TAKAO HINOI

Last Updated :2025/06/04

Affiliations, Positions
Hiroshima University Hospital(Medical), Professor
E-mail
thinoihiroshima-u.ac.jp
Self-introduction
After graduating from Hiroshima University in 1989 and joining Hiroshima University Second Surgery, I conducted surgical training for five years and was instructed by Professor Akira Kikuchi of Hiroshima University First Biochemistry (currently Professor of Molecular Pathology Biochemistry, Osaka University). Under the program, I completed my doctoral course by conducting research on the signal transduction mechanism of RAS, a low molecular weight GTP-binding protein. After that, under the supervision of Professor Eric R. Fearon of the Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, USA, I was engaged in research on colorectal cancer-related genes and colorectal cancer disease model mice for eight years as a Post-doctoral fellow. After returning to Japan in 2006, I worked as a surgeon at Hiroshima University Hospital and Kure Medical Center, and conducted research on colorectal cancer-related genes as well as the treatment and research on hereditary colorectal cancer syndrome. I was appointed as a specially appointed professor at the Department of Genetic Medicine, Hiroshima University Hospital in April 2019. I was appointed as a professor of genetic medicine at Hiroshima University Hospital. It is an urgent challenge to foster genetic medical literacy.

Basic Information

Major Professional Backgrounds

  • 1989/06/01, 1990/03/30, Hiroshima University, Medical Hospital, Clinical Resident
  • 1990/04/01, 1993/05/31, Hiroshima Prefectural Hospital, Doctor
  • 1993/06/01, 1993/09/30, Hiroshima University, Hospital, Clinical Fellow
  • 1993/10/01, 1994/03/31, National Hospital Organization Yanai National Hospital
  • 1998/06/01, 2006/07/31, University of Michigan, Faculty of Medicine, Research fellow
  • 2006/08/01, 2006/09/30, Hiroshima University, Hospital, Clinical Fellow
  • 2006/10/01, 2007/03/31, Hiroshima University, Hospital, Research Associate
  • 2007/04/01, 2010/09/30, Hiroshima University, Graduate School of Biomedical Sciences, Contributing Lecturer
  • 2010/10/01, 2015/09/30, Hiroshima University, Hospital, Lecturer

Educational Backgrounds

  • Hiroshima University, Japan, 1994/04, 1998/03
  • Hiroshima University, Japan, 1983/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Human genetics
  • Medicine,dentistry, and pharmacy;Clinical surgery;Digestive surgery

Research Keywords

  • Cancer Genome Medicine
  • Hereditary Cancer, Genetic Counseling
  • Chemotherapy
  • Surgical Oncology
  • Colorectal Cancer
  • Minimum Invasive Surgery

Affiliated Academic Societies

  • Japan Surgical Society
  • Japanese Cancer Association
  • Japanese Society of Molecular Oncology
  • Japan Society of Clinical Oncology
  • The Japanese Society for Hereditary Tumor
  • Japanese Society for Genetic Counseling
  • The Japanese Society for Gene Diagnosis and Therapy
  • The Japanese Society of Gastroenterological Surgery
  • The Japanese Society of Gastroenterolog
  • Japanese Society for Cancer of the Colon and Rectum
  • Japanese Society for Gastroenterological Carcinogenesis
  • The Japan Society of Coloproctology
  • Japanese Society of Stoma and Continence Rehabilitation
  • Japanese Breast Cancer Society
  • The Japanese Society for Dialysis Therapy
  • Japanese Society for Palliative Medicine

