KIYOFUMI SHIMOJI

Last Updated :2025/06/09

Affiliations, Positions
Hiroshima University Hospital(Medical), Assistant Professor
E-mail
kshimojihiroshima-u.ac.jp
Self-introduction
I am working on basic and clinical research about interstitial pneumonia and lung cancer, while practicing respiratory medicine at Hiroshima university hospital.

Basic Information

Major Professional Backgrounds

  • 2012/04/01, 2014/03/31, JA Hiroshima General Hospital, Department of Clinival Training, Jounior resident
  • 2014/04/01, 2015/03/31, JA Hiroshima General Hospital, Respiratory Medicine, Resident
  • 2015/04/01, 2017/03/31, Higashihiroshima Medical Center, Resoiratory Medicine, Resident
  • 2017/04/01, 2018/03/31, Higashihiroshima Medical Center, Respiratory Medicine, Medical Staff
  • 2018/04/01, 2019/03/31, Hiroshima University Hospital, Respiratory Internal Medicine, Clinical Fellow
  • 2019/04/01, 2022/03/31, Hiroshima University Hospital, Respiratory Internal Medicine, Clinical Staff
  • 2022/04/01, 2024/03/31, Rikita Hospital, Internal Medicine, Clinical Fellow
  • 2024/04/01, Hiroshima University Hospital, Respiratory Internal Medicine, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Faculty of Medicine, Japan, 2006/04, 2012/03
  • Hiroshima University, Biomedical and Health Sciences, Japan, 2018/04, 2024/01

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • Interstitial pneumonia, Lung cancer, Animal disease model, HIF-1, Tumor microenvironment

Affiliated Academic Societies

  • The Japanese Society of Internal Medicine, 2014/05
    Related URL
  • The Japanese Respiratory Society, 2014/05
  • The Japan Lung Cancer Society, 2017/10

Research Activities

Academic Papers

  1. A case of cholinergic crisis with difficulty in diagnosing the cause of consciousness disorder, Hiroshima Igaku, 69(5), 442-445, 201605
  2. Severe influenza-related viral pneumonia treated with early extracorporeal membrane oxygenation: A case report, Annals of the Japanese Respiratory Society, 7(2), 109-113, 2018
  3. Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells., Beilstein journal of organic chemistry, 15, 2019
  4. ★, Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers., JAMA network open, 3(11), 2020
  5. Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer., Cancer science, 112(1), 2021
  6. Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone., Anticancer research, 41(5), 2021
  7. ★, Hypoxia-inducible factor 1a modulates interstitial pneumonia-mediated lung cancer progression., Journal of translational medicine, 21(1), 2023
  8. Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study, LUNG, 203(1), 202512
    Link to Paper Search Results by DOI
  9. Sex-related differences in efficacy of bone marrow-derived high aldehyde dehydrogenase activity cells against pulmonary fibrosis, STEM CELL RESEARCH & THERAPY, 15(1), 20240915
  10. Predictive Value of Circulatory Total VEGF-A and VEGF-A Isoforms for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Patients with Non-Small-Cell Lung Cancer, Cancers, 17(572), 20250207
  11. Cisplatin-induced severe renal-salt wasting syndrome complicated with hypovolemic shock and various electrolyte abnormalities in a patent with thymoma: A case report., Internal Medicine, 20250515

