SATOSHI OKADA
Last Updated :2021/01/05
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Professor
- E-mail
- sokada
hiroshima-u.ac.jp
Basic Information
Educational Backgrounds
- Hiroshima University, Graduate School, Division of Medical Sciences, Programs for Applied Biomedicine, Japan, 2007/09
- The University of Tokushima, Faculty of Medicine, Faculty of Medicine, Japan, 1993/04, 1999/03
Academic Degrees
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Pediatrics
Research Keywords
- MSMD
- neutropenia
- immunodeficiency
Affiliated Academic Societies
- European Society for Immunodeficiencies
- Japan Pediatric Society
- Japanese Society of Hematology
- The Japanese Society of Pediatric Hematology/Oncology
- The Japan Society for Hematopoitetic Cell Transplantation
- The Japan Endocrine Society
- The Japanese Society for Pediatric Endocrinology
- The Japan Society of Human Genetics
- Japanese Society of Immunlogy
- The Japan Society for Clinical Immunology
- Japanese Society for MassScreening
Educational Activity
Course in Charge
- 2020, Undergraduate Education, First Semester, Human genetics
- 2020, Undergraduate Education, Year, Systemic Disease Control
- 2020, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
- 2020, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
- 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Pediatrics
- 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Pediatrics
- 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Pediatrics
- 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Pediatrics
- 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pediatrics
- 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pediatrics
- 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pediatrics
- 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pediatrics
- 2020, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science
Research Activities
Academic Papers
- Ruxolitinib treatment of a patient with steroid-dependent severe autoimmunity due to STAT1 gain-of-function mutation, International Journal of Hematology, 112(2), 258-262, 20200801
- Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity, Journal of Clinical Immunology, 40(5), 729-740, 20200701
- ★, A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection, Cell, 181(6), 1194-1199, 20200611
- Human gain-of-function stat1 mutation disturbs il-17 immunity in mice, International Immunology, 32(4), 259-272, 20200401
- A case report of a Japanese boy with morquio a syndrome: Effects of enzyme replacement therapy initiated at the age of 24 months, International Journal of Molecular Sciences, 21(3), 20200201
- ★, Human STAT1 Gain-of-Function Heterozygous Mutations: Chronic Mucocutaneous Candidiasis and Type I Interferonopathy, Journal of Clinical Immunology, 20200101
- Downregulation of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) in a co-culture system with human stimulated X-linked CGD neutrophils, PLoS ONE, 15(4), 20200101
- Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusiondependent pyruvate kinase deficiency anemia, Hematology Reports, 12(1), 20200101
- A nationwide questionnaire survey targeting japanese pediatric endocrinologists regarding transitional care in childhood, adolescent, and young adult cancer survivors, Clinical Pediatric Endocrinology, 29(2), 55-62, 20200101
- Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation, Annals of the Rheumatic Diseases, 20200101
- Germline-Activating RRAS2 Mutations Cause Noonan Syndrome, American Journal of Human Genetics, 104(6), 1233-1240, 20190606
- Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency, International Journal of Hematology, 109(4), 382-389, 20190405
- Mendelian susceptibility to mycobacterial disease: 2014–2018 update, Immunology and Cell Biology, 97(4), 360-367, 20190401
- Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency, JOURNAL OF CLINICAL INVESTIGATION, 129(2), 583-597, 20190201
- Dr. Maeshima, et al, reply, Journal of Rheumatology, 46(6), 655-656, 20190101
- Gain-of-function STAT1 mutation with familial lymphadenopathy and Hodgkin Lymphoma, Frontiers in Pediatrics, 7(APR), 20190101
- Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects, Journal of Allergy and Clinical Immunology, 142(6), 1932-1946, 20181201