Educational Activity

Course in Charge

  1. 2025, Graduate Education (Master's Program) , 3Term, Data Literacy in Medicine
  2. 2025, Graduate Education (Doctoral Program) , 3Term, Utilization of data Literacy in Medicine
  3. 2025, Undergraduate Education, 4Term, Exercise in Medical and Clinical Engineering 1
  4. 2025, Undergraduate Education, First Semester, Human genetics
  5. 2025, Undergraduate Education, 2Term, Cancer Biology
  6. 2025, Graduate Education (Master's Program) , First Semester, Seminar
  7. 2025, Graduate Education (Master's Program) , Second Semester, Seminar
  8. 2025, Graduate Education (Master's Program) , First Semester, Research
  9. 2025, Graduate Education (Master's Program) , Second Semester, Research
  10. 2025, Graduate Education (Master's Program) , 1Term, Medical Ethics A
  11. 2025, Graduate Education (Doctoral Program) , 3Term, Medical Ethics B
  12. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Genetic Medicine
  13. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Genetic Medicine
  14. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Genetic Medicine
  15. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Genetic Medicine
  16. 2025, Graduate Education (Master's Program) , First Semester, Basic Human Genetics Practice
  17. 2025, Graduate Education (Master's Program) , Second Semester, Clinical Genetics
  18. 2025, Graduate Education (Master's Program) , First Semester, Medical Genetics and Bioethics
  19. 2025, Graduate Education (Master's Program) , Second Semester, Genetic Counseling Basic Practice1
  20. 2025, Graduate Education (Master's Program) , First Semester, Genetic Counseling Applied Practice2
  21. 2025, Graduate Education (Master's Program) , First Semester, Genetic Counseling Practice
  22. 2025, Graduate Education (Master's Program) , Second Semester, Genetic Counseling Practice
  23. 2025, Graduate Education (Master's Program) , First Semester, Research on Genetic Counseling
  24. 2025, Graduate Education (Master's Program) , Second Semester, Research on Genetic Counseling

