MIYAKO NAKANO

Last Updated :2024/07/17

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
minakanohiroshima-u.ac.jp
Other Contact Details
1-3-1, Kagamiyama, Higashi-Hiroshima, Japan
TEL : (+81)82-424-4539 FAX : (+81)
Self-introduction
Glycosylation, which is one of the posttranslational modifications of proteins, is involved in infection by pathogens such as bacteria and viruses, cancer and acquisition of drug-resistance. We investigate these biological mechanisms with detailed analysis of glycan structures by mass spectrometry. Home page of my research group is https://bunseika.hiroshima-u.ac.jp/

Basic Information

Major Professional Backgrounds

  • 1997/07/11, pharmacist, pharmacist
  • 1999/04/01, 2001/03/31, PHARMACEUTICAL CORPORATION, Researcher
  • 2004/04/01, 2008/03/31, Osaka University, 21COE research fellow
  • 2008/04/01, 2010/03/31, Macquarie University (Sydney, Australia), Research fellow
  • 2010/04/01, 2012/05/31, Hiroshima University, Graduate School of Advanced Sciences of Matter, Assistant Professor
  • 2010/07/01, 2011/03/31, Osaka University, SANKEN, Invited faculty member
  • 2011/04/01, 2018/03/31, RIKEN, Visiting researcher
  • 2012/06/01, 2019/03/31, Hiroshima University, Graduate School of Advanced Sciences of Matter, Associate Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor
  • 2019/04/01, Kumamoto University, Visiting lecturer
  • 2021/07/01, The Japanese Society of Carbohydrate Research, board member
  • 2021/09/01, Osaka International Cancer Institute, Visiting researcher

Educational Backgrounds

  • Kindai University, Japan, 2001/04, 2004/03
  • Johns Hopkins University, Baltimore, USA, 2001/09/26, 2002/09/19
  • Kindai University, Japan, 1997/04, 1999/03
  • Kindai University, Japan, 1992/04, 1997/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Kindai University
  • Master of Pharmaceutical Science, Kindai University

Educational Activity

  • [Bachelor Degree Program] School of Engineering : Cluster 3(Applied Chemistry, Biotechnology and Chemical Engineering) : Program of Biotechnology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology

In Charge of Primary Major Programs

  • Biotechnology

Research Fields

  • Biology;Biological Science;Structural biochemistry

Research Keywords

  • glycan analysis
  • mass spectrometry
  • glycoprotein
  • biomarker
  • cancer, tumor

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Introduction to Applied Chemistry, Chemical Engineering,and Biotechnology
  2. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  3. 2024, Undergraduate Education, 4Term, Basic life science
  4. 2024, Undergraduate Education, Second Semester, Experiments on Biotechnology II
  5. 2024, Undergraduate Education, 3Term, Biochemistry II
  6. 2024, Undergraduate Education, 4Term, Glycotechnology & Immunotechnology
  7. 2024, Undergraduate Education, Year, Graduation Thesis
  8. 2024, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  9. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  10. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  11. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  12. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  13. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  14. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. Core fucosylation within the Fc-FcrR degradation pathway promotes enhanced IgG levels via exogenous L-fucose, J Biol Chem., 20240711
  2. The K346T mutant of GnT-III bearing weak in vitro and potent intracellular activity., Biochim Biophys Acta Gen Subj., 20240625
    Link to Paper Search Results by DOI
  3. LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping., J Biol Chem., 20240604
  4. Dynamic movement of the Golgi unit and its glycosylation enzyme zones., Nat Commun., 15(1), 4514, 20240527
    Link to Paper Search Results by DOI
  5. Exogenous l-fucose attenuates neuroinflammation induced by lipopolysaccharide., J Biol Chem., 300(1), 105513, 20240101
    Link to Paper Search Results by DOI
  6. ★, Structural Analysis of GPI-glycans from GPI-anchored Proteins by Mass Spectrometry, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 35(207), E81-E85, 20230901
    Link to Paper Search Results by DOI
  7. Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model, J Biol Chem., 20230714
    Link to Paper Search Results by DOI
  8. O-GalNAc glycosylation determines intracellular trafficking of APP and Ab production, Jounal of Biological Chemistry, 20230609
  9. Core fucosylation is required for the secretion of and the enzymatic activity of SOD3 in non-small cell lung cancer cells., Antioxid Redox Signal., 20230106
  10. Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression Involvement of the TNFR2-NF-kB signaling pathway, Journal of Biological Chemistry, 20230220
  11. Proximity Labeling and Proteomics: Get to Know Neighbors, Method in Enzymology, 20220902
  12. Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2., Elife, 11, e83037, 20221208
  13. Examination of differential glycoprotein preferences of N-acetylglucosaminyltransferase-IV isozymes a and b., J Biol Chem., 20220818
  14. Shedding of N-acetylglucosaminyltransferase-V is regulated by maturity of cellular N-glycan., Commun Biol., 1(5), 743, 20220801
  15. Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells., J Biol Chem., 20220601
  16. Quality-controlled ceramide-based GPI-anchored protein sorting into selective ER exit sites, CELL REPORTS, 39(5), 20220503
    Link to Paper Search Results by DOI
  17. N-acetylglucosaminyltransferase-V requires a specific noncatalytic luminal domain for its activity toward glycoprotein substrates

