TAKUYA IMAMURA

Last Updated :2023/06/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
timamurahiroshima-u.ac.jp
Self-introduction
We are currently working for elucidating the species-dependent mechanisms of non-coding RNA-directed epigenome formation in mammals.

Basic Information

Academic Degrees

  • Ph.D., D.V.M., University of Tokyo

Educational Activity

  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology

Research Fields

  • Agricultural sciences;Animal life science;Integrative animal science
  • Biology;Basic biology;Genetics / Chromosome dynamics

Research Keywords

  • sexual differentiation
  • evolution
  • biodiversity

Educational Activity

Course in Charge

  1. 2023, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  2. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  3. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  4. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  5. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  6. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  7. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  8. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  9. 2023, Liberal Arts Education Program1, 1Term, Fundamentals of Biology
  10. 2023, Liberal Arts Education Program1, 3Term, Introduction to Biology
  11. 2023, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  12. 2023, Undergraduate Education, 1Term, Seminar on Biological Science
  13. 2023, Undergraduate Education, 2Term, Advanced Biology
  14. 2023, Undergraduate Education, 2Term, Animal Physiology B
  15. 2023, Undergraduate Education, Second Semester, Seminar for Molecular Physiology
  16. 2023, Undergraduate Education, First Semester, Special Study for Graduation
  17. 2023, Undergraduate Education, Second Semester, Special Study for Graduation
  18. 2023, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  19. 2023, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  20. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  21. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
  22. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
  23. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  24. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  25. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  26. 2023, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science

Research Activities

Academic Papers

  1. Concomitant downregulation of neuropeptide genes in a marine snail with consecutive sexual maturation after a nuclear disaster in Japan., Frontiers in Endocrinology, 14(1129666), 20230310
    Link to Paper Search Results by DOI
  2. SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia, Pharmacology Research and Perspectives, 20211022
    Link to Paper Search Results by DOI
  3. Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development, Genes and Development, 20211021
    Link to Paper Search Results by DOI
  4. Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation, Journal of Reproduction and Development, 20211007
    Link to Paper Search Results by DOI
  5. The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development, Essays in Biochemistry, EBC20200143, 20210730
    Link to Paper Search Results by DOI
  6. Generation of ovarian follicles from mouse pluripotent stem cells., Science, 373(6552), eabe0237, 20210716
    Link to Paper Search Results by DOI
  7. MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling., Cell Reports, 35, 109124, 20210518
    Link to Paper Search Results by DOI
  8. Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice., 66, 369, 20200426
    Link to Paper Search Results by DOI
  9. Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice., The Journal of reproduction and development, 66, 359, 20200420
    Link to Paper Search Results by DOI
  10. Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells., Stem cell research, 44, 101749, 2020
    Link to Paper Search Results by DOI
  11. Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion., Neuron, 101(3), 472-485, 20190206
    Link to Paper Search Results by DOI
  12. Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration, Cell and Tissue Research, 371(1), 189-199, 20180101
    Link to Paper Search Results by DOI
  13. DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells, CELL REPORTS, 20(12), 2992-3003, 201709
    Link to Paper Search Results by DOI
  14. Evolutionary acquisition of promoterassociated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals, BMC GENOMICS, 18(1), 285, 201704
    Link to Paper Search Results by DOI
  15. Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method, Methods in Molecular Biology, 1605, 83-103, 2017
  16. Manipulation of promoter-associated noncoding RNAs in mouse early embryos for controlling sequence-specific epigenetic status, Methods in Molecular Biology, 1543, 271-282, 2017
  17. Reconstitution in vitro of the entire cycle of the mouse female germ line, NATURE, 539(7628), 299-+, 201611
  18. Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells, NUCLEIC ACIDS RESEARCH, 44(11), 5105-5122, 201606
  19. miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes, CELL REPORTS, 12(11), 1887-1901, 201509
  20. Gene activation-associated long noncoding RNAs function in mouse preimplantation development, DEVELOPMENT, 142(5), 910-920, 201503
  21. Identification of Hypothalamic Arcuate Nucleus-Specific Enhancer Region of Kiss1 Gene in Mice, MOLECULAR ENDOCRINOLOGY, 29(1), 121-129, 201501
  22. Epigenetic setting and reprogramming for neural cell fate determination and differentiation, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369(1652), 201409
  23. Roles of Epigenetics in the Neural Stem Cell and Neuron, Epigenetics in Psychiatry, 51-78, 20140620
  24. Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals, BMC GENOMICS, 15, 35, 201401
  25. Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(20), E1294-E1301, 201205
  26. Single-stranded Noncoding RNAs Mediate Local Epigenetic Alterations at Gene Promoters in Rat Cell Lines, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(40), 34788-34799, 201110
  27. Epigenetic setting for long-term expression of estrogen receptor a and androgen receptor in cells, HORMONES AND BEHAVIOR, 59(3), 345-352, 201103
  28. Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats, JOURNAL OF PHYSIOLOGICAL SCIENCES, 61(2), 103-113, 201103
  29. Epigenetic processes in a tetraploid mammal, MAMMALIAN GENOME, 19(6), 439-447, 200806
  30. Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo, JOURNAL OF BIOLOGICAL CHEMISTRY, 280(20), 20171-20175, 200505
  31. Identification of genetic and epigenetic similarities of SPHK1/Sphk1 in mammals, JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(11), 1387-1393, 200411
  32. Non-coding RNA directed DNA demethylation of Sphk1 CpG island, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 322(2), 593-600, 200409
  33. Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development, BMC MOLECULAR BIOLOGY, 5(4), 4, 200406
  34. Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice, GENES TO CELLS, 7(9), 961-969, 200209
  35. CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons, GENOMICS, 76(1-3), 117-125, 200108
  36. Generation and characterization of a monoclonal antibody recognizing a fetal brain enriched O-linked sialoglycoprotein, FOG100, JOURNAL OF BIOCHEMISTRY, 124(3), 534-539, 199809
  37. Molecular cloning of rat leukemia inhibitory factor receptor alpha-chain gene and its expression during pregnancy, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1353(3), 266-276, 199709