Research Activities

Academic Papers

  1. Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery, SURGERY, 153(3), 344-356, 201303
    Link to Paper Search Results by DOI
  2. Malignant mesothelioma originating in the hepatic falciform ligament : Report of a case, Surgery Today, 28, 929-931, 19980401
  3. A case of abdominal aortic aneurysm associated with systemic lupus erythematosus, Hiroshima J. Med. Sci., 47, 85-87, 19980401
  4. PREVENTION OF ACUTE EXACERBATION OF INTERSTITIAL PNEUMONIA AFTER VATS LUNG BIOPSY BY A SELECTIVE BRONCHIAL BLOCKADE, 15th International Congress of the European Association for Endoscopic Surgery(EAES), 20070705
  5. Recording the Senior Surgeon's Advice on an Operation Video Is an Efficient Way to Make Progress on Surgical Techniques, American College of Surgeons 93rd Annual (Clinical Congress ), 20071007
  6. A Laparoscopic Assisted Low Anterior Resection with Conventional Double Stapling Technique through the Minimum Incision, 16th Asian Congress of Surgery & Chinese Surgical Week 2007, 20071021
  7. Inhibition of Wnt signaling pathway by a novel axin-binding protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(47), 37030-37037, 20001124
    Link to Paper Search Results by DOI
  8. Generating somatic mosaicism with a Cre recombinase - microsatellite sequence transgene, NATURE METHODS, 5(3), 231-233, 200803
    Link to Paper Search Results by DOI
  9. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review, PEDIATRIC SURGERY INTERNATIONAL, 26(6), 649-654, 201006
    Link to Paper Search Results by DOI
  10. Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: expression of DSC2 in gastric cancer with intestinal phenotype, JOURNAL OF PATHOLOGY, 221(3), 275-284, 201007
    Link to Paper Search Results by DOI
  11. Immunohistochemical analysis of colorectal cancer with gastric phenotype: Claudin-18 is associated with poor prognosis, PATHOLOGY INTERNATIONAL, 60(10), 673-680, 201010
    Link to Paper Search Results by DOI
  12. CDX2 Regulates Multidrug Resistance 1 Gene Expression in Malignant Intestinal Epithelium, CANCER RESEARCH, 70(17), 6767-6778, 20100901
    Link to Paper Search Results by DOI
  13. Olfactomedin 4 (GW112, hGC-1) is an independent prognostic marker for survival in patients with colorectal cancer, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 1(1), 73-78, 2010
    Link to Paper Search Results by DOI
  14. Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 9, 20110321
    Link to Paper Search Results by DOI
  15. External Validation of Two Nomograms for Predicting Patient Survival After Hepatic Resection for Metastatic Colorectal Cancer, WORLD JOURNAL OF SURGERY, 35(10), 2275-2282, 201110
    Link to Paper Search Results by DOI
  16. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer, SURGERY TODAY, 41(10), 1370-1379, 201110
    Link to Paper Search Results by DOI
  17. SINGLE-INCISION LAPAROSCOPIC COLECTOMY USING THE GELPORT SYSTEM FOR EARLY COLON CANCER, SCANDINAVIAN JOURNAL OF SURGERY, 101(1), 16-20, 2012
    Link to Paper Search Results by DOI
  18. Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 27(10), 1339-1346, 201210
    Link to Paper Search Results by DOI
  19. Single-port laparoscopic colectomy versus conventional laparoscopic colectomy for colon cancer: a comparison of surgical results, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 20120424
    Link to Paper Search Results by DOI
  20. Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer, CANCER SCIENCE, 103(9), 1744-1750, 201209
    Link to Paper Search Results by DOI
  21. Primary lung cancer presenting with metastasis to the colon: a case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 20120628
    Link to Paper Search Results by DOI
  22. Reg IV Is a Direct Target of Intestinal Transcriptional Factor CDX2 in Gastric Cancer, PLOS ONE, 7(11), 20121102
    Link to Paper Search Results by DOI
  23. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery, LANGENBECKS ARCHIVES OF SURGERY, 398(6), 833-839, 201308
    Link to Paper Search Results by DOI
  24. Surgical treatment for isolated inguinal lymph node metastasis in lower rectal adenocarcinoma patients improves outcome, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 28(12), 1675-1680, 201312