    , JOURNAL OF BIOLOGICAL CHEMISTRY, 298(3), 20220301
    Link to Paper Search Results by DOI
  18. O-GlcNAcylation regulates beta 1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis, FASEB JOURNAL, 36(2), 20220201
    Link to Paper Search Results by DOI
  19. ★, N-Glycan profiling by liquid chromatography-mass spectrometry (LC-MS)., Glycoscience Protocols (GlycoPODv2) [Internet], 20211024
  20. ★, Structural analysis of the GPI glycan., PLoS One., 16(9), e0257435-e0257435, 20210916
  21. Peptide Sequence Mapping around Bisecting GlcNAc-Bearing N-Glycans in Mouse Brain., Int J Mol Sci., 22(16), 8579, 20210809
  22. MALDI-TOF mass spectrometry imaging for N-glycans on FFPE tissue sections of mouse NASH liver through Sialic acid Benzylamidation., Glycoconj J., 38(2), 167-175, 20210401
  23. Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation., J Biol Chem., 296(100354), 100354-100354, 20210129
  24. Ceramide chain length-dependent protein sorting into selective endoplasmic reticulum exit sites., Sci Adv, 6(50), eaba8237-eaba8237, 20201211
  25. ★, Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D., Biochim Biophys Acta Gen Subj, 1864(11), 20201101
  26. The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation., J Biol Chem., 295(23), 7992-8004, 20200605
  27. Type I hypersensitivity to 15 kDa and 28 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe., Allergology International, 69(2), 253-260, 20200401
  28. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods, Molecular & Cellular Proteomics, 19(1), 11-30, 20200119
  29. Protein Paucimannosylation is an Enriched N-glycosylation Signature of Human Cancers., Proteomics, doi: 10.1002/pmic.201900010.(doi: 10.1002/pmic.201900010.), doi: 10.1002/pmic.201900010.-doi: 10.1002/pmic.201900010., 20191101
  30. ★, Bisecting GlcNAc is a general suppressor of terminal modification of N-glycan., Mol. Cell Proteomics, doi: 10.1074/mcp.RA119.001534(doi: 10.1074/mcp.RA119.001534), doi: 10.1074/mcp.RA119.001534-doi: 10.1074/mcp.RA119.001534, 20191001
  31. Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes, SCIENTIFIC REPORTS, 8, 20180314
    Link to Paper Search Results by DOI
  32. Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation., Oncotarget, 9(16), 12732-12744, 20180129
  33. An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3, CELL CHEMICAL BIOLOGY, 24(12), 1467-+, 20171221
    Link to Paper Search Results by DOI
  34. Sialylation of extracellular superoxide dismutase (EC-SOD) enhances furin-mediated cleavage and secretion, GLYCOBIOLOGY, 27(12), 1081-1088, 20171201
    Link to Paper Search Results by DOI
  35. Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells, CELL REPORTS, 20(5), 1017-1028, 20170801
    Link to Paper Search Results by DOI
  36. Replications of Two Closely Related Groups of Jumbo Phages Show Different Level of Dependence on Host-encoded RNA Polymerase, FRONTIERS IN MICROBIOLOGY, 8, 20170613
    Link to Paper Search Results by DOI
  37. ★, Epigenetic regulation of neural N-glycomics, Proteomics, 20161116
  38. Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens., World Allergy Organ J., 9(1), 27-27, 20160927
  39. High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery, CELL CHEMICAL BIOLOGY, 23(7), 782-792, 20160721
    Link to Paper Search Results by DOI
  40. Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines : HUPO Human Disease Glycomics/Proteome Initiative multi-institutional, Glycoconj J., 20160601
  41. ★, Site-specific and linkage analyses of fucosylated N-glycans on haptoglobin in sera of patients with various types of cancer: possible implication for the differential diagnosis of cancer, GLYCOCONJUGATE JOURNAL, 33(3), 471-482, 20160601
    Link to Paper Search Results by DOI
  42. Two asian jumbo phages, RSL2 and RSF1, infect Ralstonia solanacerum and show common features of KZ-related phages., Virology, 494, 56-66, 20160412
  43. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions., Biochem J., 473(1), 21-30, 20160101
  44. ★, Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism., Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism., 25(2), 225-240, 20150225
  45. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease., An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease., 7(2), 175-189, 20150115
  46. Establishment of a novel lectin-antibody ELISA system to determine core-fucosylated haptoglobin., Establishment of a novel lectin-antibody ELISA system to determine core-fucosylated haptoglobin., 446, 30-36, 20150115
  47. ★, Identification of Glycan Structure Alterations on Cell Membrane Proteins in Desoxyepothilone B Resistant Leukemia Cells, MOLECULAR & CELLULAR PROTEOMICS, 10(11), 20111101
    Link to Paper Search Results by DOI
  48. Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4, Journal of Biochemistry, 149(4), 443-453, 20110401
  49. Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1, Mol Cell Proteomics, 9(4), 719-727, 20101228
    Link to Paper Search Results by DOI
  50. Identification of a Novel Type of CA19-9 Carrier in Human Bile and Sera of Cancer Patients: An Implication of the Involvement in Nonsecretory Exocytosis, J. Proteome Res., 9(12), 6345-6353, 20101201
  51. N-Glycosylation engineering of lepidopteran insect cells by the introduction of the beta1,4-N-acetylglucosaminyltransferase III gene, Glycobiology, 20(9), 1147-1159, 20100901
  52. ★, The Lectin Riddle: Glycoproteins Fractionated from Complex Mixtures Have Similar Glycomic Profiles, OMICS A Journal of Integrative Biology, 14(4), 487-499, 20100801
  53. ★, Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry for Rapid and Sensitive N-glycan Analysis of Glycoproteins as 9-Fluorenylmethyl Derivatives, Glycobiology, 19(2), 135-143, 20081025
  54. ★, Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures., Proteomics, 8(16), 3257-3262, 20080801
  55. ★, Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer; a novel approach for the development of tumor marker, Int. J. Cancer, 122(10), 2301-2309, 20080315
  56. ★, Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase, J. Biol. Chem., 282(49), 35933-35944, 20071207
  57. From glycomics to functional glycomics of sugar chains: Identification of target proteins with functional changes using gene targeting mice and knock down cells of FUT8 as examples., Biochim Biophys. Acta, 1764(12), 1881-1889, 20061201
  58. Fucosylation of N-glycans regulates the secretion of hepatic glycoproteins into bile ducts, J. Biol. Chem., 281(40), 29797-29806, 20061006
  59. Man2C1, an alpha-mannosidase is involved in the trimming of free oligosaccharides in the cytosol., Biochem. J., 400(1), 33-41, 20061006
  60. Site-specific Labeling of Cytoplasmic Peptide:N-Glycanase by N,N'-Diacetylchitobiose-related Compounds., J. Biol. Chem., 281(31), 22152-22160, 20060804
  61. Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation., Int. J. Cancer, 118(11), 2803-2808, 20060601
  62. Fucosylated haptoblobin is a possible marker for pancreatic cancer: A detailed analysis on the oligosaccaride structure and a possible mechanism for fucosylation, Japan Journal of Molecular Tumor Marker Research, 21, 27-28, 20060510
  63. ★, Glycomics—a new target for pharmaceuticals., Drug Discovery Today: Technology, 3(1), 39-47, 20060401
  64. Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice., Proc. Natl. Acad. Sci. U.S.A., 102(44), 15791-15796, 20051101
  65. Rapid and sensitive screening of N-glycans as 9-fluorenylmethyl derivatives by high-performance liquid chromatography: a method which can recover free oligosaccharides after analysis., J. Proteome Res., 4(1), 146-152, 20050204
  66. ★, Detailed structural features of glycan chains derived from alpha1-acid glycoproteins of several different animals: the presence of hypersialylated, O-acetylated sialic acids but not disialyl residues, Glycobiology, 14(5), 431-441, 20040501
  67. ★, Sample clean-up method for analysis of complex-type N-glycans released from glycopeptides., J. Chromatogr. A, 1005(1-2), 13-21, 20030711
  68. Collection of alpha-acid glycoprotein molecular species by capillary electrophoresis and the analysis their molecular masses and carbohydrate chains. Basic studies on the analysis of glycoprotein glycoforms., J Chromatogr. A., 958(1-2), 273-278, 20020607
  69. Analysis of glycoproteins and the oligosaccharides thereof by high-performance capillary electrophoresis-significance in regulatory studies on biopharmaceutical products., Biomed. Chromatogr., 16(2), 103-115, 20020401
  70. Specific distribution of sialic acids in animal tissues as examined by LC-ESI-MS after derivatization with 1,2-diamino-4,5-methylenedioxybenzen., Anal. Chem., 73(22), 5422-5428, 20020101
  71. ★, Examination of the stability of chloral hydrate and its preparation by capillary electrophoresis. Kakehi K, Nakano M, Nishiura S, Tachibana S, Ishida S, Taneda M, Yakugaku Zasshi, 119(5), 410-416, 19990101
  72. Analysis of glucuronolactone and glucuronic acid in drug formulations by high-performance liquid chromatography., J. Chromatogr. Sci., 36(7), 357-360, 19980701