Invited Lecture, Oral Presentation, Poster Presentation

  1. A single-center retrospective study of the prognosis of patients treated with nintedanib, Yasushi Horimasu, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Naoko Higaki, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Noboru Hattori., The 65th Annual Meeting of the Japanese Respiratory Society, 2025/04/11, Without Invitation, Japanese
  2. A case of lung adenocarcinoma with KRAS G12C gene identified after chemotherapy with an ALK inhibitor and significant response to sotrasib, Eigo Mikami, Shinjiro Sakamoto, Taku Nakashima, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Yasushi Horimasu, Takeshi Masuda, Hiroshi Iwamoto, Kazunori Fujitaka, Yasunobu Hamada, Noboru Hattori., The 70th Japanese Respiratory Society Chugoku-Shikoku Local Meeting, 2024/07/19, Without Invitation, Japanese, Yonago
  3. Association between Plasminogen Activator Inhibitor-1 & Tolerance against Anti-PD-1 Antibody in Non-Small Cell Lung Cancer, Sumii M, Masuda T, Shimoji K, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Iwamoto H, Hamada H, Hattori N, 2024 World Conference on Lung Cancer, 2024/09/07, Without Invitation, English, San Diego
  4. A case of Löfgren's syndrome with pericardial effusion, Yuki Fukushiro, Yasushi Horimasu, Kiyofumi Shimoji, kakuhiro Yamaguchi, Shinjiro Sakamoto, Naoko Higaki, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Noboru Hattori., The 44th Annual Meeting of the Japanese Society for Sarcoidosis/Granulomatous Diseases, 2024/10/11, Without Invitation, Japanese, Kobe
  5. FN, frequency of secondary prevention, and length of hospital stay in SCLC patients receiving combined immunotherapy without primary prophylactic G-CSF, Noriaki Ito, Takeshi Masuda, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Noboru Hattori., The 65th Japan Lung Cancer Society Academic Conference, 2024/10/31, Without Invitation, Japanese, Yokohama
  6. Investigation of Risk and Predictors of Severe irAE and Efficacy of Combination Immunotherapy with/without Ipilimumab - A Multicenter, Backward-Looking, Observational Study -, Kousei Nomura, Takeshi Masuda, Kiyofumi Shimoji, Syun Takao, Yusuke Izumi, Yusuke Araki, Yusuke Takayama, Ken Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Nao Seno, Hiroyasu Syoda, Nobuhisa Ishikawa, Masahiro Yamasaki, Yasunobu Hamada, Morihito Okada, Noboru Hattori., The 65th Japan Lung Cancer Society Academic Conference, 2024/10/31, Without Invitation, Japanese, Yokohama
  7. Study for early diagnosis of drug-induced lung injury by torsional sound quantification, Kanako Nakamoto, Yasushi Horimasu, Kiyofumi Shimoji, kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Takuma Sadamori, Shinichiro Oshimo, Nobuaki Shime, Noboru Hattori., The 65th Japan Lung Cancer Society Academic Conference, 2024/10/31, Without Invitation, Japanese, Yokohama
  8. Overcoming Early Resistance to Anti-PD-1 Antibodies in Non-Small Cell Lung Cancer - Development of Therapy Targeting PAI-1, Mituhiko Sumii, Takeshi Masuda, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Noboru Hattori., The 65th Japan Lung Cancer Society Academic Conference, 2024/10/31, Without Invitation, Japanese
  9. Low serum VEGF121 is a predictor of ICI efficacy, Tetu Hirakawa, Kakuhiro Yamaguchi, Kiyofumi Shimoji, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Yasunobu hamada, Shingo Yamada, Noboru Hattori., The 65th Japan Lung Cancer Society Academic Conference, 2024/10/31, Without Invitation, Japanese, Yokohama
  10. A case of tracheal carcinoid with airway stenosis treated with radiotherapy after tracheostomy, Taturo Yamakawa, Toshihiro Shimada, Shinjiro Sakamoto, Kiyofumi Shimoji, Kentaro Tokumo, Yasutomo Fujii, Kakuhiro Yamaguchi, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Wataru Hamada, Noboru Hattori., 71st Japanese Respiratory Society Chugoku-Shikoku Local Meeting, 2024/11/29, Without Invitation, Japanese
  11. A case of advanced small cell lung cancer complicated by cirrhosis and pancytopenia treated with IMpower 133 regimen, Natuko Yanagitani, Takeshi Masuda, Nanami Kotuki, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Noboru Hattori., 71st Japanese Respirratory Society Chugoku-Shikoku Local Meeting, 2024/11/29, Without Invitation, Japanese
  12. Two cases of interstitial pneumonia in which torsional sounds could be quantified and followed over time, Hanae Konishi, Yasushi Horimasu, Yuki Fukushiro, Kanako Nakamoto, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Yasunobu Hamada, Takuma Sadamori, Shinichiro Ohshimo, Nobuaki Shime, Noboru Hattori., 71st Japanese Respiratory Society Chugoku-Shikoku Local Meeting, 2024/11/29, Without Invitation, Japanese
  13. A case of bronchial asthma with rescued with ECCO2R (Extracorporeal CO2 removal), Kiyofumi Shimoji, Masaaki Sakuraya, Akira Hirata, Akihiro Takaba, Natsuki Kawamura, Kenichi Yoshida, The 41st Annual Meeting of the Japanese Society of Intensive Care Medicine, 2014/02/27, Without Invitation, Japanese, Japanese Society of Intensive Care Medicine, Kyoto
  14. A case of ANCA-associated vasculitis with alveolar hemorrhage requiring VV-ECMO successfully treated with Rituximab, Kiyofumi Shimoji, Tomohiro Kondo, Masaaki Sakuraya, Kentaro Tokumo, Satoshi Kurozumi, Hidekazu Kohno, Kenichi Yoshida, The 51st Annual Meeting of the Japanese Respiratory Society, Chugoku-Shikoku branch, 2014/07/11, Without Invitation, Japanese
