RYO NAKAJIMA

Last Updated :2024/02/20

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
E-mail
nakajimahiroshima-u.ac.jp
Self-introduction
My study focuses on Medicinal Chemistry developing a novel medicine. To put it into practice, my viewpoint is different from that of organic synthetic chemists in terms of considering solubility, patent availability, metabolism, toxicity of compounds. Contact me if you want to optimize compound structure and develop a new medicine.

Basic Information

Major Professional Backgrounds

  • 2015/04, 2016/03, University of Tsukuba, Research Fellowships for Young Scientists(DC2)
  • 2016/04, 2017/03, University of Tsukuba, Research Fellowships for Young Scientists(PD)
  • 2016/04, 2017/09, University of Illinois at Chicago, College of Pharmacy, Postdoctoral Research Associate
  • 2017/10/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor

Academic Degrees

  • Kitasato University
  • University of Tsukuba

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Drug development chemistry
  • Chemistry;Applied chemistry;Bio-related chemistry

Research Keywords

  • Medicinal Chemistry
  • Organic Chemistry

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  2. 2023, Undergraduate Education, 1Term, Organic Chemistry III
  3. 2023, Undergraduate Education, 2Term, Medicinal Organic Chemistry
  4. 2023, Undergraduate Education, Intensive, Medicinal Organic Chemistry
  5. 2023, Undergraduate Education, 3Term, Organic Chemistry IV
  6. 2023, Undergraduate Education, 2Term, General Organic Chemistry and Practice
  7. 2023, Undergraduate Education, Second Semester, Experiments in Organic Chemistry
  8. 2023, Graduate Education (Master's Program) , First Semester, Seminar on Synthetic Organic Chemistry
  9. 2023, Graduate Education (Master's Program) , Second Semester, Seminar on Synthetic Organic Chemistry
  10. 2023, Graduate Education (Master's Program) , First Semester, Research on Synthetic Organic Chemistry
  11. 2023, Graduate Education (Master's Program) , Second Semester, Research on Synthetic Organic Chemistry
  12. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Synthetic Organic Chemistry
  13. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Synthetic Organic Chemistry
  14. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Synthetic Organic Chemistry

Research Activities

Academic Papers

  1. Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies. Part 1., Bioorganic & Medicinal Chemistry Letters, 21, 4104-4107, 2011
  2. Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies. Part 2: Propellane derivatives with an amide side chain., Bioorganic & Medicinal Chemistry Letters, 22, 2775-2779, 2012
  3. ★, Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons., Bioorganic & Medicinal Chemistry Letters, 22, 7697-7701, 2012
  4. The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, delta opioid receptor agonists., Bioorganic & Medicinal Chemistry, 21, 7628-7647, 2013
  5. ★, Design and synthesis of quinolinopropellane derivatives with selective delta opioid receptor agonism., Bioorganic & Medicinal Chemistry Letters, 24, 2851-2854, 2014
  6. ★, Investigation of 7-benzylidenenaltrexon derivatives as a novel structural antitrichomonal lead compound., Bioorganic & Medicinal Chemistry Letters, 25, 4890-4892, 2015
  7. ★, Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain., Bioorganic & Medicinal Chemistry, 23, 6271-6279, 2015
  8. A non-peptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models., Proceedings of the National Academy of Sciences of the United State of America., 114, 5731-5736, 2017
  9. Antitrichomonal activity of d opioid receptor antagonists, 7-benzylidenenaltrexone derivatives., Bioorganic & Medicinal Chemistry, 25, 4375-4383, 2017
  10. ★, 2-Aminoadipic Acid–C(O)–Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics, ACS Medicinal Chemistry Letters, 9, 1099-1104, 20181024
  11. ★, Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity, Bioorganic and Medicinal Chemistry Letters, 29(18), 2655-2658, 20190915
  12. ★, Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group, Bioorganic & Medicinal Chemistry Letters, 30, 126893, 20200201
  13. Asymmetric Total Synthesis of Brasiliquinones B and C via Oxidative Cyclization of a Hydroquinone-Silyl Enol Ether Hybrid, Journal of Organic Chemistry, 87(18), 12491-12497, 20220830
  14. Palladium-Catalyzed Reductive Heck Hydroarylation of Unactivated Alkenes Using Hydrosilane at Room Temperature, The Journal of Organic Chemistry, 89(4), 2787-2793, 20240201
  15. ★, Targeted Therapy for Prostate Cancer by Prostate-Specific Membrane Antigen-Targeted Small-Molecule Drug Conjugates, Chemical and Pharmaceutical Bulletin, 72(2), 136-142, 20240201