Publications such as books

  1. 2021/10/24, Glycoscience Protocols (GlycoPODv2) [Internet], N-Glycan profiling by liquid chromatography-mass spectrometry (LC-MS)., NIH, 2021, 10, Others, Single work, English, Miyako Nakano
  2. 2020/02/18, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Glycan Biomarkers in Pancreatic Cancer"., Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Glycan Biomarkers in Pancreatic Cancer"., Elsevier, 2020, Scholarly Book, Joint work, English, Eiji Miyoshi, Koichi Morishita, Tatsuya Asuka, Tomoya Fukuoka, Shinji Takamatsu, Yoshihiro Kamada, Miyako Nakano.
  3. 2019/07, Glycoscience: Basic Science to Applications - Insights from the Japan Consortium for Glycobiology and Glycotechnology, Drug resistance, Springr Nature, 2019, Scholarly Book, Joint work, 英語
  4. 2010/11, CAPILLARY ELECTROPHORESIS OF CARBOHYDRATES FROM MONOSACCHARIDES TO COMPLEX POLYSACCHARIDES, Chapter 9 ""CE and CE-MS for structural analysis of N-glycans derived from glycoproteins"", 2010, 11, Scholarly Book, Cocompilation, 277

Invited Lecture, Oral Presentation, Poster Presentation

  1. Glycoproteomic analysis for identification of glycosites for GnT-V reaction, Miyako Nakano, Kazuya Ono, Yasuhiko Kizuka, Glyco-core Symposium 2024, 2024/07/16, Without Invitation, English, J-GlycoNet, iGcore, HGA, Toyoda Auditorium of Nagoya University
  2. Glycoprotoemic and Glycomic analysis of haptoglobin: possible implication for the differential diagnosis of cancer, Miyako Nakano, Korean Human Proteome Organization 2024 (KHUPO2024), 2024/06/25, With Invitation, English, Korean Human Proteome Organization, Yeos, South Korea
  3. Structural changes of N-glycans on cell membrane protein of leukemia cells acquired resistance against anthracycline antitumor drug, Sayaka Morii, Tomoya Isaji, Tomohiko Fukuda, Jianguo Gu, Miyako Nakano, 41st JSCR, 2022/09/29, Without Invitation, Japanese
  4. Structural analysis of GPI glycans by LC-ESI MS, Miyako Nakano, 41st JSCR, 2022/09/29, Without Invitation, Japanese, Osaka Univ.
  5. Glycan structural analysis to elucidate the selective export mechanism of GPI anchored proteins, Miyako Nakano, Kouta Okazaki, The 40th Annual Meeting of Japanese Society of Carbohydrate Research, 2021/10/27, Without Invitation, Japanese, Japanese Society of Carbohydrate Research, Kagoshima
  6. Induction of bisecting GlcNAc by microenvironment enhances malignant phenotypes in tumor, Yuki Ohkawa, Kana Nakano, Noriko Kanto, Miyako Nakano, Eiji Miyoshi, Yoichiro Harada and Naoyuki Taniguchi, The 80th Annual Meeting of the Japanese Cancer Association, 2021/09/30, Without Invitation, Japanese, Japanese Cancer Association, Yokohama
  7. Protein N-Glycosylation of extracellular vesicles may define human lung cancer types, Kiyotaka Kondo, Yoichi Harada, Keiko Mizuno, Naoyuki Taniguchi, Takuro Kanekura, Naoshi Dohmae, Miyako Nakano, Hiromasa Inoue, The 80th Annual Meeting of the Japanese Cancer Association, 2021/09/30, Without Invitation, Japanese, Japanese Cancer Association, Yokohama
  8. Bisecting GlcNAc is a brake monosaccharide for further modification of N-glycan terminal, Nakano M, Takata M, Kizuka Y, Taniguchi N., 3rd Australasian Glycoscience Symposium, 2021/06/03, Without Invitation, English
  9. Functional analysis of langerin against keratan sulfate disaccharide L4 and derivatives in langerin knockout mice, Yuki Ohkawa, Noriko Kanto, Miyako Nakano, Reiko Fujinawa, Yasuhiko Kizuka, Yoichiro Harada, Jun-ichi Tamura and Naoyuki Taniguchi, 3rd Australasian Glycoscience Symposium, 2021/06/03, Without Invitation, English, Miyako Nakano, Hiroshima
  10. The therapeutic effect of keratan sulfate disaccharide L4 and derivatives thereof through langerin in COPD mouse model, Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Harada Y, Tamura J, Taniguchi N, 39th Japanese Carbohydrate Symposium, 2020/11/21, Without Invitation, Japanese
  11. Bisecting GlcNAc is a brake monosaccharide for further modification of N-glycan terminal., Nakano M, Takata M, KizukaY, Taniguchi N, 39th Japanese Carbohydrate Symposium, 2020/11/21, Without Invitation, Japanese
  12. Anti-inflammatory effect of keratan sulfate disaccharide L4 and derivatives through langerin in COPD mouse model., Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Harada Y, Tamura J, Taniguchi N., Society for Glycobiology, 2020/11/09, Without Invitation, English
  13. Low glucose enhances tumor sphere formation by modulating N-glycan structure, Ohkawa Y, Nakano K, Nakano M, Kizuka Y, Harada Y, Miyoshi E, Taniguchi N., 2020/10/01, Without Invitation, Japanese
  14. Suppression of terminal modifications of N-glycans by bisecting GlcNAc, Yasuhiko Kizuka, Miyako Nakano, Naoyuki Taniguchi, 18th Human Proteome Organization World Congress, 2019/09/15, Without Invitation, English, Human Proteome Organization, Adelaide, Australia