- Gain-of-function IKBKB mutation causes human combined immune deficiency, Journal of Experimental Medicine, 215(11), 2715-2724, 20181101
- Increased risk for malignancies in 131 affected CTLA4 mutation carriers, Frontiers in Immunology, 9(SEP), 20180910
- Enhanced AKT phosphorylation of circulating B cells in patients with activated PI3Kdelta syndrome, Frontiers in Immunology, 9(APR), 20180405
- Incidence and Characteristics of Adrenal Crisis in Children Younger than 7 Years with 21-Hydroxylase Deficiency: A Nationwide Survey in Japan, Hormone Research in Paediatrics, 89(3), 166-171, 20180401
- ★, Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection, Cell, 172(5), 952-965.e18, 20180222
- ★, Hematopoietic stem cell transplantation in patients with gain-of-function signal transducer and activator of transcription 1 mutations, Journal of Allergy and Clinical Immunology, 141(2), 704-717.e5, 20180201
- Flow cytometry-based diagnosis of primary immunodeficiency diseases, Allergology International, 67(1), 43-54, 20180101
- Human IFN- immunity to mycobacteria is governed by both IL-12 and IL-23, Science Immunology, 3(30), 20180101
- Individual clinically diagnosed with CHARGE syndrome but with a mutation in KMT2D, a gene associated with Kabuki syndrome: A case report, Frontiers in Genetics, 8(DEC), 20171211
- Significant augmentation of regulatory T cell numbers occurs during the early neonatal period, Clinical and Experimental Immunology, 190(2), 268-279, 20171101
- Anti-human neutrophil antigen-1a, -1b, and -2 antibodies in neonates and children with immune neutropenias analyzed by extracted granulocyte antigen immunofluorescence assay, Transfusion, 57(11), 2586-2594, 20171101
- Newborn screening for carnitine palmitoyltransferase II deficiency using (C16 + C18:1)/C2: Evaluation of additional indices for adequate sensitivity and lower false-positivity, Molecular Genetics and Metabolism, 122(3), 67-75, 20171101
- A case with Spondyloenchondrodysplasia treated with growth hormone, Frontiers in Endocrinology, 8(JUL), 20170710
- Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial, Clinical Endocrinology, 87(1), 10-19, 20170701
- ★, Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants, Journal of Allergy and Clinical Immunology, 140(1), 232-241, 20170701
- ★, Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations, Journal of Allergy and Clinical Immunology, 140(1), 223-231, 20170701
- A Gain-of-function mutation of stat1: A novel genetic factor contributing to chronic mucocutaneous candidiasis, Acta Microbiologica et Immunologica Hungarica, 64(2), 191-201, 20170601
- Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ, Brain Pathology, 27(3), 323-331, 20170501
- Molecular mechanism and structural basis of gain-offunction of STAT1 caused by pathogenic R274Q mutation, Journal of Biological Chemistry, 292(15), 6240-6254, 20170414
- Characteristic clinical features of adipsic hypernatremia patients with subfornical organ-targeting antibody, Clinical Pediatric Endocrinology, 26(4), 197-205, 20170101
- Clinical characteristics of septo-optic dysplasia accompanied by congenital central hypothyroidism in Japan, Clinical Pediatric Endocrinology, 26(4), 207-213, 20170101
- Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency, Proceedings of the National Academy of Sciences of the United States of America, 113(51), E8277-E8285, 20161220
- Screening of MCAD deficiency in Japan: 16 years' experience of enzymatic and genetic evaluation, Molecular Genetics and Metabolism, 119(4), 322-328, 20161201
- Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome–like immunodeficiency, Journal of Allergy and Clinical Immunology, 138(6), 1672-1680.e10, 20161201
- Non-androgen secreting adrenocortical carcinoma in preadolescence: A case report and literature review, Journal of Pediatric Endocrinology and Metabolism, 29(11), 1313-1317, 20161101
- A 2-year-old Japanese girl with TNF receptor–associated periodic syndrome: A case report of the youngest diagnosed proband in Japan, Modern Rheumatology, 26(5), 798-801, 20160902
- Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets, Journal of Experimental Medicine, 213(8), 1589-1608, 20160725
