SILVIA NATSUK AKUTSU

Last Updated :2022/10/03

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Assistant Professor
E-mail
silvia-akutsuhiroshima-u.ac.jp
Self-introduction
Bachelor of Science in Biological Sciences, Specialization in Hematological Cytogenetic, Master of Science in Hematology and PhD. in Medical Science PhD. Specialty of Radiation Disaster Medicine of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster. Experience with Cytogenetics of peripheral blood, bone marrow in hematologic malignancies, fetal miscarriage material and several cell lines, such as hiPSC. Molecular and cell biology, genetics, induced pluripotent stem cells, genome editing technology. Currently, I work as an Assistant Professor in the Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine at Hiroshima University, Japan.

Basic Information

Major Professional Backgrounds

  • 2018/03/01, Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor
  • 2013/10/01, 2014/03/31, Hiroshima University, RIRBM, Department of Genetics and Cell Biology, Visiting Researcher
  • 2017/09/25, 2017/10/27, University of Sussex, UK, Genome Damage and Stability Centre School of Life Sciences, Visiting Research

Educational Backgrounds

  • Hiroshima University, Phoenix Leader Education Program Hiroshima Initiative for Renaissance from Radiation Disaster, Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, PhD, Japan, 2014/10, 2018/03
  • Universidade Federal de São Paulo, Department of Experimental Clinical Oncology- Haematology and Hemotherapy, Master in Sciences, Brazil, 2012/08, 2014/10
  • Universidade Federal de São Paulo, Department of Experimental Clinical Oncology- Haematology and Hemotherapy, Specialization in Hematological Cytogenetics, Brazil, 2011/03, 2012/02
  • Universidade Estadual Paulista Júlio de Mesquita Filho, Department of Biology Sciences, Brazil, 2007/02, 2010/12

Academic Degrees

  • Ph.D (Science), Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Biology;Basic biology;Genetics / Chromosome dynamics
  • Biological Sciences;Genome science;Medical genome science

Research Keywords

  • Chromosome Genome Instability iPS technology Genome Editing

Affiliated Academic Societies

  • The Japanese Society for Genome Editing
  • The Japanese Radiation Research Society
  • The Japan Society of Human Genetics

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Intensive, Practice for medical research
  2. 2022, Graduate Education (Master's Program) , First Semester, Molecular Biology and Radiological Science
  3. 2022, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology
  4. 2022, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Award of Education

  1. 2019/.0, Hiroshima University, Chromosomal analysis of Down Syndrome patient cells by reprograming

Research Activities

Academic Papers

  1. ★, iPSC reprogramming-mediated aneuploidy correction in autosomal trisomy syndromes, PLOS ONE, 17(3), e0264965, 20220310
  2. Familial rhabdomyosarcoma due to germline bi-allelic variants of BUB1B, Pediatr Blood Cancer, 66(e28049), S69-S69, 2019
  3. Imaging of the ciliary cholesterol underlying the Sonic Hedgehog Signal transduction, Methods Mol Biol, 49-57, 2022
  4. Analysis of individual differences in radiosensitivity using genome editing., Ann ICRP, 45(1), 290-296, 2016
  5. Experimental trials for the chromosome aneuploidy correction in Down syndrome cell lines, 93(1), 286-290, 20180603
  6. ★, Applications of Genome Editing Technology in Research on Chromosome Aneuploidy Disorders, CELLS, 9(1), 202001
  7. Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation., Aging Cell., 19(11), 13251, 20201023
  8. Updated summary of genome editing technology in human cultured cells linked to human genetics studies, JOURNAL OF HUMAN GENETICS, 63(2), 133-143, 2018
  9. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, 2018
  10. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation, HUMAN MOLECULAR GENETICS, 26(22), 4429-4440, 2017
  11. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, 2017
  12. Quantitative evaluation of the NBS1 I171V variant as a candidate genetic factor underlying individual differences in radiation sensitivity, 224-227, 2020
  13. Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation, AGING CELL, 19(11), 202011
  14. Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome, EMBO JOURNAL, 39(12), 20200617
  15. NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations, SCIENTIFIC REPORTS, 11(1), 20211004

Publications such as books

  1. 2021/09/26, Methods in Molecular Biology, Imaging of the Ciliary Cholesterol Underlying the Sonic Hedgehog Signal Transduction, 2021, 09, Scholarly Book, Joint work, Tatsuo Miyamoto, Kosuke Hosoba, Silvia Natsuko Akutsu, Shinya Matsuura, 9