  15. A case of a patient with lung squamous cell carcinoma rescued and QOL-improved with airway-esophageal double stent placement, Kiyofumi Shimoji, Tomohiro Kondo, Akiko Tominaga, Akira Furudoi, Satoshi Kurozumi, Hidekazu Kohno, The 52nd Annual Meeting of the Japanese Respiratory Society, Chugoku-Shikoku branch, 2014/12/13, Without Invitation, Japanese
  16. A case of refractory ANCA-associated vasculitis with alveolar hemorrhage requiring VV-ECMO management, Kiyofumi Shimoji, Tomohiro Kondo, Masaaki Sakuraya, Kentaro Tokumo, Satoshi Kurozumi, Hidekazu Kohno, Kenichi Yoshida, The 42nd Annual Meeting of The Japanese Society of Intensive Care Medicine, 2015/02/09, Without Invitation, Japanese, Tokyo
  17. A case of thoracic tuberculosis developed after 2 years of pulmonary tuberculosis treatment, which was cured by conservative treatment., Kiyofumi Shimoji, Isao Murakami, Masahiro Nomura, Takashi Ogawa, Kozue Miyazaki, Eriko Shigeto, The 66th Annual Meeting of the Japanese Society for Tuberculosis and Non-tuberculous Mycobacterial Infection, Chugoku-Shikoku Branch, 2015/12/19, Without Invitation, Japanese, Japanese Society for Tuberculosis and Non-tuberculous Mycobacterial Infection, Chugoku-Shikoku Branch, Tottori
  18. A case of primary lung adenocarcinoma in which autopsy revealed EGFR activating mutations in extra-thoracic metastases similar to those in the primary tumor, Kiyofumi Shimoji, Takashi Ogawa, Kozue Miyazaki, Atsushi Kagimoto, Satoshi Shibata, Isao Murakami, The 58th Annual Meeting of the Japan Lung Cancer Society, 2017/10/14, Without Invitation, Japanese, Japan Lung Cancer Society, Yokohama
  19. Severe influenza-related viral pneumonia treated with early extracorporeal membrane oxygenation: A case report, Kiyofumi Shimoji, Takashi Ogawa, Kozue Miyazaki, Kazuhiro Nitta, Isao Murakami, The 116th Annual Meeting of the Japan Society of Internal Medicine, Chugoku branch, 2017/06/03, Without Invitation, Japanese, Japan Society of Internal Medicine, Chugoku branch, Yamaguchi
  20. A study of advanced pulmonary sarcoma-like carcinoma in our hospital, Kiyofumi Shimoji, Takashi Ogawa, Kozue Miyazaki, Makoto Fujiwara, Hiroaki Harada, Satoshi Shibata, Isao Murakami, The 58th Annual Meeting of the Japanese Respiratory Society, Chugoku-Shikoku branch, 2017/10/28, Without Invitation, Japanese
  21. Comparison of the incidence of anti-PD-1 antibodies-induced lung disease in NSCLC and other carcinomas, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Takeshi Masuda, Yu Nakanishi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Yoshihiro Miyata, Hironobu Hamada, Morihito Okada, Noboru Hattori, The 59th Annual Meeting of the Japan Lung Cancer Society, 2018/11/29, Without Invitation, Japanese, Japan Lung Cancer Society, Tokyo
  22. A case of thymoma responding to chemoradiotherapy with cisplatin and etoposide, Shinji Kakumoto, Kiyofumi Shimoji, Takeshi Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori, 2018/12/15, Without Invitation, Japanese, Takamatsu
  23. A case of EGFR mutation-positive lung cancer with T790M mutation and sarcoma-like component in EGFR tyrosine kinase inhibitor resistance, Shinji Kakumoto, Kiyofumi Shimoji, Yasushi Horimasu, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori, The 61th Chugoku-Shikoku Regional Meeting of the Japanese Respiratory Society, 2019/07/14, Without Invitation, Japanese, Tokushima
  24. Risk Factors for anti-PD-1 Antibodies-Induced Lung Disease in Non-Lung Cancer Patients, Kiyofumi Shimoji, Takeshi Masuda, Yu Nakanishi, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Yasunobu Hamada, Noboru Hattori, The 60th Annual Meeting of the Japan Lung Cancer Society, 2019/12/06, Without Invitation, Japanese, Japan Lung Cancer Society, Osaka
  25. EGFR gene mutation is not a significant prognostic factor in patients with EGFR mutated non-small cell lung cancer who receive best supportive care alone., Takeshi Masuda, Yu Wakabayashi, Taku Nakashima, Yoshifumi Nishimura, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Tadashi Senoo, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori, 2020 ASCO ANNUAL MEETING, 2020/05/29, Without Invitation, Japanese, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, Virtual Congress
  26. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-NSCLC cancers., Kiyofumi Shimoji, Takeshi Masuda, Yu Nakanishi, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori, 2020 ASCO ANNUAL MEETING, 2020/05/29, Without Invitation, English, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, Virtual Congress
  27. Association of Pre-Existing Interstitial Lung Abnormalities with Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients with Non-Lung Cancers, Kiyofumi Shimoji, Takeshi Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Sachio Takeno, Michihiro Hide, Jun Teishima, Hideki Ohdan, Noboru Hattori, 2021 the Japanese Society of Medical Oncology Annual Meeting, 2021/02/18, Without Invitation, Japanese, Japanese Society of Medical Oncology, Virtual Congress
  28. Hypoxia-inducible factor 1a modulates interstitial pneumonia-mediated lung cancer progression, Kiyofumi Shimoji, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Takahiro Mimae, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Morihito Okada and Noboru Hattori, The 64th Annual Meeting of the Japanese Respiratory Society, 2024/04/05, Without Invitation, Japanese, Japanese Respiratory Society, Yokohama

Social Activities

History as Peer Reviews of Academic Papers

  1. 2025, PLOS ONE, Others, reviewer, 1
  2. 2025, Cancer Cell International, Others, reviewer, 1
  3. 2024, Scientific Reports, Others, reviewer, 1
  4. 2024, BMC Pulmonary Medicine, Others, reviewer, 1