- ★, Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype, Blood, 127(25), 3154-3164, 20160623
- Significance of ACADM mutations identified through newborn screening of MCAD deficiency in Japan, Molecular Genetics and Metabolism, 118(1), 9-14, 20160501
- Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation, Journal of Allergy and Clinical Immunology, 137(2), 619-622.e1, 20160201
- A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer, Journal of Clinical Immunology, 36(1), 28-32, 20160101
- Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies, Journal of Allergy and Clinical Immunology, 136(4), 993-1006.e1, 20151001
- ★, Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome, Journal of Experimental Medicine, 212(10), 1641-1662, 20150921
- ★, Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations, Science, 349(6248), 606-613, 20150807
- Mosaicism of an ELANE Mutation in an Asymptomatic Mother in a Familial Case of Cyclic Neutropenia, Journal of Clinical Immunology, 35(5), 512-516, 20150725
- Two Japanese patients with the renal form of pseudohypoaldosteronism type 1 caused by mutations of NR3C2, Clinical Pediatric Endocrinology, 24(3), 135-138, 20150718
- ★, Inherited DOCK2 deficiency in patients with early-onset invasive infections, New England Journal of Medicine, 372(25), 2409-2422, 20150618
- ★, Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency, Science, 348(6233), 448-453, 20150424
- ★, Human intracellular ISG15 prevents interferon-a/b over-amplification and auto-inflammation, Nature, 517(7532), 89-93, 20150101
- IL-17 T cells' defective differentiation in vitro despite normal range ex vivo in chronic mucocutaneous candidiasis due to STAT1 mutation, Journal of Investigative Dermatology, 134(4), 1155-1157, 20140101
- Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis, Journal of Leukocyte Biology, 95(4), 667-676, 20140101
- Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis, Haematologica, 98(10), 1641-1649, 20131001
- Management of advanced-stage neuroblastoma in a patient with 21-hydroxalase deficiency, Pediatrics International, 55(4), 20130801
- New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe, Journal of Medical Genetics, 50(9), 567-578, 20130729
- Acute severe encephalopathy related to human herpesvirus-6 infection in a patient with carnitine palmitoyltransferase 2 deficiency carrying thermolabile variants, Brain and Development, 35(5), 449-453, 20130501
- Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region, American Journal of Human Genetics, 92(3), 407-414, 20130307
- A Novel Homozygous p.R1105X Mutation of the AP4E1 Gene in Twins with Hereditary Spastic Paraplegia and Mycobacterial Disease, PLoS ONE, 8(3), 20130305
- Identification of the integrin b3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis, British Journal of Haematology, 160(4), 521-529, 20130201
- Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease, Human Molecular Genetics, 22(4), 769-781, 20130201
- VLCAD deficiency in a patient who recovered from ventricular fibrillation, but died suddenly of a respiratory syncytial virus infection, Pediatrics International, 55(6), 775-778, 20130101
- Partial IFN-gR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation, Blood, 122(14), 2390-2401, 20130101
- ★, Mycobacterial disease and impaired IFN-g immunity in humans with inherited ISG15 deficiency, Science, 337(6102), 1684-1688, 20120928
- ★, Dominant-negative STAT1 SH2 domain mutations in unrelated patients with mendelian susceptibility to mycobacterial disease, Human Mutation, 33(9), 1377-1387, 20120901
- Inborn errors of human STAT1: Allelic heterogeneity governs the diversity of immunological and infectious phenotypes, Current Opinion in Immunology, 24(4), 364-378, 20120801
- Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency, Blood, 119(23), 5458-5466, 20120607
- DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice, Journal of Experimental Medicine, 208(11), 2305-2320, 20111024
- Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency, Journal of Clinical Immunology, 31(5), 762-772, 20111001
