DAISUKE MATSUMOTO

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
Web Site
E-mail
dmatsumohiroshima-u.ac.jp
Self-introduction
We are developing technology to apply genome editing technology for gene therapy safely. We are also working on the development of a new gene transfer system that can contribute to gene therapy.

Basic Information

Academic Degrees

  • Tokyo University of Agriculture and Technology
  • Tokyo Medical and Dental University

Research Fields

  • Biological Sciences;Genome science;Medical genome science
  • Medicine,dentistry, and pharmacy;Pharmacy;Drug development chemistry
  • Chemistry;Applied chemistry;Bio-related chemistry

Research Keywords

  • Gene therapy
  • Genome Editing

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, Intensive, Advanced Seminar(Introduction of Genome Editing?How can we rewrite our genome??)
  2. 2024, Undergraduate Education, 2Term, Physiological Chemistry
  3. 2024, Undergraduate Education, Second Semester, Experiments of Biological Chemistry
  4. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  5. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  6. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  7. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  8. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  9. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  10. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  11. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiological Chemistry
  12. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiological Chemistry
  13. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiological Chemistry
  14. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiological Chemistry
  15. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Mechanisms of Signal Transduction
  16. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Mechanisms of Signal Transduction
  17. 2024, Graduate Education (Master's Program) , First Semester, Research on Mechanisms of Signal Transduction
  18. 2024, Graduate Education (Master's Program) , Second Semester, Research on Mechanisms of Signal Transduction
  19. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiological Chemistry for Medicinal Sciences
  20. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiological Chemistry for Medicinal Sciences
  21. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiological Chemistry for Medicinal Sciences
  22. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiological Chemistry for Medicinal Sciences
  23. 2024, Graduate Education (Doctoral Program) , 3Term, Trends of Genome Editing in Life Science

Research Activities

Academic Papers

  1. ★, SpCas9-HF1 Enhances Accuracy of Cell Cycle-dependent Genome Editing by Increasing HDR Efficiency, and by Reducing Off-target Effects and Indel Rates, Molecular Therapy -Nucleic Acids, 35(1), 102124, 20240203
  2. The history of genome editing: advances from the interface of chemistry & biology, Chemical Communications, 2023
  3. ★, Cas9-Geminin and Cdt1-fused anti-CRISPR protein synergistically increase editing accuracy, FEBS LETTERS, 597(7), 985-994, 202304
  4. Molecular Switch Engineering for Precise Genome Editing, Bioconjugate Chemistry, 32(4), 639-648, 2021
  5. ★, A Cell Cycle-dependent CRISPR-Cas9 Activation System Based on an Anti-CRISPR Protein Increased the Accuracy of Genome Editing, Communications Biology, 3, 20201023
  6. ★, TALEN-based chemically inducible, dimerization-dependent, sequence-specific nucleases, Biochemistry, 59, 197-204, 2019
  7. ★, Direct Delivery of Cas9-sgRNA Ribonucleoproteins into Cells Using a Nanoneedle Array, Applied Sciences-Basel, 9, 965, 2019
  8. Efficient and orthogonal transcription regulation by chemically inducible artificial transcription factors, Biochemistry, 57, 6452-6459, 2018
  9. DNA aptamers against FokI nuclease domain for genome editing applications, Biosensors and Bioelectronics, 93, 26-31, 2017
  10. ★, Mechanoporation of living cells for delivery of macromolecules using nanoneedle array, Journal of bioscience and bioengineering, 122, 748-752, 2016
  11. ATP-mediated release of a DNA-binding protein from a silicon nanoneedle array, Electrochemistry, 84, 305-307, 2016
  12. ★, Oscillating high-aspect-ratio monolithic silicon nanoneedle array enables efficient delivery of functional bio-macromolecules into living cells, Scientific Reports, 5, 15325, 2015