  15. Elucidation of the biosynthetic mechanism of fucosylated haptoglobin, Hiromu Kawaguchi, Shinji Takamatsu, Eiji Miyoshi, Miyako Nakano, Human Proteome Organization 18th Annual World Congress, 2019/09/15, Without Invitation, English, Human Proteome Organization, Adelaide Convention Centre (Address: North Terrace, Adelaide SA 5000, Australia)
  16. Development of Cancer Biomarker for Biliary Tract Cancer and Pancreatic Cancer with Serum Haptoglobin Glycan Analyses, Miyako Nakano, Soya Usui, Taiki Sugiyama, Shiro Takahashi, Eiji Miyoshi, 2nd Australasian Glycoscience Symposium, 2019/09/14, Without Invitation, English, Adelaide Convention Centre (Address: North Terrace, Adelaide SA 5000, Australia)
  17. Protein paucimannosylation is an enriched N-glycosylation signature of human cancers, Sayantani Chatterjee, Ling Y. Lee2, Rebeca Kawahara3, Jodie L. Abrahams4, Barbara Adamczyk5, Merrina Anugraham6, Christopher Ashwood7, Zeynep Sumer-Bayraktar8, Matthew T. Briggs9, Jenny H.L. Chik10, Arun Everest-Dass4, Sarah Förster11, Hannes Hinneburg1, Katia R.M. Leite12, Ian Loke13, Uwe Möginger14, Edward S.X. Moh1, Miyako Nakano15, Saulo Recuero12, Manveen K. Sethi16, Miguel Srougi12, Kathrin Stavenhagen17, Vignesh Venkatakrishnan18, Katherine Wongtrakul-Kish19, Simone Diestel20, Peter Hoffmann9, Niclas G. Karlsson5, Daniel Kolarich4, Mark P. Molloy21, Michael H. Muders11, Martin K. Oehler22, Nicolle H. Packer1, Giuseppe Palmisano3, Morten Thaysen-Andersen1, 2nd Australasian Glycoscience Symposium, 2019/09/14, Without Invitation, English, Australasian Glycoscience Symposium, Adelaide, Australia
  18. MALDI imaging mass spectrometry for N-glycans on NASH liver FFPE tissue sections through Sialic Acid derivatization, T. Saito, K. Matsuo, A. Watanabe, M. Nakano, The Mass Spectrometry Society of Japan, 2019/05/17, Without Invitation, Japanese, The Mass Spectrometry Society of Japan
  19. ABO antigens on the epithelial cell membrane decrease in cancerous parts, Naya Asaka, Yoshimi Higashi, Miyo Oda, Koji Arihiro, Miyako Nakano, Human Proteome Organization 17th Annual World Congress, 2018/09/30, Without Invitation, English, uman Proteome Organization, Loews Royal Pacific Hotel, 6300 Hollywood Way, Orlando, FL 32819 USA
  20. Development of biomarker for biliary tract cancer and cholelithiasis using serum haptoglobin glycan, Miyako Nakano, Taiki Sugiyama, Shiro Takahashi, Eiji Miyoshi, Human Proteome Organization 17th Annual World Congress, 2018/09/30, Without Invitation, English, Human Proteome Organization, Loews Royal Pacific Hotel, 6300 Hollywood Way, Orlando, FL 32819 USA
  21. Glycomic Approach for Biomarker Discovery, Nakano M, International Symposium,“Systems Glycobiology and Beyond” -Toward a bridge between fundamental research and applied science-, 2017/11/16, With Invitation, English, RIKEN 理研（和光）, Suzuki Umetaro Hall, RIKEN 理研（和光）
  22. Glycosylation changes of cell membrane proteins in pancreatic cancer., Higashi Y, Oda M, Arihiro K, Nakano M., Human Proteome Organization 16th Annual World Congress, 2017/09/17, Without Invitation, English, Human Proteome Organization, Dublin, Ireland
  23. Analyses of glycans on haptoglobin in sera of patients with various types of cancer., Nakano M, Sugiyama T, Takahashi S, Miyoshi E., Human Proteome Organization 16th Annual World Congress, 2017/09/17, Without Invitation, English, Human Proteome Organization, Dublin, Ireland
  24. Neural Glycoproteomics and Epigenetic Regulation., Nakano M, Kizuka Y, MiuraY, Taniguchi N, Human Proteome Organization 15th Annual World Congress, 2016/09/18, Without Invitation, English, HUPO, Taipei, Taiwan
  25. A highly sensitive probe for fucosylated glycans for biomarker discovery., Kizuka Y, Funayama S, Shogomori H, Nakano M, Nakajima K, Wong C, Taniguchi N., Human Proteome Organization 15th Annual World Congress, 2016/09/18, Without Invitation, English, HUPO, Taipei, Taiwan
  26. Measuring Variability of Glycosylation Analysis Methods for Monoclonal Antibodies: A NIST Interlaboratory Study, M. Lorna, De Leoz, David Duewer, Stephen Stein, Nakano M, 64th ASMS conference, 2016/06/08, Without Invitation, English, San Antonio, TX
  27. Structural analyses of murine plasma glycoproteins to find biomarker candidates for chronic obstructive lung disease (COPD), Miyako Nakano, Shirai K, Ryohei Inoue, Fujinawa R, Kobayashi S, Kitazume S, Taniguchi N, RIKEN-Max Plank Joint Research Center for Systems Chemical Biology, The 5th Symposium, 2016/04/17, Without Invitation, English, Berlin, Germany
  28. Physiological and pathological roles of bisecting GlcNAc, Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Naoyuki Taniguchi, RIKEN-Max Plank Joint Research Center for Systems Chemical Biology, The 5th Symposium, 2016/04/17, Without Invitation, English, Berlin, Germany