Publications such as books

  1. 2021/08/21, Roles of epigenetics in the neural stem cell and neuron. In: Jacob Peedicayil, Dennis Grayson, Dimitri Avramopoulos (eds) Epigenetics in Psychiatry, Academic Press, 英語, Naoki Yamamoto, Masahiro Uesaka, Takuya Imamura, Kinichi Nakashima, 978-0-12-823577-5, 816, 53-85

Invited Lecture, Oral Presentation, Poster Presentation

  1. Evolutionary acquisition of lncRNAs involved in the diversification of mammalian brains, Takuya IMAMURA, KBRI Seminar, 2023/03/30, With Invitation, English, Korean Brain Research Institute, Daegu
  2. Species difference in structure and function of COMMD3-BMI1 loci in human/mouse neural stem cells, Arisa Makimura, Tomonori Kameda, Boyang An, Akari Ando, Mayuri Tokunaga, Fumihiro Morishita, Takuya Imamura, MBSJ2022, 2022/11/30, Without Invitation, Japanese, MBSJ, Makuhari Messe (Chiba)
  3. Evolutionary acquisition of gene-activation-associated lncRNA involved in the diversification of mammalian brains, Takuya Imamura, RNA Frontier Meeting 2022, 2022/10/12, With Invitation, English, RNA Frontier Meeting, Suita, Osaka
  4. Functional alteration of neural stem cell behavior upon acquisition of human-specific promoter-associated non-coding RNA (pancRNA), Takuya Imamura, ASN-PSJ 2022, 2022/09/18, Without Invitation, Japanese, Kyoto, Japan
  5. Epilepsy-associated gene EFHC1 regulates neural stem cell behavior through human-specific noncoding RNA-mediated gene activation, Sota Nishida, Boyang An, Arisa Makimura, Fumihiro Morishita, Takuya Imamura, The 115th SRD meeting, 2022/09/13, Without Invitation, Japanese
  6. Involvement of human PRTG in neural stem cell proliferation and predicton of PRTG upstream gene, Naoyuki Kishida, Boyang An, Hiroto Akuta, Fumihiro Morishita, Risako Nakai, Masanori Imamura, Takuya Imamura, The 115th SRD meeting, 2022/09/13, Without Invitation, Japanese
  7. The human-specific pancTMEM25-TMEM25, a molecular pair involved in the expansion of the cerebral cortex, Boyang An, Akari Ando, Fumihiro Morishita, Takuya Imamura, The 115th SRD meeting, 2022/09/13, Without Invitation, English
  8. Differential regulation of human and mouse neural stem cells mediated by species-specific promoter-associated non-coding RNAs (pancRNAs), Takuya Imamura, Boyang An, Akari Ando, Arisa Makimura, Mayuri Tokunaga, Tatsuya Ueki, Fumihiro Morishita, Neuro2022, 2022/07/02, Without Invitation, English, Ginowan, Japan
  9. Deciphering the functional difference between human and chimpanzee neural stem cells development from transcriptomes of iPS-derived cells, Hiroto Akuta, Risako Nakai, Mayu Hirata, Kenji Ichiyanagi, Masanori Imamura, Takuya Imamura, The 15th Annnual Meeting of the Japanese Society for Epigenetics, 2022/06/09, Without Invitation, Japanese