    Link to Paper Search Results by DOI
  25. Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer, WORLD JOURNAL OF SURGERY, 37(12), 2935-2943, 201312
    Link to Paper Search Results by DOI
  26. Overexpression of Hypoxia Inducible Factor-1 Alpha is an Independent Risk Factor for Recurrence After Curative Resection of Colorectal Liver Metastases, ANNALS OF SURGICAL ONCOLOGY, 20, S527-S536, 201312
    Link to Paper Search Results by DOI
  27. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer, INTERNATIONAL JOURNAL OF CANCER, 134(8), 1926-1934, 20140415
    Link to Paper Search Results by DOI
  28. Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 29(2), 217-223, 201402
    Link to Paper Search Results by DOI
  29. Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13, 20150326
    Link to Paper Search Results by DOI
  30. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13, 20150424
    Link to Paper Search Results by DOI
  31. Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case-Control Study, ANNALS OF SURGICAL ONCOLOGY, 22(6), 2040-2050, 201506
    Link to Paper Search Results by DOI
  32. Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10(7), 20150717
    Link to Paper Search Results by DOI
  33. Oxaliplatin and molecular-targeted drug therapies improved the overall survival in colorectal cancer patients with synchronous peritoneal carcinomatosis undergoing incomplete cytoreductive surgery, SURGERY TODAY, 45(8), 986-992, 201508
    Link to Paper Search Results by DOI
  34. A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report, BMC MEDICAL GENETICS, 21(1), 20200701
    Link to Paper Search Results by DOI
  35. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral, JOURNAL OF BIOLOGICAL CHEMISTRY, 273(2), 814-821, 1998
  36. Malignant mesothelioma originating in the hepatic falciform ligament: Report of a case, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 28(9), 929-931, 1998
  37. Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis, ONCOGENE, 18(43), 5915-5922, 1999
  38. Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(44), 34399-34406, 2000
  39. Inhibition of Wnt signaling pathway by a novel axin-binding protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(47), 37030-37037, 2000
  40. Reduced CDX2 expression and high-frequency microsatellite instability in anaplastic carcinomas of the colon., MODERN PATHOLOGY, 14(1), 96A-96A, 2001
  41. Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(29), 26875-26882, 2001
  42. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon, AMERICAN JOURNAL OF PATHOLOGY, 159(6), 2239-2248, 2001
  43. L1-cadherin, a key transcriptional target of the CDX2 homeobox protein, GASTROENTEROLOGY, 122(4), A105-A105, 2002
  44. Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system, GUT, 51(2), 184-190, 2002
  45. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia, GASTROENTEROLOGY, 123(5), 1565-1577, 2002
  46. Impact of insulin resistance and hyperinsulin response on arterial stiffness, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 41(6), 309A-309A, 2003
  47. Silencing of CDX2 expression in colon cancer via a dominant repression pathway, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(45), 44608-44616, 2003
  48. Intravascular ultrasound-guided coronary artery stenting for spontaneous coronary artery dissection in a case of acute myocardial infarction associated with vasospasm in a non-culprit coronary artery during the hospitalization, INTERNAL MEDICINE, 45(12), 763-767, 2006
  49. Chlorinated drinking water alters carcinogenesis in a mice model of colon cancer, CANCER RESEARCH, 72, 2012
  50. CDX2 regulates expression of ceruloplasmin-related protein hephaestin in intestinal and colonic epithelium, GASTROENTEROLOGY, 126(4), A132-A132, 2004
  51. cis elements of the human CDX2 gene regulate expression of transgenes in mouse colonic epithelial cells, GASTROENTEROLOGY, 126(4), A133-A133, 2004
  52. Paradoxical peripheral embolism coincident with acute pulmonary thromboembolism, INTERNAL MEDICINE, 44(3), 243-245, 2005
  53. CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium, GASTROENTEROLOGY, 128(4), 946-961, 2005