  29. Glycan analyses of murine plasma and lung membrane to find biomarker candidate for COPD (oral presentation), Miyako Nakano, Shirai K, Fujinawa R, Kobayashi S, Kitazume S, Taniguchi N, Human Proteome Organization 14th Annual World Congress, 2015/09/27, Without Invitation, English, Human Proteome Organization, Vancouver, Canada
  30. Glycan analyses of murine plasma and lung membrane to find biomarker candidate for COPD (poster presentation), Miyako Nakano, Shirai K, Fujinawa R, Kobayashi S, Kitazume S, Taniguchi N, Human Proteome Organization 14th Annual World Congress, 2015/09/27, Without Invitation, English, Human Proteome Organization, Vancouver, Canada
  31. N-Acetylglucosaminyltransfease III (GnT-III) Is a Novel Drug Target for Alzheimer’s Disease (oral presentaion), Naoyuki Taniguchi, Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Takaomi C. Saido,Yasuhiro Hashimoto, Tamao Endo, Human Proteome Organization 14th Annual World Congress, 2015/09/27, With Invitation, English, Human Proteome Organization, Vancouver, Canada
  32. N-Acetylglucosaminyltransfease III (GnT-III) Is a Novel Drug Target for Alzheimer’s Diseas (poster presentation), Naoyuki Taniguchi, Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Takaomi C. Saido,Yasuhiro Hashimoto, Tamao Endo, Human Proteome Organization 14th Annual World Congress, 2015/09/27, With Invitation, English, Human Proteome Organization, Vancouver, Canada
  33. Acquired drug resistance by decrease of sialylated glycans on acute lymphoblastic leukemia cell-membrane glycoproteins, Nakano M, Nakano M, Shirai R, Ito J, Kavallaris M , Packer N, Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of the Carbohydrate Resarch (JSCR), 2014/11/16, Without Invitation, English, SFG and JSCR, Honolulu, Hawaii
  34. Structural analyses of plasma glycoproteins in exacerbation and emphysema model mice as biomarker candidates for chronic obstructive lung disease (COPD), Shirai K, Shirai K, Fujinawa R, Kobayashi S, Ota F, Kitazume S, Taniguchi N, Nakano M, Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of the Carbohydrate Resarch (JSCR), 2014/11/16, Without Invitation, English, SFG and JSCR, Honolulu, Hawaii
  35. Glycan changes of plasma transferrin in elastase-induced emphysema and LPS- induced acute lung injury mice models, Nakano M, Nakano M, Shirai K, Fujinawa R, Kobayashi S, Kitazume S, Taniguchi N, Human Proteome Organization 13th Annual World Congress, 2014/10/05, Without Invitation, English, Human Proteome Organization, Madrid, Spain
  36. 疾患で変化する糖タンパク質糖鎖構造の網羅的/特異的LC-MS分析, Nakano M, Nakano M, Takahashi S, Shirai R, Ito J, Kavallaris M, Miyoshi E, Packer N, The Japan Society for Analytical Chemistry 63th Annual Congress, 2014/09/17, Without Invitation, Japanese, The Japan Society for Analytical Chemistry, Hiroshima, Japan
  37. 細胞膜上糖鎖構造の網羅的分析による抗癌剤耐性獲得機構の解明, Shirai R, Shirai R, Packer N, Kavallaris M, Nakano M, The Japan Society for Analytical Chemistry 63th Annual Congress, 2014/09/17, Without Invitation, Japanese, The Japan Society for Analytical Chemistry, Hiroshima, Japan
  38. 少量血液中のリンパ球の表面糖鎖構造分析法の開発, Ito J, Ito J, Kavallaris M, Packer N, Nakano M, The Japan Society for Analytical Chemistry 63th Annual Congress, 2014/09/17, Without Invitation, Japanese, The Japan Society for Analytical Chemistry, Hiroshima, Japan
  39. Analysis of Glycan Structures on Glycoproteins for Finding Cancer Biomarkers, Nakano M, Nakano M, Human Proteome Organization 12th Annual World Congress, 2013/09/14, With Invitation, Japanese, Human Proteome Organization, Yokohama, Japan
  40. Site-Specific Analyses of N-glycans on Haptoglobin in Sera of Patients with Various Kinds of Cancers: A Possible Implication of Differential Diagnosis for Cancer, Nakano M, Nakano M, Takahashi S, Miyoshi E, Human Proteome Organization 12th Annual World Congress, 2013/09/14, Without Invitation, English, Human Proteome Organization, Yokohama, Japan
  41. Acquired Drug Resistance by Alteration of Glycan Structure on Leukemia Cell-Membrane Glycoproteins, Shirai R, Shirai R, Packer N, Kavallaris M, Nakano M, Human Proteome Organization 12th Annual World Congress, 2013/09/14, Without Invitation, English
  42. Glycomic Approach for Identification of Diagnostic Markers of the Acquisition of Drug Resistance Against Microtubule-Targeting Drugs, Ito J, Ito J, Kavallaris M, Packer N, Nakano M, Human Proteome Organization, 2013/09/14, Without Invitation, English
  43. Proteomic Analysis of Liver Microsomes in X. tropicalis, Suzuki K, Suzuki K, Nakano M, Watanabe Y, FukutaY, Iwata H, Human Proteome Organization 12th Annual World Congress, 2013/09/14, Without Invitation, English, Human Proteome Organization, Yokohama, Japan