- Disseminated BCG infection mimicking metastatic nasopharyngeal carcinoma in an immunodeficient child with a novel hypomorphic NEMO mutation, Journal of Clinical Immunology, 31(5), 802-810, 20111001
- ★, Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis, Journal of Experimental Medicine, 208(18), 1635-1648, 20110801
- Clinical and host genetic characteristics of mendelian susceptibility to mycobacterial diseases in Japan, Journal of Clinical Immunology, 31(3), 309-314, 20110601
- Empty sella/pituitary atrophy and endocrine impairments as a consequence of radiation and chemotherapy in long-term survivors of childhood leukemia., International journal of hematology, 94(4), 399-402, 20110101
- Quantification of k-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects, Journal of Allergy and Clinical Immunology, 128(1), 223-225.e2, 20110101
- Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential, Proceedings of the National Academy of Sciences of the United States of America, 107(50), 21529-21534, 20101214
- Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency, Human Genetics, 127(6), 619-628, 20100601
- Clinical characteristics of perinatal lethal hypophosphatasia: A report of 6 cases, Clinical Pediatric Endocrinology, 19(1), 7-13, 20100101
- Development of a new enzymatic diagnosis method for very-long-chain acyl-CoA dehydrogenase deficiency by detecting 2-hexadecenoyl-CoA production and its application in tandem mass spectrometry-based selective screening and newborn screening in Japan, Pediatric Research, 64(6), 667-672, 20081201
- ★, Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene, Journal of Medical Genetics, 45(12), 802-807, 20081201
- Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity, Proceedings of the National Academy of Sciences of the United States of America, 105(30), 10396-10401, 20080729
- ★, The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-g receptor 1 and has a dominant-negative effect on interferon-g signal transduction, Journal of Medical Genetics, 44(8), 485-491, 20070801
- A novel mutation (Gln433Glu) in exon 12 combined with the G insertion in exon 13 causes severe factor XI deficiency in Japanese patients, Blood Coagulation and Fibrinolysis, 18(5), 519-523, 20070701
- Steroid-dependent ACTH-produced thymic carcinoid: Regulation of POMC gene expression by cortisol via methylation of its promoter region, Hormone Research, 67(5), 257-262, 20070401
- Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency., Haematologica, 92(12), 20070101
- A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia, Haematologica, 90(8), 1032-1041, 20050801
Invited Lecture, Oral Presentation, Poster Presentation
- Primary immunodeficiency caused by gain-of-function mutations in STAT1, Satoshi Okada, Infectious Diseases Society of Taiwan (Cross talk between infection and immune system), 2019/10/05, With Invitation, English, Taipei
- HSCT in Patients with STAT1 Gain-of-function Mutation, Satoshi Okada, 2018 the Korean Society of Pediatric Hematology-Oncology Autumn Meeting, 2018/10/19, With Invitation, English
- STAT1 gain of function etiology, molecular biology, and treatment, Satoshi Okada, The 2nd APSID Scientific Congress, 2018/05/07, With Invitation, English
- Primary immunodeficiency associate with functional defect of RORgammaT, Satoshi Okada, Janet Markle, Anne Puel, Masao Kobayashi, Jean-Laurent Casanova, The 39th Annual Meeting of the Molecular Biology, 2016/12/01, With Invitation, English, Yokohama
- International survey of clinical manifestations of patients with STAT1 gain-of-function mutations, Satoshi Okada, Miyuki Tsumura, Shiho Nishimura, Sonoko Sakata, Reiko Kagawa, Julie Toubiana, Anne Puel, Jean-Laurent Casanova, Masao Kobayashi, The 78th annual meeting of the Japanese Society of Hematology, 2016/10/13, Without Invitation, Japanese, Yokohama
- Primary immunodeficiencies associated with germline STAT1 mutations, Satoshi Okada, Wright-Fleming Institute Infection and Immunity Seminar, 2016/09/27, With Invitation, English, Imperial University, London
- Alanine-scanning mutagenesis of human STAT1 to estimate the loss- or gain-of-function nature of variants, Satoshi Okada, Ryoji Fujiki, Reiko Kagawa, Miyuki Tsumura, Xiaofei Kong, Sonoko Sakata, Shiho Nishimura, Zenichiro Kato, Hidenori Ohnishi, Yuval Itan, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Osamu Ohara, and Masao Kobayashi, 17th Biennial Meeting of the European Sciety for immunodeficiencies, 2016/09/22, Without Invitation, English, Barcelona