  54. CDX2 and sonic hedgehog expression in intestinal metaplasia: the implication for gastric carcinogenesis, GASTROENTEROLOGY, 128(4), A351-A351, 2005
  55. Acute effect of atorvastatin on coronary circulation measured by transthoracic Doppler echocardiography in patients without coronary artery disease by angiography, AMERICAN JOURNAL OF CARDIOLOGY, 96(1), 89-91, 2005
  56. Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 24, 71-80, 2006
  57. Drosophila split ends homologue SHARP functions as a positive regulator of wnt/beta-catenin/T-cell factor signaling in neoplastic transformation, CANCER RESEARCH, 67(2), 482-491, 2007
  58. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation, CANCER RESEARCH, 67(20), 9721-9730, 2007
  59. Feasibility of a rapid protocol of 1-day single-isotope rest/adenosine stress Tc-99m sestamibi ECG-gated myocardial perfusion imaging, JOURNAL OF NUCLEAR CARDIOLOGY, 15(1), 35-41, 2008
  60. Generating somatic mosaicism with a Cre recombinase - microsatellite sequence transgene, NATURE METHODS, 5(3), 231-233, 2008
  61. Telmisartan, an angiotensin II type I receptor blocker, improves coronary microcirculation and insulin resistance among essential hypertensive patients without left ventricular hypertrophy, HYPERTENSION RESEARCH, 31(4), 615-622, 2008
  62. Abscess in the inguinal hernial sac after peritonitis surgery: A case report, WORLD JOURNAL OF GASTROENTEROLOGY, 15(8), 1007-1009, 2009
  63. Coronary flow reserve: a new target for treating hypertension Response, HYPERTENSION RESEARCH, 32(4), 317-317, 2009
  64. Retroperitoneal abscess complicated with necrotizing fasciitis of the thigh in a patient with sigmoid colon cancer, WORLD JOURNAL OF SURGICAL ONCOLOGY, 7, 2009
  65. Hybrid Hand-Assisted Colectomy for Transverse Colon Cancer: A Useful Technique for Non-Expert Laparoscopic Surgeons, WORLD JOURNAL OF SURGERY, 33(12), 2683-2687, 2009
  66. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review, PEDIATRIC SURGERY INTERNATIONAL, 26(6), 649-654, 2010
  67. Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 9, 2011
  68. External Validation of Two Nomograms for Predicting Patient Survival After Hepatic Resection for Metastatic Colorectal Cancer, WORLD JOURNAL OF SURGERY, 35(10), 2275-2282, 2011
  69. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer, SURGERY TODAY, 41(10), 1370-1379, 2011
  70. SINGLE-INCISION LAPAROSCOPIC COLECTOMY USING THE GELPORT SYSTEM FOR EARLY COLON CANCER, SCANDINAVIAN JOURNAL OF SURGERY, 101(1), 16-20, 2012
  71. Single-port laparoscopic colectomy versus conventional laparoscopic colectomy for colon cancer: a comparison of surgical results, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 2012
  72. Primary lung cancer presenting with metastasis to the colon: a case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 2012
  73. Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 27(10), 1339-1346, 2012
  74. Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery, SURGERY, 153(3), 344-356, 2013
  75. Multicenter matched case-control study comparing laparoscopic surgery with open surgery for elderly colon and rectal cancer patients, JOURNAL OF CLINICAL ONCOLOGY, 30(15), 2012
  76. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery, LANGENBECKS ARCHIVES OF SURGERY, 398(6), 833-839, 2013
  77. Surgical treatment for isolated inguinal lymph node metastasis in lower rectal adenocarcinoma patients improves outcome, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 28(12), 1675-1680, 2013
  78. Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer, WORLD JOURNAL OF SURGERY, 37(12), 2935-2943, 2013
  79. Overexpression of Hypoxia Inducible Factor-1 Alpha is an Independent Risk Factor for Recurrence After Curative Resection of Colorectal Liver Metastases, ANNALS OF SURGICAL ONCOLOGY, 20, S527-S536, 2013
  80. Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 29(2), 217-223, 2014
  81. Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13, 2015
  82. IMPACT OF INTRAOPERATIVE BLOOD LOSS ON MORBIDITY AND SURVIVAL AFTER RADICAL SURGERY FOR COLORECTAL CANCER PATIENTS AGED 80 YEARS OR OLDER., DISEASES OF THE COLON & RECTUM, 58(5), E366-E366, 2015
  83. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13, 2015