  44. 質量分析法を用いた網羅的/特異的な糖鎖構造解析 ～疾患で変化する糖タンパク質糖鎖構造の高感度高詳細検出を目指して～, Nakano M, Nakano M, 32nd Japanese Carbohydrate Symposium, 2013/08/05, Without Invitation, Japanese
  45. Analyses of N-glycans on haptoglobin in sera of patients with various kinds of cancers, Shiro Takahashi, Shiro Takahashi, Ryohei Shirai, Jun Ito, Eiji Miyoshi, Miyako Nakano, 32nd Japanese Carbohydrate Symposium, 2013/08/05, Without Invitation, Japanese, Japanese Carbohydrate Society, Osaka, Japan
  46. Analysis of Glycan Structures on Glycoproteins for Finding Cancer Biomarkers (New Technologies in Proteomics and Industry Presentations), Nakano M, Nakano M, Human Proteome Organization 12th Annual World Congress, 2013/09/14, With Invitation, English, Human Proteome Organization, Yokohama, Japan
  47. Alterations of glycan structures on cell membrane glycoproteins in microtubule-targeting drug-resistant leukemia cells, Nakano M, Nakano M, Shirai R, Ito J, Takahashi S, 31st Japanese Carbohydrate Symposium, 2012/09/17, Without Invitation, Japanese, Japanese Carbohydrate Sciety, Kagoshima, Japan
  48. Identification of alterations in glycan structure on cell membrane proteins in microtubule-targeting drug-resistant leukemia cells, Nakano M, Nakano M, Taniguchi N, Ito J, Shirai R, Kavallaris M, Packer N, Human Proteome Organization 11th Annual World Congress, 2012/09/09, Without Invitation, English, Human Proteome Organization, Boston, MA, U.S.A.
  49. Site-specific analyses of N-glycans on haptoglobin in sera of patients with various kinds of gastroenterological cancers, Takahashi S, Takahashi S, Amimoto T, Kawamoto S, Ono K, Miyoshi E, Nakano M, Human Proteome Organization 11th Annual World Congress, 2012/09/09, Without Invitation, English, Human Proteome Organization, Boston, MA, U.S.A.
  50. Drug-resistance inhibits expression of alpha2-6 sialylation on cell membrane glycoproteins, Nakano M, Nakano M, Ota F, Nakajima K, Taniguchi N, Kavallaris M, Packer N, 21st International Symposium glycoconjugates,, 2011/08/21, Without Invitation, English, SFG, Vienna, Austria
  51. Alterations of glycoforms on cell membrane proteins by acquired resistance to microtubule targeted antitumor drugs., Nakano M, Nakano M and Packer N, 131回日本薬学会, 2011/03/28, With Invitation, Japanese, The Pharmaceutical Society of Japan, Shizuoka, Japan
  52. Glycoanalytical methods and their application to cancer glycomics, Nakano M, Nakano M, Packer N, Miyoshi E, Kakehi K, Kondo A, Taniguchi N, The 28th Naito Conference on Glycan Expression and Regulation [I], Functions and Disease Mechanisms, 2010/07/27, Without Invitation, English, Naito Fundation, Kanagawa, Japan
  53. Drug resistance inhibits expression of 2-6 sialylated glycans on cell membrane proteins, Nakano M, Nakano M, Jensen P, Lee A, Saldanha R, Kolarich D, Kavallaris M and Packer H, Human Proteome Organization 8th Annual World Congress, 2009/09/26, Without Invitation, English, Human Proteome Organization, Toronto, Canada
  54. Alteration of glycan structures on cancer cell membrane proteins by acquired drug-resistance, Nakano M, Nakano M, Jensen P, Lee A, Saldanha R, Kolarich D, Kavallaris M and Packer H, 14th Lorne Proteomics Symposium, 2009/02/05, Without Invitation, English
  55. Glycoanalytical methods and their application to cancer glycomics, Nakano M, Nakano M, Kavallaris M, Packer N, Japan Consortium for Glycobiology and Glycotechnology 7th Symposium, 2009/12/07, With Invitation, English, Osaka, Japan
  56. Alterations of glycoforms on human leukaemia cell membrane proteins by acquired resistance to microtubule targeted antitumor drugs, Nakano M, Nakano M, Kavallaris M, Packer N, Clinical and Translation Research on Cancer: Glycomics Applications, 2009/03/24, With Invitation, English, Mie, Japan
  57. Glycomic analysis of serum haptoglobin for the development of tumor marker of pancreatic cancer, Nakano M, Nakano M, Nakagawa T, Tajiri M, Wada Y, Miyoshi E, Taniguchi N, Human Proteome Organization 6th Annual World Congress, 2007/10/06, Without Invitation, English, Human Proteome Organization, Seoul, Korea
  58. Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer; a novel approach for the development of tumor markers, Nakano M, Nakano M, Nakagawa T, Tajiri M, Wada Y, Taniguchi N, Miyoshi E, Japan Human Proteome Organization 5th Conference, 2007/07/30, Without Invitation, Japanese, Japan Human Proteome Organization, Tokyo, Japan
  59. Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer; a novel approach for the development of tumor markers, Nakano M, Nakano M, Nakagawa T, Tajiri M, Wada Y, Taniguchi N, Miyoshi E, 19th International Symposium glycoconjugates, 2007/07/15, Without Invitation, English, SFG, Cairns, Australia