  10. Human-specific pancCD63-CD63 pair contribute to the generation of basal neural progenitors forevolutionary expansion of cerebral cortex, Boyang An, Tomonori Kameda, Takuya Imamura, 55th Annual Meeting of the Japan Society of Developmental Biologist, 2022/06/01, Without Invitation, English, Kanazawa, Japan
  11. UCP2/Ucp2 can control the number of neural stem/progenitor cells to differentiate mouse and human brain development, Akari Ando, Boyang An, Mayuri Tokunaga, Arisa Makimura, Fumihiro Morishita,Tomonori Kameda, Takuya Imamura, 55th Annual Meeting of the Japan Society of Developmental Biologist, 2022/06/01, Without Invitation, English, Kanazawa, Japan
  12. Discovery of a species-specific long non-coding RNA for differentiating expression of human NRSN2 and mouse Nrsn2 in neural stem cells, Mayuri Tokunaga , Boyang An , Akari Ando , Arisa Makimura , Fumihiro Morishita , Tomonori Kameda , Takuya Imamura, The 80th Fujiwara Seminar "Molecular and cellular mechanisms of brain systems generating individuality", 2021/08/30, Without Invitation, English
  13. Potentials of UCP2/Ucp2 for developing brain individuality through metabolic reprogramming of neural stem cells, Akari Ando, Boyang An, Mayuri Tokunaga, Arisa Makimura, Fumihiro Morishita, Tomonori Kameda, Takuya Imamura, The 80th Fujiwara Seminar "Molecular and cellular mechanisms of brain systems generating individuality", 2021/08/30, Without Invitation, English
  14. Species difference in structure and function of a gene for epigenome modification, BMI1/Bmi1, in human/mouse neural stem cells, Arisa Makimura, Boyang An, Akari Ando, Mayuri Tokunaga, Fumihiro Morishita,Tomonori Kameda, Takuya Imamura, The 80th Fujiwara Seminar "Molecular and cellular mechanisms of brain systems generating individuality", 2021/08/30, Without Invitation, English
  15. The human-specific pancCD63-CD63 pair can be involved in developing brain individuality by promoting basal progenitor proliferation, Boyang An, Tomonori Kameda, Takuya Imamura, The 80th Fujiwara Seminar "Molecular and cellular mechanisms of brain systems generating individuality", 2021/08/30, Without Invitation, English
  16. Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation, Takuya IMAMURA, The 14th Annual Meeting for Japanese Developmental Neuroscientists, 2021/03/19, Without Invitation, Japanese
  17. Molecular characterization of aging choroid plexus that regulates neural stem cells behavior and brain functions, 2020/12/02, Without Invitation, Japanese
  18. Utilizing ncRNA-regulated genes towards functional recovery of the fetal mouse brain exposed to maternal inflammation, Takuya IMAMURA, "Understanding environmental responses of neural cells towards development of brain disorder treatment", The 43rd Annual Meeting of the Japan Neuroscience Society, 2020/08/01, Without Invitation, Japanese, Japan Neuroscience Society, Web