  84. Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case-Control Study, ANNALS OF SURGICAL ONCOLOGY, 22(6), 2040-2050, 2015
  85. A multi-institutional feasibility study of S-1/oxaliplatin (SOX) plus bevacizumab in patients with advanced/metastatic colorectal cancer: HiSCO-02 prospective phase II study., JOURNAL OF CLINICAL ONCOLOGY, 33(3), 2015
  86. Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10(7), 2015
  87. Oxaliplatin and molecular-targeted drug therapies improved the overall survival in colorectal cancer patients with synchronous peritoneal carcinomatosis undergoing incomplete cytoreductive surgery, SURGERY TODAY, 45(8), 986-992, 2015
  88. Predictive factor for toxicities and treatment termination in adjuvant capecitabine therapy for stage III colorectal cancer; based on the data of a randomized trial, JCOG0910, EUROPEAN JOURNAL OF CANCER, 51, S375-S375, 2015
  89. Significance of miR-148a in Colorectal Neoplasia: Downregulation of miR-148a Contributes to the Carcinogenesis and Cell Invasion of Colorectal Cancer, PATHOBIOLOGY, 82(5), 233-241, 2015
  90. Impact of intraoperative blood loss on morbidity and survival after radical surgery for colorectal cancer patients aged 80 years or older, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 31(2), 327-334, 2016
  91. Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 46(4), 310-315, 2016
  92. Causes of Cancer Death Among First-Degree Relatives in Japanese Families with Lynch Syndrome, ANTICANCER RESEARCH, 36(4), 1985-1989, 2016
  93. Chemotherapeutic outcomes for metastatic colorectal cancer in elderly patients aged >= 75 years: A single-institutional retrospective analysis, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 12(2), 151-158, 2016
  94. Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 21(4), 713-722, 2016
  95. Lower body mass index predicts worse cancer-specific prognosis in octogenarians with colorectal cancer, JOURNAL OF GASTROENTEROLOGY, 51(8), 779-787, 2016
  96. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer, ONCOGENESIS, 5, 2016
  97. Feasibility of laparoscopic total proctocolectomy with ileal pouch-anal anastomosis and total colectomy with ileorectal anastomosis for familial adenomatous polyposis: results of a nationwide multicenter study, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 21(5), 953-961, 2016
  98. Therapeutic approaches for patients with coexisting familial adenomatous polyposis and colorectal cancer, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 46(9), 819-824, 2016
  99. Childbirth after surgery for familial adenomatous polyposis in Japan, SURGERY TODAY, 47(2), 233-237, 2017
  100. Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency, PLOS ONE, 12(1), 2017
  101. Association between the age and the development of colorectal cancer in patients with familial adenomatous polyposis: a multi-institutional study, SURGERY TODAY, 47(4), 470-475, 2017
  102. Current status of prophylactic surgical treatment for familial adenomatous polyposis in Japan, SURGERY TODAY, 47(6), 690-696, 2017
  103. Influence of previous abdominal surgery on surgical outcomes between laparoscopic and open surgery in elderly patients with colorectal cancer: subanalysis of a large multicenter study in Japan, JOURNAL OF GASTROENTEROLOGY, 52(6), 695-704, 2017
  104. The treatment of desmoid tumors associated with familial adenomatous polyposis: the results of a Japanese multicenter observational study, SURGERY TODAY, 47(10), 1259-1267, 2017
  105. Prognostic impact of hospital volume on familial adenomatous polyposis: a nationwide multicenter study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 32(10), 1489-1498, 2017
  106. Multicenter phase II study of biweekly XELIRI plus bevacizumab as a second-line therapy in patients with metastatic colorectal cancer (JSWOG-C3 study), ANNALS OF ONCOLOGY, 28, 2017
  107. PREOPERATIVE SERUM OXIDATIVE STRESS LEVELS ARE ASSOCIATED WITH ABERRANT PCDH10 METHYLATION IN SERUM AND POOR CLINICAL OUTCOMES IN CURATIVELY RESECTED NODE-NEGATIVE NON-SMALL CELL LUNG, RESPIROLOGY, 22, 112-113, 2017
  108. Pten haploinsufficiency enhances carcinogenesis in mouse colon epithelium with Apc deficiency, CANCER SCIENCE, 109, 174-174, 2018