Invited Lecture, Oral Presentation, Poster Presentation

  1. Reprogramming can induce chromosome self-correction, The 46th Chugoku Regional Radiation Effects Research Conference, 2022/09/07, Without Invitation, English
  2. Chromosome self-correction induced by cell reprogramming, Silvia Natsuko Akutsu, Risa Matsumura, Shinya Matsuura, The 6th International Symposium of the Network-type Joint Usage, 2022/06/04, Without Invitation, English
  3. iPSC reprogramming-mediated random trisomy correction in aneuploidy syndromes, Hybrid session in the 6th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science, 2022/02/07, Without Invitation, English, The 6th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science
  4. iPSC reprogramming-mediated aneuploidy correction in autosomal trisomy syndromes, The 64th Annual Meeting of the Japanese Radiation Research Society, 2021/09/22, Without Invitation, English
  5. iPSC reprogramming-mediated aneuploidy correction in autosomal trisomy syndromes, Silvia Natsuko Akutsu, Tatsuo Miyamoto, Keita Tomioka, Daiju Oba, Hirofumi Ohashi, Shinya Matsuura, The 5th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medicine Science, 2021/02/08, Without Invitation, English
  6. Unravelling the pathological mechanisms of structure-chromosomal instability post IR in PCS (MVA) syndrome, 2018/01/27, Without Invitation, English, other
  7. Experimental trials for the chromosome aneuploidy correction in Down syndrome cell lines., 2018/06/03, Without Invitation, English, published
  8. Development of chromosomal Therapies to rescue trisomy 21 to normal karyotype, 2018/07/31, Without Invitation, English, experimental
  9. Experimental Strategies for the Chromosome therapy in Down syndrome cell, The 61th Annual Meeting of the Japanese Radiation Research Society (JRRS), 2018/11/07, Without Invitation, Japanese
  10. Generation of NBS1 I171V knock-in mice using genome editing technology, Miyamoto T, Tomioka K, Akutsu SN, Tauchi H, Matsuura S, 2019/01/13, Without Invitation, English
  11. Down Syndrome trisomy rescued iPS cells enables construction of mosaic model cells tagged with fluorescence nuclear marker by CRISPR/Obligare, Akutsu SN, Ochiai H, Yamamoto T, Miyamoto T, Ohashi H, Matsuura S., The 4th Annual Meeting of the Japanese Society for Genome Editing, 2019/06/03, Without Invitation, English, experimental
  12. The generation of mosaic trisomy 21 model cells using patient cells with full trisomy 21 by trisomy rescue during cell reprogramming and their modification with fluorescent nuclear markers by genome editing technique, The 65th Brazilian International Congress of Genetics, 2019/08/20, With Invitation, English, other
  13. Generation of Down syndrome iPS cells tagged with fluorescence marker in chromosome 21 using genome editing technology, Akutsu SN, Miyamoto T, Tomioka K, Ochiai H, Yamamoto T, Ohashi H, Matsuura S, 2019/11/07, Without Invitation, English
  14. Quantitative evaluation of the NBS1 I171V variant on radiosensitivity, Tomioka K, Akutsu SN, Yanagihara H, Tauchi H, Yamamoto T, Kobayashi M, Kudo Y, Miyamoto T, Matsuura S, 2019/11/14, Without Invitation, Japanese
  15. Reverse Genetics analysis of the NBS1 I171V variant as a candidate factor underlying the individual differences in radiosensitivity, Tomioka K, Akutsu SN, Yanagihara H, Tauchi H, Yamamoto T, Kobayashi M, Kudo Y, Miyamoto T, Matsuura S, Without Invitation, Japanese
  16. Quantitative evaluation of the NBS1 I171V variant on radiosensitivity, Tomioka K, Fujita K, Akutsu SN, Tauchi H, Yamamoto T, Kobayashi M, Kudo Y, Miyamoto T, Matsuura S, 2020/02/12, Without Invitation, Japanese
  17. A novel premature aging syndrome showing random chromosome number instability with CDC20 mutation, 2020/11/18, Without Invitation, English
  18. Peroxisome biogenesis disorder Zellweger syndrome as a ciliopathy, 2020/11/18, Without Invitation, Japanese
  19. Peroxisomes ensure to supply cholesterol into the ciliary membrane : a lesson from a peroxisome-biogenesis disorder Zellweger syndrome., Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu SN, Ochiai H, Saito Y, Yamamoto T, Matsuura S, 2020/12/04, Without Invitation, English

Awards

  1. 2022/02/07, Excellent poster presentation, Hybrid session in the 6th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science, iPSC reprogramming-mediated random trisomy correction in aneuploidy syndromes
  2. 2015, Excellent Poster Award, The 4th International Symposium of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Chromosomal analysis in myelodysplastic syndrome and acute myeloid leukemia cell lines through the cytokinesis-­block micronucleus assay (CBMN) and cytogenetic study.
  3. 2017/02/11, Excellent Poster Presentation, The 6th International Symposium of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, The insufficiency of BUB1B gene increases structural-chromosomal instability post ionizing radiation
  4. 2018/01/27, Excellent Poster Presentation, The 7th International Symposium of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Unravelling the pathological mechanisms of structure-chromosomal instability post IR in PCS (MVA) syndrome
  5. 2019/07/29, 医学研究実習2019年度配属, 医学研究実習2019年度配属, Chromosomal analysis of Down Syndrome patient cells by reprograming

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2021

Social Activities

Other Social Contributions

  1. The Global Education Course and Institute for the promotion of interculturalism in education present, How do you engage with your community? Insights from Brazil, Japan, and Beyond, The Global Education Course and Institute for the promotion of interculturalism in education present, 2021/12/09, Presenter, Seminar or workshop, Graduate students
  2. The 6th HiHa Young Researchers Workshop -Saijo and Kasumi, Correction of aneuploidy in human cell cultures derived from patients with autosomal trisomy syndromes, Hiroshima Research Center for Healthy Aging (HiHA), The 6th HiHa Young Researchers Workshop -Saijo and Kasumi, 2021/06/23, 2021/06/23, Presenter, Seminar or workshop, Researchesrs
  3. Participation on Examination for Doctoral degrees by dissertation, 2018/08/20, 2018/08/20, Contribution, Others, Graduate students
  4. HICARE, 2019/02/20, 2019/02/20, Lecturer, Visiting lecture, Researchesrs