  60. Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer; a novel approach for the development of tumor markers, Nakano M, Nakano M, Nakagawa T, Tajiri M, Wada Y, Taniguchi N, Miyoshi E, The 27th Sapporo Cancer Seminar International Symposium “Glycomics”, 2007/07/11, Without Invitation, English, Hokkaido, Japan
  61. Normal phase LC-ESI MS Analyses for N-Glycans at the Femto-mole Level, Nakano M, Nakano M, Miyoshi E, Kondo A, Taniguchi N, Human Proteome Organization 5th Annual World Congress, 2006/10/28, Without Invitation, English, Human Proteome Organization, Long Beach, CA, U.S.A.
  62. Fucosylated haptoglobin is a novel marker for pancreatic cancer: The detailed structure of oligosaccharide and a possible mechanism for fucosylation, Nakano M, Nakano M, Miyoshi E, Noriko Okuyama N, Taniguchi N, Human Proteome Organization 5th Annual World Congress, 2006/10/28, Without Invitation, English, Human Proteome Organization, Long Beach, CA, U.S.A.
  63. Analysis of Femto-mole Level N-Glycans by Hyphenated Technique of Normal Phase Liquid Chromatography and ESI MS, 26th Japanese Carbohydrate Symposium, Nakano M, Nakano M, Iwata K, Taniguchi N, Kondo A, 2006/08/22, Without Invitation, Japanese, Japanese Carbohydrate Society, Sendai, Japan
  64. Fucosylated haptoglobin is a novel marker for pancreatic cancer: A detailed analysis of the glycans structure by mass spectrometry, Nakano M, Nakano M, Okuyama N, Ide Y, Nakagawa T, Moriwaki K, Murata K, Taniguchi N, Miyoshi E, Japan Human Proteome Organization 4th Conference, 2006/07/18, Without Invitation, Japanese, Japan Human Proteome Organization, Tokyo, Japan
  65. Capillary Electrophoresis-Electrospray Mass Spectrometry for Rapid and Sensitive Analysis of N-glycans as 9-Fluorenylmethyl (Fmoc) Drivatives, Nakano M, Nakano M, Kakehi K, Taniguchi N, Kondo A, International Union of Biochemistry and Molecular Biology, 8th Conference, 2006/06/18, Without Invitation, English, Biochemistry and Molecular Biology, Kyoto, Japan
  66. Femto-mole Level Glycan Analyses by Micro-flow LC/ESI-MS, Kondo A, Kondo A, Nakano M, Nakagawa T, Taniguchi N, International Union of Biochemistry and Molecular Biology, 8th Conference, 2006/06/18, Without Invitation, English, Biochemistry and Molecular Biology, Kyoto, Japan
  67. Identification of the binding site for oligosaccharide-related compounds with the cytoplasmic PNGase by mass spectrometry, Nakano M, Nakano M, Hara I, Totani K, Matsuo I, Ito Y, Taniguchi N, Suzuki T, 126th The Pharmaceutical Society of Japan, Sendai, Japan, 2006/03/28, Without Invitation, Japanese, The Pharmaceutical Society of Japan, Sendai, Japan
  68. Fucosylated Haptoglobin as a Marker for Pancreatic Cancer, Nakano M, Nakano M, Miyoshi E, Taniguchi N, Bio Korea 2006, 2006/09/06, With Invitation, English, Seoul, Korea
  69. Capillary Electrophoresis-Electrospray Mass Spectrometry for Rapid and Sensitive Analysis of N-glycans as 9-Fluorenylmethyl Drivatives, Nakano M, Nakano M, Nakagawa T, Kakehi K, Taniguchi N, Kondo A, 18th International Symposium glycoconjugates, 2005/09/04, Without Invitation, English
  70. Analysis of fluorescent labeled N-glycans by on-line ESI MS, Nakano M, Nakano M, Human Disease Glycomics/ Proteome initiative 8th Conference, 2005/09/03, Without Invitation, English
  71. Capillary Electrophoresis-Electrospray Mass Spectrometry for Rapid and Sensitive Analysis of N-glycans as 9-Fluorenylmethyl (Fmoc) Drivatives, Nakano M, Nakano M, Nakagawa T, Kakehi K, Taniguchi N, Kondo A, Human Proteome Organization 4th Annual World Congress, 2005/08/28, Without Invitation, English, Human Proteome Organization, Munich, Germany
  72. Increases of fucosylated haptoglobin in the sera of patients with pancreatic cancer, Miyoshi E, Miyoshi E, Nakano M, Ide Y, Moriwaki K, Nakagawa T, Okuyama N, Taniguchi N, Human Proteome Organization 4th Annual World Congress, 2005/08/28, Without Invitation, English, Human Proteome Organization, Munich, Germany
  73. Capillary Electrophoresis-Electrospray Mass Spectrometry for Rapid and Sensitive Analysis of N-glycans as 9-Fluorenylmethyl Drivatives, Nakano M, Nakano M, Kakehi K, Taniguchi N, Kondo A, Japan Human Proteome Organization 3rd Conference, 2005/08/01, Without Invitation, Japanese, Japan Human Proteome Organization, Yokohama, Japan
  74. Analysis of fluorescent labeled N-glycans by on-line ESI MS, Nakano M, Nakano M, Okuyama N, Nakagawa T, Nakagawa T, Miyoshi E, Kakehi K, Taniguchi N, Kondo A, 25th Japanese Carbohydrate Symposium, 2005/07/20, Without Invitation, Japanese, Japanese Carbohydrate Society, Shiga, Japan
  75. CE-ESI MS analysis of glycans on glycoproteins using Fmoc-labeling method, Nakano M, Nakano M, Kondo A, Kakehi K, Taniguchi N, 125回日本薬学会, 2005/03/29, Without Invitation, Japanese, The Pharmaceutical Society of Japan, Tokyo, Japan