  109. Clinicopathological significance of RCAN-2 expression in gastric carcinoma, CANCER SCIENCE, 109, 1086-1086, 2018
  110. SURVIVAL BENEFIT OF LYMPH NODE DISSECTION IN SURGERY FOR COLON CNACER IN ELDERLY PATIENTS: A MULTICENTER POPEN-SITYY SCORE-MATCHED CASE-CONTROL STUDY IN JAPAN., DISEASES OF THE COLON & RECTUM, 61(5), E146-E146, 2018
  111. RIGHT-SIDED VS LEFT-SIDED COLORECTAL CNCER AFTER CURATIVE RESECTION IN PATIENTS OVER 80 YEARS OF AGE: AN ANALYSIS OF A LARGE MULTICENTER STUDY IN JAPAN, DISEASES OF THE COLON & RECTUM, 61(5), E227-E228, 2018
  112. Risk factors for postoperative pneumonia in elderly patients with colorectal cancer: a sub-analysis of a large, multicenter, case-control study in Japan, SURGERY TODAY, 48(8), 756-764, 2018
  113. Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum, SURGERY TODAY, 48(8), 810-814, 2018
  114. A colorectal cancer organoid library provides a promising screening tool for assessment of chemosensitivity, CANCER RESEARCH, 77, 2017
  115. Construction of Integrated Database of Clinical and Genetic Information for Lynch syndrome in Japan, CANCER SCIENCE, 109, 779-779, 2018
  116. Identification of pathways associated with tumor invasion in mouse model for colon cancer with Pten haploinsufficiency, CANCER SCIENCE, 109, 1236-1236, 2018
  117. Clinicopathological significance of ADAM28 expression in colorectal cancer, CANCER SCIENCE, 109, 1346-1346, 2018
  118. Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review, SURGERY TODAY, 49(1), 72-81, 2019
  119. Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review, WORLD JOURNAL OF SURGICAL ONCOLOGY, 17, 2019
  120. Clinicopathological significance of RCAN2 production in gastric carcinoma, HISTOPATHOLOGY, 74(3), 430-442, 2019
  121. BRAF(V600E) mutation and loss of CDX2 synergize in serrated colorectal tumorigenesis, CANCER RESEARCH, 78(13), 2018
  122. Expression analysis of transcribed-ultraconserved regions in cancer stem cell population using colorectal cancer organoids, CANCER RESEARCH, 78(13), 2018
  123. Pten haploinsufficiency promotes tumor invasion and carcinogenesis in mouse colon epithelium with Apc deficiency, CANCER RESEARCH, 78(13), 2018
  124. Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model, PLOS ONE, 14(6), 2019
  125. CLINICOPATHOLOGICAL CHARACTERISTICS OF UPPER TRACT UROTHELIAL CANCER WITH LOSS OF IMMUNOHISTOCHEMICAL EXPRESSION OF MISMATCH REPAIR PROTEINS IN UNIVERSAL SCREENING, JOURNAL OF UROLOGY, 203, E1246-E1246, 2020
  126. A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report, BMC MEDICAL GENETICS, 21(1), 2020
  127. Oncogenic mutation in RAS-RAF axis leads to increased expression ofGREB1, resulting in tumor proliferation in colorectal cancer, CANCER SCIENCE, 2020
  128. Antithrombin attenuates the progression of hepatocellular carcinoma by regulating neutrophil/interleukin-8 signaling, HEPATOLOGY RESEARCH, 2020
  129. BACTERIOLOGICAL INVESTIGATION OF BILE IN PATIENTS WITH CHOLELITHIASIS, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 23(5), 390-395, 1993
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External Funds

Acceptance Results of Competitive Funds

  1. 2018/04/01, 2021/03/31
  2. KAKENHI, 2013, 2016
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  3. KAKENHI, Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis, 2010, 2013
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  4. KAKENHI, Generation of intestinal epithelial cell line from induced pluripotent stem cell and establishment of colorectal cancer stem cell model, 2010, 2011
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  5. KAKENHI, Mouse model of colonic adenoma-carcinoma progression, 2007, 2008
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Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, Frontier Oncology, 1
  2. International J Cancer, 1
  3. Surgical Case Reports, 3
  4. 2020, Japanese Journal of Clinical Oncology, 2
  5. 2020, Surgery Today, 1
  6. 2020, Asia-Pacific Journal of Clinical Oncology, 1
  7. 2019, Surgical Case Reports, 1
  8. 2019, Japanese Journal of Clinical Oncology, 1
  9. 2019, Journal of Cellular and Molecular Medicine, 1
  10. 2019, Cancer Science, 1
  11. 2019, Cancer Medicine, 1
  12. 2019, Asian Journal of Endoscopic Surgery, 1