Invited Lecture, Oral Presentation, Poster Presentation

  1. Development of chemoselective removal of prenyl protecting group by hydroboration, Ryo Nakajima, Ryota Yara, Runa Hayashi, Takahiro Shirai, Takuya Kumamoto, 2022/11/06, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Hiroshima
  2. Development of chemoselective removal of prenyl protecting group by hydroboration, Ryota Yara, Ryo Nakajima, Takahiro Shirai, Takuya Kumamoto, the 142nd Annual Meeting of the Pharmaceutical Society of Japan, 2022/03/26, Without Invitation, Japanese, the Pharmaceutical Society of Japan, Nagoya
  3. Asymmetric synthesis of brasiliquinones, Takuya Kumamoto, Hiroki Miyake, Ryo Nakajima, 47th Progress of Reaction and Synthesis Symposium, 2021/10/02, Without Invitation, Japanese, Pharmaceutical Society of Japan, Zoom
  4. Optimization of Prostate-Specific Membrane Antigen Ligands as PET imaging agents for prostate cancer, Ryo Nakajima, HU-CSIR Joint International Workshop 2021, 2021/09/29, Without Invitation, English, Hiroshima University and Council of Scientific & Industrial Research, Online
  5. Asymmetric total synthesis of brasiliquinones, Hiroki Miyake, Ryo Nakajima, Takuya Kumamoto, 37th Organic Synthesis Seminer, 2021/09/16, Without Invitation, Japanese, Online
  6. Designed and synthesized a new series of Prostate-Specific Membrane Antigen (PSMA) targeting ligands as PET imaging agents and chemotherapeutics for prostate cancer, Ryo Nakajima, Alan P. Kozikowski, The 55th Annual MIKI Medicinal Chemistry Meeting-in-Miniature, 2017/04, Without Invitation, English, University of Minnesota, Minnesota, US
  7. Designed and synthesized a new series of Prostate-Specific Membrane Antigen (PSMA) targeting ligands as PET imaging agents and chemotherapeutics for prostate cancer, Ryo Nakajima, Alan P. Kozikowski, The 97th CSJ Annual Meeting, 2017/03, Without Invitation, English, The Chemical Society of Japan, Keio University, Tokyo, Japan
  8. Design and Synthesis of kappa Opioid Receptor Selective Ligand with a Propellane Skeleton, Ryo Nakajima, Naoshi Yamamoto, Shigeto Hirayama, Takashi Iwai, Akiyoshi Saito, Yasuyuki Nagumo, Hideaki Fujii, Hiroshi Nagase, The 96th CSJ Annual Meeting, 2016/03, Without Invitation, English, The Chemical Society of Japan, Doshisha University, Kyoto, Japan
  9. Synthesis of novel pentacyclic derivatives with propellane skeleton and their structure-activity relationships, Ryo Nakajima, Naoshi yamamoto, Shigeto Hirayama, Takashi Iwai, Toru Nemoto, Hideaki Fujii, Hiroshi Nagase, The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem), 2015/12, Without Invitation, English, Honolulu, Hawaii, USA
  10. Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound, Yasuaki Koyama, Noriki Kutsumura, Ryo Nakajima, Yasuyuki Nagumo, Tsuyoshi Saitoh, Yoshiyuki Miyata, Hiroshi Nagase, The International Narcotics Research Conference 2016, 2016/07, Without Invitation, Japanese, England
  11. Development of efficient synthesis of antitrichomonal BNTX derivatives and discovery of new rearrangement reaction, Yasuaki Koyama, Noriki Kutsumura, Ryo Nakajima, Yasuyuki Nagumo, Tsuyoshi Saitoh, Yoshiyuki Miyata, Hiroshi Nagase, The 25th French-Japanese Symposium on Medicinal and Fine Chemistry, 2016/05, Without Invitation, English, Tokyo
  12. Synthesis of novel penatacyclic derivatives with propellane skeleton and their structure-activity relationships, Ryo Nakajima, The 6th Ohtsu Conference, 2015/10, Without Invitation, English
  13. Design and Synthesis of Propellane Type Opioid Derrivatives snd Their Phamacologies, Ryo Nakajima, Naoshi Yamamoto, Junko Akiyama, Hideaki Fujii, Toru Nemoto, Shigeto Hirayama, Hiroshi Nagase, Italian-Japanese International Seminar for Neurosciences, 2011/09, Without Invitation, English, Miyagi

Awards

  1. 2017/03/19, CSJ Presentation Award 2017, The Chemical Society of Japan
  2. 2016/03/27, CSJ Student Presentation Award 2016, The Chemical Society of Japan
  3. 2015/10/19, Otsu Conference Award Fellow, MSD Life Science Foundation
  4. 2011/03/31, KItasato Award, Kitasato University

Social Activities

Organizing Academic Conferences, etc.

  1. Frontier researches in medicinal chemistry contribute to the field of pharmacy (2022), organizer, 2021/07, 2022/03

History as Peer Reviews of Academic Papers

  1. 2018, Bioorganic & Medicinal Chemistry Letters, Others, Reviewer, 3
  2. 2017, Bioorganic & Medicinal Chemistry Letters, Others, Reviewer, 1