology, Assistant Professor
  • 2012/04, 2015/03, Nagoya University, Cellular and Structural Physiology Institute
  • 2011/04, 2012/03, Kyoto University

Educational Backgrounds

  • Kyoto University, Graduate School of Science, Division of Biological Sciences, 2008/04, 2011/03
  • Kyoto University, Graduate School of Science, Division of Biological Sciences, 2006/04, 2008/03
  • Kyoto University, Faculty of Science, 2002/04, 2006/03

Academic Degrees

  • Kyoto University
  • Kyoto University

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Physiology and Biochemistry
  2. 2026, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B

Research Activities

Academic Papers

  1. ★, Extracellular K+ modulates the pore conformations of Cys-loop receptor anion channels., Nature communications, 17(1), 2026
  2. Characterization and Engineering of a Blue-Sensitive, Gi/o-Biased, and Bistable Ciliary Opsin from a Fan Worm., Biochemistry, 64(5), 2025
  3. Descending to inhibit: Antagonist-induced downward shift of VSD II in TPC2., Structure (London, England : 1993), 32(8), 2024
  4. ★, Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels., Proceedings of the National Academy of Sciences of the United States of America, 120(6), 2023
  5. Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific., The Journal of general physiology, 154(7), 2022
  6. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior., Cell reports, 40(10), 2022
  7. Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization., BMC molecular and cell biology, 22(1), 2021
  8. Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 3., The Journal of biological chemistry, 297(6), 2021
  9. A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence., eLife, 9, 2020
  10. Phosphoinositides modulate the voltage dependence of two-pore channel 3., The Journal of general physiology, 151(8), 2019
  11. SLO potassium channels antagonize premature decision making in C. elegans, COMMUNICATIONS BIOLOGY, 1, 123-123, 2018
  12. Optimized expression and purification of NavAb provide the structural insight into the voltage dependence., FEBS letters, 592(2), 2018
  13. Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain., The Journal of physiology, 596(19), 2018
  14. SLO potassium channels antagonize premature decision making in C. elegans., Communications biology, 1, 2018
  15. Control of Spontaneous Ca2+ Transients Is Critical for Neuronal Maturation in the Developing Neocortex., Cerebral cortex (New York, N.Y. : 1991), 26(1), 2016
  16. Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics., The FEBS journal, 283(15), 2016
  17. Two alternative conformations of a voltage-gated sodium channel., Journal of molecular biology, 425(22), 2013
  18. The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate., Nature communications, 3, 2012
  19. Arrangement and mobility of the voltage sensor domain in prokaryotic voltage-gated sodium channels., The Journal of biological chemistry, 286(9), 2011
  20. Comparative study of the gating motif and C-type inactivation in prokaryotic voltage-gated sodium channels., The Journal of biological chemistry, 285(6), 2010
  21. Evidence for lateral mobility of voltage sensors in prokaryotic voltage-gated sodium channels., Biochemical and biophysical research communications, 399(3), 2010

Invited Lecture, Oral Presentation, Poster Presentation

  1. Extracellular K+ dependence of the Cys-loop receptor anion channels, Takushi Shimomura, The 55th NIPS International Symposium
  2. A switching role of the 2nd S4 helix in the voltage- and PIP2-dependence of Two-Pore channels revealed by voltage clamp fluorometry, Takushi Shimomura, Endolysosomal Ion Channels & Diseases 2025, 2025/10/25, Taipei
  3. A distinct role of the 2nd voltage-sensor domain in Two-pore channels revealed by voltage clamp fluorometry, Takushi Shimomura, Yonsei University – Korea University – NIPS joint symposium, 2024/11/21
  4. A switching mechanism between PIP2-and voltage-dependence in two-pore channels, The 101st Annual Meeting of The Physiological Society of Japan, 2024/03/29
  5. Contribution of the 2nd S4 helix for switching PIP2- and voltage-gating modes in two-pore channels, Takushi Shimomura, 2023/05/17

External Funds

Acceptance Results of Competitive Funds

  1. 2025/01, 2027/01
  2. 2023/04/01, 2026/03/31
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  3. 2025/02
  4. 2022/04/01, 2024/03/31
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  5. 2021/10, 2024/03
  6. 2020/04/01, 2023/03/31
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  7. 2020/04/01, 2022/03/31
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  8. 2022
  9. Grants-in-Aid for Scientific Research, Analysis of the involvment of TPC3 channel for polyspermy, 2018/04/01, 2020/03/31
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  10. Grants-in-Aid for Scientific Research, Analysis of the unique voltage-dependent mechanism of a Na+ channel by voltage-clamp fluorometry, 2016/04/01, 2018/03/31
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