Awards

  1. 2005/07/20, Poster award, Japanese Carbohydrate Symposium, Analysis of fluorescent labeled N-glycans by on-line ESI MS
  2. 2017/11/04, Phoenix Outstanding Researcher Award, Hirohima University

Patented

  1. Patent, 5358952, 2013/09/13
  2. Patent

External Funds

Acceptance Results of Competitive Funds

  1. 2022/04/01, 2023/04/01
  2. 2022/04/01, 2024/03/31
  3. 2022/01/01, 2022/03/31
  4. Bilateral Joint Research Projects/Seminars, 3rd Australasian Glycoscience Symposium (3rd AGS), 2021/04/01, 2022/03/31
  5. Grant of Higashihiroshima City for the Promotion of Science, 2021/04/01, 2021/06/04
  6. 2021/01/01, 2021/03/31
  7. 2020/04/01, 2023/03/31
  8. 2019/04/01, 2023/03/31
  9. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020
  10. Project focused on developing key technology of discovering and manufacturing drug for next-generation treatment and diagnosis , 2018/04/01, 2021/03/31
  11. KAKENHI, 2018/04/01, 2021/33
  12. KAKENHI, 2017/04/01, 2019/03/31
  13. Project focused on developing key technology of discovering and manufacturing drug for next-generation treatment and diagnosis , 2017/04/01, 2018/03/31
  14. KAKENHI, 2014, 2016
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  15. KAKENHI, 2013, 2015
  16. KAKENHI, Reverse Glycomic Approach for Development of Simple Diagnostic Method of Antitumor-Drug Resistance, 2011, 2012
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Social Activities

History as Committee Members

  1. JSCR, 2022/07, 2023/06
  2. JSCR, 2021/07, 2022/06

Organizing Academic Conferences, etc.

  1. 4th Australasian Glycoscience Symposium (4th AGS), International Advisory committee, 2022/05, 2023/03
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  2. 3rd Australasian Glycoscience Symposium (3rd AGS), Symposium Chair, 2021/06, 2021/06
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  3. 2019/04, 2019/11
  4. 2015/04, 2015/09
  5. The Japan Society for Analytical Chemistry, 2014/04, 2014/09

Other Social Contributions

  1. 4th Australasian Glycoscience Symposium (4th AGS), International Advisory committee, Daniel Kolarich, 2022/11/22, 2022/11/25, Gold Coast, Australia, Organizing Member, Meeting or assembly, Researchesrs
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  2. 3rd AGS, Symposium Chair, Miyako Nakano, 2021/04/01, 2022/03/31, Organizing Member, Meeting or assembly, Researchesrs
    Related URL