- International survey of clinical manifestation of patients with gain-of-function mutations in STAT1, Satoshi Okada, Miyuki Tsumura, Shiho Nishimura, Sonoko Sakata, Julie Toubiana, Anne Puel, Jean-Laurent Casanova, Masao Kobayashi, The 44th annual meeting for the Japan Society for Clinical Immunology, 2016/09/09, Without Invitation, Japanese, Tokyo
- Loss-of-function and dominant negative STAT1 coiled-coil domain mutations in MSMD, Satoshi Okada, Reiko Kagawa, Ryoji Fujiki, Zenichiro Kato, Hidenori Ohnishi, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Osamu Ohara, and Masao Kobayashi, Congress of Asia Pacific Society for Immunodeficiencies, 2016/04/30, Without Invitation, English, Hong Kong
- Impairment of IL-17 Immunity to Candida and IFN-γ Immunity to Mycobacterium in Humans with Bi-Allelic RORC mutations, Satoshi Okada, Janet Markle, Masao Kobayashi, Jacinta Bustamante and Jean-Laurent Casanova, The 57th ASH Annual Meeting, 2015/12/06, Without Invitation, English
- Impairment of IL-17 immunity to Candida and IFN-γ immunity to Mycobacterium in humans with inherited RORγT deficiency, Satoshi Okada, Janet Markle, Anne Puel, Jacinta Bustamante, Masao Kobayashi, and Jean-Laurent Casanova, The 44th Annual Meeting of the Japanese Society for Immunology, 2015/11/18, Without Invitation, English
- Chronic Mucocutaneous Candidiasis, Satoshi Okada, Pediatric Academic Societies annual meeting 2015, 2015/04/26, With Invitation, English
- Gain-of-function mutations in STAT1 underlie autosomal dominant chronic mucocutaneous candidiasis, Satoshi Okada, Xiao-Fei Kong, Sophie Cypowyj, Alexandra Y. Kreins, Luyan Liu, Laurent Abel, Capucine Picard, Stéphanie Boisson-Dupuis, Anne Puel and Jean-Laurent Casanova, 15th Biennial Meeting (ESID 2012), 2012/10/04, Without Invitation, English
- Gain-of-function mutation in STAT1 causes chronic mucocutaneous candidiasis (CMC), Satoshi Okada, Masao Kobayashi, Luyan Liu, Xiao-Fei Kong, Alexandra Y. Kreins, Sophie Cypowyj, Laurent Abel, Capucine Picard, Stéphanie Boisson-Dupuis, Anne Puel, Jean-Laurent Casanova, The 5th Meeting of the Japanese Society for Immunodeficiencies, 2012/01/21, Without Invitation, English
- Novel Dominant Negative Defects Affecting STAT1-SH2 Domain Predispose to Mycobacterial Diseases, Satoshi Okada, Miyuki Tsumura, Hidemasa Sakai, Ryuta Nishikomori, Toshio Heike, Tatsutoshi Nakahata, Shin’ichiro Yasunaga, Xiaofei Kong, Avinash Abhyankar, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova, Yoshihiro Takihara, and Masao Kobayashi, 2011 PAS/ASPR Joint Meeting, 2011/04/30, Without Invitation, English, Denver
- Novel Dominant Negative Defects Affecting STAT1-SH2 Domain Predispose to Mycobacterial Diseases, 2011/04/30, Without Invitation, English
- A novel heterozygous mutation, K673R, in SH2 domain of STAT identified in a patient with MSMD., Satoshi Okada, Miyuki Tsumura, Hidemasa Sakai, Ryuta Nishikomori, Shin’ichiro Yasunaga, Motoaki Ohtsubo, Takuji Murata, Hideto Obata, Takahiro Yasumi, Toshio Heike, Tatsutoshi Nakahata, Yoshihiro Takihara, Jean-Laurent Casanova and Masao Kobayashi, First North American Primary Immune Deficiency National Conference, 2010/05/21, Without Invitation, English, Philadelphia
External Funds
Acceptance Results of Competitive Funds
- 2018, 2020
- Practical Research Project for Rare/Intractable Diseases (AMED), Genome editing based allele labeling of ELANE to analyze molecular pathogenesis of severe congenital neutropenia, 2017, 2020
- Practical Research Project for Rare/Intractable Diseases (AMED), Identification of new responsible genes for primary immunodeficiency, 2016, 2019
- KAKENHI, 2016, 2019
- KAKENHI, Analysis of disseminated BCG associated with RORgT deficiency, 2016, 2018
- KAKENHI, Establishment of disease model mouse of chronic mucocutaneous candidiasis, 2013, 2015
- KAKENHI, Identification of novel responsible genes for chronic mucocutaneous candidiasis, 2013, 2016
- KAKENHI, Analysis of Primary Immunodeficiency Syndromes using model mice., 2008, 2010