TAKUYA IMAMURA

Last Updated :2021/07/26

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
timamurahiroshima-u.ac.jp
Self-introduction
We are currently working for elucidating the species-dependent mechanisms of non-coding RNA-directed epigenome formation in mammals.

Basic Information

Research Keywords

  • sexual differentiation
  • evolution
  • biodiversity

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  2. 2021, Undergraduate Education, 1Term, Seminar on Biological Science
  3. 2021, Undergraduate Education, 2Term, Advanced Biology
  4. 2021, Undergraduate Education, 2Term, Animal Physiology B
  5. 2021, Undergraduate Education, Second Semester, Seminar for Molecular Physiology
  6. 2021, Undergraduate Education, First Semester, Special Study for Graduation
  7. 2021, Undergraduate Education, Second Semester, Special Study for Graduation
  8. 2021, Graduate Education (Doctoral Program) , First Semester, Seminar for Molecular Physiology
  9. 2021, Graduate Education (Doctoral Program) , Second Semester, Seminar for Molecular Physiology
  10. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Basic Biology A
  11. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Basic Biology A
  12. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Basic Biology B
  13. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Basic Biology B
  14. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Biomedical Science A
  15. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Biomedical Science A
  16. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  17. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  18. 2021, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  19. 2021, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  20. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Biomedical Science B
  21. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Biomedical Science B
  22. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  23. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. Generation of ovarian follicles from mouse pluripotent stem cells., Science, 373(6552), eabe0237, 20210716
  2. MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling., Cell Reports, 35, 109124, 20210518
  3. Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice., The Journal of reproduction and development, 20200426
  4. Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice., The Journal of reproduction and development, 20200420
  5. Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells., Stem cell research, 44, 101749-101749, 20200228
  6. Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion., Neuron, 101(3), 472-485, 20190206
  7. Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration, Cell and Tissue Research, 371(1), 189-199, 20180101
  8. DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells, CELL REPORTS, 20(12), 2992-3003, 201709
  9. Evolutionary acquisition of promoterassociated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals, BMC GENOMICS, 18(1), 285, 201704
  10. Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method, Methods in Molecular Biology, 1605, 83-103, 2017
  11. Manipulation of promoter-associated noncoding RNAs in mouse early embryos for controlling sequence-specific epigenetic status, Methods in Molecular Biology, 1543, 271-282, 2017
  12. Reconstitution in vitro of the entire cycle of the mouse female germ line, NATURE, 539(7628), 299-+, 201611
  13. Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells, NUCLEIC ACIDS RESEARCH, 44(11), 5105-5122, 201606
  14. miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes, CELL REPORTS, 12(11), 1887-1901, 201509
  15. Gene activation-associated long noncoding RNAs function in mouse preimplantation development, DEVELOPMENT, 142(5), 910-920, 201503
  16. Identification of Hypothalamic Arcuate Nucleus-Specific Enhancer Region of Kiss1 Gene in Mice, MOLECULAR ENDOCRINOLOGY, 29(1), 121-129, 201501
  17. Epigenetic setting and reprogramming for neural cell fate determination and differentiation, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369(1652), 201409
  18. Roles of Epigenetics in the Neural Stem Cell and Neuron, Epigenetics in Psychiatry, 51-78, 20140620
  19. Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals, BMC GENOMICS, 15, 35, 201401
  20. Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(20), E1294-E1301, 201205
  21. Single-stranded Noncoding RNAs Mediate Local Epigenetic Alterations at Gene Promoters in Rat Cell Lines, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(40), 34788-34799, 201110
  22. Epigenetic setting for long-term expression of estrogen receptor a and androgen receptor in cells, HORMONES AND BEHAVIOR, 59(3), 345-352, 201103
  23. Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats, JOURNAL OF PHYSIOLOGICAL SCIENCES, 61(2), 103-113, 201103
  24. Epigenetic processes in a tetraploid mammal, MAMMALIAN GENOME, 19(6), 439-447, 200806
  25. Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo, JOURNAL OF BIOLOGICAL CHEMISTRY, 280(20), 20171-20175, 200505
  26. Identification of genetic and epigenetic similarities of SPHK1/Sphk1 in mammals, JOURNAL OF VETERINARY MEDICAL SCIENCE, 66(11), 1387-1393, 200411
  27. Non-coding RNA directed DNA demethylation of Sphk1 CpG island, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 322(2), 593-600, 200409
  28. Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development, BMC MOLECULAR BIOLOGY, 5(4), 4, 200406
  29. Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice, GENES TO CELLS, 7(9), 961-969, 200209
  30. CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons, GENOMICS, 76(1-3), 117-125, 200108
  31. Generation and characterization of a monoclonal antibody recognizing a fetal brain enriched O-linked sialoglycoprotein, FOG100, JOURNAL OF BIOCHEMISTRY, 124(3), 534-539, 199809
  32. Molecular cloning of rat leukemia inhibitory factor receptor alpha-chain gene and its expression during pregnancy, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1353(3), 266-276, 199709

Invited Lecture, Oral Presentation, Poster Presentation

  1. Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation, Takuya IMAMURA, The 14th Annual Meeting for Japanese Developmental Neuroscientists, 2021/03/19, Without Invitation, Japanese
  2. Molecular characterization of aging choroid plexus that regulates neural stem cells behavior and brain functions, 2020/12/02, Without Invitation, Japanese
  3. Utilizing ncRNA-regulated genes towards functional recovery of the fetal mouse brain exposed to maternal inflammation, Takuya IMAMURA, "Understanding environmental responses of neural cells towards development of brain disorder treatment", The 43rd Annual Meeting of the Japan Neuroscience Society, 2020/08/01, Without Invitation, Japanese, Japan Neuroscience Society, Web